Immunology & Inflammation related

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2286 Cyclosporin A <1 mg/mL 100 mg/mL 100 mg/mL
S5004 Pimecrolimus <1 mg/mL 100 mg/mL 100 mg/mL
S1211 Imiquimod <1 mg/mL 1 mg/mL <1 mg/mL
S3032 Bindarit <1 mg/mL 64 mg/mL 64 mg/mL
S1407 Bimatoprost <1 mg/mL 36 mg/mL 83 mg/mL
S3774 Dehydroandrographolide Succinate Potasium Salt -1 mg/mL 10 mg/mL -1 mg/mL
S3775 Ligustrazine hydrochloride -1 mg/mL 34 mg/mL -1 mg/mL
S3758 Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride -1 mg/mL 73 mg/mL -1 mg/mL
S3932 Astilbin -1 mg/mL 100 mg/mL -1 mg/mL
S3837 Echinocystic acid -1 mg/mL 94 mg/mL -1 mg/mL
S3827 Royal jelly acid -1 mg/mL 37 mg/mL -1 mg/mL
S3841 Eleutheroside B -1 mg/mL 74 mg/mL -1 mg/mL
S3956 Tetramethylpyrazine -1 mg/mL 27 mg/mL -1 mg/mL
S3614 Lupeol <1 mg/mL 1 mg/mL <1 mg/mL
S3685 4-Biphenylacetic acid <1 mg/mL 42 mg/mL 42 mg/mL
S3680 NLRP3 Inflammasome Inhibitor I <1 mg/mL 73 mg/mL <1 mg/mL
S3745 Balsalazide disodium 87 mg/mL 87 mg/mL <1 mg/mL
S3648 Amlexanox <1 mg/mL 59 mg/mL 1 mg/mL
S3726 Selexipag <1 mg/mL 99 mg/mL 49 mg/mL
S3668 Thymopentin 100 mg/mL 100 mg/mL <1 mg/mL
S3622 Diammonium Glycyrrhizinate 100 mg/mL 100 mg/mL <1 mg/mL
S3608 Demethylzeylasteral (T-96) <1 mg/mL 96 mg/mL 33 mg/mL
S4753 Ganoderic acid A <1 mg/mL 100 mg/mL 100 mg/mL
S8522 Compstatin 100 mg/mL -1 mg/mL -1 mg/mL
S8141 Cl-amidine 70 mg/mL 84 mg/mL 84 mg/mL
S8291 Atractylenolide I <1 mg/mL 46 mg/mL 46 mg/mL
S1439 Tranilast <1 mg/mL 66 mg/mL <1 mg/mL
S1737 Prednisolone <1 mg/mL 72 mg/mL 10 mg/mL
S1622 Prednisone <1 mg/mL 71 mg/mL <1 mg/mL
S4169 Teriflunomide <1 mg/mL 32 mg/mL ,1 mg/mL
S2413 Geniposidic acid <1 mg/mL 16 mg/mL 2 mg/mL
S1508 Alprostadil <1 mg/mL 71 mg/mL 71 mg/mL
S1733 Methylprednisolone <1 mg/mL 75 mg/mL 2 mg/mL
S1939 (-)-Tetramisole 48 mg/mL <1 mg/mL <1 mg/mL
S2787 Laquinimod <1 mg/mL 61 mg/mL 1 mg/mL
S1681 Mesalamine <1 mg/mL 31 mg/mL 31 mg/mL
S2910 Tempol 34 mg/mL 34 mg/mL 34 mg/mL
S1679 Flurbiprofen <1 mg/mL 49 mg/mL 49 mg/mL
S1829 Pranlukast <1 mg/mL 11 mg/mL <1 mg/mL
S1514 Cyclosporine <1 mg/mL 100 mg/mL 100 mg/mL
S1576 Sulfasalazine <1 mg/mL 80 mg/mL <1 mg/mL
S1654 Phenylbutazone <1 mg/mL 62 mg/mL 62 mg/mL
S2512 Tenoxicam <1 mg/mL 68 mg/mL <1 mg/mL
S3062 Diclofenac Potassium 10 mg/mL 69 mg/mL <1 mg/mL
S7515 VGX-1027 <1 mg/mL 41 mg/mL 41 mg/mL
S4098 Halcinonide <1 mg/mL 90 mg/mL 4 mg/mL
S1823 Fenoprofen Calcium <1 mg/mL 105 mg/mL 10 mg/mL
S8301 AS101 <1 mg/mL 62 mg/mL <1 mg/mL
S4268 Flufenamic acid <1 mg/mL 56 mg/mL 56 mg/mL
S4529 Idramantone 33 mg/mL 33 mg/mL 33 mg/mL
S7211 PF-04418948 <1 mg/mL 81 mg/mL <1 mg/mL
S4152 Ethamsylate 53 mg/mL 53 mg/mL <1 mg/mL
S4165 Benzydamine HCl 69 mg/mL 69 mg/mL 69 mg/mL
S4170 Coumarin <1 mg/mL 29 mg/mL 29 mg/mL
S7809 85 mg/mL <1 mg/mL 40 mg/mL
S2400 Rheic Acid <1 mg/mL <1 mg/mL <1 mg/mL
S4188 Sasapyrine <1 mg/mL 52 mg/mL 52 mg/mL
S7448 CORM-3 <1 mg/mL 38 mg/mL <1 mg/mL
S4682 Loxoprofen <1 mg/mL 49 mg/mL 49 mg/mL
S7516 Y-320 <1 mg/mL 11 mg/mL <1 mg/mL
S3027 Fenoprofen calcium hydrate <1 mg/mL 48 mg/mL 18 mg/mL
S8097 C-DIM12 <1 mg/mL 71 mg/mL 71 mg/mL
S2350 Rutin <1 mg/mL 100 mg/mL 2 mg/mL
S7434 TAPI-1 60 mg/mL 99 mg/mL 99 mg/mL
S4690 Escin <1 mg/mL 66 mg/mL <1 mg/mL
製品コード 製品説明 文献中の使用例 お客様のフィードバック
S2286

Cyclosporin A

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

S5004

Pimecrolimus

Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.

S1211

Imiquimod

Imiquimod is a novel synthetic agent with immune response modifying activity.

S3032

Bindarit

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

S1407

Bimatoprost

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

S3774

Dehydroandrographolide Succinate Potasium Salt

S3775

Ligustrazine hydrochloride

S3758

Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride

S3932

Astilbin

S3871

Muscone

S3837

Echinocystic acid

S3893

Bornyl acetate

S3827

Royal jelly acid

S3841

Eleutheroside B

S3956

Tetramethylpyrazine

S3614

Lupeol

S3685

4-Biphenylacetic acid

S3680

NLRP3 Inflammasome Inhibitor I

S3745

Balsalazide disodium

S3648

Amlexanox

Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.

S3726

Selexipag

Selexipag is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).

S3668

Thymopentin

Thymopentin has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.

A2009

Rituximab

Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.

S3622

Diammonium Glycyrrhizinate

Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.

S3608

Demethylzeylasteral (T-96)

Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.

S8559

INF39

INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.

A2001

Ipilimumab

Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor.

S4753

Ganoderic acid A

Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.

S8522

Compstatin

Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.

S8141

Cl-amidine

Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively.

S8291

Atractylenolide I

Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.

S1439

Tranilast

Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.

S1737

Prednisolone

Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

S1622

Prednisone

Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

S4169

Teriflunomide

Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.

S2413

Geniposidic acid

Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.

S1508

Alprostadil

Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.

S1733

Methylprednisolone

Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.

S1939

(-)-Tetramisole

(-)-Tetramisole is an inhibitor of alkaline phosphatase, used as an anthelmintic.

S2787

Laquinimod

Laquinimod is a potent immunomodulator. Phase 3.

S1681

Mesalamine

Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.

S2910

Tempol

Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.

S1679

Flurbiprofen

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).

S1829

Pranlukast

Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.

S1514

Cyclosporine

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

S1576

Sulfasalazine

Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis.

S1654

Phenylbutazone

Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.

S2512

Tenoxicam

Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.

S3062

Diclofenac Potassium

Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

S7515

VGX-1027

VGX-1027 is an orally active immunomodulator. Phase 1.

S4098

Halcinonide

Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.

S1823

Fenoprofen Calcium

Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.

S8301

AS101

AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.

S4268

Flufenamic acid

Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.

S4529

Idramantone

Idramantone is an immune agonist.

S7211

PF-04418948

PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.

S4152

Ethamsylate

Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.

S4165

Benzydamine HCl

Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.

S4170

Coumarin

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

S7809

MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.

S2400

Rheic Acid

Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities.

S4188

Sasapyrine

Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.

S7448

CORM-3

CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

S4682

Loxoprofen

Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.

S7516

Y-320

Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.

S3027

Fenoprofen calcium hydrate

Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).

S4706

Eugenol

Eugenol is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.

S8097

C-DIM12

C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.

S4709

Latanoprost

Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.

S2350

Rutin

Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.

S7434

TAPI-1

TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.

S4690

Escin

Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).

S4524

2-Ethoxybenzamide

2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.