ホスホリパーゼ(e.g. PLA)

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1110 Varespladib (LY315920) <1 mg/mL 76 mg/mL <1 mg/mL
S4089 Halobetasol Propionate <1 mg/mL 97 mg/mL 38 mg/mL
S4255 Quinacrine 2HCl 53 mg/mL 14 mg/mL 28 mg/mL
S6522 ST 271 <1 mg/mL 54 mg/mL 54 mg/mL
S3220 Trigonelline -1 mg/mL 50 mg/mL -1 mg/mL
S0766 RHC 80267 <1 mg/mL 79 mg/mL '79 mg/mL
S7321 FIPI <1 mg/mL 45 mg/mL <1 mg/mL
S8011 U73122 <1 mg/mL 0.01 mg/mL <1 mg/mL
S6564 ML348 <1 mg/mL 83 mg/mL 10 mg/mL
S2390 Polydatin <1 mg/mL 78 mg/mL <1 mg/mL
S7520 Darapladib (SB-480848) <1 mg/mL 100 mg/mL 100 mg/mL
S7609 GW4869 <1 mg/mL <1 mg/mL <1 mg/mL
S2364 Tanshinone I <1 mg/mL 23 mg/mL <1 mg/mL
S4107 Clofazimine <1 mg/mL 5 mg/mL <1 mg/mL
S0053 CAY10593 (VU0155069) <1 mg/mL 30 mg/mL <1 mg/mL

Phospholipase (e.g. PLA)製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1110

Varespladib (LY315920)

Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.

S4089

Halobetasol Propionate

Halobetasol Propionate (BMY-30056, CGP-14458) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.

S4255

Quinacrine 2HCl

Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.

S6522

ST 271

ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.

S3220

Trigonelline

Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.

S0766

RHC 80267

RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) with IC50 of 4 μM in canine platelets. RHC-80267 inhibits the hydrolysis of phosphatidylcholine (PC) and cholinesterase activity with IC50 of 4 μM. RHC 80267 is also an inhibitor of COX.

S7321

FIPI

FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively.

S8011

U73122

U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO).

S6564

ML348

ML348 is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.

S2390

Polydatin

Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.

S7520

Darapladib (SB-480848)

Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.

S7609

GW4869

GW4869 (GW69A, GW554869A) is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM.

S2364

Tanshinone I

Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.

S4107

Clofazimine

Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.

S0053

CAY10593 (VU0155069)

CAY10593 (VU0155069) is a selective phospholipase D1 (PLD1) antagonist that impairs human P2X7 acivation.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1110

Varespladib (LY315920)

Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.

S4089

Halobetasol Propionate

Halobetasol Propionate (BMY-30056, CGP-14458) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.

S4255

Quinacrine 2HCl

Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.

S6522

ST 271

ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.

S3220

Trigonelline

Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.

S0766

RHC 80267

RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) with IC50 of 4 μM in canine platelets. RHC-80267 inhibits the hydrolysis of phosphatidylcholine (PC) and cholinesterase activity with IC50 of 4 μM. RHC 80267 is also an inhibitor of COX.

S7321

FIPI

FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively.

S8011

U73122

U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO).

S6564

ML348

ML348 is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.

S2390

Polydatin

Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.

S7520

Darapladib (SB-480848)

Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.

S7609

GW4869

GW4869 (GW69A, GW554869A) is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM.

S2364

Tanshinone I

Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S4107

Clofazimine

Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.

2020, acsinfecdis.0c00486

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S0053

CAY10593 (VU0155069)

CAY10593 (VU0155069) is a selective phospholipase D1 (PLD1) antagonist that impairs human P2X7 acivation.