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Cuproptosis

Cuproptosis製品

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S1052 Elesclomol (STA-4783) Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.Elesclomol (STA-4783) is a potent copper ionophore and can be used in the research of copper-dependent cell death (cuproptosis).
Nat Commun, 2025, 16(1):212
Cell Prolif, 2025, e70101.
J Transl Med, 2025, 23(1):127
Elesclomol-S105201Y0120140521.gif
E1166 Tetrathiomolybdate (TM) Tetrathiomolybdate (TM) is used in the clinic for the treatment of Wilson’s disease by inducing dimerization of the metal-binding domain of the cellular copper efflux protein ATP7B (WLN4) through a unique sulfur-bridged Mo2S6O2 cluster.
Phytomedicine, 2025, 143:156883
J Exp Clin Cancer Res, 2024, 43(1):68
Cell Death Dis, 2024, 15(2):149
E1166 Tetrathiomolybdate (TM) Tetrathiomolybdate (TM) is used in the clinic for the treatment of Wilson’s disease by inducing dimerization of the metal-binding domain of the cellular copper efflux protein ATP7B (WLN4) through a unique sulfur-bridged Mo2S6O2 cluster.
Phytomedicine, 2025, 143:156883
J Exp Clin Cancer Res, 2024, 43(1):68
Cell Death Dis, 2024, 15(2):149
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