アドレナリン受容体

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研究分野

阻害剤の選択性比較
溶解度

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S2507	Salbutamol Sulfate	68 mg/mL	<1 mg/mL	<1 mg/mL
S1324	Doxazosin Mesylate	<1 mg/mL	15 mg/mL	<1 mg/mL
S1283	Asenapine maleate	<1 mg/mL	80 mg/mL	<1 mg/mL
S4009	Mirabegron	<1 mg/mL	79 mg/mL	8 mg/mL
S2516	Xylazine HCl	12 mg/mL	50 mg/mL	50 mg/mL
S5088	Labetalone hydrochloride	-1 mg/mL	72 mg/mL	-1 mg/mL
S5042	NC-1400 hydrochloride	52 mg/mL	76 mg/mL	61 mg/mL
S4817	Atenolol	35 mg/mL	53 mg/mL	53 mg/mL
S3960	Higenamine hydrochloride	-1 mg/mL	61 mg/mL	-1 mg/mL
S3643	Amitraz	<1 mg/mL	58 mg/mL	<1 mg/mL
S3664	Flupenthixol dihydrochloride	100 mg/mL	100 mg/mL	30 mg/mL
S3640	Methoxyphenamine Hydrochloride	43 mg/mL	43 mg/mL	43 mg/mL
S3727	Vilanterol Trifenate	<1 mg/mL	100 mg/mL	14 mg/mL
S3656	Piribedil	<1 mg/mL	59 mg/mL	59 mg/mL
S1409	Alfuzosin HCl	85 mg/mL	85 mg/mL	85 mg/mL
S3083	Indacaterol Maleate	<1 mg/mL	102 mg/mL	<1 mg/mL
S2566	Isoprenaline HCl	50 mg/mL	50 mg/mL	<1 mg/mL
S2020	Formoterol Hemifumarate	<1 mg/mL	80 mg/mL	<1 mg/mL
S1613	Silodosin	<1 mg/mL	99 mg/mL	99 mg/mL
S1549	Nebivolol HCl	<1 mg/mL	88 mg/mL	<1 mg/mL
S2521	Epinephrine Bitartrate	67 mg/mL	67 mg/mL	<1 mg/mL
S2691	BMY 7378 Dihydrochloride	92 mg/mL	92 mg/mL	20 mg/mL
S2458	Clonidine HCl	53 mg/mL	53 mg/mL	53 mg/mL
S1424	Prazosin HCl	<1 mg/mL	4 mg/mL	<1 mg/mL
S4076	Propranolol HCl	6 mg/mL	59 mg/mL	<1 mg/mL
S2038	Phentolamine Mesylate	76 mg/mL	76 mg/mL	76 mg/mL
S3041	Droxidopa	<1 mg/mL	<1 mg/mL	<1 mg/mL
S3075	Dexmedetomidine	<1 mg/mL	40 mg/mL	40 mg/mL
S2522	L-Adrenaline	<1 mg/mL	4 mg/mL	<1 mg/mL
S1206	Bisoprolol fumarate	88 mg/mL	88 mg/mL	88 mg/mL
S1856	Metoprolol Tartrate	100 mg/mL	100 mg/mL	31 mg/mL
S2059	Terazosin HCl Dihydrate	<1 mg/mL	26 mg/mL	<1 mg/mL
S1387	Naftopidil DiHCl	<1 mg/mL	41 mg/mL	2 mg/mL
S2517	Maprotiline HCl	<1 mg/mL	63 mg/mL	24 mg/mL
S1831	Carvedilol	<1 mg/mL	81 mg/mL	4 mg/mL
S4113	Desvenlafaxine	<1 mg/mL	37 mg/mL	3 mg/mL
S2569	Phenylephrine HCl	41 mg/mL	41 mg/mL	41 mg/mL
S2126	Naftopidil	<1 mg/mL	79 mg/mL	<1 mg/mL
S2499	Phenoxybenzamine HCl	17 mg/mL	68 mg/mL	68 mg/mL
S2509	Sotalol HCl	61 mg/mL	61 mg/mL	<1 mg/mL
S4123	Timolol Maleate	<1 mg/mL	86 mg/mL	86 mg/mL
S4065	Guanabenz Acetate	<1 mg/mL	58 mg/mL	5 mg/mL
S2519	Naphazoline HCl	49 mg/mL	17 mg/mL	22 mg/mL
S2533	Ritodrine HCl	65 mg/mL	65 mg/mL	65 mg/mL
S2438	Synephrine HCl	41 mg/mL	14 mg/mL	4 mg/mL
S2090	Dexmedetomidine HCl	<1 mg/mL	48 mg/mL	48 mg/mL
S4010	Acebutolol HCl	75 mg/mL	75 mg/mL	75 mg/mL
S3061	Epinephrine HCl	44 mg/mL	44 mg/mL	7 mg/mL
S3060	Medetomidine HCl	47 mg/mL	12 mg/mL	47 mg/mL
S1437	Tizanidine HCl	15 mg/mL	10 mg/mL	<1 mg/mL
S1827	Betaxolol HCl	69 mg/mL	69 mg/mL	69 mg/mL
S2092	Detomidine HCl	45 mg/mL	45 mg/mL	45 mg/mL
S2545	Scopine	<1 mg/mL	31 mg/mL	<1 mg/mL
S4296	Salmeterol Xinafoate	<1 mg/mL	100 mg/mL	4 mg/mL
S2607	Buflomedil HCl	69 mg/mL	31 mg/mL	7 mg/mL
S2523	DL-Adrenaline	<1 mg/mL	0.02 mg/mL	<1 mg/mL
S4266	Brimonidine Tartrate	75 mg/mL	88 mg/mL	<1 mg/mL
S2615	Noradrenaline bitartrate monohydrate	64 mg/mL	64 mg/mL	<1 mg/mL
S7974	L755507	<1 mg/mL	100 mg/mL	<1 mg/mL
S4729	Tamsulosin hydrochloride	17 mg/mL	88 mg/mL	8 mg/mL
S4124	Tolazoline HCl	39 mg/mL	39 mg/mL	39 mg/mL
S4127	Terbutaline Sulfate	100 mg/mL	<1 mg/mL	<1 mg/mL
S4135	Clorprenaline HCl	50 mg/mL	50 mg/mL	50 mg/mL
S4043	Tetrahydrozoline HCl	47 mg/mL	12 mg/mL	26 mg/mL
S1642	Methyldopa	<1 mg/mL	2 mg/mL	<1 mg/mL
S2576	Xylometazoline HCl	56 mg/mL	27 mg/mL	56 mg/mL
S4649	Atipamezole hydrochloride	21 mg/mL	12 mg/mL	49 mg/mL
S4650	Atipamezole	<1 mg/mL	42 mg/mL	42 mg/mL
S4693	Guanfacine Hydrochloride	30 mg/mL	56 mg/mL	56 mg/mL
S4679	Terazosin HCl	1 mg/mL	84 mg/mL	<1 mg/mL
S4085	Levobetaxolol HCl	69 mg/mL	69 mg/mL	69 mg/mL
S8114	ICI-118551 Hydrochloride	21 mg/mL	62 mg/mL	62 mg/mL
S4100	Esmolol HCl	66 mg/mL	66 mg/mL	66 mg/mL
S4112	Desvenlafaxine Succinate	<1 mg/mL	80 mg/mL	<1 mg/mL
S4243	Deoxycorticosterone acetate	<1 mg/mL	11 mg/mL	6 mg/mL
S2086	Ivabradine HCl	82 mg/mL	101 mg/mL	101 mg/mL
S2091	Betaxolol	62 mg/mL	62 mg/mL	<1 mg/mL
S4277	Bambuterol HCl	72 mg/mL	80 mg/mL	28 mg/mL
S4278	Carteolol HCl	65 mg/mL	65 mg/mL	<1 mg/mL
S2362	Synephrine	<1 mg/mL	33 mg/mL	2 mg/mL
S2113	Cisatracurium Besylate	47 mg/mL	249 mg/mL	249 mg/mL
S2373	Yohimbine HCl	<1 mg/mL	12 mg/mL	<1 mg/mL
S4291	Labetalol HCl	8 mg/mL	72 mg/mL	7 mg/mL
S3185	Adrenalone HCl	44 mg/mL	44 mg/mL	<1 mg/mL

亜型選択性的な製品

Adrenergic Receptor阻害剤(84)
新Adrenergic Receptor製品

製品コード	製品説明	文献中の使用例	お客様のフィードバック
S2507	Salbutamol Sulfate Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.	Sci Rep, 2015, 5:7681 Eur J Immunol, 2016, 1948-58	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S1324	Doxazosin Mesylate Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.	J Clin Invest, 2013, 123(12):5119-34 Antiviral Res, 2015, 120:140-6 J Ocul Pharmacol Ther, 2017, 33(1):50-56
S1283	Asenapine maleate Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
S4009	Mirabegron Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
S2516	Xylazine HCl Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.	Biomed Rep, 2016, 5(3):357-360 Acad Radiol, 2012, 19(3):358-65
S5088^新	Labetalone hydrochloride
S5042^新	NC-1400 hydrochloride
S4817^新	Atenolol Atenolol is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.
S3960^新	Higenamine hydrochloride Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S3643^新	Amitraz Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.
S3664^新	Flupenthixol dihydrochloride Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.
S3640^新	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3727^新	Vilanterol Trifenate Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.
S3656^新	Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S1409	Alfuzosin HCl Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S3083	Indacaterol Maleate Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pK_i of 7.36 for β1-adrenoceptor and pK_i of 5.48 for β2-adrenoceptor.
S2566	Isoprenaline HCl Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
S2020	Formoterol Hemifumarate Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).
S1613	Silodosin Silodosin is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.
S1549	Nebivolol HCl Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.
S2521	Epinephrine Bitartrate Epinephrine bitartrate is an alpha- and beta-adrenergic receptor stimulator.
S2691	BMY 7378 Dihydrochloride BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pK_i of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pK_i of 8.3.
S2458	Clonidine HCl Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
S1424	Prazosin HCl Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.
S4076	Propranolol HCl Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.
S2038	Phentolamine Mesylate Phentolamine Mesylate is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.
S3041	Droxidopa Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
S3075	Dexmedetomidine Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
S2522	L-Adrenaline L-Adrenaline belongs to a group of the compounds known as catecholamines.
S1206	Bisoprolol fumarate Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.
S1856	Metoprolol Tartrate Metoprolol Tartrate is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.
S2059	Terazosin HCl Dihydrate Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).
S1387	Naftopidil DiHCl Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
S2517	Maprotiline HCl Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
S1831	Carvedilol Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.	Res Pharm Sci, 2015, 10(5):388-96
S4113	Desvenlafaxine Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with K_i of 40.2 nM and 558.4 nM, respectively.
S2569	Phenylephrine HCl Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.	Stem Cells Dev, 2017, 26(7):528-540	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S2126	Naftopidil Naftopidil is a selective α1-adrenergic receptor antagonist with K_i of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.
S2509	Sotalol HCl Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.	Toxicol Appl Pharmacol, 2015, 285(1):51-60
S4123	Timolol Maleate Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with K_i of 1.97 nM/2.0 nM.
S4065	Guanabenz Acetate Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.
S2519	Naphazoline HCl Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.
S2533	Ritodrine HCl Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.
S2438	Synephrine HCl SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.
S2090	Dexmedetomidine HCl Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.
S4010	Acebutolol HCl Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
S3061	Epinephrine HCl Epinephrine HCl is a hormone and a neurotransmitter.
S3060	Medetomidine HCl Medetomidine is a selective α2-adrenoceptor agonist, with K_i of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
S1437	Tizanidine HCl Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
S1827	Betaxolol HCl Betaxolol is a β₁ adrenergic receptor blocker with IC50 of 6 μM.
S2092	Detomidine HCl Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.
S2545	Scopine Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
S4296	Salmeterol Xinafoate Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
S2607	Buflomedil HCl Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.
S2523	DL-Adrenaline DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.
S4266	Brimonidine Tartrate Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.
S7974	L755507 L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
S4729	Tamsulosin hydrochloride Tamsulosin is a potent and selective α_1a adrenergic receptor antagonist.	Prostate, 2016, 76(8):757-66	The presence of autophagosomes was visualized by fluorescent microscopy. (Cytotoxicity, caspase-3 activity and autophagy induced by treatment of PC-3 and LNCap cells with prazosin or doxazosin for 24 hr)
S4124	Tolazoline HCl Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.
S4127	Terbutaline Sulfate Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
S4135	Clorprenaline HCl Clorprenaline HCl is a β2-receptor agonist, it has a significant expansion of the bronchial effect.
S4043	Tetrahydrozoline HCl Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.
S1642	Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
S2576	Xylometazoline HCl Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α_2B-adrenoceptor subtype with EC50 of 99 μM.
S4649	Atipamezole hydrochloride Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.
S4650	Atipamezole Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.
S4679	Terazosin HCl Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
S4085	Levobetaxolol HCl Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with K_i value of 0.76 nM and 32.6 nM, respectively.
S8114	ICI-118551 Hydrochloride ICI-118551 is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
S4100	Esmolol HCl Esmolol is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with K_i of 40.2 nM and 558.4 nM respectively.
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.
S2086	Ivabradine HCl Ivabradine HCl, a new I_f inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
S2091	Betaxolol Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
S4277	Bambuterol HCl Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.
S4278	Carteolol HCl Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
S2362	Synephrine Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
S2113	Cisatracurium Besylate Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.
S2373	Yohimbine HCl Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
S4291	Labetalol HCl Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.
S3185	Adrenalone HCl Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

研究分野別

製品類型

アドレナリン受容体

シグナル伝達経路

研究分野

亜型選択性的な製品