Peroxidases

亜型選択性的な製品

Peroxidases製品

All (17)
Peroxidases阻害剤 (14)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S8155	RSL3	RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.	Nature, 2024, 626(7998):411-418. Nat Commun, 2024, 15(1):1429 Cell Rep Med, 2024, 5(3):101471
S0788	ML 210	ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity.	Sci Adv, 2024, 10(7):eadk1835 Redox Biol, 2023, 62:102678 Redox Biology, 2023, Volume 62
S9803	Elamipretide (MTP-131, SS-31)	Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.	BMC Biol, 2024, 22(1):33 bioRxiv, 2024, 2024.02.22.581432 Geroscience, 2023, 10.1007/s11357-023-00845-y
S1988	Propylthiouracil	Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.	J Biol Chem, 2020, jbc.RA120.015020 BMC Neurosci, 2015, 16:33
S4452	ML162	ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis.	Sci Adv, 2024, 10(7):eadk1835 Int J Mol Sci, 2023, 24(2)1667 Cell Metab, 2022, S1550-4131-2200411-9
S0018	Verdiperstat	Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.	J Chromatogr B Analyt Technol Biomed Life Sci, 2021, 1181:122924
S6648	PF-06282999	PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.	J Chromatogr B Analyt Technol Biomed Life Sci, 2021, 1181:122924
S9874	4-Aminobenzohydrazide	4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells.	Front Bioeng Biotechnol, 2022, 10:855755
E1375^New	JKE-1674	JKE-1674 is an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. It is an orally active inhibitor of glutathione peroxidase 4 (GPX4) and also is an active metabolite of GPX4 inhibitor ML-210. JKE-1674 can convert into a nitrile oxide JKE-1777.
E0471	Alkyne tyramide	Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe, substantially improves APEX-labeling efficiency in intact yeast cells, also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins.
S0316	MPO-IN-28	MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM.
S6822	TMB dihydrochloride	TMB dihydrochloride (3,3',5,5'-Tetramethylbenzidine dihydrochloride hydrate, TMB-d, BM blue, Sure Blue TMB) is an excellent colorimetric substrate for detection of horseradish peroxidase (HRP) labeled probes and is used in staining procedures in immunohistochemistry and in enzyme-linked immunosorbent assays (ELISA).
S4966	4-Methylesculetin	4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.
S6106	3-Chloro-L-tyrosine	3-Chloro-L-tyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
S3298	Caulophylline (N-Methylcytisine)	Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.
S3274	Glucosyl-vitexin	Glucosyl-vitexin (Glucosylvitexin), the major C-glycosylflavone present in millet, inhibits thyroid peroxidase (TPO) activity.
S3299	Demethyleneberberine	Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.
S8155	RSL3	RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.	Nature, 2024, 626(7998):411-418. Nat Commun, 2024, 15(1):1429 Cell Rep Med, 2024, 5(3):101471
S0788	ML 210	ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity.	Sci Adv, 2024, 10(7):eadk1835 Redox Biol, 2023, 62:102678 Redox Biology, 2023, Volume 62
S9803	Elamipretide (MTP-131, SS-31)	Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.	BMC Biol, 2024, 22(1):33 bioRxiv, 2024, 2024.02.22.581432 Geroscience, 2023, 10.1007/s11357-023-00845-y
S1988	Propylthiouracil	Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.	J Biol Chem, 2020, jbc.RA120.015020 BMC Neurosci, 2015, 16:33
S4452	ML162	ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis.	Sci Adv, 2024, 10(7):eadk1835 Int J Mol Sci, 2023, 24(2)1667 Cell Metab, 2022, S1550-4131-2200411-9
S0018	Verdiperstat	Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.	J Chromatogr B Analyt Technol Biomed Life Sci, 2021, 1181:122924
S6648	PF-06282999	PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.	J Chromatogr B Analyt Technol Biomed Life Sci, 2021, 1181:122924
S9874	4-Aminobenzohydrazide	4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells.	Front Bioeng Biotechnol, 2022, 10:855755
E1375^New	JKE-1674	JKE-1674 is an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. It is an orally active inhibitor of glutathione peroxidase 4 (GPX4) and also is an active metabolite of GPX4 inhibitor ML-210. JKE-1674 can convert into a nitrile oxide JKE-1777.
S0316	MPO-IN-28	MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM.
S4966	4-Methylesculetin	4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.
S3298	Caulophylline (N-Methylcytisine)	Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.
S3274	Glucosyl-vitexin	Glucosyl-vitexin (Glucosylvitexin), the major C-glycosylflavone present in millet, inhibits thyroid peroxidase (TPO) activity.
S3299	Demethyleneberberine	Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.
E1375^New	JKE-1674	JKE-1674 is an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. It is an orally active inhibitor of glutathione peroxidase 4 (GPX4) and also is an active metabolite of GPX4 inhibitor ML-210. JKE-1674 can convert into a nitrile oxide JKE-1777.

Peroxidases阻害剤の選択性比較