Insulin (human)

製品コード：S6955 純度：99.99%

Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg.

Amino-acid Sequence

Insulin regular

CAS No. 11061-68-0

サイズ	価格(税別)	在庫状況
25mg	JPY 22000	国内在庫なし(納期7~10日)
バルクサイズ	バルク特価あり

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製品安全説明書

現在のバッチを見る：純度： 99.99%

99.99

化学情報

保管	3 years -20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			１ケ月-20°Cin solvent

In vitro
Batch:

0.01M HCl : 13 mg/mL

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo Batch: Add solvents to the product individually and in order.				投与溶液組成計算機
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.500mg/ml (0.43mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.400mg/ml (0.07mM)	Taking the 1 mL working solution as an example, add 50 μL of 8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

生物活性

製品説明	Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg.

In vitro
In vitro	Insulin (human), an inducer of AKT phosphorylation, reduces the levels of LC3-II, VP1 by the AKT-AMPKMAPK-MTOR pathway in SVV-infected cells.^[2]
細胞実験	細胞株	BHK-21 cells and PK-15 cells
	濃度	200 ng/ml
	反応時間	1 h
	実験の流れ	BHK-21 cells and PK-15 cells are grown to 80% confluence in well plates and pretreated with insulin (human) (200 ng/ml) for 1 h. The pretreated cells are then infected with SVV for 1 h. The cells are then washed with phosphate-buffered saline (PBS) and incubated with new medium containing the same chemical reagents. Cell viability in the presence of this compound is tested.

参考
https://pubmed.ncbi.nlm.nih.gov/26537234/ https://pubmed.ncbi.nlm.nih.gov/34757844/

参考

https://pubmed.ncbi.nlm.nih.gov/26537234/
https://pubmed.ncbi.nlm.nih.gov/34757844/

製品情報

Molecular Formula	C₂₅₇H₃₈₃N₆₅O₇₇S₆
Molecular Weight	5807.57
CAS No.	11061-68-0
Storage (From the date of receipt)	3 years -20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)