Immunology & Inflammation related

Immunology & Inflammation related製品

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S2286 Cyclosporin A Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.
Signal Transduct Target Ther, 2023, 8(1):371
Signal Transduct Target Ther, 2023, 8(1):371
Theranostics, 2023, 10.7150/thno.87288
S8141 Cl-amidine Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. Cl-amidine induces apoptosis.
Heliyon, 2024, 10(1):e23633
Cell Discov, 2023, 9(1):104
Cell Discov, 2023, 9(1):104
S7434 TAPI-1 TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).
Br J Cancer, 2024, 10.1038/s41416-024-02576-z
PLoS Pathog, 2023, 19(9):e1011629
J Transl Med, 2023, 21(1):530
S3032 Bindarit ビンダリットは、独特な抗炎症性活動が単球走化性タンパク質MCP-1/CCL2、MCP-3/CCL7とMCP-2/CCL8を含む炎症性ケモカインの亜族の選択的な抑制のためにある最初の合成物です。NMRとHPLCによって確かめられる品質。顧客レビュー、確認と紙表彰状を見てください。
Exp Mol Med, 2024, 56(2):408-421.
J Biol Chem, 2023, S0021-9258(23)02393-1
Cell Death Discov, 2022, 8(1):466
S4169 Teriflunomide Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.
Front Cell Dev Biol, 2023, 11:1089945
Cell Death Discov, 2022, 8(1):464
iScience, 2022, 25(5):104293
S1576 Sulfasalazine Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.
Adv Sci (Weinh), 2023, 10(20):e2300517
Proc Natl Acad Sci U S A, 2022, 119(36):e2117396119
Cell Mol Life Sci, 2022, 79(5):228
S1737 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Life Sci Alliance, 2023, 6(10)e202302009
Life Sci Alliance, 2023, 6(10)e202302009
Front Oncol, 2022, 12:905665
A2001 Ipilimumab (anti-CTLA-4) Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
Cells, 2023, 12(8)1145
Cells, 2023, 12(8)1145
Cancers (Basel), 2023, 16(1)80
S5004 Pimecrolimus Pimecrolimus (Elidel,ASM 981,SDZ-ASM 981) is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S2910 Tempol Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
Cell Signal, 2023, 108:110712
J Ginseng Res, 2023, 47(1):144-154
Theranostics, 2021, 11(8):3796-3812
S1439 Tranilast Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
Antiviral Res, 2023, 216:105674
iScience, 2023, 26(6):106929
Exp Ther Med, 2023, 25(4):160
S3648 Amlexanox Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
Signal Transduct Target Ther, 2023, 8(1):246
Signal Transduct Target Ther, 2023, 8(1):246
Nucleic Acids Res, 2022, 50(15):8700-8718
A2102 Anti-mouse CD8α-InVivo Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).
Nat Commun, 2023, 14(1):7709.
Nat Commun, 2023, 14(1):7709
Cell Rep Med, 2023, 4(10):101229
S2359 Sinomenine Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
Sci Rep, 2023, 13(1):3933
Biomed Res Int, 2022, 2022:4914005
Int J Neurosci, 2022, 1-9
S1514 Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
Cells, 2023, 12(23)2696
Int J Mol Sci, 2023, 24(11)9708
Cell Rep, 2021, 34(10):108832
A2009 Rituximab (anti-CD20) Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.
Oncoimmunology, 2023, 12(1):2163784
Heliyon, 2023, 9(12):e22991
Front Immunol, 2022, 13:1016263
S8301 Ossirene (AS101) Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
Cell Rep, 2023, 42(7):112660
Cells, 2022, 11(24)4013
Syst Biol Reprod Med, 2022, 1-15
S5804 N-Acetylcysteine amide N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.
Nat Commun, 2023, 14(1):5165
Nat Commun, 2023, 14(1):5165
J Mol Biol, 2023, 435(13):168128
S2413 Geniposidic acid Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S1654 Phenylbutazone Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S8660 GI254023X GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively. GI254023X can inhibit MMP9.
Oncogene, 2023, 42(18):1438-1452
Signal Transduct Target Ther, 2022, 7(1):72
Pharmacol Res, 2022, 177:106132
S2350 Rutin Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.
Metabolites, 2022, 12(10)926
Drug Dev Res, 2022, 10.1002/ddr.21927
Hum Mol Genet, 2022, ddac116
S1591 Bestatin (Ubenimex) Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.
Aging (Albany NY), 2022, 14(7):3259-3275
Phytother Res, 2021, 35(6):3167-3180
Clin Transl Med, 2020, 10(8):e233
S1622 Prednisone Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Blood Cancer J, 2022, 12(3):36
Int J Mol Sci, 2022, 23(7)3834
Front Immunol, 2021, 12:739605
S5501 Hydrocortisone acetate Hydrocortisone Acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
Reprod Toxicol, 2022, S0890-6238(22)00068-5
Front Cell Dev Biol, 2021, 9:641527
Int J Radiat Biol, 2021, 1-11
S8760 Iberdomide (CC220) Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.
bioRxiv, 2024, 10.1101/2024.01.28.577572
Mol Cancer Ther, 2023, 22(5):659-666
Mol Cancer Ther, 2023, 22(5):659-666
S7448 CORM-3 CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
Cell Death Discov, 2024, 10(1):42
Exp Neurol, 2021, 341:113683
Inflammation, 2021, 10.1007/s10753-021-01419-w
S1211 Imiquimod Imiquimod is a novel synthetic agent with immune response modifying activity.
Biomaterials, 2023, 302:122319
J Neuroinflammation, 2022, 19(1):315
Mater Today Bio, 2022, 14:100238
S5260 ATP ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.
Cell Rep, 2024, 43(2):113779
Cell Rep Med, 2023, 4(8):101129
Immunology, 2022, 10.1111/imm.13493
S5318 Acacetin Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
Mediators Inflamm, 2021, 2021:5265444
Biochem Biophys Res Commun, 2021, 583:146-153
Front Pharmacol, 2020, 11:582520
S9311 Germacrone Germacrone, a major activity component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antimicrobial activities.
Front Pharmacol, 2022, 13:1033043
Exp Ther Med, 2022, 24(1):456
Cell Commun Signal, 2019, 17(1):122
S2338 Oxymatrine Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.
Bioengineered, 2022, 13(5):12912-12926
Front Cell Dev Biol, 2021, 9:684007
Clin Transl Oncol, 2020, 10.1007/s12094-020-02464-x
S2383 Gastrodin Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
Cell Death Discov, 2023, 9(1):364
Cell Death Discov, 2023, 9(1):364
Cell Signal, 2023, 110:110851
S7892 Avadomide (CC-122) Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.
bioRxiv, 2024, 10.1101/2024.01.28.577572
Cell Chem Biol, 2022, S2451-9456(22)00204-5
Leukemia, 2021, 35(5):1330-1343
S8291 Atractylenolide I Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.
Front Oncol, 2021, 11:738534
Mol Med Rep, 2021, 24(4)691
Front Pharmacol, 2020, 26;11:273
S7516 Y-320 Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
mBio, 2022, e0066422
J Virol, 2021, JVI0111921
Research Square, 2021, 10.21203/rs.3.rs-742937/v1
S1733 Methylprednisolone Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
Drug Test Anal, 2020, 10.1002/dta.2917
Nat Med, 2017, 23(4):424-428
Trop J Pharm Res, 2014, 13 (1): 53-59
S5500 Amodiaquine hydrochloride Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9
bioRxiv, 2020, 10.1101/2020.04.13.039917
bioRxiv, 2020, 2020/9/20.4.7.30734
S3758 Sinomenine hydrochloride Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
Biomed Res Int, 2022, 2022:4914005
Cancer Manag Res, 2021, 13:1189-1204
Bioorg Med Chem, 2020, 31:115986
S9430 Tomatidine Hydrochloride Tomatidine Hydrochloride, a natural steroidal alkaloid, possesses potent antibacterial activity and has anti-inflammatory effects in macrophages.
Viruses, 2021, 13(8)1533
Vet Res, 2020, 51(1):136
Biosci Rep, 2019, 39(8)
S4761 Thymoquinone Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa with anti-inflammatory and anti-oxidant effects.
Int J Mol Sci, 2022, 23(4)2305
Chem Biol Interact, 2022, 365:110070
Chem Biol Interact, 2022, 353:109801
S2787 Laquinimod Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.
Int Immunopharmacol, 2020, 88:106989
J Neuroinflammation, 2018, 15(1):183
S1681 Mesalazine (5-ASA) Mesalazine (5-ASA) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.
Front Vet Sci, 2021, 8:670949
Antiviral Res, 2020, 185:104993
S3608 Demethylzeylasteral (T-96) Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.
J Cancer, 2021, 12(13):3967-3975
Front Biosci (Landmark Ed), 2020, 25:498-512
S3614 Lupeol Lupeol (Clerodol, Monogynol B, Fagarasterol, Farganasterol) is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.
Toxicol Appl Pharmacol, 2023, 478:116699
Drug Chem Toxicol, 2022, 1-12
S4268 Flufenamic acid Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
Theranostics, 2022, 12(18):7681-7698
Biochim Biophys Acta Mol Cell Biol Lipids, 2020, 1865(12):158793
S3824 Quercitrin Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.
J Biol Chem, 2023, 299(6):104789
Molecules, 2023, 28(3)1444
S5648 Iguratimod Iguratimod (T-614) is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.
Front Pharmacol, 2022, 13:865363
Front Microbiol, 2019, 10:2225
S9038 Calycosin Calycosin (3'-Hydroxyformononetin), an isoflavonoid, is the major active component in Radix Astragali. It shows antitumor, anti-inflammatory, neuroprotective and pro-angiogenesis effects.
Immun Inflamm Dis, 2023, 10.1002/iid3.935
Pharmacol Res, 2022, 185:106489
S9032 Sanguinarine Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.
Front Oncol, 2022, 12:732860
Onco Targets Ther, 2020, 13:8989-9003
S8097 C-DIM12 C-DIM12 is a Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
Front Mol Neurosci, 2020, 23724
Cell Death Dis, 2018, 9(3):411
S9131 Punicalagin Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.
SLAS Discov, 2024, S2472-5552(24)00007-8
Cell, 2020, 30;181(3):637-652.e15.
Cell, 2020, 30;181(3):637-652e15
S6812 Z-Guggulsterone Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Z-Guggulsterone exhibits anti-inflammatory effects in microglia. Z-Guggulsterone induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway.
Int J Biol Sci, 2023, 19(11):3456-3471
Int J Biol Sci, 2023, 19(11):3456-3471
S5517 Fenamic acid Fenamic acid (N-Phenylanthranilic acid, 2-(Phenylamino)benzoic acid, 2-Anilinobenzoic acid, Diphenylamine-2-carboxylic acid) serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.
Antiviral Res, 2023, 216:105674
J Biol Chem, 2019, 294(45):16908-16917
A2028 Tiragolumab (anti-TIGIT) Tiragolumab (anti-TIGIT) (RG6058, MTIG7192A) is a humanized IgG1/kappa monoclonal antibody that binds TIGIT to prevent its interaction with its ligand PVR (CD155).
Cell Commun Signal, 2024, 22(1):35
J Immunother Cancer, 2023, 11(12)e007502
S1829 Pranlukast Pranlukast (ONO-1078,ono-rs-411) is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.
Cancer Immunol Immunother, 2021, 70(1):203-213
S3062 Diclofenac Potassium Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
Pharm Res, 2022, 39(10):2515-2527
S7515 VGX-1027 VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1.
Eur J Pharmacol, 2019, 842:373-383
S1823 Fenoprofen Calcium Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
Genome Med, 2021, 13(1):168
S2411 Geniposide Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis.
Phytomedicine, 2023, 117:154918
S5737 Diclofenac Epolamine Diclofenac Epolamine (DHEP, DIEP, diclofenac hydroxyethylpyrrolidine) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.
Pharm Res, 2022, 39(10):2515-2527
S5157 Thymol Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.
J Microbiol Biotechnol, 2023, 33(1):43-50
S5674 Lodoxamide Tromethamine Lodoxamide Tromethamine (Alomide, Lodoxamidetromethamine) is the tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound with anti-inflammatory activity.
Exp Eye Res, 2022, 219:109065
S9213 Jujuboside A Jujuboside A, isolated from Semen Ziziphi Spinosae, exerts anti-oxidant, anti-inflammatory activities, and reduces the cell apoptosis.
Cancer Med, 2022, 10.1002/cam4.4977
S3956 Tetramethylpyrazine Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
Biomed Pharmacother, 2022, 150:113010
S6239 PMX-53 PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
Thromb J, 2022, 20(1):24
S9043 6-Shogaol 6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.
Biomolecules, 2020, 10(10)E1380
S9247 Isoliensinine Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.
Cell Death Dis, 2022, 13(11):1000
S5661 Tiaprofenic acid Tiaprofenic acid (Tiaprofensaeure, Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.
Antiviral Res, 2023, 216:105674
S2387 Lappaconite HBr Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
Int J Mol Sci, 2018, 19(6)
S6185 Arachidonic acid Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Bone Res, 2022, 10(1):20
S9289 Astragalin Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities.
Chem Biol Drug Des, 2021, 10.1111/cbdd.13933
S9290 Linarin Linarin (Acaciin, Buddleoside, Acacetin-7-O-rutinoside), a natural flavonoid cpompound, has pharmacological effects, including anti-inflammatory, neuro-protective, cardioprotective and antioxidative effects.
Front Pharmacol, 2020, 11:582520
S9293 Isoliquiritin Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.
Front Med (Lausanne), 2022, 9:873739
S4170 Coumarin Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
Biosci Rep, 2021, BSR20211828
S9304 Platycodin D Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anti-inflammatory, anti-allergic, cholesterol-lowering and neuroprotective properties.
Sci Rep, 2016, 6:37997
S2400 Rheic Acid Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.
Cell Chem Biol, 2016, 23(3):415-25
S6322 Pipecolic acid Pipecolic acid (piperidine-2-carboxylic acid), a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike.
Pharmaceuticals (Basel), 2023, 16(7)1051
S3675 Umbelliferone Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.
Food Chem Toxicol, 2022, S0278-6915(22)00089-8
S3668 Thymopentin Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.
Front Oncol, 2021, 11:741403
S9055 Salvianolic acid A Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.
Clin Exp Pharmacol Physiol, 2021, 48(4):508-514
S9052 Auraptene Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5).
Plant Physiology, 2012, 81–94
S9057 Sinigrin Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.
J Invest Dermatol, 2018, 138(12):2644-2652
S3027 Fenoprofen calcium hydrate Fenoprofen calcium hydrate(Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).
Genome Med, 2021, 13(1):168
S9035 Isovitexin Isovitexin (saponaretin, Apigenin-6-C-glucoside), an active component of many traditional Chinese medicines, has various activities, such as anti-oxidant, anti-inflammatory, anti-alzheimer disease (AD) effects and so on.
Front Pharmacol, 2020, 11:582520
S3871 Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
J Pharm Pharmacol, 2019, 71(11):1706-1713
S9074 Buddlejasaponin IVb Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells.
Vet Microbiol, 2022, 272:109516
S3877 Lysionotin Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.
Front Oncol, 2021, 11:674492
S9411 Liensinine Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.
Cell Death Dis, 2022, 13(11):1000
S9105 Ginsenoside CK Ginsenoside CK is a ginsenoside found in Panax species and has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent.
J Ginseng Res, 2023, 47(2):274-282
S5083 Lentinan Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.
Iran J Basic Med Sci, 2023, 26(7):836-842
S9115 Wogonoside Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.
FASEB J, 2021, 35(9):e21870
S3813 Bakuchiol Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
Cell Prolif, 2019, 52(5):e12666
S3745 Balsalazide disodium Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
Front Microbiol, 2020, 10:2936
S9127 Carnosol Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities.
ACS Sustain Chem Eng, 2023, 11(12):4727-4737
S9502 Madecassic acid Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition.
Drug Des Devel Ther, 2022, 16:3793-3804
S9474 Acetylharpagide Acetylharpagide is a monomeric compound extracted from Ajuga decumbens, widely used for remedying infectious and inflammatory diseases.
Molecules, 2020, 25(23)5523
Molecules, 2020, 25(23)E5523
S9146 Anwuligan Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.
Front Nutr, 2022, 9:892558
E0206 Ginkgetin Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities.
Biomed Pharmacother, 2022, 154:113628
S6476 Eicosapentaenoic Acid (EPA) Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid with antiinflammatory properties, and is present in fish and fish oils, including salmon, cod, and krill oils.
Int Immunopharmacol, 2023, 10.1016/j.intimp.2023.111181
S5686 Tryptanthrin Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.
BMC Complement Med Ther, 2024, 24(1):28
Cancers (Basel), 2020, 12(9)E2668
S5869 Cortisone Cortisone is a pregnane steroid hormone and one of main substance released by the body as a reaction to stress. It suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury.
Drug Test Anal, 2020, 10.1002/dta.2917
S1939 Levamisole hydrochloride (-)-Tetramisole is an inhibitor of alkaline phosphatase, used as an anthelmintic.
S1679 Flurbiprofen Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
S2512 Tenoxicam Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM.
S4098 Halcinonide Halcinonide(SQ-18566) is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
E0212 Cornuside Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et ZUCC. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting NF-κB activation in RAW 264.7 macrophages. Cornuside attenuates apoptosis in rat cortical neurons.
S5459 Aucubin Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.
S3622 Diammonium Glycyrrhizinate Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
S5457 Curculigoside Curculigoside (Curculigoside A), a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects.
E0215 Isorhapontigenin Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.
S3982 Batyl alcohol Batyl alcohol (Batilol, Stearyl monoglyceride, 1-O-Octadecylglycerol, Batilolum), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.
S5471 Monotropein Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.
S5361 Bendazac Bendazac (bendazolic acid, AF-983) is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.
E0150 Carrageenan Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
E0216 Hinokiflavone Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway.
S5871 Trans-Tranilast Trans-Tranilast is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.
S4842 Balsalazide Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
S5458 Verbascoside Verbascoside (Acteoside, Kusaginin), a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.
S3997 Oxaceprol Oxaceprol (N-acetyl-L-hydroxyproline) is an anti-inflammatory drug used in the treatment of osteoarthritis.
S6249 Picolinic acid (PCL 016) Picolinic acid (PCL 016) is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.
A2036 Magrolimab (anti-CD47)

Magrolimab (anti-CD47) (5F9, GS-4721,Hu5F9 G4,ONO 7913) is a first-in-class macrophage immune checkpoint inhibitor that mainly binds to N-terminal pyroglutamate of CD47.

S5322 Sodium gualenate Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects.
S9203 Notopterol Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities.
S9204 Oroxylin A Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties.
S0920 Ginkgolide J Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. Ginkgolide J also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. Ginkgolide J exhibits anti‑inflammatory activity.
S9216 Esculentoside A Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity.
S4529 Idramantone Idramantone (Kemantane, 5-Hydroxy-2-adamantanone) is an immune agonist.
S9222 Dipotassium glycyrrhizinate Glycyrrhizinate dipotassium (Neubormitin) is a widely used anti-inflammatory agent isolated from the licorice root.
S9033 Incensole acetate Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation.
S9228 Schisandrin C Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation.
S9071 Nootkatone Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.
S3969 Veratric acid Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
S0947 Cafestol Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60.
S9225 Santalol Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.
S9237 Berberrubine Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects.
S9240 Isofraxidin Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
E2634 H-Leu-Leu-OMe Hydrochloride H-Leu-Leu-OMe Hydrochloride (H-LEU-LEU-OME HCL, L-Leucyl-L-Leucine methyl ester), a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential, also can induce endolysosomal pathway stress.
S9242 Narirutin Narirutin (Naringenin-7-O-rutinoside, Isonaringin), a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects.
E0365 Fucoidan

Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.

S9243 Protosappanin B Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.
S9245 Phellodendrine chloride Phellodendrine chloride, isolated from the Phellodrndron amurensis, exhibits immunosuppressive and anti-inflammatory activities.
S9246 Tiliroside Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities.
E0174 Betamethasone sodium phosphate

Betamethasone sodium phosphate (Betamethasone 21-Phosphate Disodium Salt) is a potent glucocorticoid with anti-inflammatory activity.

S9248 Homoorientin Homoorientin (Isoorientin, Luteolin-6-C-glucoside) is a flavone that acts as a radical scavenger and an antineoplastic agent.
S9005 Stearyl Glycyrrhetinate Stearyl glycyrrhetinate, the stearyl ester of 18-β-glycyrrhetinic acid, has been demonstrated to improve antiviral effects, reduce inflammation and suppress allergies in the pharmaceutical and cosmetic industry.
S9254 Skimmin Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent.
S8091New 25-Hydroxycholesterol 25-Hydroxycholesterol is a side-chain oxysterol and a selective suppressor of IgA production by B cells with an EC50≈65 nM. It affects the immune system and has a key role in the pathogenesis of atherosclerosis.
S6058 β-Caryophyllene β-Caryophyllene is a natural bicyclic sesquiterpene that is a constituent of many essential oils. It acts as a non-steroidal anti-inflammatory drug, a fragrance and a metabolite.
S5138 Citral Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil.
S9266 Ginsenoside Rc Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects.
S3837 Echinocystic acid Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.
S9272 Koumine Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities.
S6136 (±)-α-Bisabolol α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties.
S3841 Eleutheroside B Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.
E0022 Ophiopogonin D Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.
E0020 Lupenone Lupenone (Lup-20(29)-en-3-one, lupeone) is an isolated compound exhibiting anti-oxidative, anti-inflammation, and anti-diabetic activities. Lupenone can protect SH-SY5y cells against METH-induced neuronal apoptosis through the PI3K/Akt pathway.
S3501 Perflubron Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. Perflubron also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties.
S3500 Pentosan Polysulfate Sodium Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity.
S9280 Demethoxycurcumin Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.
S9281 Peimine Peimine (Verticine, Wanpeinine A) is a major biologically active component of Fritillaria ussuriensis, exhibits anti-inflammatory and pain suppression properties at the cellular level.
E0025 2-Hydroxybenzylamine 2-Hydroxybenzylamine (2-(Aminomethyl)phenol, 2-HOBA, NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress.
S9287 Genkwanin Genkwanin (Apigenin 7-methyl ether) is one of the major non-glycosylated flavonoids in herbs. It has a variety of pharmacological effects including anti-inflammatory, anti-bacterial, antiplasmodial, radical scavenging, chemopreventive and inhibiting 17β-Hydroxysteroid dehydrogenase type 1 activities.
S9288 Casticin Casticin (Vitexicarpin), as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation.
S5973 Methylprednisolone Acetate Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
S6551 Adelmidrol Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.
S4165 Benzydamine HCl Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
S9296 Fraxin Fraxin (Fraxetin-8-O-glucoside), a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis.
S9297 Kirenol Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. It has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.
S9298 Corylin Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties.
S9300 Methylprotodioscin Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and anticancer activities.
S5261 Ufenamate Ufenamate (Butyl flufenamate, Flufenamic acid butyl ester, Fenazol) is an anthranilic acid derivative with anti-inflammatory activity.
S6243 Ethyl pyruvate Ethyl pyruvate (CTI-01) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.
S4966 4-Methylesculetin 4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.
E0760 Neotuberostemonine Neotuberostemonine (NTS), one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, has a significant effect on BLM-induced pulmonary fibrosis by inhibiting macrophage recruitment and M2 polarization protective effect.
S9013 Paulownin Paulownin, a furofuran lignan from Paulownia tomentosa, has anti-inflammation, analgesia, immunity, hypoglycemia properties.
S3780 Secoisolariciresinol diglucoside Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.
S3761 Eucalyptol Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects. Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
S9309 Micheliolide Micheliolide, a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, inhibits various inflammatory response and may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders.
S9019 Quillaic acid Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol and shows strong anti-inflammatory activity.
S9313 Atractylenolide III Atractylenolide III, a major component of Atractylodes rhizome, has anti-inflammatory and anti-angiogenesis activities.
S5969 Dicloxacillin Sodium hydrate Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent.
S4832 Tolmetin Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.
S9022 20S-Ginsenoside Rg3 20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.
S9023 20S-Ginsenoside Rh2 20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis.
S9317 Forsythoside A Forsythoside A, one of the main active ingredients in Forsythiae fructus, has been shown to possess anti-bacterial and immunomodulatory properties.
S9318 (20R)-Ginsenoside Rh1 (20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.
S4188 Sasapyrine Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.
S4835 Aceclofenac Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.
S3932 Astilbin Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
S9324 Alnustone Alnustone, a naturally occuring compound found in the rhizomes of Curcuma xanthorrhiza, exhibits anti-inflammatory, antihepatotoxic and antiemetic activities.
S3893 Bornyl acetate Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
S9054 Pectolinarin Pectolinarin is a major compound in Cirsium setidens with anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin induces apoptosis via inactivation of the PI3K/Akt pathway.
E0119New Iptacopan (LNP023) Hydrochloride Iptacopan (LNP023) Hydrochloride is a first-in-class, orally administered, potent and highly selective factor B inhibitor with an IC50 of 12 nM and a Kd value of 7.9 nM. Iptacopan exhibits excellent selectivity over other proteases affording IC50s of >30 μM across a panel of 41 human proteases.
S9053 Irisflorentin Irisflorentin derived from the roots of Belamcanda chinensis (L.) DC. is an herb which has been used for the treatment of inflammatory disorders in traditional Chinese medicine.
S4682 Loxoprofen Loxoprofen (Koloxo, Loxoprofene, Loxoprofeno) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
S3765 Picroside II Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
S9051 Asperuloside Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect.
S6593 Methylprednisolone sodium succinate Methylprednisolone sodium succinate (U-9088, 6α-Methylprednisolone 21-hemisuccinate Sodium) is a corticosteroid medication that reduces inflammation.
S9037 Tenacissoside H Tenacissoside H, a natural compound found in M. tenacissima, exerts anti-inflammatory and anti-tumor effects.
E2699 Tris(2-butoxyethyl) phosphate Oral exposure to low-dose Tris (2-butoxyethyl) phosphate (TBEP) levels equivalent to tolerable daily intake may exacerbate allergic pulmonary inflammation by promoting a skewed T-helper 2 cell response, upregulation of ERα and dysregulation of both MLN and BM microenvironments.
S5016 Isoprinosine Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.
S9061 Hydroxy safflor yellow A Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects.
S3774 Dehydroandrographolide Succinate Potasium Salt Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
S0836 TMN355 TMN355 (Compound 3i) is a potent inhibitor of cyclophilin A (CypA) with IC50 of 1.52 nM and reduces foam cell formation and cytokine secretion. TMN355 is used for the treatment of atherosclerosis.
S3775 Ligustrazine hydrochloride Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
S9064 Trilobatin Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
S6404 Salicylamide Salicylamide (o-hydroxybenzamide) is a non-prescription drug with analgesic and antipyretic properties.
S3776 Sophoricoside Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects.
E1134 ABR-238901 ABR-238901 is a novel S100A8/A9 blocker that potently inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4).
S9067 Pseudoprotodioscin Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
S9036 (20R)Ginsenoside Rh2 (20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor.
S9068 Trillin Trillin (Disogluside, Diosgenin glucoside) is an active ingredient isolated from Trillium tschonoshii Maxim and acts as a potential anti-inflammatory drug for chronic hepatic inflammation.
S9384 Sophocarpine Monohydrate Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.
E1386New KP-457 KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α.
S9072 Sweroside Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
S5044 Isoxepac Isoxepac is a non-steroidal arylacetic acid derivative with anti-inflammatory, analgesic and antipyretic activity.
S5046 Clonixin Clonixin (Clonixic acid) is a nonsteroidal anti-inflammatory drug with analgesic, antipyretic, and platelet-inhibitory actions.
S3790 Methyl gallate Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
S5162 Isovanillic acid Isovanillic acid (Acide isovanillique, 3-Hydroxyanisic acid, 3-Hydroxy-p-anisic acid), a metabolite of isovanillin, is a selective inhibitor of aldehyde oxidase.
S9083 Rhapontin Rhapontin (Ponticin, Rhaponticin, Rhapontigenin glucoside), a stibene-type glycoside distributed widely in medicinal plants of Rheum genus (Polygonaceae), has anti-inflammatory effect and anti-proliferative activity.
S9084 Rhoifolin Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.
S3799 Gentisic acid Gentisic acid (2,5-dihydroxybenzoic acid, 5-Hydroxysalicylic acid, Hydroquinonecarboxylic acid, DHB), an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.
S9085 Corynoline Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.
S9405 Sesamoside Sesamoside, a main chemical ingredient iridoid glycoside from Lamiophlomic rotata, has analgesic and anti-inflammatory effects in animal studies.
S9088 Calycosin-7-O-beta-D-glucoside Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities.
S9406 Sauchinone Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects.
S9407 Angoroside C Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc.
S9090 Corilagin Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α.
S9408 Beta-Elemonic acid Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.
S9091 10-Gingerol 10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity.
S4753 Ganoderic acid A Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.
S3881 Scopoletin Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.
S9095 Senegenin Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.
S5834 p-Coumaric acid ethyl ester p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid, which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties.
S9512 1,3-Dicaffeoylquinic acid 1,3-Dicaffeoylquinic acid (Cynarin; Cinarine; 1,5-Dicaffeoylquinic acid) is a phenolic compound found in artichoke. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
S9417 Homoplantaginin Homoplantaginin (Hispidulin-7-glucoside), a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin inhibits TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.
S9098 Dehydrodiisoeugenol Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition.
S9099 Orientin Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9100 Fraxinellone Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities.
S6073 Diclofenac acid Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
S4706 Eugenol Eugenol (4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol) is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.
S9106 Eleutheroside E Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.
S9425 Trifolirhizin Trifolirhizin, a natural pterocarcan flavonoid extracted from Sophora flavescens, has many pharmacological activities, such as hepatoprotective, anti-inflammatory, anti-proliferation, and skin-whitening.
A2033 Vibostolimab (anti-TIGIT) Vibostolimab (anti-TIGIT, MK-7684) is a humanized monoclonal antibody that binds to the T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), blocking the interaction between TIGIT and its ligands, CD112 and CD155, thereby activating T lymphocytes which help to destroy tumor cells.
S9427 Tabersonine Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus and shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity.
S5579 Chelidonic acid Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.
S9431 Dehydrocorydalin Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.
S9112 Kaempferitrin Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
S9113 Ononin Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.
S9433 Tubeimoside II Tubeimoside II (Tubeimoside B), a natural triterpenoid saponin isolated from herb, show anti-inflammatory, antitumor, and antitumor-promoting effects.
S4709 Latanoprost Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
E0202 Benzoylmesaconine Benzoylmesaconine (Mesaconine 14-benzoate) is a main Aconitum alkaloid isolated from several Aconitum species with potent pharmacological activities, such as analgesia and anti-inflammation.
S9116 Chikusetsusaponin IVa Chikusetsusaponin IVa (Calenduloside F), a major active ingredient of triterpenoid saponins, has numerous pharmacological activities, including cytotoxic activity against various cancer cells, anti-inflammatory activity, prevention of dental caries and induction of genta-micin nephrotoxicity. Chikusetsusaponin IVa is a novel AMPK activator.
S9437 Echinatin Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities.
S6439 Talniflumate Talniflumate (MSI-1995) is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. Talniflumate is also an inhibitor of human calcium-activated chloride channels.
S6448 Ibuprofen piconol Ibuprofen piconol (U75630) is a non-steroidal, anti-inflammatory (NSAID) drug for the topical relief of primary thermal burns and sunburns.
E0205 Strictosamide Strictosamide is the main representative constituent of Nauclea officinalis Pierre ex Pitard (Rubiaceae) with anti-inflammatory and analgesic activities.
S3106 Pidotimod Pidotimod(Pidotomod) is an immunostimulant.
S9120 Scutellarein Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities
SLAS Discov, 2024, S2472-5552(24)00007-8
S9439 Kaurenoic acid Kaurenoic acid (kaurenoate, kaur-16-en-18-oic acid) is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, the mechanisms may through inhibition of iNOS and COX-2 expression.
S9440 Naringenin chalcone Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.
S6472 Tinoridine hydrochloride Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity.
S3892 Isopsoralen Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
S9123 Eriodictyol Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties.
S9125 Apigetrin Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.
S9128 Isoacteoside Isoacteoside, a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., is an anti‐inflammatory herb widely used in traditional Chinese medicine.
S9129 20(S)-Ginsenoside Rh1 20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1) is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.
S4690 Escin Escin (Aescin) is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).
S9132 Harpagide Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects.
S9136 Neochlorogenic acid Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S2307 Roquinimex Roquinimex (FCF 89, Linomide, LS 2616) is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. Roquinimex is a potent oral active tumor antiangiogenic agent. Roquinimex inhibits the secretion of TNF-α.
S4789 5-Acetylsalicylic acid 5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid), also known as Mesalazine or Mesalamine, is an aminosalicylate anti-inflammatory drug used to treat inflammatory bowel disease.
S9144 Solasonine Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties.
S9220 Stylopine hydrochloride Stylopine (Tetrahydrocoptisine, Coptisine), a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
S5043 Benorylate Benorylate (Benorilate, Benoral, Benortan) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
S9148 Peiminine Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
S9488 Praeruptorin D Praeruptorin D, a major pyranocoumarin isolated from Radix Peucedani, exhibits antitumor and anti-inflammatory activities.
E0208 Herbacetin Herbacetin is a natural flavonoid compound found in flaxseed with strong antioxidant, antitumor and anti-inflammatory activity.
S9264 Decursin Decursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities.
A2044 Omalizumab (anti-IgE) Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research.
S9920 GYY4137 GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.
E0193 Mometasone Furoate Hydrate Mometasone Furoate (SCH 32088) Hydrate is a synthetic glucocorticoid with anti-inflammatory activity.
S9157 Neoandrographolide Neoandrographolide, a principle diterpenoids isolated from A. paniculata, exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.
E0129 Oxysophocarpine Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.
S4524 2-Ethoxybenzamide 2-Ethoxybenzamide (Ethenzamide) is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.
S5466 Saikosaponin A Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities.
S5463 Curcurbitacin IIA Curcurbitacin IIA (Cucurbitacin Iia, CuIIa, Hemslecin A, Dihydrocucurbitacin Q1) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.
S9161 Ziyuglycoside II Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties.
E0131 Luteolin-7-O-glucuronide Luteolin-7-O-glucuronide (Luteolin 7-glucuronide) is a flavone glycoside found in plants. Luteolin-7-O-glucuronide possesses anti-microbial, antioxidant, anti-mutagenic, anti-genotoxic, anti-inflammatory, and anti-arthritic activities.
S3906 Astragalus polyphenols Astragalus polyphenols(2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucopyranoside) is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.
E0222 Glaucocalyxin A Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
S9551 Uvaol Uvaol is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil, exhibiting both pro- and anti-inflammatory properties.
S9165 Poncirin Poncirin (Isosakuranetin-7-neohesperidoside), extracted from trifoliate orange, has anti-bacterial and anti-inflammatory activities.
E0226 Chebulagic acid Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.
S9167 Columbin Columbin, a diterpenoid furanolactone, is a potential anti-inflammatory drug.
S9560 Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
E0233 14-Deoxy-11,12-didehydroandrographolide 14-Deoxy-11,12-didehydroandrographolide (deAND), a diterpenoid in Andrographis paniculata (Burm. f.) Nees with hypotensive, anti-inflammatory, anti-asthma, and anti-cancer activities.
S5360 Diflorasone Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.
S9171 Harpagoside Harpagoside, a natural product found in the plant Harpagophytum procumbens, has potent anti-rheumatic, anti-inflammatory and analgesic effects.
S9172 Phellodendrine Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis.
S6742 Etofenamate Etofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.
S5412 Loxoprofen Sodium Loxoprofen sodium is a non-steroidal anti-inflammatory drug.
S9174 Xanthotoxol Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.
S9175 Macranthoidin A Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity.
E0148 Linalyl Acetate Linalyl Acetate (Bergamiol, Bergamol, Linalool acetate) is a naturally occurring phytochemical found in many flowers and spice plants. Linalyl Acetate is a potentially anti-inflammatory agent.
S9180 Tussilagone Tussilagone, isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is used as a traditional oriental medicine for asthma and bronchitis. It shows anti-inflammatory activity in in vitro studies.
E0780 MNITMT MNITMT is a more potent immunosuppressive agent without bone marrow toxicity.
S5729 Fosfosal Fosfosal (2-phosphonoxy benzoic acid) is a non-acetylated salicylic acid derivative, with analgesic and anti-inflammatory activity, but without effects on PG biosynthesis in vitro.
S9183 Ruscogenin Ruscogenin, a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been reported to exert significant anti-inflammatory and anti-thrombotic activities.
S5451 Ferulic acid methyl ester Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid, which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.
S9184 Forsythoside B Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant. Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
S3928 Baccatin Ⅲ Baccatin Ⅲ is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It exhibits immunomodulatory and anticancer chemotherapeutic activities.
E0211 Dihydroberberine Dihydroberberine, a hydrogenated derivative of Berberine (BBR), exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.
S4529 Idramantone Idramantone (Kemantane, 5-Hydroxy-2-adamantanone) is an immune agonist.
S4709 Latanoprost Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
A2102 Anti-mouse CD8α-InVivo Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).
Nat Commun, 2023, 14(1):7709.
Nat Commun, 2023, 14(1):7709
Cell Rep Med, 2023, 4(10):101229
A2028 Tiragolumab (anti-TIGIT) Tiragolumab (anti-TIGIT) (RG6058, MTIG7192A) is a humanized IgG1/kappa monoclonal antibody that binds TIGIT to prevent its interaction with its ligand PVR (CD155).
Cell Commun Signal, 2024, 22(1):35
J Immunother Cancer, 2023, 11(12)e007502
A2036 Magrolimab (anti-CD47)

Magrolimab (anti-CD47) (5F9, GS-4721,Hu5F9 G4,ONO 7913) is a first-in-class macrophage immune checkpoint inhibitor that mainly binds to N-terminal pyroglutamate of CD47.

A2033 Vibostolimab (anti-TIGIT) Vibostolimab (anti-TIGIT, MK-7684) is a humanized monoclonal antibody that binds to the T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), blocking the interaction between TIGIT and its ligands, CD112 and CD155, thereby activating T lymphocytes which help to destroy tumor cells.
A2044 Omalizumab (anti-IgE) Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research.
S2286 Cyclosporin A Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.
Signal Transduct Target Ther, 2023, 8(1):371
Signal Transduct Target Ther, 2023, 8(1):371
Theranostics, 2023, 10.7150/thno.87288
S7434 TAPI-1 TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).
Br J Cancer, 2024, 10.1038/s41416-024-02576-z
PLoS Pathog, 2023, 19(9):e1011629
J Transl Med, 2023, 21(1):530
S3032 Bindarit ビンダリットは、独特な抗炎症性活動が単球走化性タンパク質MCP-1/CCL2、MCP-3/CCL7とMCP-2/CCL8を含む炎症性ケモカインの亜族の選択的な抑制のためにある最初の合成物です。NMRとHPLCによって確かめられる品質。顧客レビュー、確認と紙表彰状を見てください。
Exp Mol Med, 2024, 56(2):408-421.
J Biol Chem, 2023, S0021-9258(23)02393-1
Cell Death Discov, 2022, 8(1):466
S1576 Sulfasalazine Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.
Adv Sci (Weinh), 2023, 10(20):e2300517
Proc Natl Acad Sci U S A, 2022, 119(36):e2117396119
Cell Mol Life Sci, 2022, 79(5):228
S5004 Pimecrolimus Pimecrolimus (Elidel,ASM 981,SDZ-ASM 981) is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S1514 Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
Cells, 2023, 12(23)2696
Int J Mol Sci, 2023, 24(11)9708
Cell Rep, 2021, 34(10):108832
S1654 Phenylbutazone Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S8660 GI254023X GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively. GI254023X can inhibit MMP9.
Oncogene, 2023, 42(18):1438-1452
Signal Transduct Target Ther, 2022, 7(1):72
Pharmacol Res, 2022, 177:106132
S1591 Bestatin (Ubenimex) Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.
Aging (Albany NY), 2022, 14(7):3259-3275
Phytother Res, 2021, 35(6):3167-3180
Clin Transl Med, 2020, 10(8):e233
S1622 Prednisone Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Blood Cancer J, 2022, 12(3):36
Int J Mol Sci, 2022, 23(7)3834
Front Immunol, 2021, 12:739605
S8291 Atractylenolide I Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.
Front Oncol, 2021, 11:738534
Mol Med Rep, 2021, 24(4)691
Front Pharmacol, 2020, 26;11:273
S3758 Sinomenine hydrochloride Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
Biomed Res Int, 2022, 2022:4914005
Cancer Manag Res, 2021, 13:1189-1204
Bioorg Med Chem, 2020, 31:115986
S3608 Demethylzeylasteral (T-96) Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.
J Cancer, 2021, 12(13):3967-3975
Front Biosci (Landmark Ed), 2020, 25:498-512
S4268 Flufenamic acid Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
Theranostics, 2022, 12(18):7681-7698
Biochim Biophys Acta Mol Cell Biol Lipids, 2020, 1865(12):158793
S9032 Sanguinarine Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.
Front Oncol, 2022, 12:732860
Onco Targets Ther, 2020, 13:8989-9003
S6812 Z-Guggulsterone Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Z-Guggulsterone exhibits anti-inflammatory effects in microglia. Z-Guggulsterone induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway.
Int J Biol Sci, 2023, 19(11):3456-3471
Int J Biol Sci, 2023, 19(11):3456-3471
S6239 PMX-53 PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
Thromb J, 2022, 20(1):24
S5661 Tiaprofenic acid Tiaprofenic acid (Tiaprofensaeure, Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.
Antiviral Res, 2023, 216:105674
S9055 Salvianolic acid A Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.
Clin Exp Pharmacol Physiol, 2021, 48(4):508-514
E0206 Ginkgetin Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities.
Biomed Pharmacother, 2022, 154:113628
S2512 Tenoxicam Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM.
S3622 Diammonium Glycyrrhizinate Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
S5361 Bendazac Bendazac (bendazolic acid, AF-983) is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.
E0150 Carrageenan Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
S0920 Ginkgolide J Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. Ginkgolide J also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. Ginkgolide J exhibits anti‑inflammatory activity.
S9033 Incensole acetate Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation.
S0947 Cafestol Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60.
E0365 Fucoidan

Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.

S8091New 25-Hydroxycholesterol 25-Hydroxycholesterol is a side-chain oxysterol and a selective suppressor of IgA production by B cells with an EC50≈65 nM. It affects the immune system and has a key role in the pathogenesis of atherosclerosis.
E0022 Ophiopogonin D Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.
E0020 Lupenone Lupenone (Lup-20(29)-en-3-one, lupeone) is an isolated compound exhibiting anti-oxidative, anti-inflammation, and anti-diabetic activities. Lupenone can protect SH-SY5y cells against METH-induced neuronal apoptosis through the PI3K/Akt pathway.
S3501 Perflubron Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. Perflubron also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties.
S3500 Pentosan Polysulfate Sodium Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity.
S3761 Eucalyptol Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects. Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
E0119New Iptacopan (LNP023) Hydrochloride Iptacopan (LNP023) Hydrochloride is a first-in-class, orally administered, potent and highly selective factor B inhibitor with an IC50 of 12 nM and a Kd value of 7.9 nM. Iptacopan exhibits excellent selectivity over other proteases affording IC50s of >30 μM across a panel of 41 human proteases.
S0836 TMN355 TMN355 (Compound 3i) is a potent inhibitor of cyclophilin A (CypA) with IC50 of 1.52 nM and reduces foam cell formation and cytokine secretion. TMN355 is used for the treatment of atherosclerosis.
S9064 Trilobatin Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
E1134 ABR-238901 ABR-238901 is a novel S100A8/A9 blocker that potently inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4).
E1386New KP-457 KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α.
S9072 Sweroside Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
S9090 Corilagin Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α.
S4753 Ganoderic acid A Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.
S9106 Eleutheroside E Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.
S3892 Isopsoralen Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
S9148 Peiminine Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
S9920 GYY4137 GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.
E0129 Oxysophocarpine Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.
S5466 Saikosaponin A Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities.
E0131 Luteolin-7-O-glucuronide Luteolin-7-O-glucuronide (Luteolin 7-glucuronide) is a flavone glycoside found in plants. Luteolin-7-O-glucuronide possesses anti-microbial, antioxidant, anti-mutagenic, anti-genotoxic, anti-inflammatory, and anti-arthritic activities.
E0226 Chebulagic acid Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.
S5360 Diflorasone Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.
S5412 Loxoprofen Sodium Loxoprofen sodium is a non-steroidal anti-inflammatory drug.
E0148 Linalyl Acetate Linalyl Acetate (Bergamiol, Bergamol, Linalool acetate) is a naturally occurring phytochemical found in many flowers and spice plants. Linalyl Acetate is a potentially anti-inflammatory agent.
E0780 MNITMT MNITMT is a more potent immunosuppressive agent without bone marrow toxicity.
A2001 Ipilimumab (anti-CTLA-4) Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
Cells, 2023, 12(8)1145
Cells, 2023, 12(8)1145
Cancers (Basel), 2023, 16(1)80
A2009 Rituximab (anti-CD20) Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.
Oncoimmunology, 2023, 12(1):2163784
Heliyon, 2023, 9(12):e22991
Front Immunol, 2022, 13:1016263
S1829 Pranlukast Pranlukast (ONO-1078,ono-rs-411) is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.
Cancer Immunol Immunother, 2021, 70(1):203-213
S4529 Idramantone Idramantone (Kemantane, 5-Hydroxy-2-adamantanone) is an immune agonist.
S4709 Latanoprost Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
S1737 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Life Sci Alliance, 2023, 6(10)e202302009
Life Sci Alliance, 2023, 6(10)e202302009
Front Oncol, 2022, 12:905665
S3648 Amlexanox Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
Signal Transduct Target Ther, 2023, 8(1):246
Signal Transduct Target Ther, 2023, 8(1):246
Nucleic Acids Res, 2022, 50(15):8700-8718
S8301 Ossirene (AS101) Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
Cell Rep, 2023, 42(7):112660
Cells, 2022, 11(24)4013
Syst Biol Reprod Med, 2022, 1-15
S8760 Iberdomide (CC220) Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.
bioRxiv, 2024, 10.1101/2024.01.28.577572
Mol Cancer Ther, 2023, 22(5):659-666
Mol Cancer Ther, 2023, 22(5):659-666
S7892 Avadomide (CC-122) Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.
bioRxiv, 2024, 10.1101/2024.01.28.577572
Cell Chem Biol, 2022, S2451-9456(22)00204-5
Leukemia, 2021, 35(5):1330-1343
S7516 Y-320 Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
mBio, 2022, e0066422
J Virol, 2021, JVI0111921
Research Square, 2021, 10.21203/rs.3.rs-742937/v1
S1733 Methylprednisolone Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
Drug Test Anal, 2020, 10.1002/dta.2917
Nat Med, 2017, 23(4):424-428
Trop J Pharm Res, 2014, 13 (1): 53-59
S2787 Laquinimod Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.
Int Immunopharmacol, 2020, 88:106989
J Neuroinflammation, 2018, 15(1):183
S7515 VGX-1027 VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1.
Eur J Pharmacol, 2019, 842:373-383
S3668 Thymopentin Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.
Front Oncol, 2021, 11:741403
S5083 Lentinan Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.
Iran J Basic Med Sci, 2023, 26(7):836-842
S4842 Balsalazide Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
S5973 Methylprednisolone Acetate Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
S5969 Dicloxacillin Sodium hydrate Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent.
S2307 Roquinimex Roquinimex (FCF 89, Linomide, LS 2616) is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. Roquinimex is a potent oral active tumor antiangiogenic agent. Roquinimex inhibits the secretion of TNF-α.
S8091New 25-Hydroxycholesterol 25-Hydroxycholesterol is a side-chain oxysterol and a selective suppressor of IgA production by B cells with an EC50≈65 nM. It affects the immune system and has a key role in the pathogenesis of atherosclerosis.
E0119New Iptacopan (LNP023) Hydrochloride Iptacopan (LNP023) Hydrochloride is a first-in-class, orally administered, potent and highly selective factor B inhibitor with an IC50 of 12 nM and a Kd value of 7.9 nM. Iptacopan exhibits excellent selectivity over other proteases affording IC50s of >30 μM across a panel of 41 human proteases.
E1386New KP-457 KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α.

Immunology & Inflammation related阻害剤の選択性比較

Tags: Immunology & Inflammation related inhibitor|Immunology & Inflammation related agonist|Immunology & Inflammation related activator|Immunology & Inflammation related inducer|Immunology & Inflammation related antagonist|Immunology & Inflammation related signaling pathway|Immunology & Inflammation related assay kit