cAMP

亜型選択性的な製品

cAMP製品

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• cAMP阻害剤 (12)
• cAMP抗体(1)
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• cAMP作動薬(1)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2449	Forskolin (Colforsin)	コルホルチン (Forskolin (Colforsin)) は、広範な細胞腫における真核生物のアデニル酸シクラーゼ (adenylate cyclase, AC) の遍在する活性化因子であり、細胞生理学の研究において cAMP のレベルを上げるために一般的に使用されています。ホルスコリン (Forskolin) は、PXR と FXR も活性化します。 ホルスコリンはオートファジー (autophagy) を刺激します。	Cell Host Microbe, 2025, 33(3):408-419.e8 Gut, 2025, gutjnl-2025-336105 Cell Stem Cell, 2025, S1934-5909(25)00265-6
S8283	SQ22536	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.	J Cachexia Sarcopenia Muscle, 2025, 16(3):e13853 J Cachexia Sarcopenia Muscle, 2025, 16(3):e13853 J Ethnopharmacol, 2025, 347:119679
S7499	ESI-09	ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.	Pharmacol Res, 2025, 211:107562 J Biol Chem, 2023, 299(6):104749 J Biol Chem, 2023, 299(6):104749
S8415	PACAP 1-38	PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.	Int J Biol Sci, 2025, 21(6):2824-2842 Biomed Pharmacother, 2024, 179:117427 Invest Ophthalmol Vis Sci, 2022, 63(3):18
S4552	Bithionol	Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.	iScience, 2023, 10.1016/j.isci.2023.106661 Cancer Lett, 2020, 479:100-111 Inflammation, 2019, 42(5):1530-1541
S8416	PACAP 6-38 acetate	PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.	Front Immunol, 2021, 12:714244
S7500	HJC0350	HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.	J Mol Cell Biol, 2019, 11(5):395-407
F1121	ATF3 Antibody [B23E24]	ATF3 Rabbit mAb detects endogenous levels of total ATF3 protein. Stimulation may be required to allow detection of the target protein due to low levels of endogenous expression in some samples. Please see images below for recommended treatment conditions and positive controls.
F0681	EPAC2 Antibody [P2D3]	EPAC2 Rabbit mAb recognizes endogenous levels of total EPAC2 protein.
F0573	EPAC1 Antibody [A3P21]
A2385	Zelminemab (Anti-PAC1)	Zelminemab (AMG-301) is a human monoclonal antibody that inhibits the PACAP type I (PAC1) receptor. MW: 145.5 kD.
S3382	ESI-05	ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation.
E6418New	MDL12330A	MDL12330A is an inhibitor of adenylyl cyclase that blocks vasopressin-induced short-circuit current (SCC). It also inhibits cAMP phosphodiesterase, which may mask its effect on adenylyl cyclase.
S8414	PACAP 1-27	Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
S0837	HJC0197	HJC0197 is a selective Epac1/2 dual antagonists with an IC50 of 5.9 μM for Epac2.
S6850	NE 52-QQ57	NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).	Exp Hematol Oncol, 2024, 13(1):13
S6478	Fipexide hydrochloride	Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
S0451	ST034307	ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
E6044New	3-O-Methylquercetin	3-O-Methylquercetin is a flavone isolated from Rhamnus nakaharai Hayata (Rhamnaceae), an inhibitor of cAMPand cGMP-phosphodiesterases(PDE) with an IC50 of 13.8 μM and 14.3 μM respectively. It also inhibits β-secretase with an IC50 of 6.5 μM. It exhibits antiviral activity and has been used in folk medicine for constipation, inflammation, tumors, and asthma.
S8415	PACAP 1-38	PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.	Int J Biol Sci, 2025, 21(6):2824-2842 Biomed Pharmacother, 2024, 179:117427 Invest Ophthalmol Vis Sci, 2022, 63(3):18
S8283	SQ22536	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.	J Cachexia Sarcopenia Muscle, 2025, 16(3):e13853 J Cachexia Sarcopenia Muscle, 2025, 16(3):e13853 J Ethnopharmacol, 2025, 347:119679
S7499	ESI-09	ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.	Pharmacol Res, 2025, 211:107562 J Biol Chem, 2023, 299(6):104749 J Biol Chem, 2023, 299(6):104749
S4552	Bithionol	Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.	iScience, 2023, 10.1016/j.isci.2023.106661 Cancer Lett, 2020, 479:100-111 Inflammation, 2019, 42(5):1530-1541
S8416	PACAP 6-38 acetate	PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.	Front Immunol, 2021, 12:714244
S7500	HJC0350	HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.	J Mol Cell Biol, 2019, 11(5):395-407
S3382	ESI-05	ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation.
E6418New	MDL12330A	MDL12330A is an inhibitor of adenylyl cyclase that blocks vasopressin-induced short-circuit current (SCC). It also inhibits cAMP phosphodiesterase, which may mask its effect on adenylyl cyclase.
S8414	PACAP 1-27	Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
S6850	NE 52-QQ57	NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).	Exp Hematol Oncol, 2024, 13(1):13
S6478	Fipexide hydrochloride	Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
S0451	ST034307	ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
E6044New	3-O-Methylquercetin	3-O-Methylquercetin is a flavone isolated from Rhamnus nakaharai Hayata (Rhamnaceae), an inhibitor of cAMPand cGMP-phosphodiesterases(PDE) with an IC50 of 13.8 μM and 14.3 μM respectively. It also inhibits β-secretase with an IC50 of 6.5 μM. It exhibits antiviral activity and has been used in folk medicine for constipation, inflammation, tumors, and asthma.
A2385	Zelminemab (Anti-PAC1)	Zelminemab (AMG-301) is a human monoclonal antibody that inhibits the PACAP type I (PAC1) receptor. MW: 145.5 kD.
S2449	Forskolin (Colforsin)	コルホルチン (Forskolin (Colforsin)) は、広範な細胞腫における真核生物のアデニル酸シクラーゼ (adenylate cyclase, AC) の遍在する活性化因子であり、細胞生理学の研究において cAMP のレベルを上げるために一般的に使用されています。ホルスコリン (Forskolin) は、PXR と FXR も活性化します。 ホルスコリンはオートファジー (autophagy) を刺激します。	Cell Host Microbe, 2025, 33(3):408-419.e8 Gut, 2025, gutjnl-2025-336105 Cell Stem Cell, 2025, S1934-5909(25)00265-6
S0837	HJC0197	HJC0197 is a selective Epac1/2 dual antagonists with an IC50 of 5.9 μM for Epac2.
S8415	PACAP 1-38	PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.	Int J Biol Sci, 2025, 21(6):2824-2842 Biomed Pharmacother, 2024, 179:117427 Invest Ophthalmol Vis Sci, 2022, 63(3):18
E6418New	MDL12330A	MDL12330A is an inhibitor of adenylyl cyclase that blocks vasopressin-induced short-circuit current (SCC). It also inhibits cAMP phosphodiesterase, which may mask its effect on adenylyl cyclase.
E6044New	3-O-Methylquercetin	3-O-Methylquercetin is a flavone isolated from Rhamnus nakaharai Hayata (Rhamnaceae), an inhibitor of cAMPand cGMP-phosphodiesterases(PDE) with an IC50 of 13.8 μM and 14.3 μM respectively. It also inhibits β-secretase with an IC50 of 6.5 μM. It exhibits antiviral activity and has been used in folk medicine for constipation, inflammation, tumors, and asthma.

cAMPシグナル伝達経路