アドレナリン受容体

信号経路図

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2507 Salbutamol Sulfate 68 mg/mL <1 mg/mL <1 mg/mL
S1324 Doxazosin Mesylate <1 mg/mL 15 mg/mL <1 mg/mL
S1283 Asenapine maleate <1 mg/mL 80 mg/mL <1 mg/mL
S4009 Mirabegron <1 mg/mL 79 mg/mL 8 mg/mL
S2516 Xylazine HCl 12 mg/mL 50 mg/mL 50 mg/mL
S4729 Tamsulosin hydrochloride 17 mg/mL 88 mg/mL 8 mg/mL
S1409 Alfuzosin HCl 85 mg/mL 85 mg/mL 85 mg/mL
S3083 Indacaterol Maleate <1 mg/mL 102 mg/mL <1 mg/mL
S2566 Isoprenaline HCl 50 mg/mL 50 mg/mL <1 mg/mL
S2020 Formoterol Hemifumarate <1 mg/mL 80 mg/mL <1 mg/mL
S1613 Silodosin <1 mg/mL 99 mg/mL 99 mg/mL
S1549 Nebivolol HCl <1 mg/mL 88 mg/mL <1 mg/mL
S2521 Epinephrine Bitartrate 67 mg/mL 67 mg/mL <1 mg/mL
S2691 BMY 7378 Dihydrochloride 92 mg/mL 92 mg/mL 20 mg/mL
S2458 Clonidine HCl 53 mg/mL 53 mg/mL 53 mg/mL
S1424 Prazosin HCl <1 mg/mL 4 mg/mL <1 mg/mL
S4076 Propranolol HCl 6 mg/mL 59 mg/mL <1 mg/mL
S2038 Phentolamine Mesylate 76 mg/mL 76 mg/mL 76 mg/mL
S3041 Droxidopa <1 mg/mL <1 mg/mL <1 mg/mL
S3075 Dexmedetomidine 40 mg/mL 40 mg/mL 40 mg/mL
S2522 L-Adrenaline <1 mg/mL 4 mg/mL <1 mg/mL
S1206 Bisoprolol fumarate 88 mg/mL 88 mg/mL 88 mg/mL
S1856 Metoprolol Tartrate 100 mg/mL 100 mg/mL 31 mg/mL
S2059 Terazosin HCl Dihydrate <1 mg/mL 26 mg/mL <1 mg/mL
S1387 Naftopidil DiHCl <1 mg/mL 41 mg/mL 2 mg/mL
S2517 Maprotiline HCl <1 mg/mL 63 mg/mL 24 mg/mL
S1831 Carvedilol <1 mg/mL 81 mg/mL 4 mg/mL
S4113 Desvenlafaxine <1 mg/mL 37 mg/mL 3 mg/mL
S2569 Phenylephrine HCl 41 mg/mL 41 mg/mL 41 mg/mL
S2126 Naftopidil <1 mg/mL 79 mg/mL <1 mg/mL
S2499 Phenoxybenzamine HCl 17 mg/mL 68 mg/mL 68 mg/mL
S2509 Sotalol HCl 61 mg/mL 61 mg/mL <1 mg/mL
S4123 Timolol Maleate <1 mg/mL 86 mg/mL 86 mg/mL
S4065 Guanabenz Acetate <1 mg/mL 58 mg/mL 5 mg/mL
S2519 Naphazoline HCl 49 mg/mL 17 mg/mL 22 mg/mL
S2533 Ritodrine HCl 65 mg/mL 65 mg/mL 65 mg/mL
S2438 Synephrine HCl 41 mg/mL 14 mg/mL 4 mg/mL
S2090 Dexmedetomidine HCl <1 mg/mL 48 mg/mL 48 mg/mL
S4010 Acebutolol HCl 75 mg/mL 75 mg/mL 75 mg/mL
S3061 Epinephrine HCl 44 mg/mL 44 mg/mL 7 mg/mL
S3060 Medetomidine HCl 47 mg/mL 12 mg/mL 47 mg/mL
S1437 Tizanidine HCl 15 mg/mL 10 mg/mL <1 mg/mL
S1827 Betaxolol HCl 69 mg/mL 69 mg/mL 69 mg/mL
S2092 Detomidine HCl 45 mg/mL 45 mg/mL 45 mg/mL
S2545 Scopine <1 mg/mL 31 mg/mL <1 mg/mL
S4296 Salmeterol Xinafoate <1 mg/mL 100 mg/mL 4 mg/mL
S2607 Buflomedil HCl 69 mg/mL 31 mg/mL 7 mg/mL
S2523 DL-Adrenaline <1 mg/mL 0.02 mg/mL <1 mg/mL
S4266 Brimonidine Tartrate 75 mg/mL 88 mg/mL <1 mg/mL
S2615 Noradrenaline bitartrate monohydrate 64 mg/mL 64 mg/mL <1 mg/mL
S7974 L755507 <1 mg/mL 100 mg/mL <1 mg/mL
S4124 Tolazoline HCl 39 mg/mL 39 mg/mL 39 mg/mL
S4127 Terbutaline Sulfate 100 mg/mL <1 mg/mL <1 mg/mL
S4135 Clorprenaline HCl 50 mg/mL 50 mg/mL 50 mg/mL
S4043 Tetrahydrozoline HCl 47 mg/mL 12 mg/mL 26 mg/mL
S1642 Methyldopa <1 mg/mL 2 mg/mL <1 mg/mL
S2576 Xylometazoline HCl 56 mg/mL 27 mg/mL 56 mg/mL
S4649 Atipamezole hydrochloride 21 mg/mL 12 mg/mL 49 mg/mL
S4650 Atipamezole <1 mg/mL 42 mg/mL 42 mg/mL
S4693 Guanfacine Hydrochloride 30 mg/mL 56 mg/mL 56 mg/mL
S4679 Terazosin HCl 1 mg/mL 84 mg/mL <1 mg/mL
S4085 Levobetaxolol HCl 69 mg/mL 69 mg/mL 69 mg/mL
S8114 ICI-118551 Hydrochloride 21 mg/mL 62 mg/mL 62 mg/mL
S4100 Esmolol HCl 66 mg/mL 66 mg/mL 66 mg/mL
S4112 Desvenlafaxine Succinate <1 mg/mL 80 mg/mL <1 mg/mL
S4243 Deoxycorticosterone acetate <1 mg/mL 11 mg/mL 6 mg/mL
S2086 Ivabradine HCl 82 mg/mL 101 mg/mL 101 mg/mL
S2091 Betaxolol 62 mg/mL 62 mg/mL <1 mg/mL
S4277 Bambuterol HCl 72 mg/mL 80 mg/mL 28 mg/mL
S4278 Carteolol HCl 65 mg/mL 65 mg/mL <1 mg/mL
S2362 Synephrine <1 mg/mL 33 mg/mL 2 mg/mL
S2113 Cisatracurium Besylate 47 mg/mL 249 mg/mL 249 mg/mL
S2373 Yohimbine HCl <1 mg/mL 12 mg/mL <1 mg/mL
S4291 Labetalol HCl 8 mg/mL 72 mg/mL 7 mg/mL
S3185 Adrenalone HCl 44 mg/mL 44 mg/mL <1 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中の使用例 お客様のフィードバック
S2507

Salbutamol Sulfate

Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.

S1324

Doxazosin Mesylate

Doxazosin mesylate is an alpha-1 adrenergic receptor blocker.

S1283

Asenapine maleate

Asenapine maleateは一種の高度親和力セロトニン、ノルエピネフリン(norepinephrine)、ドパミンとヒスタミンの受容体拮抗剤ですが、精神分裂症と急性マニア(acute mania)関連の躁鬱病の治療に使用します。

S4009

Mirabegron

Mirabegronは、選択的なbeta3-副腎受容体 作用薬で、EC50 が 22.4 nMです。

S2516

Xylazine HCl

Xylazine HCl is α2 class of adrenergic receptor agonist.

S4729

Tamsulosin hydrochloride

S1409

Alfuzosin HCl

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

S3083

Indacaterol Maleate

Indacaterol Maleateis an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36.

S2566

Isoprenaline HCl

Isoprenaline HClは非選択β-アドレナリン受容体3 H-イノシトールリン酸の蓄積を阻害して、IC50 が0.08 μMです。

S2020

Formoterol Hemifumarate

Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively.

S1613

Silodosin

Silodosin is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.

S1549

Nebivolol HCl

Nebivolol HClは、ウサギ肺β1-副腎受容体結合実験において0.8nMのIC50価値で活動を妨害しているβ1つのレセプターを選択的にします。

S2521

Epinephrine Bitartrate

Epinephrine Bitartrate is alpha- and beta-adrenergic receptor stimulator.

S2691

BMY 7378 Dihydrochloride

BMY 7378は一種の多ターゲット阻害剤ですが、α2C-adrenoceptorとα1D-adrenoceptorに作用する時のpKi値が6.54と8.2に分かれます。BMY 7378も一種の混合型5-HT1A受容体作動剤と拮抗剤で、pKi値が8.3です。

S2458

Clonidine HCl

Clonidine HClは一種の直接に役立つα2アドレナリン作動薬で、ED50値が0.02±0.01 mg/kgです。

S1424

Prazosin HCl

Prazosin hydrochloride, a quinazoline derivative, is the first of a new chemical class of antihypertensives.

S4076

Propranolol HCl

Propranolol HCl は、競争的選択的でないベータ受容体阻害剤で、IC50 が 12 nMです。

S2038

Phentolamine Mesylate

Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM.

S3041

Droxidopa

Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

S3075

Dexmedetomidine

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

S2522

L-Adrenaline

L-Adrenaline belongs to a group of the compounds known as catecholamines.

S1206

Bisoprolol fumarate

Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.

S1856

Metoprolol Tartrate

Metoprolol Tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.

S2059

Terazosin HCl Dihydrate

Terazosin HCl is an alpha-adrenergic blocker used to treat high blood pressure and enlarged prostate.

S1387

Naftopidil DiHCl

Naftopidil DiHClは、選択的な5-HT1Aα1-アドレナリン受容体</b> 敵対者 で、IC50 がそれぞれ 0.1 μM と 0.2 μMです。

S2517

Maprotiline HCl

Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.

S1831

Carvedilol

Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.

S4113

Desvenlafaxine

Desvenlafaxineは一種のセロトニン(5-HT)とノルエピネフリン(NE)の再摂取阻害剤で、Ki値が40.2 nMと558.4nMに分かれることです。

S2569

Phenylephrine HCl

Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.

S2126

Naftopidil

Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.

S2499

Phenoxybenzamine HCl

Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.

S2509

Sotalol HCl

Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM

S4123

Timolol Maleate

Timolol Maleateは、選択的でない、ベータアドレナリンによるレセプターの敵対者で、β1/β2のため、Ki が 1.97 nM/2.0 nMです。

S4065

Guanabenz Acetate

Guanabenz Acetate はα2a-アドレナリン受容体α2b-アドレナリン受容体α2c-アドレナリン受容体の選択的な作用薬、 pEC50 がそれぞれ 8.25、 7.01 、 ~5です。

S2519

Naphazoline HCl

Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.

S2533

Ritodrine HCl

Ritodrine HCl is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.

S2438

Synephrine HCl

Synephrine HClは、交感神経興奮剤α-アドレナリン受容体(AR、α-副腎受容体)作用薬です。

S2090

Dexmedetomidine HCl

Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.

S4010

Acebutolol HCl

Acebutolol HCl は、 ベータ受容体 高血圧、狭心症と心臓不整脈の処置において使われる敵対者。

S3061

Epinephrine HCl

Epinephrine HCl is a hormone and a neurotransmitter.

S3060

Medetomidine HCl

Medetomidine HCl is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.

S1437

Tizanidine HCl

Tizanidine HCl is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

S1827

Betaxolol HCl

Betaxolol HCl is a β1 adrenergic receptor blocker with IC50 of 6 μM.

S2092

Detomidine HCl

Detomidine HCl produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.

S2545

Scopine

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

S4296

Salmeterol Xinafoate

Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.

S2607

Buflomedil HCl

Buflomedil is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease.

S2523

DL-Adrenaline

DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.

S4266

Brimonidine Tartrate

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.

S2615

Noradrenaline bitartrate monohydrate

Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.

S7974

L755507

L-755507 は1種の 有効的で、セレクティブβ3アドレナリン(adrenergic)受容体の部分刺激剤(EC50値:0.43 nM)です。L-755507 はiPSCsと他の細胞類型でCRISPR媒介のホモロジー再編成(homology-directed)の修復効率を増強できます。

S4124

Tolazoline HCl

Tolazoline HClは、選択的でない競争的α-アドレナリン受容体 敵対者です。

S4127

Terbutaline Sulfate

Terbutaline Sulfateは、選択的β2-アドレナリン受容体のアゴニストで、IC50 が 53 nMです。

S4135

Clorprenaline HCl

Clorprenaline HClは、β2-受容体アゴニストである、それは、気管支の効果を大幅に拡大しています。

S4043

Tetrahydrozoline HCl

Tetrahydrozoline HCl 、アルファ受容体アゴニスト活性を有するイミダゾリン誘導体です。

S1642

Methyldopa

Methyldopaは一種のDOPAデカルボキシラーゼ(decarboxylase)の競争性的な阻害剤で、 ED50値が21.8 mg/kgです。

S2576

Xylometazoline HCl

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 4 μM.

S4649

Atipamezole hydrochloride

Atipamezole hydrochlorideは1種の 合成の α2アドレナリン(adrenergic)受容体拮抗剤で、潜在的な抗パーキンソン薬として、人間に研究されます。Atipamezole hydrochlorideはhydrochlorideのアチパメゾール(atipamezole)形式です。

S4650

Atipamezole

Atipamezole は1種の 合成の α2アドレナリン(adrenergic)受容体拮抗剤で、潜在的な抗パーキンソン薬として、人間に研究されます。

S4693

Guanfacine Hydrochloride

Guanfacine Hydrochlorideは1種のセレクティブα2Aアドレナリン受容体刺激薬で、抗高血圧効果を持っています。

S4679

Terazosin HCl

Terazosinは1種の セレクティブalpha-1拮抗剤(antagonist)で、前立腺腫大(BPH)症の治療に使用されます。Terazosinは膀胱平滑筋と血管壁でのアドレナリン(adrenaline)の作用を抑制することを通じて、役に立ちます。

S4085

Levobetaxolol HCl

Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively.

S8114

ICI-118551 Hydrochloride

S4100

Esmolol HCl

Esmolol is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.

S4112

Desvenlafaxine Succinate

Desvenlafaxine Succinateは一種の新たなセロトニン (5-HT)とNET(norepinephrine transporter)の再摂取阻害剤で、Ki値が40.2 nMと558.4 nMです。

S4243

Deoxycorticosterone acetate

Deoxycorticosterone acetateは、副腎皮質ステロイドの補充療法のための筋肉内注射のために使用ステロイドホルモンです。

S2086

Ivabradine HCl

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

S2091

Betaxolol

Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

S4277

Bambuterol HCl

Bambuterol HCl is a potent β-adrenoceptor agonist, used in the treatment of asthma.

S4278

Carteolol HCl

Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.

S2362

Synephrine

Synephrine is a compound commonly used for weight loss.

S2113

Cisatracurium Besylate

Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.

S2373

Yohimbine HCl

Yohimbine HCl has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

S4291

Labetalol HCl

Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.

S3185

Adrenalone HCl

Adrenalone HCl is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Tags: adrenergic receptor activation | adrenergic receptor types | adrenergic receptor location | adrenergic receptor drugs | adrenergic receptor signaling | adrenergic receptor pathway | beta adrenergic receptor pathway | beta adrenergic receptor activation | beta 2 adrenergic receptor activation | beta 2 adrenergic receptor pathway | alpha adrenergic receptor pathway | alpha 1 adrenergic receptor pathway | beta 1 adrenergic receptor pathway | adrenergic receptor inhibitor review