Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。

サイズ 価格(税別)  
JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00

カスタマーフィードバック(4)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NX\0[VFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nDVmlEPTB;MD6wNFAxODByM{W5JO69VQ>? MVPTRW5ITVJ?
MV-4-11 NEHhS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fWbGlEPTB;MD6wNFAxQTV4IN88US=> M3vwUHNCVkeHUh?=
MEG-01 NVj1UWV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\sdnNpUUN3ME2wMlAxODF{ODFOwG0> MYPTRW5ITVJ?
LAMA-84 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj1W2lKSzVyPUCuNFAxOTZ3IN88US=> M{jae3NCVkeHUh?=
CGTH-W-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXGOppCUUN3ME2wMlAxOTZ7IN88US=> NFTOcWZUSU6JRWK=
KASUMI-1 M1jxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkKxTWM2OD1yLkCwNlE4KM7:TR?= MV3TRW5ITVJ?
BE-13 M2DUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHGVZNTUUN3ME2wMlAxOjV7IN88US=> MXPTRW5ITVJ?
CTV-1 NGXzbVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PmUmlEPTB;MD6wNFUzOSEQvF2= M3v6bXNCVkeHUh?=
NKM-1 M17QWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnWzTWM2OD1yLkCwOlU2KM7:TR?= M2HzRnNCVkeHUh?=
MONO-MAC-6 NETjSXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\GTWM2OD1yLkCwPFM4KM7:TR?= MnzlV2FPT0WU
A204 M13ySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfhTWM2OD1yLkCxNlE5KM7:TR?= M3vK[nNCVkeHUh?=
GDM-1 NFrETVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TuR2lEPTB;MD6wNVg{OyEQvF2= NIC3[otUSU6JRWK=
AN3-CA M33pU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XpVmlEPTB;MD6wNVg4OyEQvF2= MYfTRW5ITVJ?
BL-70 M3SwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml60TWM2OD1yLkCyNVk6KM7:TR?= NULhRXloW0GQR1XS
Daudi NWnZfoFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDzUnNKSzVyPUCuNFI2OzdizszN MUfTRW5ITVJ?
KU812 M3LOdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPzTWM2OD1yLkCyPFQ5KM7:TR?= NUi4cIxVW0GQR1XS
KG-1 NWXmWGJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\BTWM2OD1yLkCzNlk1KM7:TR?= MXjTRW5ITVJ?
DOHH-2 NUGzbJVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUexXGZzUUN3ME2wMlA1QDB|IN88US=> MofKV2FPT0WU
HuO9 Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PIVWlEPTB;MD6wOVQ1QCEQvF2= M3y5dnNCVkeHUh?=
EB2 MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLFSWhzUUN3ME2wMlA2PTd4IN88US=> NUHOUWN{W0GQR1XS
G-402 NGC1SnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L3UmlEPTB;MD6wOlM1OSEQvF2= MU\TRW5ITVJ?
SU-DHL-1 Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwME[zO|kh|ryP NEXYcpNUSU6JRWK=
NCI-H719 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMEe4PFgh|ryP NIqxSIxUSU6JRWK=
MLMA NXzFSHptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHFdm12UUN3ME2wMlA6ODZizszN MUfTRW5ITVJ?
KM12 Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\LdGlEPTB;MD6wPVc{PyEQvF2= M1r3W3NCVkeHUh?=
SUP-T1 NH7OXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnJdmZXUUN3ME2wMlA6QTh{IN88US=> MoPVV2FPT0WU
MZ1-PC M3L0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMUGzN|Yh|ryP MUjTRW5ITVJ?
MFE-296 NEKybJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMUG4N|kh|ryP NHX1cnBUSU6JRWK=
ALL-PO NXqzOWhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mme1TWM2OD1yLkGyOFQ{KM7:TR?= M{jHPXNCVkeHUh?=
GB-1 NGDWdIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMUK1NVIh|ryP MXjTRW5ITVJ?
SIG-M5 NGGw[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX0eXNKSzVyPUCuNVM{PyEQvF2= M4TWWXNCVkeHUh?=
P30-OHK M3fm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInsXIZKSzVyPUCuNVU3PzJizszN MoTuV2FPT0WU
NCI-H716 NULVNmRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHHXm1pUUN3ME2wMlE3OjZ4IN88US=> MXrTRW5ITVJ?
MPP-89 M2G5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMU[5N|Mh|ryP NUThU2JGW0GQR1XS
SF126 NHvIcHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKwcHJKSzVyPUCuNVcxPjNizszN NHPh[mtUSU6JRWK=
CTB-1 MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMUezNVYh|ryP NWDLeJU{W0GQR1XS
CA46 NW\z[21bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXKc4dVUUN3ME2wMlE4PDh7IN88US=> NWW2VIUzW0GQR1XS
NCI-H520 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{frbGlEPTB;MD6xO|c{OiEQvF2= MY\TRW5ITVJ?
CAL-85-1 M1TNe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi3XoNWUUN3ME2wMlE4QTJ5IN88US=> MUjTRW5ITVJ?
NCI-H2342 NYfVZnJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT1V2dGUUN3ME2wMlE5PTd5IN88US=> NUHWZXM2W0GQR1XS
697 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:5WGlEPTB;MD6xPFg4OSEQvF2= NGDDRY9USU6JRWK=
NY NWq2[lZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Dj[mlEPTB;MD6xPVI5PyEQvF2= MX3TRW5ITVJ?
T98G NWm3NpRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf3TWM2OD1yLkG5N|E5KM7:TR?= MVXTRW5ITVJ?
NCI-H1703 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfXeVJKSzVyPUCuNVk3OTVizszN MUTTRW5ITVJ?
NCI-H2087 M3;5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMkC0N|kh|ryP M1HyTHNCVkeHUh?=
PF-382 M4\pSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMkC4O|Mh|ryP MWrTRW5ITVJ?
HCT-116 NF3sc5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jSS2lEPTB;MD6yNVA3QSEQvF2= MUnTRW5ITVJ?
CAKI-1 NUPaXmx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn72TWM2OD1yLkKxOlY3KM7:TR?= M2nyRXNCVkeHUh?=
CCF-STTG1 NGnQNnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq3SHNKSzVyPUCuNlI1PzVizszN MlrPV2FPT0WU
D-392MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jKTWlEPTB;MD6yN|E4PyEQvF2= M{izXXNCVkeHUh?=
RT-112 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M321W2lEPTB;MD6yN|c6PSEQvF2= NGXjU|dUSU6JRWK=
MES-SA MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nERWlEPTB;MD6yOFE5PyEQvF2= M3TEdXNCVkeHUh?=
LC-2-ad Mly2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rHOmlEPTB;MD6yOFI3PSEQvF2= M2qw[XNCVkeHUh?=
NOS-1 M3vYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXIcJhKSzVyPUCuNlQ{PjdizszN NGraOnhUSU6JRWK=
NALM-6 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm1UGhKSzVyPUCuNlU2PDNizszN NHmxfHBUSU6JRWK=
TE-15 NHTEfFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\heY5KSzVyPUCuNlYxQTFizszN M2PwU3NCVkeHUh?=
786-0 NF;UfZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMk[yNlgh|ryP M4HNRXNCVkeHUh?=
IST-MES1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLDTWM2OD1yLkK2PFI6KM7:TR?= MlXFV2FPT0WU
KYSE-180 MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3MXm1KSzVyPUCuNlY5QTFizszN MXjTRW5ITVJ?
YT MlviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TFTWlEPTB;MD6yOlk4PCEQvF2= NEfJPWNUSU6JRWK=
A427 NInNdIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMkeyOlQh|ryP M{HrfHNCVkeHUh?=
KYSE-450 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT5XmRnUUN3ME2wMlI4OzJ7IN88US=> M3HmNXNCVkeHUh?=
HuH-7 NHS5S4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX6XFFKSzVyPUCuNlc4PjNizszN M3HXXXNCVkeHUh?=
CAS-1 Mo\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq1XlBKSzVyPUCuNlg{ODNizszN M{LSW3NCVkeHUh?=
KURAMOCHI NHvObJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\m[mlEPTB;MD6yPFQyQSEQvF2= MnjvV2FPT0WU
ACHN MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnIcoZUUUN3ME2wMlI6OzJ|IN88US=> MUjTRW5ITVJ?
HGC-27 NVnJSoQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjRXlFKSzVyPUCuNlk{PTNizszN MYHTRW5ITVJ?
A172 NXrZTWcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXoTWM2OD1yLkK5OVc4KM7:TR?= MU\TRW5ITVJ?
SNU-449 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jtdGlEPTB;MD6yPVk3PCEQvF2= NV\2cZg1W0GQR1XS
SW982 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMkm5O|gh|ryP MkS0V2FPT0WU
EFO-21 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHVU2RbUUN3ME2wMlMxPDFzIN88US=> NYr6ZWE5W0GQR1XS
NCI-H2030 NEPoZpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknoTWM2OD1yLkOxNVY1KM7:TR?= M{HOdXNCVkeHUh?=
HT-144 NWTpR5NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLzUHpwUUN3ME2wMlMyOjhizszN MYLTRW5ITVJ?
MFE-280 NIG1WnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PKTWlEPTB;MD6zNVQ2OyEQvF2= M{m0WHNCVkeHUh?=
SK-LU-1 NX7nU2lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu0[m81UUN3ME2wMlMyPDZ4IN88US=> NH7tV|lUSU6JRWK=
NCI-H2052 NGLsNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGq2TI1KSzVyPUCuN|E1QDRizszN M4X1RnNCVkeHUh?=
SK-HEP-1 NWXzbYVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHiTWM2OD1yLkOzN|Y5KM7:TR?= MknBV2FPT0WU
QIMR-WIL M{P0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fEfWlEPTB;MD6zN|QzPCEQvF2= MXXTRW5ITVJ?
A2780 Ml7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;sSoR2UUN3ME2wMlM1OzB2IN88US=> MkWxV2FPT0WU
ACN MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLjTWM2OD1yLkO0PFc{KM7:TR?= MWrTRW5ITVJ?
BxPC-3 M{HKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TPXmlEPTB;MD6zOFk5QSEQvF2= NFHVeFJUSU6JRWK=
BCPAP NX7B[Hk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fnWWlEPTB;MD6zOlAxOSEQvF2= NYPqW5lZW0GQR1XS
HOP-62 NV7mc2o3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XTeWlEPTB;MD6zOlExPiEQvF2= NWPjS|N5W0GQR1XS
SW1710 NHm2dnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLsTWM2OD1yLkO2OFU2KM7:TR?= M2e4e3NCVkeHUh?=
OPM-2 M3;1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjLXFlIUUN3ME2wMlM3PDd|IN88US=> MXzTRW5ITVJ?
DBTRG-05MG MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwM{iwOVQh|ryP M1L0fnNCVkeHUh?=
SK-MEL-24 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInSS3BKSzVyPUCuN|k4QTFizszN NUTU[ZJbW0GQR1XS
8305C M2\lS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLhOohKSzVyPUCuN|k4QTNizszN MWXTRW5ITVJ?
OVCAR-4 NF\vc3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnOUXE5UUN3ME2wMlQyPTh4IN88US=> NH;mcFVUSU6JRWK=
HLE Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7j[pJbUUN3ME2wMlQyQDZizszN MljSV2FPT0WU
NCI-H747 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwNEKxN|ch|ryP NYXQTJRzW0GQR1XS
SW780 M13ufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL0fWtKSzVyPUCuOFI{PDZizszN MoHhV2FPT0WU
KYSE-150 NVL5R5JyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrHN2xKSzVyPUCuOFI1OTVizszN NY\mbXlOW0GQR1XS
H4 NFrvNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV65bldqUUN3ME2wMlQzPDVzIN88US=> NVTxcYJbW0GQR1XS
SW1088 M4S1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIizTYNKSzVyPUCuOFQ{QSEQvF2= MnG2V2FPT0WU
SF268 NHLJeJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHwTWM2OD1yLkS0PFYh|ryP M1HkSHNCVkeHUh?=
RT4 M1PkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny4TWM2OD1yLkS1NVEyKM7:TR?= MUjTRW5ITVJ?
NCI-H522 NIPxT45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHKwRmhKSzVyPUCuOFUzPyEQvF2= M{TEeXNCVkeHUh?=
LCLC-97TM1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwNE[xPVUh|ryP NHy0[WhUSU6JRWK=
CAL-39 MlqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHkNWQ6UUN3ME2wMlQ3PTF7IN88US=> NU\vTIdqW0GQR1XS
CAL-120 NWPXW2RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LyW2lEPTB;MD60O|Y1OyEQvF2= M3PBZ3NCVkeHUh?=
ESS-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LrbWlEPTB;MD60O|gzOSEQvF2= MYTTRW5ITVJ?
KARPAS-45 NI\4NXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjiWWxKSzVyPUCuOFg6OzNizszN M{Hje3NCVkeHUh?=
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SK-NEP-1 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHrdJJKSzVyPUGuPFM4PjdizszN MWjTRW5ITVJ?
D-542MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTFwOEW4OVEh|ryP MYjTRW5ITVJ?
KNS-42 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\qW3FKSzVyPUGuPFYzPjZizszN M2XXTnNCVkeHUh?=
NCI-H2452 NEDjdmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nEbWlEPTB;MT64PVA4PCEQvF2= M3\PUnNCVkeHUh?=
SK-MEL-2 M3zT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnDcnRKSzVyPUGuPVAzPzFizszN NGq5ZXFUSU6JRWK=
OVCAR-5 M3LnbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFwOUC2O|Uh|ryP NV7kdIh6W0GQR1XS
SNG-M NFm1[ohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHwTWM2OD1zLkm1PFU5KM7:TR?= NGq2No9USU6JRWK=
A673 M2LhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLqTWM2OD1zLkm3OVE3KM7:TR?= NXHOVmpsW0GQR1XS
L-428 M1[5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;OeWlEPTB;MT65PVE4QSEQvF2= MlrpV2FPT0WU
KM-H2 NIKyeIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDRWGdKSzVyPUKuNFExQSEQvF2= M1XXc3NCVkeHUh?=
MC-IXC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLxS2xKSzVyPUKuNFIzPzNizszN NYfWWFlsW0GQR1XS
COLO-678 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorwTWM2OD1{LkC0NlA4KM7:TR?= MVTTRW5ITVJ?
MEL-JUSO MoniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJwMEe4OVEh|ryP MUDTRW5ITVJ?
HCC38 MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Gw[GlEPTB;Mj6wPFQ{OyEQvF2= MmfTV2FPT0WU
UACC-62 NUK1XmFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETPbYZKSzVyPUKuNFg5PTVizszN NHS3[nJUSU6JRWK=
OAW-42 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37KT2lEPTB;Mj6wPVcyOSEQvF2= MluxV2FPT0WU
LB996-RCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XNUWlEPTB;Mj6xN|gyPyEQvF2= MWTTRW5ITVJ?
COR-L105 NXrwdJMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPHOlhKSzVyPUKuNVY{PzNizszN MXXTRW5ITVJ?
RCC10RGB NIL3No9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4WzNWlEPTB;Mj6xPFU4PiEQvF2= NULvVppIW0GQR1XS
A431 NIjPV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfTc|VKSzVyPUKuNVkxOTlizszN NVLWO3RYW0GQR1XS
NCI-H292 NWDK[mRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTJwMkO5OVEh|ryP MXvTRW5ITVJ?
SK-UT-1 NVfSWpFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPKSZRRUUN3ME2yMlM{OTh2IN88US=> M1vYdXNCVkeHUh?=
PANC-08-13 M{LGZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Sy[WlEPTB;Mj6zN|I{PSEQvF2= NXrINHM4W0GQR1XS
ST486 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvOS4F[UUN3ME2yMlQyODR6IN88US=> NIPIWJlUSU6JRWK=
SJSA-1 NF;HZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DEPWlEPTB;Mj60NVI4OSEQvF2= MWLTRW5ITVJ?
RKO M2e0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\RSpFrUUN3ME2yMlQzODJ7IN88US=> MYnTRW5ITVJ?
NCI-H1793 NUnsXm9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3JfldKSzVyPUKuOFQxOjlizszN M3X4[3NCVkeHUh?=
639-V NHPSVXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHOUYtyUUN3ME2yMlQ2Ozh{IN88US=> M{nW[3NCVkeHUh?=
ES3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJwNEm3N|ch|ryP M3TuTXNCVkeHUh?=
NCI-H1792 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr4TWM2OD1{LkW2PFI3KM7:TR?= MnzpV2FPT0WU
NCI-H1651 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;sTWlEPTB;Mj61PFIyKM7:TR?= MnzIV2FPT0WU
SN12C MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXJPIh7UUN3ME2yMlU5PDh5IN88US=> NGDHTlNUSU6JRWK=
COLO-679 NIiyVVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV35XnlqUUN3ME2yMlU5PjB3IN88US=> M{\TRXNCVkeHUh?=
U-118-MG NH2zUotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nIUWlEPTB;Mj61PFg4OiEQvF2= MnryV2FPT0WU
Ramos-2G6-4C10 M1viNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfiTWM2OD1{Lk[0PFA4KM7:TR?= Mn3PV2FPT0WU
HCT-15 NEm0ZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLDTWM2OD1{Lk[4O|kzKM7:TR?= M2W2c3NCVkeHUh?=
MDA-MB-157 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwN{C3OFch|ryP NUL1cXRHW0GQR1XS
K5 NFztSVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEGzboRKSzVyPUKuO|E5PDVizszN NIPoOZZUSU6JRWK=
MKN45 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\FTWM2OD1{LkezN|Y3KM7:TR?= NYrOcIRnW0GQR1XS
DMS-273 NHjVfHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnPVm5XUUN3ME2yMlc2PjN{IN88US=> MojEV2FPT0WU
C8166 NH;3XW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJwN{i1NVMh|ryP NITkNHRUSU6JRWK=
Calu-3 MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTYTWM2OD1{Lke4PVY6KM7:TR?= NIf1UYdUSU6JRWK=
SNB75 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPLTWM2OD1{Lki4OVM2KM7:TR?= NVLvfJR3W0GQR1XS
BFTC-905 NUHISHB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vo[mlEPTB;Mj65NFE6OSEQvF2= MWPTRW5ITVJ?
C-4-II MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLXTWM2OD1{LkmxN|U{KM7:TR?= MUTTRW5ITVJ?
MS-1 M3Hvbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFiwN4lKSzVyPUKuPVY4PjlizszN MoDGV2FPT0WU
A375 M4ewZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLPUYVKSzVyPUOuNFgyQDRizszN MoHOV2FPT0WU
KYSE-70 NEX3dodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrCTJhKSzVyPUOuNFg5QDJizszN NET0NGNUSU6JRWK=
KYSE-510 NGnZdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXjdWZKSzVyPUOuNVA6QTVizszN M2TSenNCVkeHUh?=
LN-405 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTNwMUO1NVgh|ryP Ml\iV2FPT0WU
BOKU NEnGNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnCO4FKSzVyPUOuNVQzPTZizszN M17tXnNCVkeHUh?=
TE-10 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XE[mlEPTB;Mz6xO|M3OiEQvF2= MVfTRW5ITVJ?
MKN1 M3vtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXxdldKSzVyPUOuNVg1QDNizszN M3vyV3NCVkeHUh?=
M059J MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTNwMkCxO|Mh|ryP NX7QZYYzW0GQR1XS
GOTO NGDxN4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTNwMkKwN|kh|ryP NGfLVIVUSU6JRWK=
DK-MG NIDsZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTNwMkW5O|Yh|ryP NHHy[nRUSU6JRWK=
NCI-H727 M{PFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnTXG1{UUN3ME2zMlI3PThizszN MV7TRW5ITVJ?
NB12 NXu4RoYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD6blJ3UUN3ME2zMlM{OjJ2IN88US=> NGPoXYtUSU6JRWK=
DOK NFrwPXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTNwM{[xPFYh|ryP M2LTSHNCVkeHUh?=
KYSE-410 MoDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3LTWM2OD1|LkO2Nlg4KM7:TR?= NUPhWWY2W0GQR1XS
AM-38 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfa[mlKSzVyPUOuN|gxPTFizszN NXGyXnprW0GQR1XS
GR-ST NWX6b49wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXNOpZtUUN3ME2zMlQ2PzN{IN88US=> NGTETWJUSU6JRWK=
D-247MG NYHMTJZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jTRmlEPTB;Mz60PFI3OyEQvF2= NInGfWJUSU6JRWK=
TE-8 NVv0d2tET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2niZmlEPTB;Mz60PVM{OyEQvF2= MYLTRW5ITVJ?
LS-411N M2\LcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnH[WZKSzVyPUOuOFk3QTJizszN NWTCVZp6W0GQR1XS
SK-MES-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mof4TWM2OD1|LkW2OFM{KM7:TR?= MX3TRW5ITVJ?
SF295 NH\QXHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTNwNkG1OVIh|ryP MoLYV2FPT0WU
SK-MEL-30 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3tV|VNUUN3ME2zMlY2QTJzIN88US=> NFvhcXRUSU6JRWK=
LB2241-RCC NX36UFh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDPTWM2OD1|Lk[2NlYh|ryP MWfTRW5ITVJ?
PC-14 M4\ROWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7HTWM2OD1|Lk[2OFM4KM7:TR?= NWTRcVRXW0GQR1XS
EW-7 NX7YWXVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTNwNke2PVMh|ryP MXHTRW5ITVJ?
NMC-G1 NEfDeGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;5S|ZxUUN3ME2zMlcyQDN5IN88US=> MlzzV2FPT0WU
TE-441-T M3HIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDJTWM2OD1|LkezNFI5KM7:TR?= M2XXUnNCVkeHUh?=
NCI-H1618 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITnNmtKSzVyPUOuPFE5PzVizszN MUXTRW5ITVJ?
PANC-03-27 NHvUO2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrpc2FGUUN3ME2zMlgyQTF4IN88US=> MV7TRW5ITVJ?
NCI-H2228 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoKzTWM2OD1|LkizNVI3KM7:TR?= MVPTRW5ITVJ?
CAPAN-1 NXXGboQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTNwOEewNFkh|ryP M3;RcnNCVkeHUh?=
KLE M3LrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNwOUC2O{DPxE1? NI\XWYlUSU6JRWK=
Becker MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[0SGlEPTB;Mz65Nlg1QSEQvF2= MXvTRW5ITVJ?
SK-PN-DW MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoO0TWM2OD12LkC3PVc1KM7:TR?= NH\kd5BUSU6JRWK=
Hs-578-T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLqTWM2OD12LkC4N|A3KM7:TR?= NF[zV45USU6JRWK=
RS4-11 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf0e4JJUUN3ME20MlEyOjV3IN88US=> MVfTRW5ITVJ?
D-502MG Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TGPGlEPTB;ND6xOlk6PyEQvF2= M2LwTnNCVkeHUh?=
GI-1 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3jXGRKSzVyPUSuNlgzQTlizszN M17zTnNCVkeHUh?=
NCI-H209 NWS1WI1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL0SGN7UUN3ME20MlM{PzhizszN MnLvV2FPT0WU
SK-OV-3 NEHyRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK5TWM2OD12LkS4NVQ6KM7:TR?= M3zTOnNCVkeHUh?=
LOUCY M3vHRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nJVWlEPTB;ND60PFQ{OiEQvF2= NETFe4JUSU6JRWK=
NCI-H69 NYjPVGN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTZTWM2OD12LkWxO|k{KM7:TR?= M{\6PXNCVkeHUh?=
SCC-9 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXKTIdKSzVyPUSuOVMyPzJizszN Mk\TV2FPT0WU
NCI-H526 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTRwNUmyPVMh|ryP M3HFOHNCVkeHUh?=
NCI-H2170 MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf1PZNKSzVyPUSuOlY4PzFizszN NESzfVdUSU6JRWK=
SR NHHLU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\lRWlEPTB;ND63NFA1QCEQvF2= NH:5W5pUSU6JRWK=
CMK M2XL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DDUGlEPTB;ND63NlExOSEQvF2= MVHTRW5ITVJ?
COLO-829 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTRwN{ewOFMh|ryP MYnTRW5ITVJ?
HuO-3N1 Mon5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXJU|ZKSzVyPUSuPFMzQDFizszN M{OyO3NCVkeHUh?=
5637 NGn4e|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLDW29KSzVyPUSuPVA1QDdizszN M3S5T3NCVkeHUh?=
A253 NHXMTGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTITWM2OD12Lkm3O|A5KM7:TR?= NXPmNYF4W0GQR1XS
NB10 M4H4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLQXlUxUUN3ME21MlA4PDl5IN88US=> NWnvUJdlW0GQR1XS
SF539 NEP1[nNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;WTWM2OD13LkC5PVU6KM7:TR?= MXfTRW5ITVJ?
HAL-01 NXPRSmJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj2SFdKSzVyPUWuNVQ3PDVizszN MkPIV2FPT0WU
MHH-ES-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnUTWM2OD13LkG2PVI2KM7:TR?= NYm4cohQW0GQR1XS
DEL Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDzOFBKSzVyPUWuNlc2QDJizszN MkfqV2FPT0WU
NCI-H1299 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTVwM{WwNFch|ryP NHTKWpZUSU6JRWK=
ChaGo-K-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTVwM{WxNFch|ryP MlnZV2FPT0WU
HMV-II NX\5Z2U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;5WmlEPTB;NT6zPVQ{KM7:TR?= M3T4bnNCVkeHUh?=
NB69 NYT2NJRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTQUZR3UUN3ME21MlM6PjNzIN88US=> MUDTRW5ITVJ?
NCI-H1882 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDHTWM2OD13LkSzN|Y1KM7:TR?= M1TaVHNCVkeHUh?=
SNU-475 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle2TWM2OD13LkS3NVcyKM7:TR?= MYPTRW5ITVJ?
RXF393 MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHGRm9KSzVyPUWuOFg1QTRizszN MYDTRW5ITVJ?
CAL-51 MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrCU5ZKSzVyPUWuOlI5PTNizszN MmTrV2FPT0WU
SW1573 NF\v[o5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTVwNkO1N|Qh|ryP M3jkfHNCVkeHUh?=
GCT NXTOSI0xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3YUno5UUN3ME21Mlc2QTJ7IN88US=> NF;FT5ZUSU6JRWK=
COR-L88 MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fSXWlEPTB;NT63Olg1PiEQvF2= MlXPV2FPT0WU
MDA-MB-134-VI NVPQN3NtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDzOmV2UUN3ME21Mlg4PTN4IN88US=> MoPTV2FPT0WU
NB5 NX21bnNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLTdFBKSzVyPUWuPVI1PCEQvF2= M4e4SXNCVkeHUh?=
GMS-10 M4DZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\6TWM2OD13Lkm2PFYyKM7:TR?= NULicFVoW0GQR1XS
CHP-212 MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzRfpRKSzVyPU[uOFgzPjdizszN Mo\wV2FPT0WU
TE-11 NGKydFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DWWmlEPTB;Nj61OVE5OiEQvF2= M1[0SnNCVkeHUh?=
SW962 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjQVZppUUN3ME22MlY2Pzd2IN88US=> NWrDNmg3W0GQR1XS
MZ2-MEL NUn6flVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTZwOEKwNVEh|ryP M3vYO3NCVkeHUh?=
C-33-A NGW1dXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;XTWM2OD14LkmxOlg5KM7:TR?= MoPvV2FPT0WU
IGR-1 NELEVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHyTWM2OD14Lkm3PFI3KM7:TR?= MV7TRW5ITVJ?
MOLT-4 NF3mZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTdwMUW0NFYh|ryP NGT5e3VUSU6JRWK=
NCI-H1650 NHvXe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fvb2lEPTB;Nz6yO|A1PiEQvF2= MW\TRW5ITVJ?
AsPC-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37tVWlEPTB;Nz6yPFYxPSEQvF2= NHXzflBUSU6JRWK=
SNU-C2B MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfzRZpMUUN3ME23MlI6PTdzIN88US=> M4LVW3NCVkeHUh?=
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D-263MG M1iycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTdwNEW3OlIh|ryP MYHTRW5ITVJ?
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Detroit562 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDEeJNnUUN3ME24Mlc2PDV3IN88US=> NFPt[WtUSU6JRWK=
SW954 M3fiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4qyO2lEPTB;OD63Olg{OiEQvF2= MWLTRW5ITVJ?
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RPMI-8402 MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;QXnhxUUN3ME24Mlg6QTJ4IN88US=> NV\XUGNuW0GQR1XS
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NCI-H2196 Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPXTWM2OD16Lkm4OlA3KM7:TR?= MV3TRW5ITVJ?
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NCI-H1993 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q2WGlEPTB;MUCuOVY6OyEQvF2= MXvTRW5ITVJ?
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HN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;XenF[UUN3ME2xNU4yOTNzIN88US=> MYHTRW5ITVJ?
NCI-H1304 MlnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;rdGlEPTB;MUGuNVU4PiEQvF2= NHzM[FZUSU6JRWK=
Daoy Ml\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETCeplKSzVyPUGxMlQ{OzZizszN NIHs[|ZUSU6JRWK=
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IPC-298 NHO3THFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnvTWM2OD1zMT65N|g{KM7:TR?= M4fHUXNCVkeHUh?=
NCI-H2126 NEXvSZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonUTWM2OD1zMj6wNlE5KM7:TR?= M3;nfHNCVkeHUh?=
OVCAR-8 NF3T[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF{LkGxOFEh|ryP NEjKZplUSU6JRWK=
SJRH30 NHHETVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF{LkKyPVkh|ryP M3LxdnNCVkeHUh?=
DMS-53 NH\rPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zt[2lEPTB;MUKuNlY1QSEQvF2= NE\iclZUSU6JRWK=
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NCI-H1648 Mnf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3ic3hKSzVyPUG1MlU{ODVizszN MX7TRW5ITVJ?
ABC-1 M4r2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTF3LkiwN|Mh|ryP NYrQPY57W0GQR1XS
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BC-3 M1G5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF4LkC1OlIh|ryP M1jnc3NCVkeHUh?=
NCI-H1437 M3j6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj1Nm0{UUN3ME2xOk4xPjZ5IN88US=> M4TC[HNCVkeHUh?=
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KINGS-1 NViw[XBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTF4LkiyO|Mh|ryP MUnTRW5ITVJ?
C32 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;jZ4hLUUN3ME2xOk46PzF5IN88US=> MVrTRW5ITVJ?
SBC-5 MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTF5LkG0O|kh|ryP NFfCO4NUSU6JRWK=
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NCI-H226 M2Wze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknpTWM2OD1zNz65OVQ3KM7:TR?= NVTnSIhzW0GQR1XS
CAL-33 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHvcmRxUUN3ME2xPE4zPzhzIN88US=> Mm\lV2FPT0WU
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RMG-I M4m2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD5VVBUUUN3ME2xPE43QTR5IN88US=> M3voSXNCVkeHUh?=
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HCC70 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHlTXF4UUN3ME2xPU4{QDl2IN88US=> M1LhTHNCVkeHUh?=
C2BBe1 MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF7LkSxOFgh|ryP MnOzV2FPT0WU
NCI-H650 MojlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofPTWM2OD1zOT61PFk6KM7:TR?= NWK5OlJrW0GQR1XS
CAL-72 NUHWUIxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHyW2tqUUN3ME2xPU43PzN5IN88US=> MYTTRW5ITVJ?
L-363 NG\sd4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYToOXlrUUN3ME2yNE4xOjF{IN88US=> Ml7WV2FPT0WU
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PLC-PRF-5 NEPQXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjGUlVEUUN3ME2yNE4{QTB4IN88US=> MWrTRW5ITVJ?
SW1463 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon5TWM2OD1{MD60OVI2KM7:TR?= MmD0V2FPT0WU
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DMS-79 NH;0N4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7JTWM2OD1{MD64OFkh|ryP M1zke3NCVkeHUh?=
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DB MnS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jQc2lEPTB;MkGuOlE1OiEQvF2= NIXxXodUSU6JRWK=
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COR-L23 NH\YT25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;rTWM2OD1{MT64NFUyKM7:TR?= NGS0[3BUSU6JRWK=
KU-19-19 MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDZcHFyUUN3ME2yNU45QTh{IN88US=> NILoVHBUSU6JRWK=
T84 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT6TWM2OD1{MT65PFE6KM7:TR?= Ml7KV2FPT0WU
NCI-H630 M3[1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnCTWM2OD1{Mj61N|Y{KM7:TR?= MWDTRW5ITVJ?
LU-165 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFWweXVKSzVyPUKyMlU2PCEQvF2= NWTJR3BPW0GQR1XS
COLO-792 MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJ{LkexNVEh|ryP M4fQNHNCVkeHUh?=
CAL-62 NF\COJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJ{Lke1NVch|ryP NH;LZYhUSU6JRWK=
HCE-T NXvQN4lQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlziTWM2OD1{Mj64OlA3KM7:TR?= MoTHV2FPT0WU
BB65-RCC NWDo[|lRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ|LkCzOFQh|ryP NH;DS3FUSU6JRWK=
SiHa M1fXeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Lr[2lEPTB;MkOuN|k3QCEQvF2= NV\kUI51W0GQR1XS
NCI-H2081 NYLiZXRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ2LkC2OFEh|ryP MoXwV2FPT0WU
U251 M1XGfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{T2PGlEPTB;MkSuNFY3QCEQvF2= Mn\zV2FPT0WU
LoVo MnO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjx[XRKSzVyPUK0MlkzQDJizszN MWLTRW5ITVJ?
GCIY NGHzWGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfPNpRKSzVyPUK1MlI5PzdizszN MmDiV2FPT0WU
NUGC-3 NFzKNo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJ3LkOzNVYh|ryP NHTmZ|NUSU6JRWK=
LNCaP-Clone-FGC NF3vR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJ3LkO0PVgh|ryP NF[3S5RUSU6JRWK=
PA-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXDVZpKSzVyPUK1MlY5OzNizszN MmLyV2FPT0WU
OE33 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4POcmlEPTB;MkWuOlg2OyEQvF2= MlTDV2FPT0WU
HT-29 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJ3Lke4O|kh|ryP MUnTRW5ITVJ?
RCM-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLuW3RKSzVyPUK1Mlk3PTZizszN NIr2OGhUSU6JRWK=
NCI-H1522 NGrHVHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjBdJdiUUN3ME2yOU46QTFzIN88US=> MUPTRW5ITVJ?
LB373-MEL-D NYX0VJVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULVcY1LUUN3ME2yOk4yPzB6IN88US=> MmTrV2FPT0WU
NCI-H1436 MlnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TKcGlEPTB;Mk[uNlc{QCEQvF2= MnHVV2FPT0WU
COLO-824 NX[4bot2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonsTWM2OD1{Nj60NFAzKM7:TR?= NWHCenlDW0GQR1XS
CP50-MEL-B NFnHVJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ4LkW2O|Uh|ryP NF3FWIdUSU6JRWK=
EGI-1 MoLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr5TWM2OD1{Nz6yOlk5KM7:TR?= NEjpOmlUSU6JRWK=
LAN-6 NFXYcIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHm[m9KSzVyPUK3MlM2QThizszN M4TTdnNCVkeHUh?=
GAK MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn73TWM2OD1{Nz60NlI2KM7:TR?= M2nNSHNCVkeHUh?=
MDA-MB-175-VII NWfGTXJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJ5LkWwOVMh|ryP MWHTRW5ITVJ?
JVM-2 M4fQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEK3ZYdKSzVyPUK3MlY3OjJizszN NHLaXYdUSU6JRWK=
UACC-257 M1XmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLabYpGUUN3ME2yO{43QDd6IN88US=> M{fMb3NCVkeHUh?=
SW1783 M{KxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJ5Lke3PFMh|ryP NGnQNHZUSU6JRWK=
HT-3 M{XsVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJ6LkKxOlYh|ryP NH;4enZUSU6JRWK=
RL NXPiN2huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljCTWM2OD1{OD61PVEyKM7:TR?= MmH3V2FPT0WU
TK10 M1fMSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonvTWM2OD1{OD62OVM2KM7:TR?= MmTPV2FPT0WU
HT55 MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJ7LkC1OlUh|ryP MXfTRW5ITVJ?
BT-20 NHnTcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fUSmlEPTB;MkmuNFU5PiEQvF2= M1LzRXNCVkeHUh?=
TGBC24TKB M4rreWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3lTY9KSzVyPUK5MlE5OzFizszN MYDTRW5ITVJ?
HSC-2 NYDHellOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJ7LkOwNFEh|ryP MXfTRW5ITVJ?
COLO-205 NYHyO25MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJ7LkO5OFQh|ryP MV;TRW5ITVJ?
GT3TKB Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e1XWlEPTB;MkmuOlg4PyEQvF2= NUDje5RUW0GQR1XS
T47D NUCzXZZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTkeVhKSzVyPUK5Mlg2QDJizszN NF7ve3RUSU6JRWK=
OMC-1 NFexfXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTNyLkG5NVkh|ryP NVntWoNuW0GQR1XS
PFSK-1 NVvheoNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTXc21XUUN3ME2zNU4zPjV7IN88US=> NXXzOmViW0GQR1XS
JEG-3 NIO4Xm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7yTo9KSzVyPUOxMlM2PjFizszN NF;rc4lUSU6JRWK=
RD Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTNzLkWxNVUh|ryP MXrTRW5ITVJ?
NCI-H64 Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fJNmlEPTB;M{KuOFE4QSEQvF2= M1vEV3NCVkeHUh?=
DMS-114 Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTN{LkSxPFIh|ryP NUHMcpk2W0GQR1XS
NCI-H661 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN{Lk[1NFEh|ryP M33NbHNCVkeHUh?=
CAL-148 NXu1Vnp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;VTWM2OD1|Mj62OlY2KM7:TR?= MnrQV2FPT0WU
HuP-T3 Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTN{LkmzN|gh|ryP NWezXJZxW0GQR1XS
ES4 NWTuSWNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTN|LkG3NFUh|ryP MnHXV2FPT0WU
Ca9-22 NVjjbJR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfYSJBKSzVyPUOzMlQ3ODFizszN NIiyWotUSU6JRWK=
LP-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPDOWd6UUN3ME2zOE4xQSEQvF2= NFzrd45USU6JRWK=
AU565 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfod3k4UUN3ME2zOE42ODZ7IN88US=> MmD0V2FPT0WU
MDA-MB-453 NVzGbJVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnZV2Q{UUN3ME2zOU4yPDJ4IN88US=> MYfTRW5ITVJ?
SNU-C1 M1X0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;kTWM2OD1|NT6xO|Eh|ryP MUjTRW5ITVJ?
SW13 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLoTWM2OD1|NT60NFc3KM7:TR?= NXzSSJB[W0GQR1XS
NCI-H2122 M2H3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rFNmlEPTB;M{WuOVU6QCEQvF2= NF7ZOHNUSU6JRWK=
NCI-H1395 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPJWm9KSzVyPUO1MlY3QTFizszN NEHEbW5USU6JRWK=
J-RT3-T3-5 Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\u[2hDUUN3ME2zOk4xOjl2IN88US=> Mlu2V2FPT0WU
COR-L279 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TuTmlEPTB;M{[uNVk5OSEQvF2= MonVV2FPT0WU
ATN-1 NV3YZolVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfiUlRnUUN3ME2zOk45PTF4IN88US=> M3r4[HNCVkeHUh?=
HCC2998 M3\ZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTN4Lki1O|Eh|ryP MVnTRW5ITVJ?
UM-UC-3 NEPzVodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnFTWM2OD1|Nj64Olc2KM7:TR?= MWDTRW5ITVJ?
DV-90 NWGwWIRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTN4LkmwOlch|ryP MYLTRW5ITVJ?
ES8 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD4WlVPUUN3ME2zOk46OzF6IN88US=> Mn64V2FPT0WU
YAPC NH6wN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITNRVFKSzVyPUO2Mlk3PTRizszN NWnEbGg3W0GQR1XS
HCC1599 M3PJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnexTWM2OD1|Nz6xOlE5KM7:TR?= NYexNVR7W0GQR1XS
UMC-11 NVHhR2JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjxcm9wUUN3ME2zO{4zPTB|IN88US=> MVjTRW5ITVJ?
THP-1 NUL2W5NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO1TWM2OD1|Nz6yPFY5KM7:TR?= MU\TRW5ITVJ?
OCUB-M M3TnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWxNo9KSzVyPUO3MlI5QTFizszN MnXSV2FPT0WU
NCI-H1693 NULES4xUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Lyd2lEPTB;M{euN|I{OyEQvF2= NH3C[2NUSU6JRWK=
NCI-H345 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTN5LkO2NlQh|ryP MVPTRW5ITVJ?
COLO-800 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jQU2lEPTB;M{euOVY4KM7:TR?= NHuwVFNUSU6JRWK=
COLO-320-HSR NXXkdJFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvVTWM2OD1|OD6zOFkzKM7:TR?= NFLFdXFUSU6JRWK=
NCI-H596 NUXUWW0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETne5hKSzVyPUO4MlQ1QDlizszN NH7X[JBUSU6JRWK=
NCI-H187 M4TjVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK5[3NKSzVyPUO4Mlc{PDRizszN MYHTRW5ITVJ?
ECC4 M4Pzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzxeGZKSzVyPUO5MlA5OTRizszN M{L2[nNCVkeHUh?=
KP-4 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP0dnQ3UUN3ME2zPU4yOjN3IN88US=> M2\lWnNCVkeHUh?=
NCI-H2227 M3f0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuzeJlZUUN3ME2zPU4{QTR7IN88US=> MXTTRW5ITVJ?
22RV1 NU\pRopNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPzTWM2OD1|OT64N|k5KM7:TR?= NU\zTHFqW0GQR1XS
SAS MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NViwRpozUUN3ME20NE4xQTZizszN NFvUZohUSU6JRWK=
PANC-10-05 MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTRyLkG4Nlgh|ryP M3PYW3NCVkeHUh?=
MDA-MB-468 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrRSoVQUUN3ME20NE42OzR4IN88US=> Mn\2V2FPT0WU
RPMI-7951 NFrabXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTRzLkKwO|Uh|ryP M{\RZXNCVkeHUh?=
BB49-HNC NWLNTm1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTRzLkKxO|kh|ryP NHL2dWdUSU6JRWK=
23132-87 NIX6R|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv0TWM2OD12MT6yO|MzKM7:TR?= NVXFe2g2W0GQR1XS
HCC1569 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3JTWM2OD12MT6yPFg2KM7:TR?= NXfNWppkW0GQR1XS
CP66-MEL M373XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTR{LkG4PFYh|ryP MVHTRW5ITVJ?
K-562 NGrnPXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnUTWM2OD12Mj6yPFU1KM7:TR?= MX3TRW5ITVJ?
OCI-AML2 M1j4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXafopKSzVyPUSyMlg6PzRizszN NHXiXo5USU6JRWK=
SW756 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTR|LkCzPFgh|ryP MX7TRW5ITVJ?
M14 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f0bmlEPTB;NEOuN|E5QSEQvF2= MmLmV2FPT0WU
NCI-H1623 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTR|LkS2OEDPxE1? MmfVV2FPT0WU
KNS-81-FD NH7wd2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPae5NKSzVyPUSzMlc3OiEQvF2= MVTTRW5ITVJ?
TGBC1TKB M1vpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHUTWM2OD12Mz65NFk6KM7:TR?= M13pU3NCVkeHUh?=
RERF-LC-MS M{PMNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTR|LkmyPFEh|ryP M3vUO3NCVkeHUh?=
PC-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3YZmhnUUN3ME20OE41OzR5IN88US=> MlXvV2FPT0WU
HuP-T4 NFWxb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HGfmlEPTB;NESuOFQ4PCEQvF2= MW\TRW5ITVJ?
NCI-H510A NXiw[IdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTR2LkewPEDPxE1? M1PSOHNCVkeHUh?=
LB2518-MEL NG[1OYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXvcVRKSzVyPUS0Mlc6OzdizszN MV3TRW5ITVJ?
TE-5 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\uTWM2OD12NT65OVgyKM7:TR?= M3;lVHNCVkeHUh?=
EW-24 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3m5N2lEPTB;NE[uNVczOyEQvF2= MXzTRW5ITVJ?
LB647-SCLC M2D0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jUemlEPTB;NE[uNlE2PSEQvF2= NUHCOFB6W0GQR1XS
NCI-H524 M4PsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ETWM2OD12Nj63NVg2KM7:TR?= M1uxWXNCVkeHUh?=
EW-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH3TWM2OD12Nj65N|c{KM7:TR?= M2r2UXNCVkeHUh?=
KALS-1 NYHnbIdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\IOodPUUN3ME20O{4zODZ4IN88US=> M3H6fXNCVkeHUh?=
BT-474 NVnaWlU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILFWoJKSzVyPUS3MlQzOTZizszN M2HHVHNCVkeHUh?=
SK-N-AS MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn3N49XUUN3ME20O{45QDhizszN NEPwXJdUSU6JRWK=
HCC2157 M2Dic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDENVlKSzVyPUS4MlA4PiEQvF2= MV7TRW5ITVJ?
HCC1954 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnWcHVKSzVyPUS4MlE4ODRizszN NIfaNJpUSU6JRWK=
FADU MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTBSlRsUUN3ME20PE4{ODNzIN88US=> MkjKV2FPT0WU
S-117 NH\CNWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH0PY1RUUN3ME20PE4{QDF3IN88US=> NEfZNoJUSU6JRWK=
LS-1034 M2jMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;wc2dKSzVyPUS4MlcxPjdizszN NYrDXGdVW0GQR1XS
CAMA-1 NFvBOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTR7LkW1OFMh|ryP MlHRV2FPT0WU
LU-134-A NGfoSZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjHd2RKSzVyPUS5MlgxQDVizszN Mn\BV2FPT0WU
NCI-H1838 NGfrVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTR7LkiwPFch|ryP MX3TRW5ITVJ?

多くの細胞株試験データを見る場合、クリックしてください

体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 順序で溶剤を入れること:
1% CMC Na
30mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Bcr-Abl信号経路図

Bcr-Abl Inhibitors with Unique Features

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID