Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。

サイズ 価格(税別) 在庫  
JPY 16600.00 あり
JPY 18260.00 あり
JPY 61420.00 あり
JPY 161020.00 あり

カスタマーフィードバック(4)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NGPqNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfWTWM2OD1yLkCwNFAxODB|NUmg{txO NG\RdG1USU6JRWK=
MV-4-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMECwNFk2PiEQvF2= MUHTRW5ITVJ?
MEG-01 NIfhd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLybXpKSzVyPUCuNFAxOTJ6IN88US=> MmrQV2FPT0WU
LAMA-84 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMECwNVY2KM7:TR?= NXfs[ldXW0GQR1XS
CGTH-W-1 NXW1dJdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj5TWM2OD1yLkCwNVY6KM7:TR?= NEXoTIlUSU6JRWK=
KASUMI-1 NHzZZplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMECyNVch|ryP NEPsOIFUSU6JRWK=
BE-13 MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMECyOVkh|ryP MXrTRW5ITVJ?
CTV-1 MkH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH3WGdmUUN3ME2wMlAxPTJzIN88US=> M1rB[3NCVkeHUh?=
NKM-1 NVHqSmI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HQO2lEPTB;MD6wNFY2PSEQvF2= NHnhd|lUSU6JRWK=
MONO-MAC-6 NWfrN2poT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{CwNGlEPTB;MD6wNFg{PyEQvF2= MUTTRW5ITVJ?
A204 NWCxV|FVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zEPGlEPTB;MD6wNVIyQCEQvF2= NFvsbI9USU6JRWK=
GDM-1 NFjEOotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEG4N|Mh|ryP MXHTRW5ITVJ?
AN3-CA NFT6dmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHSO|UyUUN3ME2wMlAyQDd|IN88US=> NHXhWo5USU6JRWK=
BL-70 NWnxWJhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDEVmpKSzVyPUCuNFIyQTlizszN M4j2U3NCVkeHUh?=
Daudi NXXW[4ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX6TWM2OD1yLkCyOVM4KM7:TR?= NHrPdIZUSU6JRWK=
KU812 NVjY[oxGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nzTGlEPTB;MD6wNlg1QCEQvF2= NIfWWHlUSU6JRWK=
KG-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDySolKSzVyPUCuNFMzQTRizszN MY\TRW5ITVJ?
DOHH-2 MnLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3PTWM2OD1yLkC0PFA{KM7:TR?= NV34fpZOW0GQR1XS
HuO9 M3;FZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFqzd4pKSzVyPUCuNFU1PDhizszN NGDFfXVUSU6JRWK=
EB2 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnwV3dQUUN3ME2wMlA2PTd4IN88US=> Mn7BV2FPT0WU
G-402 NWXQVHp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TDdmlEPTB;MD6wOlM1OSEQvF2= M4DYSXNCVkeHUh?=
SU-DHL-1 MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL0TIJwUUN3ME2wMlA3Ozd7IN88US=> NEP3T3NUSU6JRWK=
NCI-H719 NUSwO5lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L3PWlEPTB;MD6wO|g5QCEQvF2= MmK5V2FPT0WU
MLMA MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEmwOkDPxE1? NV\pVFQ{W0GQR1XS
KM12 NGS5O4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInGPWpKSzVyPUCuNFk4OzdizszN M2i3OnNCVkeHUh?=
SUP-T1 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3O5cGlEPTB;MD6wPVk5OiEQvF2= MYPTRW5ITVJ?
MZ1-PC Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjpdJNKSzVyPUCuNVE{OzZizszN NHnwWYVUSU6JRWK=
MFE-296 M3e4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjS[WtKSzVyPUCuNVE5OzlizszN MWnTRW5ITVJ?
ALL-PO MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi4b|ZKSzVyPUCuNVI1PDNizszN MnH0V2FPT0WU
GB-1 M3Lj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rMV2lEPTB;MD6xNlUyOiEQvF2= MoLYV2FPT0WU
SIG-M5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[wUmlEPTB;MD6xN|M4KM7:TR?= NHLae5lUSU6JRWK=
P30-OHK MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXYeWlKSzVyPUCuNVU3PzJizszN MlPGV2FPT0WU
NCI-H716 NEXKZ|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TDfmlEPTB;MD6xOlI3PiEQvF2= Mn7RV2FPT0WU
MPP-89 M{HF[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfpTWM2OD1yLkG2PVM{KM7:TR?= MnrKV2FPT0WU
SF126 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMUewOlMh|ryP MoS0V2FPT0WU
CTB-1 M3zKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XiN2lEPTB;MD6xO|MyPiEQvF2= MVLTRW5ITVJ?
CA46 NIXlcpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\QfGlEPTB;MD6xO|Q5QSEQvF2= MY\TRW5ITVJ?
NCI-H520 NUDBb25ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHyfIh5UUN3ME2wMlE4PzN{IN88US=> NVrnSmVKW0GQR1XS
CAL-85-1 MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvOWHVKSzVyPUCuNVc6OjdizszN MkTGV2FPT0WU
NCI-H2342 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml74TWM2OD1yLkG4OVc4KM7:TR?= Mk[4V2FPT0WU
697 NV7ObYdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DFSWlEPTB;MD6xPFg4OSEQvF2= M1vERXNCVkeHUh?=
NY NEjUWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL4TWM2OD1yLkG5Nlg4KM7:TR?= NGrjU2ZUSU6JRWK=
T98G MlvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjDVolKSzVyPUCuNVk{OThizszN NXPvSW9YW0GQR1XS
NCI-H1703 M{fmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3LTWM2OD1yLkG5OlE2KM7:TR?= MUXTRW5ITVJ?
NCI-H2087 M3S1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvzbIRVUUN3ME2wMlIxPDN7IN88US=> NEfJ[IpUSU6JRWK=
PF-382 NYLV[nVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonBTWM2OD1yLkKwPFc{KM7:TR?= MXTTRW5ITVJ?
HCT-116 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTXTWM2OD1yLkKxNFY6KM7:TR?= Ml\pV2FPT0WU
CAKI-1 M2PqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nEfGlEPTB;MD6yNVY3PiEQvF2= MX7TRW5ITVJ?
CCF-STTG1 Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHCcFNKSzVyPUCuNlI1PzVizszN NUDMUIhVW0GQR1XS
D-392MG NF\pcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMkOxO|ch|ryP M{fU[HNCVkeHUh?=
RT-112 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXkTWM2OD1yLkKzO|k2KM7:TR?= MlfLV2FPT0WU
MES-SA NFPMO41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrhO|JDUUN3ME2wMlI1OTh5IN88US=> NX;Hb4JIW0GQR1XS
LC-2-ad MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLUTWM2OD1yLkK0NlY2KM7:TR?= NGe1eW1USU6JRWK=
NOS-1 Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMkSzOlch|ryP M3OxWnNCVkeHUh?=
NALM-6 NUfnfZB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HY[2lEPTB;MD6yOVU1OyEQvF2= MWTTRW5ITVJ?
TE-15 NFTIeWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7iZ3lKSzVyPUCuNlYxQTFizszN MkDNV2FPT0WU
786-0 NVXac41zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMk[yNlgh|ryP M3:zVXNCVkeHUh?=
IST-MES1 NHnqRZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrLeGRKSzVyPUCuNlY5OjlizszN M1frWnNCVkeHUh?=
KYSE-180 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMk[4PVEh|ryP NIX5O5VUSU6JRWK=
YT MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PvdmlEPTB;MD6yOlk4PCEQvF2= M37E[HNCVkeHUh?=
A427 M4i1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHWyelVKSzVyPUCuNlczPjRizszN NGLoRnRUSU6JRWK=
KYSE-450 NVjMV3RpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPReHhKSzVyPUCuNlc{OjlizszN M3nWXnNCVkeHUh?=
HuH-7 M4DifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz0PXRVUUN3ME2wMlI4PzZ|IN88US=> MYTTRW5ITVJ?
CAS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDhWFFKSzVyPUCuNlg{ODNizszN MnnxV2FPT0WU
KURAMOCHI NVnhUHg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMki0NVkh|ryP NHW5b5pUSU6JRWK=
ACHN MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH4fI43UUN3ME2wMlI6OzJ|IN88US=> MXHTRW5ITVJ?
HGC-27 NH\FbZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMkmzOVMh|ryP MmjwV2FPT0WU
A172 NGf2XndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHpTWM2OD1yLkK5OVc4KM7:TR?= M{j2UXNCVkeHUh?=
SNU-449 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXZfoJKSzVyPUCuNlk6PjRizszN NEnpWJFUSU6JRWK=
SW982 NGPESZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq4RmpKSzVyPUCuNlk6PzhizszN M1OyTXNCVkeHUh?=
EFO-21 NYLufm9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\HfmlEPTB;MD6zNFQyOSEQvF2= M3PVeHNCVkeHUh?=
NCI-H2030 NF\TVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPkPYdKSzVyPUCuN|EyPjRizszN Mm\4V2FPT0WU
HT-144 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe0WpdEUUN3ME2wMlMyOjhizszN NV\iNYZkW0GQR1XS
MFE-280 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TpS2lEPTB;MD6zNVQ2OyEQvF2= NVLJdlQzW0GQR1XS
SK-LU-1 NUP0[pdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vqfGlEPTB;MD6zNVQ3PiEQvF2= MYfTRW5ITVJ?
NCI-H2052 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\XeWlEPTB;MD6zNVQ5PCEQvF2= NGez[G5USU6JRWK=
SK-HEP-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwM{OzOlgh|ryP MYjTRW5ITVJ?
QIMR-WIL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwM{O0NlQh|ryP NYDOZ5dnW0GQR1XS
A2780 NYruNVNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPFe41KSzVyPUCuN|Q{ODRizszN M2XHZXNCVkeHUh?=
ACN MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT2b4VKSzVyPUCuN|Q5PzNizszN NHjrZY1USU6JRWK=
BxPC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHp[5RTUUN3ME2wMlM1QTh7IN88US=> MknlV2FPT0WU
BCPAP NVHWelZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfl[GZKSzVyPUCuN|YxODFizszN MYLTRW5ITVJ?
HOP-62 NIK3c4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH6wc25KSzVyPUCuN|YyODZizszN NVfOPFlTW0GQR1XS
SW1710 NFnBeGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\YZoxKSzVyPUCuN|Y1PTVizszN Mmf2V2FPT0WU
OPM-2 M{n2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfLTWM2OD1yLkO2OFc{KM7:TR?= M2jlO3NCVkeHUh?=
DBTRG-05MG MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;uTWM2OD1yLkO4NFU1KM7:TR?= NHfLbY9USU6JRWK=
SK-MEL-24 NXHkTFA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwM{m3PVEh|ryP MUPTRW5ITVJ?
8305C M2T5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPjcWx7UUN3ME2wMlM6Pzl|IN88US=> NWXUdolpW0GQR1XS
OVCAR-4 Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILoTZFKSzVyPUCuOFE2QDZizszN M4jVZ3NCVkeHUh?=
HLE MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rGZ2lEPTB;MD60NVg3KM7:TR?= MYTTRW5ITVJ?
NCI-H747 NFGzNpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTZV4pXUUN3ME2wMlQzOTN5IN88US=> MknvV2FPT0WU
SW780 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXxfVVSUUN3ME2wMlQzOzR4IN88US=> NGnxVopUSU6JRWK=
KYSE-150 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwNEK0NVUh|ryP MVnTRW5ITVJ?
H4 M3HBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfHS5dGUUN3ME2wMlQzPDVzIN88US=> NFPMWVdUSU6JRWK=
SW1088 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLLTWM2OD1yLkS0N|kh|ryP M{X1cHNCVkeHUh?=
SF268 M4G1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwNES4OkDPxE1? M1XRU3NCVkeHUh?=
RT4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwNEWxNVEh|ryP NEL6bWFUSU6JRWK=
NCI-H522 NGj6OHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjrNoFKSzVyPUCuOFUzPyEQvF2= NFHJfVRUSU6JRWK=
LCLC-97TM1 NX60S|NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;0W4xRUUN3ME2wMlQ3OTl3IN88US=> NIrlNmVUSU6JRWK=
CAL-39 M4jqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDXW2RKSzVyPUCuOFY2OTlizszN M2\OTXNCVkeHUh?=
CAL-120 M{XOU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwNEe2OFMh|ryP M37OS3NCVkeHUh?=
ESS-1 NXzVSlVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr0TWM2OD1yLkS3PFIyKM7:TR?= NY\oUopvW0GQR1XS
KARPAS-45 M2jufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnlbWZsUUN3ME2wMlQ5QTN|IN88US=> MkTNV2FPT0WU
DU-4475 M2K0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;KPXdKSzVyPUCuOFk2OTFizszN MWfTRW5ITVJ?
VMRC-RCZ NHzkNJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHJ[|NKSzVyPUCuOFk6ODRizszN M1X1eXNCVkeHUh?=
HOS NYPITIxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjkTWM2OD1yLkWwN|Y2KM7:TR?= MmTyV2FPT0WU
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D-542MG NF[4OodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfE[pdlUUN3ME2xMlg2QDVzIN88US=> NIiweoZUSU6JRWK=
KNS-42 NUjxTWtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDWUnNKSzVyPUGuPFYzPjZizszN MXXTRW5ITVJ?
NCI-H2452 NHziWHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFwOEmwO|Qh|ryP M2Gy[nNCVkeHUh?=
SK-MEL-2 NVyyN2g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HRemlEPTB;MT65NFI4OSEQvF2= MkOxV2FPT0WU
OVCAR-5 NEX1V5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTFwOUC2O|Uh|ryP M{Hhc3NCVkeHUh?=
SNG-M M2D3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G5WmlEPTB;MT65OVg2QCEQvF2= M1SyO3NCVkeHUh?=
A673 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFwOUe1NVYh|ryP M3nxUHNCVkeHUh?=
L-428 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zpbGlEPTB;MT65PVE4QSEQvF2= NI[yOYNUSU6JRWK=
KM-H2 M4XwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fE[2lEPTB;Mj6wNVA6KM7:TR?= MXjTRW5ITVJ?
MC-IXC MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPRTWM2OD1{LkCyNlc{KM7:TR?= NIXCPY5USU6JRWK=
COLO-678 NUC0S4tzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX5UohqUUN3ME2yMlA1OjB5IN88US=> M3HTcHNCVkeHUh?=
MEL-JUSO NX7GXY5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfXSmhEUUN3ME2yMlA4QDVzIN88US=> M3vEdXNCVkeHUh?=
HCC38 NIjWdlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTITWM2OD1{LkC4OFM{KM7:TR?= M3z0OHNCVkeHUh?=
UACC-62 NYj0UnNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r5[mlEPTB;Mj6wPFg2PSEQvF2= MWrTRW5ITVJ?
OAW-42 MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJwMEm3NVEh|ryP M2n5NXNCVkeHUh?=
LB996-RCC NEjMOnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELmXlZKSzVyPUKuNVM5OTdizszN NF74SGFUSU6JRWK=
COR-L105 NYrZeFNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnUfXBJUUN3ME2yMlE3Ozd|IN88US=> NWTkO|RWW0GQR1XS
RCC10RGB NGj4cGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHsTnV{UUN3ME2yMlE5PTd4IN88US=> MV;TRW5ITVJ?
A431 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJwMUmwNVkh|ryP NYjDb4JVW0GQR1XS
NCI-H292 NGnCXJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDIc4FoUUN3ME2yMlI{QTVzIN88US=> NGrzXY1USU6JRWK=
SK-UT-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYq3XIgzUUN3ME2yMlM{OTh2IN88US=> M4L4[nNCVkeHUh?=
PANC-08-13 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJwM{OyN|Uh|ryP NVzNPIhpW0GQR1XS
ST486 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPPVlZyUUN3ME2yMlQyODR6IN88US=> Mm\GV2FPT0WU
SJSA-1 NWL2PWMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[5XGlEPTB;Mj60NVI4OSEQvF2= M4qwfnNCVkeHUh?=
RKO NYS2PVViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon5TWM2OD1{LkSyNFI6KM7:TR?= M4rEbXNCVkeHUh?=
NCI-H1793 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XvXWlEPTB;Mj60OFAzQSEQvF2= NIfHbWVUSU6JRWK=
639-V NWrlUnVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHQVHJKSzVyPUKuOFU{QDJizszN M{nsd3NCVkeHUh?=
ES3 NGTyVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPZRopKSzVyPUKuOFk4OzdizszN NYTGc5R7W0GQR1XS
NCI-H1792 M3XvcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLvV5l{UUN3ME2yMlU3QDJ4IN88US=> MXPTRW5ITVJ?
NCI-H1651 MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJwNUiyNUDPxE1? NXvSXppNW0GQR1XS
SN12C M4XB[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLmTWM2OD1{LkW4OFg4KM7:TR?= NWXlfZc6W0GQR1XS
COLO-679 M1TvWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\JTWM2OD1{LkW4OlA2KM7:TR?= M3u2SnNCVkeHUh?=
U-118-MG NIDTRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DROWlEPTB;Mj61PFg4OiEQvF2= NVHIelRpW0GQR1XS
Ramos-2G6-4C10 NYrqeolTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PIeGlEPTB;Mj62OFgxPyEQvF2= Mmf5V2FPT0WU
HCT-15 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnqTWM2OD1{Lk[4O|kzKM7:TR?= MYrTRW5ITVJ?
MDA-MB-157 NIfBRoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwN{C3OFch|ryP M2XmeXNCVkeHUh?=
K5 MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUCwW4kxUUN3ME2yMlcyQDR3IN88US=> M3XxXnNCVkeHUh?=
MKN45 Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHTTWM2OD1{LkezN|Y3KM7:TR?= Mmm3V2FPT0WU
DMS-273 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmwc2tSUUN3ME2yMlc2PjN{IN88US=> MV3TRW5ITVJ?
C8166 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\3W|lKSzVyPUKuO|g2OTNizszN M1uwRXNCVkeHUh?=
Calu-3 NHTUcI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3ITWM2OD1{Lke4PVY6KM7:TR?= MV3TRW5ITVJ?
SNB75 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP5TWM2OD1{Lki4OVM2KM7:TR?= MU\TRW5ITVJ?
BFTC-905 MlXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX1OGV4UUN3ME2yMlkxOTlzIN88US=> MljNV2FPT0WU
C-4-II NFW4cYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nJbWlEPTB;Mj65NVM2OyEQvF2= M4TJcXNCVkeHUh?=
MS-1 NXPk[|I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjFZmhKSzVyPUKuPVY4PjlizszN NYS1TZhCW0GQR1XS
A375 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXhTWM2OD1|LkC4NVg1KM7:TR?= NI\E[3FUSU6JRWK=
KYSE-70 MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fRdmlEPTB;Mz6wPFg5OiEQvF2= MoP4V2FPT0WU
KYSE-510 NGDKOmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OxVWlEPTB;Mz6xNFk6PSEQvF2= MY\TRW5ITVJ?
LN-405 NIHvUFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljsTWM2OD1|LkGzOVE5KM7:TR?= NHvVNGZUSU6JRWK=
BOKU MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTNwMUSyOVYh|ryP NG\zOHdUSU6JRWK=
TE-10 NWO3cWN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO3SFJKSzVyPUOuNVc{PjJizszN NVnQVJh5W0GQR1XS
MKN1 NIS2XWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHnTWM2OD1|LkG4OFg{KM7:TR?= NIHIUIhUSU6JRWK=
M059J MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:2cVNiUUN3ME2zMlIxOTd|IN88US=> NEPTVlRUSU6JRWK=
GOTO NETHWFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[5TWM2OD1|LkKyNFM6KM7:TR?= M{S1NnNCVkeHUh?=
DK-MG MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWeyd5R5UUN3ME2zMlI2QTd4IN88US=> MVzTRW5ITVJ?
NCI-H727 NHnwRY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkexTWM2OD1|LkK2OVgh|ryP MUjTRW5ITVJ?
NB12 Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rUPWlEPTB;Mz6zN|IzPCEQvF2= NF3NfGFUSU6JRWK=
DOK NXXvbXJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTNwM{[xPFYh|ryP MXXTRW5ITVJ?
KYSE-410 NIjw[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNwM{[yPFch|ryP NYPKbYFXW0GQR1XS
AM-38 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfCN4ZiUUN3ME2zMlM5ODVzIN88US=> NWPpUWxQW0GQR1XS
GR-ST NEG5[ZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P0WmlEPTB;Mz60OVc{OiEQvF2= NXfiO2N2W0GQR1XS
D-247MG NI\3[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTNwNEiyOlMh|ryP NXPzWXFOW0GQR1XS
TE-8 NFy4VoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr0[lBKSzVyPUOuOFk{OzNizszN NF[1O|dUSU6JRWK=
LS-411N MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTNwNEm2PVIh|ryP MlzBV2FPT0WU
SK-MES-1 NEDub2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO1TWM2OD1|LkW2OFM{KM7:TR?= MnvQV2FPT0WU
SF295 NF\nW4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjuVlNsUUN3ME2zMlYyPTV{IN88US=> Mk\aV2FPT0WU
SK-MEL-30 NU\GZ4pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTNwNkW5NlEh|ryP M1W0d3NCVkeHUh?=
LB2241-RCC NY\CVJZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PHd2lEPTB;Mz62OlI3KM7:TR?= NGXZeHdUSU6JRWK=
PC-14 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTNwNk[0N|ch|ryP M{LuS3NCVkeHUh?=
EW-7 NGD3SHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrmVoRKSzVyPUOuOlc3QTNizszN MX\TRW5ITVJ?
NMC-G1 NEnLUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7tdpJ6UUN3ME2zMlcyQDN5IN88US=> NI\FV2hUSU6JRWK=
TE-441-T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTNwN{OwNlgh|ryP NUHh[ldbW0GQR1XS
NCI-H1618 M4KzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTNwOEG4O|Uh|ryP M{\SfnNCVkeHUh?=
PANC-03-27 NG[yZ2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\RcGdKSzVyPUOuPFE6OTZizszN M{naN3NCVkeHUh?=
NCI-H2228 M1H1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLGTWM2OD1|LkizNVI3KM7:TR?= M37JNnNCVkeHUh?=
CAPAN-1 M1zIcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ntWWlEPTB;Mz64O|AxQSEQvF2= NXHr[m9oW0GQR1XS
KLE NHOzOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPJfZlKSzVyPUOuPVA3PyEQvF2= NHrrbphUSU6JRWK=
Becker NUjNdXJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mke1TWM2OD1|LkmyPFQ6KM7:TR?= MXrTRW5ITVJ?
SK-PN-DW NFLXW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DHV2lEPTB;ND6wO|k4PCEQvF2= M1;GfHNCVkeHUh?=
Hs-578-T NUnJOYFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fiOGlEPTB;ND6wPFMxPiEQvF2= M{ftNnNCVkeHUh?=
RS4-11 MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTRwMUGyOVUh|ryP NGnvVphUSU6JRWK=
D-502MG NIj4UG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vEemlEPTB;ND6xOlk6PyEQvF2= MnPEV2FPT0WU
GI-1 M{Di[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\uUW9KSzVyPUSuNlgzQTlizszN M3vnTnNCVkeHUh?=
NCI-H209 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLaUGtCUUN3ME20MlM{PzhizszN MVjTRW5ITVJ?
SK-OV-3 M4LMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfpXFBKSzVyPUSuOFgyPDlizszN NXuzZo5MW0GQR1XS
LOUCY M{XPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTRwNEi0N|Ih|ryP MWHTRW5ITVJ?
NCI-H69 NV7MOmd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHWWmhKSzVyPUSuOVE4QTNizszN M3zQWXNCVkeHUh?=
SCC-9 MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPKTJFjUUN3ME20MlU{OTd{IN88US=> MUTTRW5ITVJ?
NCI-H526 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTRwNUmyPVMh|ryP M{TNbHNCVkeHUh?=
NCI-H2170 MlXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPvTWM2OD12Lk[2O|cyKM7:TR?= MYfTRW5ITVJ?
SR NV7YV|FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v0eWlEPTB;ND63NFA1QCEQvF2= MoW5V2FPT0WU
CMK Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XmWWlEPTB;ND63NlExOSEQvF2= M1;UUHNCVkeHUh?=
COLO-829 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTRwN{ewOFMh|ryP MVvTRW5ITVJ?
HuO-3N1 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDIUo85UUN3ME20Mlg{OjhzIN88US=> MUjTRW5ITVJ?
5637 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfhTWM2OD12LkmwOFg4KM7:TR?= MUTTRW5ITVJ?
A253 NH3RepFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjBe3RKSzVyPUSuPVc4ODhizszN NXjtPWRnW0GQR1XS
NB10 M372bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTVwMEe0PVch|ryP MlTFV2FPT0WU
SF539 NUfJOZltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTVwMEm5OVkh|ryP MY\TRW5ITVJ?
HAL-01 NILUeWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTVwMUS2OFUh|ryP M{jEZ3NCVkeHUh?=
MHH-ES-1 MnPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTVwMU[5NlUh|ryP MoLmV2FPT0WU
DEL NILrO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljNTWM2OD13LkK3OVgzKM7:TR?= NFfKZpZUSU6JRWK=
NCI-H1299 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHrbIJKSzVyPUWuN|UxODdizszN M2Tv[XNCVkeHUh?=
ChaGo-K-1 NUCyUWN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nQSWlEPTB;NT6zOVExPyEQvF2= MYXTRW5ITVJ?
HMV-II MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTVwM{m0N{DPxE1? NGXnNHdUSU6JRWK=
NB69 NXzBUZFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPiPJdKSzVyPUWuN|k3OzFizszN NE\UeVhUSU6JRWK=
NCI-H1882 M3j6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHzfVRKSzVyPUWuOFM{PjRizszN NUTMc|Y5W0GQR1XS
SNU-475 MofwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XNSWlEPTB;NT60O|E4OSEQvF2= MXnTRW5ITVJ?
RXF393 NV;5SJVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\R[lVKSzVyPUWuOFg1QTRizszN M4jGcHNCVkeHUh?=
CAL-51 Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fHUWlEPTB;NT62Nlg2OyEQvF2= M{jyc3NCVkeHUh?=
SW1573 NXzBR5BpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XoTmlEPTB;NT62N|U{PCEQvF2= NG\MNGpUSU6JRWK=
GCT NXPYdJY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7lUINEUUN3ME21Mlc2QTJ7IN88US=> NWTWeox5W0GQR1XS
COR-L88 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTVwN{[4OFYh|ryP NWfodmhpW0GQR1XS
MDA-MB-134-VI MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rKW2lEPTB;NT64O|U{PiEQvF2= NYrwVHhzW0GQR1XS
NB5 NWm5OFlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vQ[mlEPTB;NT65NlQ1KM7:TR?= M3z6fnNCVkeHUh?=
GMS-10 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHkdnJKSzVyPUWuPVY5PjFizszN NGrhRWFUSU6JRWK=
CHP-212 Mo[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTZwNEiyOlch|ryP NX3jUWNuW0GQR1XS
TE-11 NYnEdHRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;Yd2tKSzVyPU[uOVUyQDJizszN M4rhPHNCVkeHUh?=
SW962 NGjpW5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL2XpY6UUN3ME22MlY2Pzd2IN88US=> NYi3eVNvW0GQR1XS
MZ2-MEL NEDWRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnyxTWM2OD14LkiyNFEyKM7:TR?= NH3JT4RUSU6JRWK=
C-33-A MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIf6XHFKSzVyPU[uPVE3QDhizszN M2i1XXNCVkeHUh?=
IGR-1 MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPWcHdbUUN3ME22Mlk4QDJ4IN88US=> MlzPV2FPT0WU
MOLT-4 NES4UoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTdwMUW0NFYh|ryP NV:y[2dKW0GQR1XS
NCI-H1650 M1TMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTdwMkewOFYh|ryP NHLwW5VUSU6JRWK=
AsPC-1 NEOxUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETHNnBKSzVyPUeuNlg3ODVizszN M4nZ[nNCVkeHUh?=
SNU-C2B NHS4U2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrzTGx6UUN3ME23MlI6PTdzIN88US=> MUPTRW5ITVJ?
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NCI-H630 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ{LkWzOlMh|ryP NEfJZ5JUSU6JRWK=
LU-165 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvNN5A5UUN3ME2yNk42PTRizszN M3[3cXNCVkeHUh?=
COLO-792 NIrMeGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrwTWM2OD1{Mj63NVEyKM7:TR?= MVHTRW5ITVJ?
CAL-62 MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj2TVc5UUN3ME2yNk44PTF5IN88US=> NXrlSoNPW0GQR1XS
HCE-T NHXYXGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PoRmlEPTB;MkKuPFYxPiEQvF2= NV\N[VZiW0GQR1XS
BB65-RCC M1nnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvLcZRjUUN3ME2yN{4xOzR2IN88US=> M12zdXNCVkeHUh?=
SiHa M{[3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJ|LkO5Olgh|ryP Mm\OV2FPT0WU
NCI-H2081 Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnRTWM2OD1{ND6wOlQyKM7:TR?= MlnCV2FPT0WU
U251 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\VTWM2OD1{ND6wOlY5KM7:TR?= NXjDOnBJW0GQR1XS
LoVo MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnheYpjUUN3ME2yOE46Ojh{IN88US=> NFnnXIdUSU6JRWK=
GCIY M3vQR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJ3LkK4O|ch|ryP M1LW[nNCVkeHUh?=
NUGC-3 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJ3LkOzNVYh|ryP NXjnWlVHW0GQR1XS
LNCaP-Clone-FGC NULIWHRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHZTWM2OD1{NT6zOFk5KM7:TR?= NEfiZ|JUSU6JRWK=
PA-1 NET3U3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PnVmlEPTB;MkWuOlg{OyEQvF2= MVjTRW5ITVJ?
OE33 M1LY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnlXmpEUUN3ME2yOU43QDV|IN88US=> NUnHRYJ4W0GQR1XS
HT-29 M{\q[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJ3Lke4O|kh|ryP NVr6OYp[W0GQR1XS
RCM-1 NIHQTWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\qXpRKSzVyPUK1Mlk3PTZizszN NEXyVJRUSU6JRWK=
NCI-H1522 M1vDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e0U2lEPTB;MkWuPVkyOSEQvF2= MVPTRW5ITVJ?
LB373-MEL-D MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETsW|RKSzVyPUK2MlE4ODhizszN M3nIWnNCVkeHUh?=
NCI-H1436 M{jEZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDTe|VWUUN3ME2yOk4zPzN6IN88US=> NYXjVFN7W0GQR1XS
COLO-824 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2raVWlEPTB;Mk[uOFAxOiEQvF2= M3;mfnNCVkeHUh?=
CP50-MEL-B NUHKRmduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjvTWM2OD1{Nj61Olc2KM7:TR?= MWLTRW5ITVJ?
EGI-1 NILIS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPadmQ5UUN3ME2yO{4zPjl6IN88US=> NUL4dVZlW0GQR1XS
LAN-6 NX7rXIlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPFZWxVUUN3ME2yO{4{PTl6IN88US=> MX;TRW5ITVJ?
GAK MmjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf2d3c2UUN3ME2yO{41OjJ3IN88US=> M4LveXNCVkeHUh?=
MDA-MB-175-VII NWfENnlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z1bWlEPTB;MkeuOVA2OyEQvF2= M1rMeXNCVkeHUh?=
JVM-2 M1HZTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmzUlZKUUN3ME2yO{43PjJ{IN88US=> NU\Mb|hPW0GQR1XS
UACC-257 M2C1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2qwUWlEPTB;MkeuOlg4QCEQvF2= NYi1SmY5W0GQR1XS
SW1783 M3HLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjDWWlFUUN3ME2yO{44Pzh|IN88US=> MXvTRW5ITVJ?
HT-3 M4DUcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;5U2lEPTB;MkiuNlE3PiEQvF2= NWHSb5hOW0GQR1XS
RL NGS2TJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJ6LkW5NVEh|ryP MkDsV2FPT0WU
TK10 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDJWplKSzVyPUK4MlY2OzVizszN NXzGcmR6W0GQR1XS
HT55 NVLqWnE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP2TWM2OD1{OT6wOVY2KM7:TR?= M33rNXNCVkeHUh?=
BT-20 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:5XJRYUUN3ME2yPU4xPTh4IN88US=> NHvjVYtUSU6JRWK=
TGBC24TKB NWHrVoRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTwOJVKSzVyPUK5MlE5OzFizszN NIPnV4tUSU6JRWK=
HSC-2 NGPuXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWiyN41FUUN3ME2yPU4{ODBzIN88US=> NIDKZ3NUSU6JRWK=
COLO-205 M3zLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzrVJNKSzVyPUK5MlM6PDRizszN M{\vU3NCVkeHUh?=
GT3TKB MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj3TWM2OD1{OT62PFc4KM7:TR?= Mmn0V2FPT0WU
T47D M3zPS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3YO21KSzVyPUK5Mlg2QDJizszN MnvBV2FPT0WU
OMC-1 NV6wb4ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nSSmlEPTB;M{CuNVkyQSEQvF2= NVjuRmF1W0GQR1XS
PFSK-1 M{TJWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3yTWM2OD1|MT6yOlU6KM7:TR?= NYryeXJUW0GQR1XS
JEG-3 MlzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrBWmgyUUN3ME2zNU4{PTZzIN88US=> MmH5V2FPT0WU
RD NEO5bnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XJ[mlEPTB;M{GuOVEyPSEQvF2= NHvYVJpUSU6JRWK=
NCI-H64 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m0N2lEPTB;M{KuOFE4QSEQvF2= NGnmVFhUSU6JRWK=
DMS-114 M4XhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTN{LkSxPFIh|ryP NFXH[|RUSU6JRWK=
NCI-H661 MoPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe3O4ZKSzVyPUOyMlY2ODFizszN M4HyRXNCVkeHUh?=
CAL-148 NF3kPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;sUGlEPTB;M{KuOlY3PSEQvF2= NUT6NnZwW0GQR1XS
HuP-T3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTN{LkmzN|gh|ryP NHPOOYJUSU6JRWK=
ES4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\pZWlEPTB;M{OuNVcxPSEQvF2= NVTieFNQW0GQR1XS
Ca9-22 NWDQ[nJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnexTWM2OD1|Mz60OlAyKM7:TR?= NIrlUYFUSU6JRWK=
LP-1 NGmwbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\QTWM2OD1|ND6wPUDPxE1? NWDnPWJiW0GQR1XS
AU565 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHiwWG9KSzVyPUO0MlUxPjlizszN NUDMU3c2W0GQR1XS
MDA-MB-453 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTN3LkG0NlYh|ryP M3\kPXNCVkeHUh?=
SNU-C1 NX3QcHNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnrR3NJUUN3ME2zOU4yPzFizszN M{XNWnNCVkeHUh?=
SW13 MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTN3LkSwO|Yh|ryP M2j0[HNCVkeHUh?=
NCI-H2122 Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELTNGFKSzVyPUO1MlU2QThizszN Ml\VV2FPT0WU
NCI-H1395 NIDOUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDJTWM2OD1|NT62OlkyKM7:TR?= M3TQd3NCVkeHUh?=
J-RT3-T3-5 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe5PWo1UUN3ME2zOk4xOjl2IN88US=> NHvrRpJUSU6JRWK=
COR-L279 NUHVSplkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTN4LkG5PFEh|ryP NXjLXZdpW0GQR1XS
ATN-1 NWDISGdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fnV2lEPTB;M{[uPFUyPiEQvF2= MlLvV2FPT0WU
HCC2998 M4jDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN4Lki1O|Eh|ryP M{PWXnNCVkeHUh?=
UM-UC-3 Mmj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTN4Lki2O|Uh|ryP MVHTRW5ITVJ?
DV-90 M1jhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vic2lEPTB;M{[uPVA3PyEQvF2= MYHTRW5ITVJ?
ES8 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HvSGlEPTB;M{[uPVMyQCEQvF2= MX3TRW5ITVJ?
YAPC M{G0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[4SmhKSzVyPUO2Mlk3PTRizszN NYWwcGxEW0GQR1XS
HCC1599 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;6V|dKSzVyPUO3MlE3OThizszN M3ThcXNCVkeHUh?=
UMC-11 MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLMZok2UUN3ME2zO{4zPTB|IN88US=> MWfTRW5ITVJ?
THP-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrqTWM2OD1|Nz6yPFY5KM7:TR?= M3zOTnNCVkeHUh?=
OCUB-M M4f4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonXTWM2OD1|Nz6yPFkyKM7:TR?= NVjBWZVXW0GQR1XS
NCI-H1693 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjkTWM2OD1|Nz6zNlM{KM7:TR?= NVPReHREW0GQR1XS
NCI-H345 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\BPXBKSzVyPUO3MlM3OjRizszN MXzTRW5ITVJ?
COLO-800 NGnndWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTN5LkW2O{DPxE1? NGPl[ZpUSU6JRWK=
COLO-320-HSR M3y3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnuTWM2OD1|OD6zOFkzKM7:TR?= NGjTbIJUSU6JRWK=
NCI-H596 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T2SmlEPTB;M{iuOFQ5QSEQvF2= MlfvV2FPT0WU
NCI-H187 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTN6LkezOFQh|ryP NWDwVndWW0GQR1XS
ECC4 NEDKV5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHpPGZKSzVyPUO5MlA5OTRizszN MkS0V2FPT0WU
KP-4 NWHLeYVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M375OWlEPTB;M{muNVI{PSEQvF2= MXnTRW5ITVJ?
NCI-H2227 MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonETWM2OD1|OT6zPVQ6KM7:TR?= MWTTRW5ITVJ?
22RV1 NXrq[291T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX0SZZKSzVyPUO5Mlg{QThizszN MWfTRW5ITVJ?
SAS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DVd2lEPTB;NECuNFk3KM7:TR?= M{PGS3NCVkeHUh?=
PANC-10-05 NGHBRYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fa[WlEPTB;NECuNVgzQCEQvF2= Ml3yV2FPT0WU
MDA-MB-468 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nD[mlEPTB;NECuOVM1PiEQvF2= M4TMPXNCVkeHUh?=
RPMI-7951 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTRzLkKwO|Uh|ryP M1PySHNCVkeHUh?=
BB49-HNC M3fiPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrRdWlKSzVyPUSxMlIyPzlizszN NG\P[WxUSU6JRWK=
23132-87 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWCwVYs5UUN3ME20NU4zPzN{IN88US=> MXPTRW5ITVJ?
HCC1569 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrqTWM2OD12MT6yPFg2KM7:TR?= MUjTRW5ITVJ?
CP66-MEL NE\ib2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq2UYhKSzVyPUSyMlE5QDZizszN M2DCfXNCVkeHUh?=
K-562 MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTR{LkK4OVQh|ryP NV3ye4ZYW0GQR1XS
OCI-AML2 NGixWGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfSUmdNUUN3ME20Nk45QTd2IN88US=> MXTTRW5ITVJ?
SW756 NETlPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jDN2lEPTB;NEOuNFM5QCEQvF2= M3Xsd3NCVkeHUh?=
M14 NXnUR4pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnmPItoUUN3ME20N{4{OTh7IN88US=> MlvHV2FPT0WU
NCI-H1623 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPIfZlKSzVyPUSzMlQ3PCEQvF2= MWjTRW5ITVJ?
KNS-81-FD M2ixXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\YcYJKSzVyPUSzMlc3OiEQvF2= M4nQTnNCVkeHUh?=
TGBC1TKB M1nSUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTR|LkmwPVkh|ryP NXHBVZVjW0GQR1XS
RERF-LC-MS M3jDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTR|LkmyPFEh|ryP M1npPHNCVkeHUh?=
PC-3 M3fiSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTR2LkSzOFch|ryP MVrTRW5ITVJ?
HuP-T4 NGHkXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\HV5ZOUUN3ME20OE41PDd2IN88US=> NVG4SGpPW0GQR1XS
NCI-H510A M2fNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR2LkewPEDPxE1? MluxV2FPT0WU
LB2518-MEL M{fr[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjxTppKSzVyPUS0Mlc6OzdizszN MlzNV2FPT0WU
TE-5 M1O4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDuTWM2OD12NT65OVgyKM7:TR?= M3LPSXNCVkeHUh?=
EW-24 NXLhZ2VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK4WYV2UUN3ME20Ok4yPzJ|IN88US=> MXfTRW5ITVJ?
LB647-SCLC NGPheGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTR4LkKxOVUh|ryP MkHFV2FPT0WU
NCI-H524 NUT4XZNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDMTWM2OD12Nj63NVg2KM7:TR?= NES3Z2pUSU6JRWK=
EW-11 NYT4fmg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTwNY1LUUN3ME20Ok46Ozd|IN88US=> NYjxbYVxW0GQR1XS
KALS-1 NHPxWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv5TlZCUUN3ME20O{4zODZ4IN88US=> M2Xxd3NCVkeHUh?=
BT-474 M2HlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPNbllKSzVyPUS3MlQzOTZizszN MWXTRW5ITVJ?
SK-N-AS M1zxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTR5Lki4PEDPxE1? NX\IVXBXW0GQR1XS
HCC2157 M2DJdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrCbmFKSzVyPUS4MlA4PiEQvF2= NE\0T4lUSU6JRWK=
HCC1954 M4T2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIC4RXZKSzVyPUS4MlE4ODRizszN NWfZXXpUW0GQR1XS
FADU Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XNS2lEPTB;NEiuN|A{OSEQvF2= M1zwWHNCVkeHUh?=
S-117 NUPHW4pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmSzTWM2OD12OD6zPFE2KM7:TR?= MYjTRW5ITVJ?
LS-1034 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF71TopKSzVyPUS4MlcxPjdizszN MX3TRW5ITVJ?
CAMA-1 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTR7LkW1OFMh|ryP MojNV2FPT0WU
LU-134-A NFP6bWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHWTWM2OD12OT64NFg2KM7:TR?= M{HR[XNCVkeHUh?=
NCI-H1838 NYnhR5JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jpZ2lEPTB;NEmuPFA5PyEQvF2= M4fUOnNCVkeHUh?=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 順序で溶剤を入れること:
30% PEG400+0.5% Tween80+5% propylene glycol
10 mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl信号経路図

Bcr-Abl Inhibitors with Unique Features

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID