Neprilysin antagonist | Neprilysin inhibitor | Neprilysin agonist

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抗体

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S7678	Sacubitril/valsartan (LCZ696)	Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.	Biomed Pharmacother, 2023, 162:114569 FEBS J, 2023, 290(8):2180-2198 Oxid Med Cell Longev, 2022, 2022:5009289
S3388	Sacubitrilat	Sacubitrilat (Sac, LBQ-657) is an active inhibitor of neprilysin (NEP).
E4454^New	DL-Thiorphan	Thiorphan (DL-3-Mercapto-2-benzylpropanoylglycine) is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM. It is also a potent inhibitor of enkephalinase, with antinociceptive activity.
S4426	Sacubitril hemicalcium salt	Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).
S7678	Sacubitril/valsartan (LCZ696)	Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.	Biomed Pharmacother, 2023, 162:114569 FEBS J, 2023, 290(8):2180-2198 Oxid Med Cell Longev, 2022, 2022:5009289
S3388	Sacubitrilat	Sacubitrilat (Sac, LBQ-657) is an active inhibitor of neprilysin (NEP).
E4454^New	DL-Thiorphan	Thiorphan (DL-3-Mercapto-2-benzylpropanoylglycine) is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM. It is also a potent inhibitor of enkephalinase, with antinociceptive activity.
S4426	Sacubitril hemicalcium salt	Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).
E4454^New	DL-Thiorphan	Thiorphan (DL-3-Mercapto-2-benzylpropanoylglycine) is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM. It is also a potent inhibitor of enkephalinase, with antinociceptive activity.

Neprilysin

Neprilysin製品

Neprilysin阻害剤の選択性比較