ホスホリパーゼ(e.g. PLA)
シグナル伝達経路
研究分野
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1110 | Varespladib (LY315920) | <1 mg/mL | 76 mg/mL | <1 mg/mL |
| S4089 | Halobetasol Propionate | <1 mg/mL | 97 mg/mL | 38 mg/mL |
| S4255 | Quinacrine 2HCl | 53 mg/mL | 14 mg/mL | 28 mg/mL |
| S8011 | U73122 | <1 mg/mL | 0.01 mg/mL | <1 mg/mL |
| S2390 | Polydatin | <1 mg/mL | 78 mg/mL | <1 mg/mL |
| S7520 | Darapladib (SB-480848) | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S2364 | Tanshinone I | <1 mg/mL | 23 mg/mL | <1 mg/mL |
| S4107 | Clofazimine | <1 mg/mL | 5 mg/mL | <1 mg/mL |
Phospholipase (e.g. PLA)製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1110 |
Varespladib (LY315920)Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3. |
Hepatic immune cell infiltration in Mmp2 −/− mice administered the pan-sPLA 2 inhibitor varespladib (10 mg/kg per day, gavage, for 5 days). Collagenase-treated and liberated cells were surface-stained for indicated markers (A) and quantitated. n=3 WT and n=5 Mmp2 −/−. *P≤0.05 vs WT untreated. † P≤0.05 vs Mmp2 −/− untreated. MHC II, major histocompatibility complex II; sPLA2, secreted phospholipase A2; SSC, Side-scattered light (a magnitude proportional to cell granularity or internal complexity); WT, wild type. |
|
| S4089 |
Halobetasol PropionateHalobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. |
||
| S4255 |
Quinacrine 2HClQuinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor. |
||
| S8011 |
U73122U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. |
Effect of U73122 and XC on TFEB phosphorylation |
|
| S2390 |
PolydatinPolydatin is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc. |
||
| S7520 |
Darapladib (SB-480848)Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3. |
||
| S2364 |
Tanshinone ITanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. |
Tan-1 inhibited the migration of HMEC-1 cells (F). Cells were treated with vehicle (a), or Tan-1 12.5 μM (b), 25 μM (c) or 50 μM (d) in the corresponding left panel for 6 h. Magnification: 10×. The data from three independent experiments were expressed as mean ± SD in the corresponding right panel. *p < 0.05; **p < 0.01.
|
|
| S4107 |
ClofazimineClofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1110 |
Varespladib (LY315920)Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3. |
Hepatic immune cell infiltration in Mmp2 −/− mice administered the pan-sPLA 2 inhibitor varespladib (10 mg/kg per day, gavage, for 5 days). Collagenase-treated and liberated cells were surface-stained for indicated markers (A) and quantitated. n=3 WT and n=5 Mmp2 −/−. *P≤0.05 vs WT untreated. † P≤0.05 vs Mmp2 −/− untreated. MHC II, major histocompatibility complex II; sPLA2, secreted phospholipase A2; SSC, Side-scattered light (a magnitude proportional to cell granularity or internal complexity); WT, wild type. |
|
| S4089 |
Halobetasol PropionateHalobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. |
||
| S4255 |
Quinacrine 2HClQuinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor. |
||
| S8011 |
U73122U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. |
Effect of U73122 and XC on TFEB phosphorylation |
|
| S2390 |
PolydatinPolydatin is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc. |
||
| S7520 |
Darapladib (SB-480848)Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3. |
||
| S2364 |
Tanshinone ITanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. |
Tan-1 inhibited the migration of HMEC-1 cells (F). Cells were treated with vehicle (a), or Tan-1 12.5 μM (b), 25 μM (c) or 50 μM (d) in the corresponding left panel for 6 h. Magnification: 10×. The data from three independent experiments were expressed as mean ± SD in the corresponding right panel. *p < 0.05; **p < 0.01.
|
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S4107 |
ClofazimineClofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. |
