Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00

カスタマーフィードバック(4)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NVTmNXVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[xfVFKSzVyPUCuNFAxODByMEO1PUDPxE1? MXPTRW5ITVJ?
MV-4-11 NWj3N2NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle5TWM2OD1yLkCwNFA6PTZizszN MlHKV2FPT0WU
MEG-01 M4rQ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorETWM2OD1yLkCwNFEzQCEQvF2= NEjRWIZUSU6JRWK=
LAMA-84 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMECwNVY2KM7:TR?= M134NHNCVkeHUh?=
CGTH-W-1 M3zyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLrXGFRUUN3ME2wMlAxOTZ7IN88US=> NIfTeYJUSU6JRWK=
KASUMI-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXq5OnptUUN3ME2wMlAxOjF5IN88US=> MlTKV2FPT0WU
BE-13 MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkO5TWM2OD1yLkCwNlU6KM7:TR?= MnXyV2FPT0WU
CTV-1 M{DWWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrufW5KSzVyPUCuNFA2OjFizszN NVTEVYpmW0GQR1XS
NKM-1 M1jpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXLTWM2OD1yLkCwOlU2KM7:TR?= NVG2Ro5ZW0GQR1XS
MONO-MAC-6 NVvnNlJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT5NGpWUUN3ME2wMlAxQDN5IN88US=> MortV2FPT0WU
A204 NGfzO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEGyNVgh|ryP M{jUTHNCVkeHUh?=
GDM-1 M1XCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXGV2NKSzVyPUCuNFE5OzNizszN NGe3WmdUSU6JRWK=
AN3-CA MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLyTWM2OD1yLkCxPFc{KM7:TR?= MYTTRW5ITVJ?
BL-70 M2TiU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TSWWlEPTB;MD6wNlE6QSEQvF2= M2DUZ3NCVkeHUh?=
Daudi NFnFPG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfWU2NKSzVyPUCuNFI2OzdizszN MVnTRW5ITVJ?
KU812 NUPQT5dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KzdGlEPTB;MD6wNlg1QCEQvF2= MV\TRW5ITVJ?
KG-1 M1LNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXueIRKSzVyPUCuNFMzQTRizszN Mk\6V2FPT0WU
DOHH-2 NXH6PXNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4qwXmlEPTB;MD6wOFgxOyEQvF2= MkHnV2FPT0WU
HuO9 M{DObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTpNGh3UUN3ME2wMlA2PDR6IN88US=> NWXudG5lW0GQR1XS
EB2 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXTRpZKSzVyPUCuNFU2PzZizszN M37oZXNCVkeHUh?=
G-402 M1\pNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwME[zOFEh|ryP Ml21V2FPT0WU
SU-DHL-1 NIO0d3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTiWFV1UUN3ME2wMlA3Ozd7IN88US=> M1XWeHNCVkeHUh?=
NCI-H719 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVmwfmx[UUN3ME2wMlA4QDh6IN88US=> M{HjNnNCVkeHUh?=
MLMA NGXN[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrvTWM2OD1yLkC5NFYh|ryP NUjiUmFVW0GQR1XS
KM12 NV6xNos4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPyeJhzUUN3ME2wMlA6PzN5IN88US=> MV\TRW5ITVJ?
SUP-T1 NUTlNlRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLXTWM2OD1yLkC5PVgzKM7:TR?= M3rPcHNCVkeHUh?=
MZ1-PC MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfYXHJVUUN3ME2wMlEyOzN4IN88US=> NVzUSYNDW0GQR1XS
MFE-296 M1HyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUG4N|kh|ryP MkLRV2FPT0WU
ALL-PO NXKyUHJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\iVGlEPTB;MD6xNlQ1OyEQvF2= M1HMOHNCVkeHUh?=
GB-1 NFrJ[nRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfx[og3UUN3ME2wMlEzPTF{IN88US=> M{S3ZXNCVkeHUh?=
SIG-M5 NVr3[2IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojxTWM2OD1yLkGzN|ch|ryP MVjTRW5ITVJ?
P30-OHK Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfpRodKSzVyPUCuNVU3PzJizszN M{\JenNCVkeHUh?=
NCI-H716 M4fh[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:4bYxpUUN3ME2wMlE3OjZ4IN88US=> Mn\rV2FPT0WU
MPP-89 NYTCVJo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1facmlEPTB;MD6xOlk{OyEQvF2= M4Xk[HNCVkeHUh?=
SF126 NV3aU3pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PONmlEPTB;MD6xO|A3OyEQvF2= MonGV2FPT0WU
CTB-1 NHWweGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHkVoFKSzVyPUCuNVc{OTZizszN NGTjO2tUSU6JRWK=
CA46 MkjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmriTWM2OD1yLkG3OFg6KM7:TR?= NGHI[HpUSU6JRWK=
NCI-H520 NGL0RmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPBRVlKSzVyPUCuNVc4OzJizszN MkTDV2FPT0WU
CAL-85-1 M3rsSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP6WZd7UUN3ME2wMlE4QTJ5IN88US=> M2fWcXNCVkeHUh?=
NCI-H2342 M2PlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;hTWM2OD1yLkG4OVc4KM7:TR?= NUe1eVAxW0GQR1XS
697 NUL2TVVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrkSlRKSzVyPUCuNVg5PzFizszN MX7TRW5ITVJ?
NY NGX5[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXCVnZlUUN3ME2wMlE6Ojh5IN88US=> NVniOoRCW0GQR1XS
T98G NX;CWnYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnOeGxYUUN3ME2wMlE6OzF6IN88US=> NXyyfFZUW0GQR1XS
NCI-H1703 M3P5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUm2NVUh|ryP NFjHPIVUSU6JRWK=
NCI-H2087 M{Ho[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2GxVmlEPTB;MD6yNFQ{QSEQvF2= Mm\xV2FPT0WU
PF-382 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXruXJZ[UUN3ME2wMlIxQDd|IN88US=> MnnnV2FPT0WU
HCT-116 NYG2fnI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3ZfmJxUUN3ME2wMlIyODZ7IN88US=> NIfZb5ZUSU6JRWK=
CAKI-1 MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq1eJd4UUN3ME2wMlIyPjZ4IN88US=> MorzV2FPT0WU
CCF-STTG1 MkDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7XSpB5UUN3ME2wMlIzPDd3IN88US=> M1y2ZnNCVkeHUh?=
D-392MG NYXIboJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMkOxO|ch|ryP MUTTRW5ITVJ?
RT-112 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTBTWM2OD1yLkKzO|k2KM7:TR?= NV3veZpFW0GQR1XS
MES-SA NIntUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CwR2lEPTB;MD6yOFE5PyEQvF2= NGHjfnpUSU6JRWK=
LC-2-ad M3zxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PMNGlEPTB;MD6yOFI3PSEQvF2= M1fiOXNCVkeHUh?=
NOS-1 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTXfmNKSzVyPUCuNlQ{PjdizszN MlLIV2FPT0WU
NALM-6 MoDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTXTZFTUUN3ME2wMlI2PTR|IN88US=> NW\6eGR7W0GQR1XS
TE-15 NX;jb4hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHGTWM2OD1yLkK2NFkyKM7:TR?= M1WzT3NCVkeHUh?=
786-0 M{nMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzy[WFKSzVyPUCuNlYzOjhizszN NFnpSFhUSU6JRWK=
IST-MES1 NUjaVok4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOzOpNKSzVyPUCuNlY5OjlizszN NXL2SFlqW0GQR1XS
KYSE-180 M3K2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjGXoxKSzVyPUCuNlY5QTFizszN Mo[3V2FPT0WU
YT MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jidGlEPTB;MD6yOlk4PCEQvF2= NF:2O2hUSU6JRWK=
A427 NYnZR2Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[yWpZ3UUN3ME2wMlI4OjZ2IN88US=> NVTCVlk{W0GQR1XS
KYSE-450 NUezWIF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1yzOWlEPTB;MD6yO|MzQSEQvF2= MXzTRW5ITVJ?
HuH-7 M1Hm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPnTWM2OD1yLkK3O|Y{KM7:TR?= NIC4PWhUSU6JRWK=
CAS-1 NH\4TIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXHNmRKSzVyPUCuNlg{ODNizszN MmLUV2FPT0WU
KURAMOCHI MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\2VGlEPTB;MD6yPFQyQSEQvF2= M1GxUnNCVkeHUh?=
ACHN M1PHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITlVmtKSzVyPUCuNlk{OjNizszN MUnTRW5ITVJ?
HGC-27 MmXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H3OWlEPTB;MD6yPVM2OyEQvF2= Mlz5V2FPT0WU
A172 NUXoZZV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjLNY5DUUN3ME2wMlI6PTd5IN88US=> Mnf3V2FPT0WU
SNU-449 M{e5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTPTWM2OD1yLkK5PVY1KM7:TR?= M{nKSXNCVkeHUh?=
SW982 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMkm5O|gh|ryP MWrTRW5ITVJ?
EFO-21 NXTZboNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nKO2lEPTB;MD6zNFQyOSEQvF2= MYHTRW5ITVJ?
NCI-H2030 NFfZPGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3h[FJzUUN3ME2wMlMyOTZ2IN88US=> MlXnV2FPT0WU
HT-144 NHK0b5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwM{GyPEDPxE1? NWHqTJo4W0GQR1XS
MFE-280 MmTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XRd2lEPTB;MD6zNVQ2OyEQvF2= MmDLV2FPT0WU
SK-LU-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwM{G0OlYh|ryP NEX0U3ZUSU6JRWK=
NCI-H2052 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XXNmlEPTB;MD6zNVQ5PCEQvF2= NYfJVJcxW0GQR1XS
SK-HEP-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn3TWM2OD1yLkOzN|Y5KM7:TR?= MmPYV2FPT0WU
QIMR-WIL NEPoe5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\ZOGlEPTB;MD6zN|QzPCEQvF2= NXzyS2ozW0GQR1XS
A2780 NInPSoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXlPVFNUUN3ME2wMlM1OzB2IN88US=> NYTXfFF5W0GQR1XS
ACN M3nU[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTxSZZJUUN3ME2wMlM1QDd|IN88US=> NUfP[3RsW0GQR1XS
BxPC-3 NG[1do9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwM{S5PFkh|ryP MmXqV2FPT0WU
BCPAP MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D1ZWlEPTB;MD6zOlAxOSEQvF2= M1K1c3NCVkeHUh?=
HOP-62 MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwM{[xNFYh|ryP NFf4endUSU6JRWK=
SW1710 MmjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwM{[0OVUh|ryP NFLWOWZUSU6JRWK=
OPM-2 NVHNSWpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfUTWM2OD1yLkO2OFc{KM7:TR?= NFj2TWVUSU6JRWK=
DBTRG-05MG NEW3N5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwM{iwOVQh|ryP MVTTRW5ITVJ?
SK-MEL-24 M2\t[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\qTWM2OD1yLkO5O|kyKM7:TR?= NWi3ZmNzW0GQR1XS
8305C MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\ibY1OUUN3ME2wMlM6Pzl|IN88US=> NF72V4tUSU6JRWK=
OVCAR-4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwNEG1PFYh|ryP MX;TRW5ITVJ?
HLE MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPw[HF6UUN3ME2wMlQyQDZizszN NX;WN5ZiW0GQR1XS
NCI-H747 NXvKfpNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7y[3BKSzVyPUCuOFIyOzdizszN MWTTRW5ITVJ?
SW780 NYm1RoxGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzGWpBKSzVyPUCuOFI{PDZizszN MkHxV2FPT0WU
KYSE-150 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlu2TWM2OD1yLkSyOFE2KM7:TR?= MX7TRW5ITVJ?
H4 MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojITWM2OD1yLkSyOFUyKM7:TR?= MXfTRW5ITVJ?
SW1088 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLJUm84UUN3ME2wMlQ1OzlizszN M3nNTnNCVkeHUh?=
SF268 NIHK[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\z[plKSzVyPUCuOFQ5PiEQvF2= MlznV2FPT0WU
RT4 M4LhR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r5VmlEPTB;MD60OVEyOSEQvF2= NIS3VnhUSU6JRWK=
NCI-H522 MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzjTWM2OD1yLkS1Nlch|ryP NETQc4NUSU6JRWK=
LCLC-97TM1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfs[mhKSzVyPUCuOFYyQTVizszN NYHzNFJEW0GQR1XS
CAL-39 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\ENo1KSzVyPUCuOFY2OTlizszN MX\TRW5ITVJ?
CAL-120 NVjVc3FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPESZNGUUN3ME2wMlQ4PjR|IN88US=> M4rl[3NCVkeHUh?=
ESS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7LTWM2OD1yLkS3PFIyKM7:TR?= NIfWbZBUSU6JRWK=
KARPAS-45 NV\0SVd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoO1TWM2OD1yLkS4PVM{KM7:TR?= Mnu3V2FPT0WU
DU-4475 M37CSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXucXdyUUN3ME2wMlQ6PTFzIN88US=> M2DXbXNCVkeHUh?=
VMRC-RCZ NGPMZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\XTWM2OD1yLkS5PVA1KM7:TR?= M2jKdHNCVkeHUh?=
HOS MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3aT4FEUUN3ME2wMlUxOzZ3IN88US=> M3HzeHNCVkeHUh?=
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MHH-NB-11 NGHvUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP0O|RrUUN3ME2xMlE2OzZ6IN88US=> NV;aXIV7W0GQR1XS
NCI-H2405 M3zMU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTzUXo4UUN3ME2xMlE3OTZizszN MoDsV2FPT0WU
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KS-1 NYS1TnRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFwMkiyOlkh|ryP M2\SWHNCVkeHUh?=
NCI-H1734 M2jHR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqxXYI4UUN3ME2xMlI5QTF|IN88US=> NIfUWpBUSU6JRWK=
ES7 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFwMkm1OFIh|ryP MV7TRW5ITVJ?
NCI-H838 NUTrSIoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDNTWM2OD1zLkOwOlE2KM7:TR?= NX7QXJJ[W0GQR1XS
HEC-1 NWG5dYdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUThR2s5UUN3ME2xMlM{PzV3IN88US=> MlfJV2FPT0WU
ME-180 Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn2TWM2OD1zLkO3PVk{KM7:TR?= NI\6dItUSU6JRWK=
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IA-LM NH:xcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr3S3cyUUN3ME2xMlQxQTF2IN88US=> M{\DO3NCVkeHUh?=
MN-60 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHhTWM2OD1zLkSzNVE1KM7:TR?= M1TVTHNCVkeHUh?=
SIMA M1ruPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfyTWM2OD1zLkS4Olg4KM7:TR?= NHXUNWZUSU6JRWK=
NCI-H1770 M2juZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTFwNUKwOVQh|ryP MXvTRW5ITVJ?
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LB771-HNC NXu4TXdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\1SWlEPTB;MT61N|kxPiEQvF2= M3vQVXNCVkeHUh?=
SW48 M33XWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFwNUSyOFMh|ryP M3H4cHNCVkeHUh?=
KYSE-140 NH;SRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4mxWmlEPTB;MT61OVc1OSEQvF2= MWHTRW5ITVJ?
SW626 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4GybmlEPTB;MT61PFE3KM7:TR?= NETWSZBUSU6JRWK=
MC-CAR NVf1NmNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\rR2hKSzVyPUGuOVg3PjNizszN NVrWd49mW0GQR1XS
D-336MG M{T0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjPdIVyUUN3ME2xMlYzQTRizszN Mlu0V2FPT0WU
SK-MEL-3 M2\SZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULWeoIyUUN3ME2xMlY{QTB{IN88US=> NV\4SWVmW0GQR1XS
MHH-PREB-1 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\XfYo3UUN3ME2xMlY1PDd|IN88US=> NYDIV5B[W0GQR1XS
Calu-1 MmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfvTWM2OD1zLk[1N|g3KM7:TR?= M4LkUHNCVkeHUh?=
HCC1806 NF3sNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTFwNk[2NVEh|ryP M4GySnNCVkeHUh?=
A101D M1zUPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHkUYJFUUN3ME2xMlY3PzhzIN88US=> NIrBWWpUSU6JRWK=
A704 NWLvbXBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTFwNkizNVEh|ryP M3v1XXNCVkeHUh?=
LB831-BLC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFwNkm4OVQh|ryP NIHZTo1USU6JRWK=
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RPMI-2650 NW\qcJF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPxeXZKSzVyPUGuO|I4OTlizszN MonoV2FPT0WU
NH-12 NX3INlVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfZfWR2UUN3ME2xMlc{PDJ5IN88US=> MXzTRW5ITVJ?
AGS M{HONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPKeHQ6UUN3ME2xMlc3OzV6IN88US=> MmSyV2FPT0WU
NEC8 NV;DSYZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwN{i5PVUh|ryP MXTTRW5ITVJ?
NCI-H2009 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPmPYZKSzVyPUGuO|k4OjFizszN NILIdo9USU6JRWK=
A498 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPZTJJWUUN3ME2xMlgyOjh{IN88US=> MnnOV2FPT0WU
NCI-H810 NGjoS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHlUJpKSzVyPUGuPFE3ODZizszN NF\5TZlUSU6JRWK=
SK-NEP-1 NH\I[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFwOEO3Olch|ryP MmjDV2FPT0WU
D-542MG NH\WSplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfLS2lKSzVyPUGuPFU5PTFizszN MULTRW5ITVJ?
KNS-42 M{LxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwOE[yOlYh|ryP MUTTRW5ITVJ?
NCI-H2452 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfUXJZKSzVyPUGuPFkxPzRizszN MWPTRW5ITVJ?
SK-MEL-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfPTWM2OD1zLkmwNlcyKM7:TR?= NWPRUodNW0GQR1XS
OVCAR-5 MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHObVBuUUN3ME2xMlkxPjd3IN88US=> M2HWS3NCVkeHUh?=
SNG-M NE\meGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFwOUW4OVgh|ryP NVnre4dwW0GQR1XS
A673 NUT1T2VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfsTWM2OD1zLkm3OVE3KM7:TR?= Mn[xV2FPT0WU
L-428 M{fRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vEO2lEPTB;MT65PVE4QSEQvF2= MkL4V2FPT0WU
KM-H2 NHTkXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJwMEGwPUDPxE1? MmTnV2FPT0WU
MC-IXC M1fpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJwMEKyO|Mh|ryP MnTNV2FPT0WU
COLO-678 M3H3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrhTWM2OD1{LkC0NlA4KM7:TR?= Mo\HV2FPT0WU
MEL-JUSO M3nLSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJwMEe4OVEh|ryP MWfTRW5ITVJ?
HCC38 NFXl[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PhVWlEPTB;Mj6wPFQ{OyEQvF2= NYT3NFBzW0GQR1XS
UACC-62 Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jySGlEPTB;Mj6wPFg2PSEQvF2= MV3TRW5ITVJ?
OAW-42 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3KTWhKSzVyPUKuNFk4OTFizszN M1;XcXNCVkeHUh?=
LB996-RCC NXHqfnA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJwMUO4NVch|ryP M3uyOXNCVkeHUh?=
COR-L105 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;3TJdKSzVyPUKuNVY{PzNizszN Mnq4V2FPT0WU
RCC10RGB MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M373[2lEPTB;Mj6xPFU4PiEQvF2= M2iwbHNCVkeHUh?=
A431 M{LqXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJwMUmwNVkh|ryP Mor5V2FPT0WU
NCI-H292 M3XoPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXhbGtPUUN3ME2yMlI{QTVzIN88US=> NUi3S29kW0GQR1XS
SK-UT-1 Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DMbGlEPTB;Mj6zN|E5PCEQvF2= NF3sfWRUSU6JRWK=
PANC-08-13 M{e5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkewTWM2OD1{LkOzNlM2KM7:TR?= M1\JT3NCVkeHUh?=
ST486 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDoUZdKSzVyPUKuOFExPDhizszN MkfoV2FPT0WU
SJSA-1 M3TsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\vVI9KSzVyPUKuOFEzPzFizszN MV;TRW5ITVJ?
RKO MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTXWohKUUN3ME2yMlQzODJ7IN88US=> Moj4V2FPT0WU
NCI-H1793 M1zXc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKzb3BLUUN3ME2yMlQ1ODJ7IN88US=> NV\rRpB7W0GQR1XS
639-V MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXoTWM2OD1{LkS1N|gzKM7:TR?= NFfVdWhUSU6JRWK=
ES3 M2faWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[2THhKSzVyPUKuOFk4OzdizszN MXzTRW5ITVJ?
NCI-H1792 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJwNU[4NlYh|ryP MXXTRW5ITVJ?
NCI-H1651 NIHWSFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;0NZNKSzVyPUKuOVgzOSEQvF2= MWjTRW5ITVJ?
SN12C NHPzXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfrTWM2OD1{LkW4OFg4KM7:TR?= NYXNcnM1W0GQR1XS
COLO-679 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXENotKSzVyPUKuOVg3ODVizszN MVXTRW5ITVJ?
U-118-MG NWTkV4FXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPZUoRKSzVyPUKuOVg5PzJizszN NGX6bXZUSU6JRWK=
Ramos-2G6-4C10 MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVWyV3A4UUN3ME2yMlY1QDB5IN88US=> M3;oSnNCVkeHUh?=
HCT-15 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fTdmlEPTB;Mj62PFc6OiEQvF2= MX\TRW5ITVJ?
MDA-MB-157 NIO1TVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwN{C3OFch|ryP MlPuV2FPT0WU
K5 Mki4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2CwW2lEPTB;Mj63NVg1PSEQvF2= MUTTRW5ITVJ?
MKN45 NXLnN3pKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJwN{OzOlYh|ryP MXfTRW5ITVJ?
DMS-273 M3HiWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHIOXhMUUN3ME2yMlc2PjN{IN88US=> NIHlUIJUSU6JRWK=
C8166 M1HuN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Pl[2lEPTB;Mj63PFUyOyEQvF2= M3nxb3NCVkeHUh?=
Calu-3 M{TycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXmeIdKSzVyPUKuO|g6PjlizszN NXThTWNrW0GQR1XS
SNB75 NW\3U2VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3sTWM2OD1{Lki4OVM2KM7:TR?= NFLFb3pUSU6JRWK=
BFTC-905 M3\hSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDWTWM2OD1{LkmwNVkyKM7:TR?= NX\Fd2RqW0GQR1XS
C-4-II MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nTPWlEPTB;Mj65NVM2OyEQvF2= MkDEV2FPT0WU
MS-1 MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LCO2lEPTB;Mj65Olc3QSEQvF2= Mmn0V2FPT0WU
A375 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTNwMEixPFQh|ryP NHyydmdUSU6JRWK=
KYSE-70 MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTNwMEi4PFIh|ryP MmK2V2FPT0WU
KYSE-510 NFzQcHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTNwMUC5PVUh|ryP M3XSSXNCVkeHUh?=
LN-405 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf3SHhWUUN3ME2zMlE{PTF6IN88US=> NFKybohUSU6JRWK=
BOKU NFr1[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS0TWM2OD1|LkG0NlU3KM7:TR?= M2rZO3NCVkeHUh?=
TE-10 M{P0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHZdJhKSzVyPUOuNVc{PjJizszN NWPCfHI2W0GQR1XS
MKN1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTNwMUi0PFMh|ryP NVu0VJVoW0GQR1XS
M059J M2\RcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTNwMkCxO|Mh|ryP NX\hWZk1W0GQR1XS
GOTO MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrFSmZoUUN3ME2zMlIzODN7IN88US=> MWnTRW5ITVJ?
DK-MG MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTTTWM2OD1|LkK1PVc3KM7:TR?= NWHGcYNZW0GQR1XS
NCI-H727 NV:3RYhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnPeZJKSzVyPUOuNlY2QCEQvF2= NH2zeINUSU6JRWK=
NB12 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjLe|dNUUN3ME2zMlM{OjJ2IN88US=> M2\4TXNCVkeHUh?=
DOK NFrOW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XKdGlEPTB;Mz6zOlE5PiEQvF2= M4fkdnNCVkeHUh?=
KYSE-410 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfBTWM2OD1|LkO2Nlg4KM7:TR?= M2\2V3NCVkeHUh?=
AM-38 MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzmS5pKSzVyPUOuN|gxPTFizszN Mlv1V2FPT0WU
GR-ST M2DFV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnThTWM2OD1|LkS1O|MzKM7:TR?= M{PueHNCVkeHUh?=
D-247MG NUfrNVdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z6TGlEPTB;Mz60PFI3OyEQvF2= MmjkV2FPT0WU
TE-8 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvzdIRKSzVyPUOuOFk{OzNizszN M{XSeXNCVkeHUh?=
LS-411N MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUiwUWlHUUN3ME2zMlQ6Pjl{IN88US=> MYPTRW5ITVJ?
SK-MES-1 M33nOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjF[YZKSzVyPUOuOVY1OzNizszN MVvTRW5ITVJ?
SF295 MmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7jTWM2OD1|Lk[xOVUzKM7:TR?= NIrr[49USU6JRWK=
SK-MEL-30 M4m3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTNwNkW5NlEh|ryP NVzHWnpyW0GQR1XS
LB2241-RCC MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X3TGlEPTB;Mz62OlI3KM7:TR?= M4LjUnNCVkeHUh?=
PC-14 M1jzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fnSmlEPTB;Mz62OlQ{PyEQvF2= MVfTRW5ITVJ?
EW-7 NXv4bWdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNwNke2PVMh|ryP Ml7NV2FPT0WU
NMC-G1 NEfDb2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTNwN{G4N|ch|ryP NFzqSIxUSU6JRWK=
TE-441-T MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1OxdGlEPTB;Mz63N|AzQCEQvF2= MUHTRW5ITVJ?
NCI-H1618 NUmyW5h{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjYTZE3UUN3ME2zMlgyQDd3IN88US=> M3\uRnNCVkeHUh?=
PANC-03-27 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XVfGlEPTB;Mz64NVkyPiEQvF2= NY[2[ppXW0GQR1XS
NCI-H2228 NFH4NIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrWeYxmUUN3ME2zMlg{OTJ4IN88US=> M3uyNHNCVkeHUh?=
CAPAN-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fLcGlEPTB;Mz64O|AxQSEQvF2= M{nlXXNCVkeHUh?=
KLE MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTNwOUC2O{DPxE1? NHXPUXhUSU6JRWK=
Becker MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPSUZpKSzVyPUOuPVI5PDlizszN NXy5clByW0GQR1XS
SK-PN-DW M4To[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHUSHFmUUN3ME20MlA4QTd2IN88US=> NXP5[mQyW0GQR1XS
Hs-578-T MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj6TWM2OD12LkC4N|A3KM7:TR?= MmewV2FPT0WU
RS4-11 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nl[mlEPTB;ND6xNVI2PSEQvF2= MXLTRW5ITVJ?
D-502MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTRwMU[5PVch|ryP MYjTRW5ITVJ?
GI-1 M1LPfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Xz[WlEPTB;ND6yPFI6QSEQvF2= MorsV2FPT0WU
NCI-H209 Mlz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTRwM{O3PEDPxE1? NGfl[pFUSU6JRWK=
SK-OV-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi3UZhYUUN3ME20MlQ5OTR7IN88US=> NVTmUm1IW0GQR1XS
LOUCY MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWftVWtwUUN3ME20MlQ5PDN{IN88US=> NYfT[Y15W0GQR1XS
NCI-H69 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfndWFKSzVyPUSuOVE4QTNizszN M4TCN3NCVkeHUh?=
SCC-9 M3zyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rtS2lEPTB;ND61N|E4OiEQvF2= NI\WcJdUSU6JRWK=
NCI-H526 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTRwNUmyPVMh|ryP NUHhPXR6W0GQR1XS
NCI-H2170 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvWTVQ3UUN3ME20MlY3PzdzIN88US=> MWLTRW5ITVJ?
SR M17Bc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfZcoRqUUN3ME20MlcxODR6IN88US=> NVG3eolrW0GQR1XS
CMK NYT3R5JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3e2VmlEPTB;ND63NlExOSEQvF2= NHy4d|BUSU6JRWK=
COLO-829 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfqTWM2OD12Lke3NFQ{KM7:TR?= NULYZ|BnW0GQR1XS
HuO-3N1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M36xbmlEPTB;ND64N|I5OSEQvF2= MmHzV2FPT0WU
5637 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnWPZlXUUN3ME20MlkxPDh5IN88US=> M{PsVHNCVkeHUh?=
A253 MmmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfxenpKSzVyPUSuPVc4ODhizszN M4C0bXNCVkeHUh?=
NB10 NEW1d3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrwXYdKSzVyPUWuNFc1QTdizszN NXv0SGZsW0GQR1XS
SF539 M4[1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTVwMEm5OVkh|ryP NGLre|hUSU6JRWK=
HAL-01 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTVwMUS2OFUh|ryP M2S4VXNCVkeHUh?=
MHH-ES-1 NWnPbY1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTVwMU[5NlUh|ryP MlHLV2FPT0WU
DEL Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\UXmhKSzVyPUWuNlc2QDJizszN M1PLSXNCVkeHUh?=
NCI-H1299 NFjDN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTVwM{WwNFch|ryP MWfTRW5ITVJ?
ChaGo-K-1 MlTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7wVZdKSzVyPUWuN|UyODdizszN Mo[1V2FPT0WU
HMV-II NXTzOFhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\zTWM2OD13LkO5OFMh|ryP M3nhbXNCVkeHUh?=
NB69 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LZdmlEPTB;NT6zPVY{OSEQvF2= MU\TRW5ITVJ?
NCI-H1882 NIDTWJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTVwNEOzOlQh|ryP MUfTRW5ITVJ?
SNU-475 MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTVwNEexO|Eh|ryP NILqeIVUSU6JRWK=
RXF393 NX;2cYZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG3TlhXUUN3ME21MlQ5PDl2IN88US=> MXvTRW5ITVJ?
CAL-51 NXTVfZk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7uTWM2OD13Lk[yPFU{KM7:TR?= NIr0PZJUSU6JRWK=
SW1573 NF7TTpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HPOmlEPTB;NT62N|U{PCEQvF2= M{fN[XNCVkeHUh?=
GCT NIrFbm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrsS49QUUN3ME21Mlc2QTJ7IN88US=> MYDTRW5ITVJ?
COR-L88 M1TUb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTVwN{[4OFYh|ryP NFLsXlJUSU6JRWK=
MDA-MB-134-VI MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTVwOEe1N|Yh|ryP M3vBeXNCVkeHUh?=
NB5 NWfycWFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{f1Z2lEPTB;NT65NlQ1KM7:TR?= MofNV2FPT0WU
GMS-10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPjR4NMUUN3ME21Mlk3QDZzIN88US=> M{fJVnNCVkeHUh?=
CHP-212 NXrxUpZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX2TWM2OD14LkS4NlY4KM7:TR?= M3rHb3NCVkeHUh?=
TE-11 M13ZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTZwNUWxPFIh|ryP NHixfldUSU6JRWK=
SW962 M{T2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W2O2lEPTB;Nj62OVc4PCEQvF2= M2K2cXNCVkeHUh?=
MZ2-MEL NGXrOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELTXWxKSzVyPU[uPFIxOTFizszN Ml;zV2FPT0WU
C-33-A MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLSd3FKSzVyPU[uPVE3QDhizszN MYPTRW5ITVJ?
IGR-1 M1TFT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jIRmlEPTB;Nj65O|gzPiEQvF2= M4DwOnNCVkeHUh?=
MOLT-4 Mn3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTdwMUW0NFYh|ryP MVvTRW5ITVJ?
NCI-H1650 M3ToZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTNTWM2OD15LkK3NFQ3KM7:TR?= MWTTRW5ITVJ?
AsPC-1 M4jOPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGX6PZBKSzVyPUeuNlg3ODVizszN NXzn[21zW0GQR1XS
SNU-C2B M3nEd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonYTWM2OD15LkK5OVcyKM7:TR?= MVTTRW5ITVJ?
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NCI-H630 M1LBXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ{LkWzOlMh|ryP MVTTRW5ITVJ?
LU-165 Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LXbGlEPTB;MkKuOVU1KM7:TR?= NI[5XFJUSU6JRWK=
COLO-792 NGnQfZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LzTmlEPTB;MkKuO|EyOSEQvF2= NHHEOFRUSU6JRWK=
CAL-62 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJ{Lke1NVch|ryP MUnTRW5ITVJ?
HCE-T MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LoPWlEPTB;MkKuPFYxPiEQvF2= M3q2NnNCVkeHUh?=
BB65-RCC Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJ|LkCzOFQh|ryP M3fjenNCVkeHUh?=
SiHa MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnmTWM2OD1{Mz6zPVY5KM7:TR?= MlrmV2FPT0WU
NCI-H2081 NFHlWYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fjWGlEPTB;MkSuNFY1OSEQvF2= NEOwUXVUSU6JRWK=
U251 MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[wN2FKSzVyPUK0MlA3PjhizszN M{jOOnNCVkeHUh?=
LoVo M{HGbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[5cINUUUN3ME2yOE46Ojh{IN88US=> MkjQV2FPT0WU
GCIY M4XMS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfP[I1KSzVyPUK1MlI5PzdizszN NUXkTm1PW0GQR1XS
NUGC-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJ3LkOzNVYh|ryP NVOxO3V5W0GQR1XS
LNCaP-Clone-FGC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i2W2lEPTB;MkWuN|Q6QCEQvF2= MorHV2FPT0WU
PA-1 NEHMU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjqeFBKSzVyPUK1MlY5OzNizszN M3jGV3NCVkeHUh?=
OE33 NX3Zcop4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTJ3Lk[4OVMh|ryP NXz5RXl7W0GQR1XS
HT-29 MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH2TWM2OD1{NT63PFc6KM7:TR?= MWfTRW5ITVJ?
RCM-1 NIe1PJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\GdoNKSzVyPUK1Mlk3PTZizszN M1fx[XNCVkeHUh?=
NCI-H1522 M1\5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrWUlk3UUN3ME2yOU46QTFzIN88US=> NYfyOG9bW0GQR1XS
LB373-MEL-D NHvZWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ztTmlEPTB;Mk[uNVcxQCEQvF2= MnvvV2FPT0WU
NCI-H1436 M131eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf4PJVbUUN3ME2yOk4zPzN6IN88US=> NYnzeJM2W0GQR1XS
COLO-824 M2HkUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jre2lEPTB;Mk[uOFAxOiEQvF2= MVPTRW5ITVJ?
CP50-MEL-B MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13iXmlEPTB;Mk[uOVY4PSEQvF2= M{f4UHNCVkeHUh?=
EGI-1 M{SxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr6XlVKSzVyPUK3MlI3QThizszN NXjncXZnW0GQR1XS
LAN-6 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXoTWM2OD1{Nz6zOVk5KM7:TR?= MU\TRW5ITVJ?
GAK NUjJRVNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\WbGhKSzVyPUK3MlQzOjVizszN MlLlV2FPT0WU
MDA-MB-175-VII NWn6b25ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjobItKSzVyPUK3MlUxPTNizszN MYfTRW5ITVJ?
JVM-2 NV3YSJUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLyTnlbUUN3ME2yO{43PjJ{IN88US=> NGO0W5RUSU6JRWK=
UACC-257 NF3NVIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJ5Lk[4O|gh|ryP NYntOXNDW0GQR1XS
SW1783 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJ5Lke3PFMh|ryP NWO2eWZTW0GQR1XS
HT-3 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJ6LkKxOlYh|ryP M1mycHNCVkeHUh?=
RL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJ6LkW5NVEh|ryP MUXTRW5ITVJ?
TK10 M{i4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TXTmlEPTB;MkiuOlU{PSEQvF2= NHiwOW9USU6JRWK=
HT55 MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j2bGlEPTB;MkmuNFU3PSEQvF2= NIPqfIlUSU6JRWK=
BT-20 NXe4WGFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPoZmtKSzVyPUK5MlA2QDZizszN NIjsTmxUSU6JRWK=
TGBC24TKB M13CSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zQfmlEPTB;MkmuNVg{OSEQvF2= M3rCOnNCVkeHUh?=
HSC-2 NE\2V2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofoTWM2OD1{OT6zNFAyKM7:TR?= NGnFfmpUSU6JRWK=
COLO-205 NFzsZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW3fJhKSzVyPUK5MlM6PDRizszN MmDZV2FPT0WU
GT3TKB NFLob25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\US2lEPTB;MkmuOlg4PyEQvF2= M2TxS3NCVkeHUh?=
T47D NUHoeGdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uwWWlEPTB;MkmuPFU5OiEQvF2= MnKwV2FPT0WU
OMC-1 Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme0TWM2OD1|MD6xPVE6KM7:TR?= NV;JV5RHW0GQR1XS
PFSK-1 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfGR3pKSzVyPUOxMlI3PTlizszN M164cXNCVkeHUh?=
JEG-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\aOYo3UUN3ME2zNU4{PTZzIN88US=> MkTMV2FPT0WU
RD MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTNzLkWxNVUh|ryP NYLYfGI6W0GQR1XS
NCI-H64 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLITWM2OD1|Mj60NVc6KM7:TR?= MX3TRW5ITVJ?
DMS-114 NF7RTWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3OXFVKSzVyPUOyMlQyQDJizszN MoPqV2FPT0WU
NCI-H661 MmPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN{Lk[1NFEh|ryP MljvV2FPT0WU
CAL-148 NH[wdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3yTIVZUUN3ME2zNk43PjZ3IN88US=> NHX3NIxUSU6JRWK=
HuP-T3 M1vxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnCNpY6UUN3ME2zNk46OzN6IN88US=> MULTRW5ITVJ?
ES4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nkTmlEPTB;M{OuNVcxPSEQvF2= MV\TRW5ITVJ?
Ca9-22 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7mOWpKSzVyPUOzMlQ3ODFizszN NXvlVZNiW0GQR1XS
LP-1 NYqw[mNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jmUmlEPTB;M{SuNFkh|ryP NUjWPWNiW0GQR1XS
AU565 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLKTWM2OD1|ND61NFY6KM7:TR?= NGe4cVVUSU6JRWK=
MDA-MB-453 NXv5cmZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnxbHhrUUN3ME2zOU4yPDJ4IN88US=> M1vFT3NCVkeHUh?=
SNU-C1 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTN3LkG3NUDPxE1? MkXpV2FPT0WU
SW13 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\xeIJKSzVyPUO1MlQxPzZizszN NXjzTFB6W0GQR1XS
NCI-H2122 NHHYdVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXNTWRKSzVyPUO1MlU2QThizszN MonhV2FPT0WU
NCI-H1395 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG2TWM2OD1|NT62OlkyKM7:TR?= NX22VHlpW0GQR1XS
J-RT3-T3-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGP3U4xKSzVyPUO2MlAzQTRizszN NEnNW2hUSU6JRWK=
COR-L279 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7uUWV[UUN3ME2zOk4yQThzIN88US=> MlrpV2FPT0WU
ATN-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHReZFKSzVyPUO2Mlg2OTZizszN MX7TRW5ITVJ?
HCC2998 NWPybWEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Poc2lEPTB;M{[uPFU4OSEQvF2= NIPMT21USU6JRWK=
UM-UC-3 M1TB[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LLc2lEPTB;M{[uPFY4PSEQvF2= M4jNUXNCVkeHUh?=
DV-90 NFXzZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN4LkmwOlch|ryP M3qwRXNCVkeHUh?=
ES8 M{HmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\1WIdyUUN3ME2zOk46OzF6IN88US=> M2jiRnNCVkeHUh?=
YAPC NEnUfGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrhc|ZKSzVyPUO2Mlk3PTRizszN MXnTRW5ITVJ?
HCC1599 MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPzTWM2OD1|Nz6xOlE5KM7:TR?= MUnTRW5ITVJ?
UMC-11 M3zKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHDS4lKSzVyPUO3MlI2ODNizszN MUXTRW5ITVJ?
THP-1 NFvIbY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jFeGlEPTB;M{euNlg3QCEQvF2= NVPXfZZiW0GQR1XS
OCUB-M NWfGSVFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTFcWlwUUN3ME2zO{4zQDlzIN88US=> NWjEXm5qW0GQR1XS
NCI-H1693 MmjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjMPG57UUN3ME2zO{4{OjN|IN88US=> MXPTRW5ITVJ?
NCI-H345 MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTN5LkO2NlQh|ryP NHPkfIJUSU6JRWK=
COLO-800 MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTN5LkW2O{DPxE1? MUPTRW5ITVJ?
COLO-320-HSR Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXXTWM2OD1|OD6zOFkzKM7:TR?= M2D0bXNCVkeHUh?=
NCI-H596 NYrYT486T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7ydJhtUUN3ME2zPE41PDh7IN88US=> Mnj0V2FPT0WU
NCI-H187 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTN6LkezOFQh|ryP NYTwUXk4W0GQR1XS
ECC4 NYrZe411T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\FTWM2OD1|OT6wPFE1KM7:TR?= MoS2V2FPT0WU
KP-4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PhZmlEPTB;M{muNVI{PSEQvF2= M4rqdXNCVkeHUh?=
NCI-H2227 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXxTWM2OD1|OT6zPVQ6KM7:TR?= NIrQb2RUSU6JRWK=
22RV1 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXXepBKSzVyPUO5Mlg{QThizszN NYG3R|NxW0GQR1XS
SAS NXziUXB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LHemlEPTB;NECuNFk3KM7:TR?= M2eycHNCVkeHUh?=
PANC-10-05 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDqXZhKSzVyPUSwMlE5OjhizszN MVHTRW5ITVJ?
MDA-MB-468 M1W5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTRyLkWzOFYh|ryP NF3TSlhUSU6JRWK=
RPMI-7951 NFq4VFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoriTWM2OD12MT6yNFc2KM7:TR?= MoD3V2FPT0WU
BB49-HNC NETmOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTRzLkKxO|kh|ryP MXnTRW5ITVJ?
23132-87 M1\4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1O5bWlEPTB;NEGuNlc{OiEQvF2= Mn:0V2FPT0WU
HCC1569 NXPLSnJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTRzLkK4PFUh|ryP MVLTRW5ITVJ?
CP66-MEL NH7zS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z1emlEPTB;NEKuNVg5PiEQvF2= M4L1ZXNCVkeHUh?=
K-562 NHrpbpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTR{LkK4OVQh|ryP MWXTRW5ITVJ?
OCI-AML2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TxZmlEPTB;NEKuPFk4PCEQvF2= NGLYN3NUSU6JRWK=
SW756 NIC5bGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\DcHd5UUN3ME20N{4xOzh6IN88US=> NWD0V2lxW0GQR1XS
M14 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTR|LkOxPFkh|ryP M1rOdXNCVkeHUh?=
NCI-H1623 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz6fIRFUUN3ME20N{41PjRizszN MXrTRW5ITVJ?
KNS-81-FD NIrkfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfoOmFKSzVyPUSzMlc3OiEQvF2= MUHTRW5ITVJ?
TGBC1TKB MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXoU3FzUUN3ME20N{46ODl7IN88US=> M3\0RXNCVkeHUh?=
RERF-LC-MS MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTR|LkmyPFEh|ryP MYLTRW5ITVJ?
PC-3 M3vGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[wbmlEPTB;NESuOFM1PyEQvF2= NVzXO3NXW0GQR1XS
HuP-T4 NETWU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTR2LkS0O|Qh|ryP MmTnV2FPT0WU
NCI-H510A MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXDRVhKSzVyPUS0MlcxQCEQvF2= NYLxVWNtW0GQR1XS
LB2518-MEL NWT2NJBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTR2Lke5N|ch|ryP MmXNV2FPT0WU
TE-5 M3ruRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LRXGlEPTB;NEWuPVU5OSEQvF2= MmXoV2FPT0WU
EW-24 NVi3e5lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i1d2lEPTB;NE[uNVczOyEQvF2= NH;nfIpUSU6JRWK=
LB647-SCLC MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLKTWM2OD12Nj6yNVU2KM7:TR?= M1m2fnNCVkeHUh?=
NCI-H524 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomzTWM2OD12Nj63NVg2KM7:TR?= M3r0V3NCVkeHUh?=
EW-11 NWnvS5k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknGTWM2OD12Nj65N|c{KM7:TR?= MV3TRW5ITVJ?
KALS-1 M1fzVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n1ZWlEPTB;NEeuNlA3PiEQvF2= MlixV2FPT0WU
BT-474 NUjwbpFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr2e5lKSzVyPUS3MlQzOTZizszN Mke5V2FPT0WU
SK-N-AS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrqWnRKSzVyPUS3Mlg5QCEQvF2= M4LjUnNCVkeHUh?=
HCC2157 NILGVHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLOTWM2OD12OD6wO|Yh|ryP M1\RSXNCVkeHUh?=
HCC1954 M4LDW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDVSo9KSzVyPUS4MlE4ODRizszN NUi3enVQW0GQR1XS
FADU NUSxPYdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR6LkOwN|Eh|ryP NYDqVIZ2W0GQR1XS
S-117 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXRTWM2OD12OD6zPFE2KM7:TR?= Mm\wV2FPT0WU
LS-1034 NFO2b3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPiN|NnUUN3ME20PE44ODZ5IN88US=> NIXvWXhUSU6JRWK=
CAMA-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTR7LkW1OFMh|ryP M{LrPHNCVkeHUh?=
LU-134-A MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDtWYc6UUN3ME20PU45ODh3IN88US=> MoXDV2FPT0WU
NCI-H1838 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK2T3JKSzVyPUS5MlgxQDdizszN NIjRWo1USU6JRWK=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 左から右までの手順で、溶剤を製品に加えることです:
1% CMC Na
いい結果が出るために、混じった後、直ちに使うと推めます。
30mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Bcr-Ablシグナル伝達経路

Bcr-Abl Inhibitors with Unique Features

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID