β-Nicotinamide Mononucleotide

別名：β-NM, NMN

製品コード：S5259 純度：99.95%

Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.

CAS No. 1094-61-7

サイズ	価格(税別)	在庫状況
25mg	JPY 22000	国内在庫あり
100mg	JPY 56500	国内在庫あり
500mg	JPY 145500	国内在庫あり
1g	JPY 220500	国内在庫あり

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

文献中Selleckの製品使用例（17）

製品安全説明書

現在のバッチを見る：純度： 99.95%

99.95

β-Nicotinamide Mononucleotideと併用されることが多い化合物

Nicotinamide N-oxide

β-Nicotinamide Mononucleotide and Nicotinamide N-oxide are the precursors of NAD+.

Nicotinamide Riboside Chloride

β-Nicotinamide Mononucleotide and Nicotinamide Riboside Chloride do not produce any gross lesions in Sprague-Dawley rats when administered orally.

Turner J, et al. Front Pharmacol. 2021 Nov 11;12:749727.

MDL-800

β-Nicotinamide Mononucleotide and MDL-800 promote DNA repair, alleviate SARS‐CoV‐2 infection and disease severity in vitro and in vivo.

Jin R, et al. Aging Cell. 2022 Dec;21(12):e13729.

KPT 9274 (ATG-019)

β-Nicotinamide Mononucleotide provides protection against KPT-9274-induced cytotoxicity.

Neggers JE, et al. Nat Commun. 2018 Feb 5;9(1):502.

Selisistat (EX 527)

Selisistat (EX 527) reverses the protective effect of β-Nicotinamide Mononucleotide against memory dysfunction, inflammatory and oxidative injuries.

Li HR, et al. Redox Biol. 2023 Jul;63:102745.

β-Nicotinamide Mononucleotide関連製品

関連製品	BAPTA-AM Mitotane ATP disodium Rat IgG2b isotype control-InVivo Bendamustine Deferiprone Blebbistatin Methyl-β-cyclodextrin (MβCD) Dexrazoxane AP-III-a4 (ENOblock) 5-Aminolevulinic acid HCl Carbazochrome sodium sulfonate (AC-17) Ursolic Acid Mesna Amifostine trihydrate Guadecitabine (SGI-110) Osthole NAD+ 4-Methylumbelliferone (4-MU) Dioscin L-carnitine (Levocarnitine) Ethidium bromide Pitstop 2 Sesamin Bilobalide Formononetin Hesperidin Palmitic acid Azeliragon (TTP488) L-Mimosine Ademetionine Carbenoxolone Sodium Gadodiamide Hydrate GO-203 Vitexin N6022 Dp44mT Chlorogenic Acid Sphingosine Chrysin Coenzyme Q10 (CoQ10) Spermine Tetrahydrochloride 2-NBDG 2-NBDG D-Lin-MC3-DMA (MC3) L-Glutamine Morin Hydrate Ethylenediaminetetraacetic acid Silibinin (NSC 651520) (+)-Fangchinoline Tyloxapol Bergenin Spermine NB 598 DMNQ Trabectedin (20S)Ginsenoside Rg2 Thiostrepton Farrerol EGCG Octaacetate D-(+)-Trehalose dihydrate Reboxetine mesylate Eprodisate disodium E7820 Gadopentetate Dimeglumine MYLS22 Hydroxytyrosol Evofosfamide (TH-302) Bromhexine HCl Gadodiamide 5-hydroxytryptophan (5-HTP) Inosine D-Mannose Anethole trithione Edetate calcium disodium DMF(N,N-Dimethylformamide) Iodoacetamide Sodium Nitroprusside Dihydrate Alendronic Acid 2,4-Pyridinedicarboxylic acid Ropivacaine Risedronate Sodium GSK805 Betaine ADP Acipimox Curcumin analog C1 Clodronate Disodium Trimetazidine 2'-Deoxyadenosine monohydrate 2,2,2-Tribromoethanol Polaprezinc N-Acetylneuraminic acid Quinacrine Dihydrochloride Dihydrate L-methionine Brucine Glycine Tranexamic Acid Stigmasterol Oleanonic Acid Substance P TFA Ginsenoside Rg3 Iopromide NSI-189 SR8278 Lycopene Lactulose Trometamol hydrochloride 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) Cilastatin Ureidosuccinic acid Hydrochlorothiazide Tea polyphenol Fructose (+)-JQ1 carboxylic acid Ligustilide Polybrene (Hexadimethrine Bromide) Taurocholic acid sodium salt hydrate Pinoresinol diglucoside 4-HNE (4-Hydroxynonenal) Iron Dextran Enoxaparin sodium Urea Methimazole Metolazone Sodium Picosulfate IM-54 Hydroxypropyl Cellulose Disufenton sodium Troxipide Orcinol glucoside Diludine 20R-Camptothecin (+)-Usniacin 3-Indolebutyric acid (IBA) HEPES Cremophor EL BMS-986176 DTT (Dithiothreitol) Esculin Norethindrone Methyl Eugenol Polyinosinic acid-polycytidylic acid D-Mannitol L-(-)-Glucose 1-Hydroxy-2-naphthoic acid Azomycin 3-Hydroxybenzoic acid Emlenoflast (MCC-7840) β-Alanine Alendronate sodium trihydrate β-Sitosterol Sorbitol Rat IgG1 isotype control-InVivo Magnesium lactate trihydrate Aminomalonic acid Helecin BRM/BRG1 ATP Inhibitor-1 23-Hydroxybetulinic acid PZ-2891 Meglumine L-Lactic acid Toosendanin 1,2-Propanediol Epibrassinolide Cyanidin-3-O-glucoside chloride Dihydrotanshinone I Hydrocortisone butyrate Gracillin Sodium Pyruvate Itaconic acid FH1 Cinnamic acid Guanidine HCl Diroximel Fumarate Triethylenetetramine (Trientine) 2HCl Molsidomine Calcium D-saccharate tetrahydrate Creatine monohydrate Oxybenzone D-Glucose 6-phosphate disodium salt DL-Dopa Indocyanine green FPH1 Glycochenodeoxycholic acid 5'-Adenylic acid Acetamide ML329 Pterostilbene Kinetin Acetyl Resveratrol GSK4112 LTI-291 Pramoxine HCl Plantamajoside Anhydroicaritin BZ1 Difluprednate Phloretic acid Anemoside B4 Avobenzone EGTA Sucralose 6-Chloropurine Glucosamine hydrochloride Sinoacutine 2,4-Dihydroxyacetophenone Stearic acid Stevioside Morin PMPA tetrasodium salt Monocrotaline Creatine phosphate disodium salt L-Hydroorotic acid Cholic acid Irigenin Dextrose Behenic Acid Metaxalone CTX-0294885 Fudosteine Magnesium chloride (R)-(-)-JQ1 Enantiomer β-Estradiol 17-Acetate 2'-Deoxyguanosine monohydrate L-Tryptophanamide Hydrochloride β-Cyclodextrin 3-Indolepropionic acid DL-Citrulline L-arginine Sclareol Ibandronate sodium monohydrate Talc Methyl protocatechuate Sodium nitroprusside Risedronate N-Nitrosodiethylamine Deoxyaconitine N-Acetyl-L-methionine Ethanolamine hydrochloride Sinapine thiocyanate Sodium succinate Senkyunolide A L-Tryptophan Swertiamarin Octyl gallate Brassinazole	もっと見る
関連化合物ライブラリー	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ Express-Pick Library	もっと見る

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	活性情報	PMID
MC3T3-E1	Cell viability assay	0.1, 1, 10 mM	6 h	AlCl3-induced reduction of MC3T3-E1 cell viability was successfully recovered by NMN treatment.	30292833
HepG2	Cell viability assay	0.5 mM	48 h	NMN was able to restore reduced NAD concentrations but not cell viability after stimulation with palmitate.	28974242
HL60 cells	Function assay	80 mM		syrosingopine-metformin-treated HL60 cells grown in medium supplemented with NMN had a partial recovery in ATP levels	30540938
他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

生物活性

製品説明	Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.

In Vitro
In vitro	Nicotinamide mononucleotide, the NAD+ precursor, rescues the NAD+/NADH ratio and exerts anti-senescent effects by activating SIRT1.^[1]
細胞実験	細胞株	mouse AT2 cells strain MLE-12
	濃度	500 μM
	反応時間	--
	実験の流れ	The mouse AT2 cells strain MLE-12 are cultured in DMEM with 10% FBS at 37 ℃ in a humidified atmosphere containing 5% CO₂. Cells are treated with rapamycin (10 nM), bafilomycin (5 nM), 3 MA (3 mM), SRT1720 (4 μM), Ex527 (10 μM), NMN (500 μM), Olaparib (40 μM) and mitoquinone (50 nM). β-galactosidase staining is performed based on the manufacture s instructions. Relative protein expression levels are measured by Western blot. The level of NAD+/NADH is quantified by an NAD+/NADH detection kit.

In Vivo
In Vivo	NMN reduces the loss of cochlear hair cells caused by cisplatin and improves hearing in C57BL/6 mice, by supplementation of NAD+ through de novo and salvage synthesis pathways.^[2]
動物実験	動物モデル	C57BL/6 mice
	投与量	100 mg/kg
	投与経路	i.g., i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試験 (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06036355	Not yet recruiting	Postoperative Prevention of Tumor	Shanghai Cell Therapy Group Co.Ltd	September 30 2023	Early Phase 1
NCT05759468	Recruiting	Type2diabetes\|Diabetic Kidney Disease	Brigham and Women''s Hospital\|Boston Medical Center	April 13 2023	Phase 2
NCT05789355	Recruiting	Sickle Cell Disease	LGD\|CEN Biotech\|Assistance Publique Hopitaux De Marseille\|Etablissement Français du Sang	April 1 2023	Not Applicable
NCT04910061	Completed	Healthy Volunteers	Seneque SA\|Dicentra Inc.\|LGD	August 5 2021	Not Applicable

参考
[1] Zhang Y, et al. Free Radic Biol Med. 2021 Apr;166:116-127. [2] Zhan T, et al. Toxicol Lett. 2021 Oct 1;349:115-123.

参考

化学情報

分子量	334.22	化学式	C₁₁H₁₅N₂O₈P
CAS No.	1094-61-7	SDF	--
Smiles	C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N
保管	3 years -20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
保管	3 years -20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1个月-20°Cin solvent

In vitro
Batch:

Water : 67 mg/mL

DMSO : Insoluble ( 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

希釈計算器分子量計算器

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量 mg/kg 動物平均体重 g 投与体積（動物毎）μL 動物数匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

* 必須

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):