Dihydrotestosterone (DHT)

製品コード:S4757 別名:androstanolone, stanolone, 5α-DHT

For research use only.

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.

Dihydrotestosterone (DHT)化学構造

CAS No. 521-18-6

サイズ 価格(税別)
10mM (1mL in DMSO) JPY 26000
JPY 24600
JPY 55200

代表番号: 03-5615-9297|電子メール:[email protected]
よく尋ねられる質問

文献中Selleckの製品使用例(17)

製品安全説明書

Androgen Receptor阻害剤の選択性比較

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生物活性

製品説明 Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.
ターゲット
Androgen Receptor [1]
体外試験

In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increased the expression of EGFR and ERBB2 both in mRNA and in protein levels. DHT additionally upregulated the levels of phosphorylation of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment, in AR-positive cells[1].

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV-1 cell MU\GeY5kfGmxbjDhd5NigQ>? Ml7ZRYdwdmm|dHnjJIFkfGm4aYT5JEhGSzVyKTDh[4FqdnO2IHj1cYFvKGGwZILv[4VvKHKnY3XweI9zKGW6cILld5Nm\CCrbjDDWk0yKGOnbHysJGVEPTB;MD6wNFYh|ryP NFT1fHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEexOVM1Lz57OEexOVM1RC:jPh?=
MDA-MB-453 cell MonGSpVv[3Srb36gZZN{[Xl? NGjZ[nVFcXOybHHj[Y1mdnRib3[gX|NJZUSKVDDmdo9uKGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCPRFGtUWIuPDV|IHPlcIx{KGK7IIfoc4xmKGOnbHygdoVk\XC2b4KgZolv\GmwZzDhd5NigSxiS3m9NE4xODB{IN88US=> MomzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyM{SxNVcoRjF5MEO0NVE4RC:jPh?=
HepG2 cell M1nWVmZ2dmO2aX;uJIF{e2G7 NYf6XG96SWO2aY\peJkh[WejaX7zeEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHjeIl3[XSrb36sJGlEPTB;MD6wNVgzKM7:TR?= NYrOS5IyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOFk5PjZpPkG3NVQ6QDZ4PD;hQi=>
MDA453 cell MXnGeY5kfGmxbjDhd5NigQ>? NIjVdHNFcXOybHHj[Y1mdnRib3[gX|NJZUSKVDDmdo9uKGi3bXHuJGFTKGmwIF3ERVQ2OyClZXzsd{whU2l;MD6wNFMh|ryP NXjlV2dbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPDFpPkG3NVgyOTRzPD;hQi=>
mouse C2C12 cell NGj3d4xHfW6ldHnvckBie3OjeR?= MUjB[49vcXO2IHHjeIl3cXS7IHH0JJJifCCDUjD0doFve2[nY4Tl[EBqdiCvb4Xz[UBEOkNzMjDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0xNjB{ODFOwG0> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG0NUc,OTdzOEGxOFE9N2F-
monkey COS7 cell M1nYW2Z2dmO2aX;uJIF{e2G7 M{TLUmJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKG2xbnvlfUBEV1N5IHPlcIx{KGK7IIfoc4xmKGOnbHygZolv\GmwZzDhd5NigSxiS3m9NE4xODB{IN88US=> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR2MkmxNkc,OTh2NEK5NVI9N2F-
CHO cell M3LXb2Z2dmO2aX;uJIF{e2G7 MYXB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGTHVlUh\XiycnXzd4VlKGmwIFPIU{Bk\WyuczDifUBtfWOrZnXyZZNmKGG|c3H5MEBGSzVyPUSuOFkh|ryP NUW2T2puRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFczQTRpPkG4N|A4Ojl2PD;hQi=>
COS7 cell NVvQZ5B2TnWwY4Tpc44h[XO|YYm= M1j3NWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgW|c1OUNibYX0ZY51KGW6cILld5Nm\CCrbjDDU3M4KGOnbHzzJIF{e2W|c3XkJIF{KGy3Y3nm[ZJie2ViYXP0bZZqfHliYX\0[ZIhOjRiaILzJIJ6KHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMUKg{txO M1XnS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEm0Nlc6Lz5{MkC5OFI4QTxxYU6=
COS7 cell NX7LN|QzTnWwY4Tpc44h[XO|YYm= NXTDWmRESWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBVQDd5QTDteZRidnRiZYjwdoV{e2WmIHnuJGNQWzdiY3XscJMh[XO|ZYPz[YQh[XNibIXjbYZmemG|ZTDhZ5Rqfmm2eTDh[pRmeiB{NDDodpMh[nlicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkCxOUDPxE1? NUnXXYg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwPVQzPzlpPkKyNFk1Ojd7PD;hQi=>
COS7 cell MkOySpVv[3Srb36gZZN{[Xl? MWrB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEV1N5IHPlcIx{KGG|c3Xzd4VlKGG|IHz1Z4ln\XKjc3WgZYN1cX[rdImgZYZ1\XJiMkSgbJJ{KGK7IILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6wNFYzKM7:TR?= Ml;yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUSyO|koRjJ{MEm0Nlc6RC:jPh?=
LNCaP-hr cell NGHYPIhHfW6ldHnvckBie3OjeR?= MmXDN{Bl[Xm| MkGzRYdwdmm|dDDhZ5Rqfmm2eTDheEBCdmS{b3flckBz\WOncITvdkBVQDd5QTDteZRidnRiaX6gbJVu[W5iTF7DZXAucHJiY3XscJMh[XO|ZYPz[YQh[XNicILvd5RifGVic4DlZ4lncWNiYX70bYdmdiC|ZXPy[ZRqd25ibXXhd5Vz\WRiYX\0[ZIhOyCmYYnzJIJ6KGWweont[U1qdW23bn;hd5NigSxiRVO1NF0xNjBzNTFOwG0> MkHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzOUm0O|coRjJ|MUm5OFc4RC:jPh?=
LNCaP-hr cell NX;EUmlJTnWwY4Tpc44h[XO|YYm= MmTFN{Bl[Xm| NF7CfGtC\2:waYP0JIFkfGm4aYT5JIF1KHerbHSgeJlx\SCDbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCOTlPhVE1peiClZXzsd{Bie3Onc4Pl[EBieyCycn;zeIF1\SC|cHXjbYZq[yCjboTp[4VvKHOnY4LleIlwdiCvZXHzeZJm\CCjZoTldkA{KGSjeYOgZpkh\W68eX3lMYludXWwb3Hzd4F6NCCHQ{WwQVAvODB4MjFOwG0> NUm0c3NtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPVk1PzdpPkKzNVk6PDd5PD;hQi=>
HEK293 cell NV7lXIRQTnWwY4Tpc44h[XO|YYm= MmjFRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjF6IH7N Mo\KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MEW2PFgoRjJ3M{C1Olg5RC:jPh?=
COS MkjhSpVv[3Srb36gZZN{[Xl? MXrCbY5lcW6pIHHm[olvcXS7IHHnZYlve3RiQX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIFPPV{Bk\WyuczygT4khRSByLkCwNkDPxE1w MlfRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTh5MUWzOEc,QTh5MUWzOFww[T5?
COS-1 NXLlSGtvTnWwY4Tpc44h[XO|YYm= NXGwfoFXSmmwZHnu[{Bi\m[rbnn0fUBnd3JiaIXtZY4hSW6mcn;n[Y4hemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPPV{0yKGOnbHzzMEBMcSB;IECuNFA{KM7:TT6= NH\rN4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OUK1O|I2Lz57OUK1O|I2RC:jPh?=
CV-1 M2DGWGZ2dmO2aX;uJIF{e2G7 MmG3RYdwdmm|dDDhZ5Rqfmm2eTDh[4FqdnO2IFj1cYFvKEGwZILv[4VvKHKnY3XweI9zKGW6cILld5Nm\CCrbjDDWk0yKGOnbHzzMEBGSzVyIE2gNE4xODVizszNMi=> MnzEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTl{NUeyOUc,QTl{NUeyOVww[T5?
COS NFSxW4pHfW6ldHnvckBie3OjeR?= MX\JckB3cXS{bzDibY5lcW6pIHHm[olvcXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IITyZY5{\mWldHXkJIlvfG9iQ1;TJINmdGy|LjygTWM2OCB;IECuNFA1KM7:TT6= NET2XIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEKzNFYzQCd-MUCyN|A3Ojh:L3G+
CV-1 NEjobnBHfW6ldHnvckBie3OjeR?= M4P3U2lvKH[rdILvJIFod26rc4TpZ{Bi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IIXzbY5oKGOxdILhcpNn\WO2aX;uJIF{e2G7IHnuJGNXNTFiY3XscJMvNCCHQ{WwJF0hOC5yME[g{txONg>? NWXYTVlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCyN|A3OjhpPkGwNlMxPjJ6PD;hQi=>
CV-1 NIj0c2FHfW6ldHnvckBie3OjeR?= MWfB[49vcXO2IHHjeIl3cXS7IITvJJRp\SCqdX3hckBidmS{b3flckBz\WOncITvdkApcEGUKTDpckBEXi1zIHPlcIx{NCCHQ{WwJF0hOC5yME[g{txONg>? NXHCXFljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCzOFA3OjRpPkGwN|QxPjJ2PD;hQi=>
CV1 MonCSpVv[3Srb36gZZN{[Xl? MmixRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDpckBEXjFiY3XscJMhdWWjc4Xy[YQh[XNic4TpcZVt[XSrb36gc4YhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIFkfGm4aYT5JIJ6KGOxdILhcpNn\WO2aX;uJIF{e2G7LDDFR|UxKD1iMD6wNFUyKM7:TT6= NIj5SHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{CzOFEyPyd-MUewN|QyOTd:L3G+
CV1 NHXzNVNHfW6ldHnvckBie3OjeR?= MoDyRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hS1ZzIHPlcIx{NCCNaTC9JFAvODByMjFOwG0v MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ3N{izPEc,OTd{NUe4N|g9N2F-
CV1 MWXGeY5kfGmxbjDhd5NigQ>? NX\WXWJNSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ2[xJINmdGy|LDDFR|UxKD1iMD6wNFUyKM7:TT6= NVnjeIpRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyOVc5OzhpPkG3NlU4QDN6PD;hQi=>
MDA-MB-453 MmjHSpVv[3Srb36gZZN{[Xl? NHW2[YpFcXOybHHj[Y1mdnRib3[gX|NJZUSKVDDmdo9uKGi3bXHuJGFTKGW6cILld5Nm\CCrbjDNSGEuVUJvNEWzJINmdGy|LDDLbUA:KDBwMECwN{DPxE1w NUHL[IVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N|kyOTJpPkG3OFM6OTF{PD;hQi=>
CV1 M4PheGZ2dmO2aX;uJIF{e2G7 M4\QfGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOYMTDj[YxteyCkeTD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwMEC1O{DPxE1w NXH4SINoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N|kyOTJpPkG3OFM6OTF{PD;hQi=>
CV1 NUTuO3lXTnWwY4Tpc44h[XO|YYm= M3:1fGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOYMTDj[YxteyCkeTD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwMEC1O{DPxE1w M2HseFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{CzPVM5Lz5zN{ewN|k{QDxxYU6=
MDA-MB-453 NXXmcpJiTnWwY4Tpc44h[XO|YYm= MmjwSIl{eGyjY3Xt[Y51KG:oIGuzTH1FUFRiZoLvcUBpfW2jbjDBcoRzd2enbjDy[YNmeHSxcjDpckBpfW2jbjDNSGEuVUJvNEWzJINmdGy|LDDLbUA:KDBwMECwPUDPxE1w MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRyMES5PUc,OTh2MEC0PVk9N2F-
CV1 NGHub|JHfW6ldHnvckBie3OjeR?= M3zu[mFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgbY4hS1ZzIHPlcIx{KGK7IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5yMEW3JO69VS5? M2LIW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NECwOFk6Lz5zOESwNFQ6QTxxYU6=
Saos2 M1;1TGZ2dmO2aX;uJIF{e2G7 MV;BZ5Rqfmm2eTDheEBidmS{b3flckBz\WOncITvdkBqdiCqdX3hckBU[W:|MjDj[YxteyCjc4Pld5Nm\CCjczDJUFYhemWycnXzd4lwdixiSVO1NEA:KDBwMECwNFUh|ryPLh?= NWPoT4sxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFI6OTJpPkG4OFQzQTF{PD;hQi=>
CV1 M4LGTmZ2dmO2aX;uJIF{e2G7 NW\MPVNDSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBi\nKrY3HuJIdz\WWwIH3vcotmgSCFVkGgZ4VtdHNiYomgZ491emGwc3\lZ5Rqd25iYYPzZZktKEWFNUCgQUAxNjByNUGg{txONg>? MmnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NEK5NVIoRjF6NESyPVEzRC:jPh?=
MDA-kb2 NXHBdnR2TnWwY4Tpc44h[XO|YYm= NWHsR41zSWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCPRFGtb4IzKGOnbHzzJIF{e2W|c3XkJIF{KHO2aX31cIF1cW:wIH;mJIx2[2moZYLhd4Uh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzF3MDC9JFAvODByNTFOwG0v NHXpeWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW5NlI1PSd-MUm1PVIzPDV:L3G+
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アッセイ
Methods Test Index PMID
Western blot Cyclin D1 / Cyclin D2 / Cyclin D3 / Cyclin E2 / Cyclin A1 / AR ; p-CDK2 / CDK2 / CDK4 / CDK6 / CDKN1A / p-RB / RB ; p27 / p-p27 ; AR / PP1 26372468 22139837 26636645
Immunofluorescence FOXO1 / p27 ; AKT(S473) / PKCα(S657) 22139837
体内試験 DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior as assessed by rota-rod and gait analyses, and an increased lifespan[2].

お薦めの試験操作(参考用のみ)

細胞試験:

[1]

  • 細胞株:Bladder cancer cells
  • 濃度: 1 nM
  • 反応時間:24 h
  • 実験の流れ:

    Bladder cancer cells at a density of 50-60% confluence in 24-well plates are co-transfected with 250 ng of MMTV-luc reporter plasmid DNA and 2.5 ng of PRL-TK-luc plasmid DNA. After 6 h of transfection, the medium is replaced with another medium supplemented with charcoal-stripped FBS in the presence or absence of ligands (DHT, HF, or both) for 24 h. Cells were harvested, lysed, and assayed for luciferase activity.

動物試験:

[2]

  • 動物モデル:SOD1-G93A mutant mice with the congenic C57BL/6J background
  • 投薬量:5 mg
  • 投与方法:silastic implant

溶解度 (25°C)

体外

化学情報

分子量 290.44
化学式

C19H30O2

CAS No. 521-18-6
Storage 3年 -20°C
2年 -80°C in solvent
Smiles CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4O)C

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

便利ツール

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04989972 Withdrawn Drug: PSIL428|Dietary Supplement: Oyster mushroom Anxiety and Depression Wake Network Inc.|Professor Roger Gibson Section of Psychiatry Faculty of Medical Sciences UWI September 15 2022 Phase 2
NCT05033444 Recruiting Drug: PRV-002|Drug: Placebo Traumatic Brain Injury (TBI) Odyssey Group International Inc.|Avance Clinical Pty Ltd. September 17 2021 Phase 1
NCT05042895 Recruiting Procedure: Group A|Procedure: Group B Infertility Woman''s Health University Hospital Egypt August 20 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

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