Immunology & Inflammation related

阻害剤の選択性比較
溶解度

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S2286	Cyclosporin A	<1 mg/mL	100 mg/mL	100 mg/mL
S5004	Pimecrolimus	<1 mg/mL	100 mg/mL	100 mg/mL
S1211	Imiquimod	<1 mg/mL	1 mg/mL	<1 mg/mL
S3032	Bindarit	<1 mg/mL	64 mg/mL	64 mg/mL
S1407	Bimatoprost	<1 mg/mL	36 mg/mL	83 mg/mL
S4753	Ganoderic acid A	<1 mg/mL	100 mg/mL	100 mg/mL
S8522	Compstatin	100 mg/mL	-1 mg/mL	-1 mg/mL
S8141	Cl-amidine	70 mg/mL	84 mg/mL	84 mg/mL
S8291	Atractylenolide I	<1 mg/mL	46 mg/mL	46 mg/mL
S8301	AS101	<1 mg/mL	62 mg/mL	<1 mg/mL
S4690	Escin	<1 mg/mL	66 mg/mL	<1 mg/mL
S1439	Tranilast	<1 mg/mL	66 mg/mL	<1 mg/mL
S1737	Prednisolone	<1 mg/mL	72 mg/mL	10 mg/mL
S1622	Prednisone	<1 mg/mL	71 mg/mL	<1 mg/mL
S4169	Teriflunomide	<1 mg/mL	32 mg/mL	,1 mg/mL
S2413	Geniposidic acid	<1 mg/mL	16 mg/mL	2 mg/mL
S1508	Alprostadil	<1 mg/mL	71 mg/mL	71 mg/mL
S1733	Methylprednisolone	<1 mg/mL	75 mg/mL	2 mg/mL
S1939	(-)-Tetramisole	48 mg/mL	<1 mg/mL	<1 mg/mL
S2787	Laquinimod	<1 mg/mL	61 mg/mL	1 mg/mL
S1681	Mesalamine	<1 mg/mL	31 mg/mL	31 mg/mL
S2910	Tempol	34 mg/mL	34 mg/mL	34 mg/mL
S1829	Pranlukast	<1 mg/mL	11 mg/mL	<1 mg/mL
S1514	Cyclosporine	<1 mg/mL	100 mg/mL	100 mg/mL
S1576	Sulfasalazine	<1 mg/mL	80 mg/mL	<1 mg/mL
S1654	Phenylbutazone	<1 mg/mL	62 mg/mL	62 mg/mL
S2512	Tenoxicam	<1 mg/mL	68 mg/mL	<1 mg/mL
S3062	Diclofenac Potassium	10 mg/mL	69 mg/mL	<1 mg/mL
S7515	VGX-1027	<1 mg/mL	41 mg/mL	41 mg/mL
S4098	Halcinonide	<1 mg/mL	90 mg/mL	4 mg/mL
S1823	Fenoprofen Calcium	<1 mg/mL	105 mg/mL	10 mg/mL
S4268	Flufenamic acid	<1 mg/mL	56 mg/mL	56 mg/mL
S4529	Idramantone	33 mg/mL	33 mg/mL	33 mg/mL
S7211	PF-04418948	<1 mg/mL	81 mg/mL	<1 mg/mL
S4152	Ethamsylate	53 mg/mL	53 mg/mL	<1 mg/mL
S4165	Benzydamine HCl	69 mg/mL	69 mg/mL	69 mg/mL
S4170	Coumarin	<1 mg/mL	29 mg/mL	29 mg/mL
S7809		85 mg/mL	<1 mg/mL	40 mg/mL
S2400	Rheic Acid	<1 mg/mL	<1 mg/mL	<1 mg/mL
S4188	Sasapyrine	<1 mg/mL	52 mg/mL	52 mg/mL
S7448	CORM-3	<1 mg/mL	38 mg/mL	<1 mg/mL
S4682	Loxoprofen	<1 mg/mL	49 mg/mL	49 mg/mL
S7516	Y-320	<1 mg/mL	11 mg/mL	<1 mg/mL
S3027	Fenoprofen calcium hydrate	<1 mg/mL	48 mg/mL	18 mg/mL
S8097	C-DIM12	<1 mg/mL	71 mg/mL	71 mg/mL
S2350	Rutin	<1 mg/mL	100 mg/mL	2 mg/mL
S7434	TAPI-1	60 mg/mL	99 mg/mL	99 mg/mL

Immunology & Inflammation related阻害剤(15)
Immunology & Inflammation related拮抗剤(2)
Immunology & Inflammation related作動薬(4)
Immunology & Inflammation relatedモジュレータ(6)
Immunology & Inflammation related化学物質(24)
新Immunology & Inflammation related製品

製品コード	製品説明	文献中の使用例	お客様のフィードバック
S2286	Cyclosporin A Cyclosporin A is an antilymphocytic agent, competitively binds to and inhibits calcineurin.	Oncogene, 2015, 10.1038/onc.2015.32 Antiviral Res, 2015, 120:140-6 Drug metab dispos, 2013, 42(3):318-22	CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.
S5004	Pimecrolimus Pimecrolimus, like all ascomycins, is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.	Mol Pharmaco, 2013, 84(1):104-13 Am J Physiol Heart Circ Physiol, 2013, 305(11):H1646-57	Pim inhibits nuclear factor of activated T-cell (NFAT) translocation of cultured human vascular smooth muscle cells. hCASM expressing green fluorescent protein-NFAT were incubated with 10 uM Pim for 30 min. Left: mean nuclear/cytosol fluorescence intensity ratio (±SE) is displayed at basal conditions and after stimulation with 500 uM ATP in the absence and presence of Pim.
S3032	Bindarit ビンダリットは、独特な抗炎症性活動が単球走化性タンパク質MCP-1/CCL2、MCP-3/CCL7とMCP-2/CCL8を含む炎症性ケモカインの亜族の選択的な抑制のためにある最初の合成物です。	Neurobiol Dis, 2014, 71C:292-304 Am J Transl Res, 2016, 8(1):28-36	Differential participation of ATRs or MCP-1/CCR2 signaling in RVLM in pressor response and tachycardia after stroke. Changes in mean diastolic (ΔDBP) blood pressure or heart rate (ΔHR) relative to baseline in rats that received pretreatment by microinjection bilaterally into the RVLM of bindarit (Bin; 10 nmol, MCP-1 synthesis inhibitor), BMS CCR2 22 (BMS; 10 pmol, CCR2 antagonist), propagermanium (Prop; 10 pmol, CCR2 antagonist) or vehicle control (Veh).Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus SC group, and +P < 0.05 versus Veh (Saline) + MCAO group in the post hoc Scheffe multiple-range test.
S8559^新	INF39
A2001^新	Ipilimumab Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor.
S4753^新	Ganoderic acid A
S8522^新	Compstatin
S8291^新	Atractylenolide I
S1622	Prednisone Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
S1514	Cyclosporine Cyclosporine (Neoral) is an immunosuppressant drug.
S1576	Sulfasalazine Sulfasalazine is a sulfa agent and a derivative of mesalazine used primarily as an anti-inflammatory agent.
S1654	Phenylbutazone Phenylbutazone(Butazolidin, Butatron) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
S2512	Tenoxicam Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM
S4268	Flufenamic acid Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
S7434	TAPI-1 TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.	Sci Rep, 2017, 7:46315 PLoS One, 2017, 12(3):e0173240	(B) Florescent images of EpEX (green) and EpICD (red) in PK-15 cells, which were transfected by pSIN-fEpCAM-mCherry and treated with or without TAPI-1/DAPT. Nuclei were stained by Hoechst 33342 (blue). Scale bar, 25 μm.
S1829	Pranlukast Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.
S7211	PF-04418948 PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.
S8301^新	AS101
S1737	Prednisolone Prednisolone(Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.	J Pharmacol Exp Ther, 2014, 350(3):646-56 PLoS One, 2014, 9(12):e111840 Leuk Lymphoma, 2014, 55(5):1144-50	Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from 0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.
S1733	Methylprednisolone Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.	Trop J Pharm Res, 2014, 13 (1): 53-59	Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
S2787	Laquinimod Laquinimod (ABR-215062) は、強力な免疫調節物質です。
S7515	VGX-1027 VGX-1027 is an orally active immunomodulator. Phase1.
S7516	Y-320 Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
S1407	Bimatoprost Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
S4709^新	Latanoprost
S1508	Alprostadil Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties.
S4529	Idramantone
S1211	Imiquimod Imiquimod is a novel synthetic agent with immune response modifying activity.
S8141^新	Cl-amidine
S4690^新	Escin
S1439	Tranilast Tranilast is an antiallergic compound.	Environ Toxicol Pharmacol, 2015, 39(1):114-24	Cells were cultured in LD collagen gels ± vehicle control (V), 100 M DFOM (D) or tranilast (T) for 24h (E-H) and assessed for P450 enzyme production.
S4169	Teriflunomide Teriflunomideは、免疫調節剤として用いられる酵素ジヒドロデヒドロゲナーゼを遮断することによってレフルノミド、阻害ピリミジンデノボ合成の活性代謝産物です。
S2413	Geniposidic acid Geniposidic acid is an effective anticancer and radioprotection agent.
S1939	(-)-Tetramisole Levamisole Hydrochloride(Ergamisol)is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function.
S1681	Mesalamine Mesalamine is an anti-inflammatory compound.
S2910	Tempol TEMPOL is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
S3062	Diclofenac Potassium Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
S4098	Halcinonide Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
S1823	Fenoprofen Calcium Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
S4152	Ethamsylate Ethamsylateは生とプロスタグランジンの作用を阻害する止血薬であり、毛細血管内皮抵抗などと血小板の接着性を向上させます。
S4165	Benzydamine HCl Benzydamine hydrochlorideは、抗炎症、鎮痛、解熱及び局所麻酔薬活性を有する局所用非ステロイド系抗炎症薬（NSAID）です。
S4170	Coumarin Coumarinは肝毒性と発がん性を有する二次植物化学物質です。
S2400	Rheic Acid Rhein(Monorhein; NSC 38629; Rheic acid; Rheinic acid) is a constituent of rhubarb which was isolated from the fresh rhizome of Rheum coreanum Nakai.
S4188	Sasapyrine Sasapyrine (salsalate)は非ステロイド経口抗炎症剤です。
S7448	CORM-3 CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
S4682	Loxoprofen Loxoprofenはプロピオン酸派生物に於いて、1種の非ステロイド性の（non-steroidal）消炎薬です。
S3027	Fenoprofen calcium hydrate フェノプロフェン・カルシウム水和物（Nalfon）は、非ステロイド性の抗炎症剤（NSAID）です。
S4706	Eugenol
S8097	C-DIM12
S2350	Rutin Rutin, a flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc.
S4524	2-Ethoxybenzamide

製品コード	製品説明	文献中の使用例	お客様のフィードバック
S2286	Cyclosporin A Cyclosporin A is an antilymphocytic agent, competitively binds to and inhibits calcineurin.	Oncogene, 2015, 10.1038/onc.2015.32 Antiviral Res, 2015, 120:140-6 Drug metab dispos, 2013, 42(3):318-22	CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.
S5004	Pimecrolimus Pimecrolimus, like all ascomycins, is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.	Mol Pharmaco, 2013, 84(1):104-13 Am J Physiol Heart Circ Physiol, 2013, 305(11):H1646-57	Pim inhibits nuclear factor of activated T-cell (NFAT) translocation of cultured human vascular smooth muscle cells. hCASM expressing green fluorescent protein-NFAT were incubated with 10 uM Pim for 30 min. Left: mean nuclear/cytosol fluorescence intensity ratio (±SE) is displayed at basal conditions and after stimulation with 500 uM ATP in the absence and presence of Pim.
S3032	Bindarit ビンダリットは、独特な抗炎症性活動が単球走化性タンパク質MCP-1/CCL2、MCP-3/CCL7とMCP-2/CCL8を含む炎症性ケモカインの亜族の選択的な抑制のためにある最初の合成物です。	Neurobiol Dis, 2014, 71C:292-304 Am J Transl Res, 2016, 8(1):28-36	Differential participation of ATRs or MCP-1/CCR2 signaling in RVLM in pressor response and tachycardia after stroke. Changes in mean diastolic (ΔDBP) blood pressure or heart rate (ΔHR) relative to baseline in rats that received pretreatment by microinjection bilaterally into the RVLM of bindarit (Bin; 10 nmol, MCP-1 synthesis inhibitor), BMS CCR2 22 (BMS; 10 pmol, CCR2 antagonist), propagermanium (Prop; 10 pmol, CCR2 antagonist) or vehicle control (Veh).Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus SC group, and +P < 0.05 versus Veh (Saline) + MCAO group in the post hoc Scheffe multiple-range test.
S8559^新	INF39
A2001^新	Ipilimumab Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor.
S4753^新	Ganoderic acid A
S8522^新	Compstatin
S8291^新	Atractylenolide I
S1622	Prednisone Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
S1514	Cyclosporine Cyclosporine (Neoral) is an immunosuppressant drug.
S1576	Sulfasalazine Sulfasalazine is a sulfa agent and a derivative of mesalazine used primarily as an anti-inflammatory agent.
S1654	Phenylbutazone Phenylbutazone(Butazolidin, Butatron) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
S2512	Tenoxicam Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM
S4268	Flufenamic acid Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
S7434	TAPI-1 TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.	Sci Rep, 2017, 7:46315 PLoS One, 2017, 12(3):e0173240	(B) Florescent images of EpEX (green) and EpICD (red) in PK-15 cells, which were transfected by pSIN-fEpCAM-mCherry and treated with or without TAPI-1/DAPT. Nuclei were stained by Hoechst 33342 (blue). Scale bar, 25 μm.

製品コード	製品説明	文献中の使用例	お客様のフィードバック
S1829	Pranlukast Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.
S7211	PF-04418948 PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.

製品コード

製品説明

文献中の使用例

お客様のフィードバック

S1829

Pranlukast

Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.

S7211

PF-04418948

PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.

製品コード	製品説明	文献中の使用例	お客様のフィードバック
S1407	Bimatoprost Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
S4709^新	Latanoprost
S1508	Alprostadil Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties.
S4529	Idramantone

製品コード	製品説明	文献中の使用例	お客様のフィードバック
S8301^新	AS101
S1737	Prednisolone Prednisolone(Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.	J Pharmacol Exp Ther, 2014, 350(3):646-56 PLoS One, 2014, 9(12):e111840 Leuk Lymphoma, 2014, 55(5):1144-50	Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from 0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.
S1733	Methylprednisolone Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.	Trop J Pharm Res, 2014, 13 (1): 53-59	Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
S2787	Laquinimod Laquinimod (ABR-215062) は、強力な免疫調節物質です。
S7515	VGX-1027 VGX-1027 is an orally active immunomodulator. Phase1.
S7516	Y-320 Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.

製品コード	製品説明	文献中の使用例	お客様のフィードバック
S1211	Imiquimod Imiquimod is a novel synthetic agent with immune response modifying activity.
S8141^新	Cl-amidine
S4690^新	Escin
S1439	Tranilast Tranilast is an antiallergic compound.	Environ Toxicol Pharmacol, 2015, 39(1):114-24	Cells were cultured in LD collagen gels ± vehicle control (V), 100 M DFOM (D) or tranilast (T) for 24h (E-H) and assessed for P450 enzyme production.
S4169	Teriflunomide Teriflunomideは、免疫調節剤として用いられる酵素ジヒドロデヒドロゲナーゼを遮断することによってレフルノミド、阻害ピリミジンデノボ合成の活性代謝産物です。
S2413	Geniposidic acid Geniposidic acid is an effective anticancer and radioprotection agent.
S1939	(-)-Tetramisole Levamisole Hydrochloride(Ergamisol)is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function.
S1681	Mesalamine Mesalamine is an anti-inflammatory compound.
S2910	Tempol TEMPOL is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
S3062	Diclofenac Potassium Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
S4098	Halcinonide Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
S1823	Fenoprofen Calcium Fenoprofen calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
S4152	Ethamsylate Ethamsylateは生とプロスタグランジンの作用を阻害する止血薬であり、毛細血管内皮抵抗などと血小板の接着性を向上させます。
S4165	Benzydamine HCl Benzydamine hydrochlorideは、抗炎症、鎮痛、解熱及び局所麻酔薬活性を有する局所用非ステロイド系抗炎症薬（NSAID）です。
S4170	Coumarin Coumarinは肝毒性と発がん性を有する二次植物化学物質です。
S2400	Rheic Acid Rhein(Monorhein; NSC 38629; Rheic acid; Rheinic acid) is a constituent of rhubarb which was isolated from the fresh rhizome of Rheum coreanum Nakai.
S4188	Sasapyrine Sasapyrine (salsalate)は非ステロイド経口抗炎症剤です。
S7448	CORM-3 CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
S4682	Loxoprofen Loxoprofenはプロピオン酸派生物に於いて、1種の非ステロイド性の（non-steroidal）消炎薬です。
S3027	Fenoprofen calcium hydrate フェノプロフェン・カルシウム水和物（Nalfon）は、非ステロイド性の抗炎症剤（NSAID）です。
S4706	Eugenol
S8097	C-DIM12
S2350	Rutin Rutin, a flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc.
S4524	2-Ethoxybenzamide

研究分野別

製品類型

Immunology & Inflammation related