DAPK

DAPK製品

All (4)
DAPK阻害剤 (4)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S1113	GSK690693	GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.	Cancer Res, 2023, 83(19):3237-3251 Biomed Pharmacother, 2023, 158:114176 Cancer Metab, 2023, 11(1):26
E1120	TC-DAPK 6	TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor with IC50 of 69 and 225 nM against DAPK1 and DAPK3, respectively.
E1346^New	HS94	HS94 (DAPK3 inhibitor HS94) is a selective inhibitor of DAPK3 with Ki of 126 nM, >20-fold selectivity over Pim kinases.
E1345^New	HS148	HS148 (DAPK3 inhibitor HS148) is a selective inhibitor of DAPK3 with Ki of 119 nM	J Immunol, 2021, 206 (9): 2061–2074
S1113	GSK690693	GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.	Cancer Res, 2023, 83(19):3237-3251 Biomed Pharmacother, 2023, 158:114176 Cancer Metab, 2023, 11(1):26
E1120	TC-DAPK 6	TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor with IC50 of 69 and 225 nM against DAPK1 and DAPK3, respectively.
E1346^New	HS94	HS94 (DAPK3 inhibitor HS94) is a selective inhibitor of DAPK3 with Ki of 126 nM, >20-fold selectivity over Pim kinases.
E1345^New	HS148	HS148 (DAPK3 inhibitor HS148) is a selective inhibitor of DAPK3 with Ki of 119 nM	J Immunol, 2021, 206 (9): 2061–2074
E1346^New	HS94	HS94 (DAPK3 inhibitor HS94) is a selective inhibitor of DAPK3 with Ki of 126 nM, >20-fold selectivity over Pim kinases.
E1345^New	HS148	HS148 (DAPK3 inhibitor HS148) is a selective inhibitor of DAPK3 with Ki of 119 nM	J Immunol, 2021, 206 (9): 2061–2074

DAPK阻害剤の選択性比較