Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

サイズ 価格(税別)  
JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00

カスタマーフィードバック(4)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7ZVINKSzVyPUCuNFAxODByMEO1PUDPxE1? NVHnPXJnW0GQR1XS
MV-4-11 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjyTWM2OD1yLkCwNFA6PTZizszN MYXTRW5ITVJ?
MEG-01 MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;ETWM2OD1yLkCwNFEzQCEQvF2= Mof6V2FPT0WU
LAMA-84 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrJWG1OUUN3ME2wMlAxODF4NTFOwG0> M4LIRXNCVkeHUh?=
CGTH-W-1 NIPMZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfDe2JKSzVyPUCuNFAyPjlizszN MoP2V2FPT0WU
KASUMI-1 NGDxNVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrnTWM2OD1yLkCwNlE4KM7:TR?= NF7OUGNUSU6JRWK=
BE-13 Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjmWWJKSzVyPUCuNFAzPTlizszN MWHTRW5ITVJ?
CTV-1 MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPEWFlwUUN3ME2wMlAxPTJzIN88US=> NGHqNmRUSU6JRWK=
NKM-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i1SWlEPTB;MD6wNFY2PSEQvF2= NXyzPHFCW0GQR1XS
MONO-MAC-6 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn22TWM2OD1yLkCwPFM4KM7:TR?= NFOxZ2FUSU6JRWK=
A204 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jxU2lEPTB;MD6wNVIyQCEQvF2= NUnWZVFMW0GQR1XS
GDM-1 NEOwNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEG4N|Mh|ryP M3vNfnNCVkeHUh?=
AN3-CA NHvX[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEG4O|Mh|ryP M2DhWXNCVkeHUh?=
BL-70 NEPWVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PwTGlEPTB;MD6wNlE6QSEQvF2= NFK2N2tUSU6JRWK=
Daudi MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LjcWlEPTB;MD6wNlU{PyEQvF2= NYn4[GZnW0GQR1XS
KU812 NIHNZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rNUmlEPTB;MD6wNlg1QCEQvF2= MojRV2FPT0WU
KG-1 NX:yeIxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nRWGlEPTB;MD6wN|I6PCEQvF2= NYPP[GExW0GQR1XS
DOHH-2 M4LFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMES4NFMh|ryP MlnRV2FPT0WU
HuO9 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fGO2lEPTB;MD6wOVQ1QCEQvF2= NHva[ZhUSU6JRWK=
EB2 M4S3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEW1O|Yh|ryP NXnPZ4ZlW0GQR1XS
G-402 M13QfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfTNGlnUUN3ME2wMlA3OzRzIN88US=> NVvWR5RSW0GQR1XS
SU-DHL-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwME[zO|kh|ryP NYS0TlF[W0GQR1XS
NCI-H719 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLvNoUzUUN3ME2wMlA4QDh6IN88US=> NGS4c3FUSU6JRWK=
MLMA M2LLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPJTnhkUUN3ME2wMlA6ODZizszN M1i5O3NCVkeHUh?=
KM12 NG\3OZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3FZ21LUUN3ME2wMlA6PzN5IN88US=> MXTTRW5ITVJ?
SUP-T1 NI\YbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHBeJZUUUN3ME2wMlA6QTh{IN88US=> MV7TRW5ITVJ?
MZ1-PC NH3T[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMUGzN|Yh|ryP MX\TRW5ITVJ?
MFE-296 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPJTWM2OD1yLkGxPFM6KM7:TR?= MU\TRW5ITVJ?
ALL-PO MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPGTWM2OD1yLkGyOFQ{KM7:TR?= NUPwSolsW0GQR1XS
GB-1 NVq1[VJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPCNWVsUUN3ME2wMlEzPTF{IN88US=> MVzTRW5ITVJ?
SIG-M5 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{myVWlEPTB;MD6xN|M4KM7:TR?= MX7TRW5ITVJ?
P30-OHK M3zNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMUW2O|Ih|ryP NWPkcWlrW0GQR1XS
NCI-H716 NEHXS4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PKW2lEPTB;MD6xOlI3PiEQvF2= MmLWV2FPT0WU
MPP-89 NF3XW4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3QU3k{UUN3ME2wMlE3QTN|IN88US=> NGHINFZUSU6JRWK=
SF126 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr3NoxKSzVyPUCuNVcxPjNizszN MoizV2FPT0WU
CTB-1 Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjY[YcyUUN3ME2wMlE4OzF4IN88US=> NHS2UpZUSU6JRWK=
CA46 NVjIfmNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjjbXRKSzVyPUCuNVc1QDlizszN M{PQSXNCVkeHUh?=
NCI-H520 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n5V2lEPTB;MD6xO|c{OiEQvF2= MVfTRW5ITVJ?
CAL-85-1 NFLXN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr3bFYyUUN3ME2wMlE4QTJ5IN88US=> MVnTRW5ITVJ?
NCI-H2342 NFT0U|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDiNmQ4UUN3ME2wMlE5PTd5IN88US=> M1HDXHNCVkeHUh?=
697 Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzZdFlMUUN3ME2wMlE5QDdzIN88US=> NWixe5l6W0GQR1XS
NY NHW1[ZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Lo[mlEPTB;MD6xPVI5PyEQvF2= MmLoV2FPT0WU
T98G NVi1d49pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn5RpAyUUN3ME2wMlE6OzF6IN88US=> NWC4XlBvW0GQR1XS
NCI-H1703 NFLReVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfl[JBKSzVyPUCuNVk3OTVizszN M4XTNHNCVkeHUh?=
NCI-H2087 NGL2NYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoSxTWM2OD1yLkKwOFM6KM7:TR?= MmXRV2FPT0WU
PF-382 MmLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDZTJFVUUN3ME2wMlIxQDd|IN88US=> Mn\BV2FPT0WU
HCT-116 M2\UXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfjfVdKSzVyPUCuNlExPjlizszN M1HXfHNCVkeHUh?=
CAKI-1 MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMkG2OlYh|ryP M2H4e3NCVkeHUh?=
CCF-STTG1 Mk\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMkK0O|Uh|ryP NHjVTpFUSU6JRWK=
D-392MG M3nKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMkOxO|ch|ryP NF\BXVBUSU6JRWK=
RT-112 NHPlZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XDcGlEPTB;MD6yN|c6PSEQvF2= MXXTRW5ITVJ?
MES-SA NYPIeHZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjEfHZKSzVyPUCuNlQyQDdizszN MXjTRW5ITVJ?
LC-2-ad M4jxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMkSyOlUh|ryP MoTSV2FPT0WU
NOS-1 NYjaZodkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDmOWdKSzVyPUCuNlQ{PjdizszN NYDibYtiW0GQR1XS
NALM-6 NVzTfYgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMkW1OFMh|ryP MkPDV2FPT0WU
TE-15 MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX1TWM2OD1yLkK2NFkyKM7:TR?= MoniV2FPT0WU
786-0 M3TPSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\1eodKSzVyPUCuNlYzOjhizszN MWPTRW5ITVJ?
IST-MES1 M4LTW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rZe2lEPTB;MD6yOlgzQSEQvF2= MYPTRW5ITVJ?
KYSE-180 Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn3[XVrUUN3ME2wMlI3QDlzIN88US=> MUHTRW5ITVJ?
YT MlHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;mOFhKSzVyPUCuNlY6PzRizszN NWD0[lh7W0GQR1XS
A427 NVnYU49bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHFOINVUUN3ME2wMlI4OjZ2IN88US=> NEfuO2xUSU6JRWK=
KYSE-450 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HiV2lEPTB;MD6yO|MzQSEQvF2= MVXTRW5ITVJ?
HuH-7 M2\pZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMke3OlMh|ryP NFPweGdUSU6JRWK=
CAS-1 MkXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHib5g6UUN3ME2wMlI5OzB|IN88US=> NUmzU2VLW0GQR1XS
KURAMOCHI M2HwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LM[2lEPTB;MD6yPFQyQSEQvF2= NG\oZppUSU6JRWK=
ACHN M3;2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33BOWlEPTB;MD6yPVMzOyEQvF2= MlzCV2FPT0WU
HGC-27 NI\3flZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMkmzOVMh|ryP MmTZV2FPT0WU
A172 NIfofHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMkm1O|ch|ryP M1LPXXNCVkeHUh?=
SNU-449 NYHRNHplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInSXoJKSzVyPUCuNlk6PjRizszN MVfTRW5ITVJ?
SW982 NHHRb3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMkm5O|gh|ryP MYPTRW5ITVJ?
EFO-21 NHXuXGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ntPGlEPTB;MD6zNFQyOSEQvF2= MlrnV2FPT0WU
NCI-H2030 M2LsOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILkXVdKSzVyPUCuN|EyPjRizszN MmnpV2FPT0WU
HT-144 M363WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwM{GyPEDPxE1? MkLaV2FPT0WU
MFE-280 NGDCUWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33KWmlEPTB;MD6zNVQ2OyEQvF2= NIGwcm1USU6JRWK=
SK-LU-1 NWi2dpZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL3cHJKSzVyPUCuN|E1PjZizszN Ml;MV2FPT0WU
NCI-H2052 NWfEO4JiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL4ZZFKSzVyPUCuN|E1QDRizszN MnrhV2FPT0WU
SK-HEP-1 M2DYVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwM{OzOlgh|ryP M2DnU3NCVkeHUh?=
QIMR-WIL M4fPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\uTWM2OD1yLkOzOFI1KM7:TR?= NYHSb2VOW0GQR1XS
A2780 M{K4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r0UGlEPTB;MD6zOFMxPCEQvF2= MlrxV2FPT0WU
ACN M2qyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfkdIVPUUN3ME2wMlM1QDd|IN88US=> MnvkV2FPT0WU
BxPC-3 NXHsOHZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjw[Ys3UUN3ME2wMlM1QTh7IN88US=> MWPTRW5ITVJ?
BCPAP Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjPTWM2OD1yLkO2NFAyKM7:TR?= MYfTRW5ITVJ?
HOP-62 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwM{[xNFYh|ryP MVXTRW5ITVJ?
SW1710 NHHuc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fWemlEPTB;MD6zOlQ2PSEQvF2= M4TUVnNCVkeHUh?=
OPM-2 NXnNVngyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrmTWM2OD1yLkO2OFc{KM7:TR?= M1fudXNCVkeHUh?=
DBTRG-05MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS2cnBoUUN3ME2wMlM5ODV2IN88US=> MoHuV2FPT0WU
SK-MEL-24 M1LpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ftWGlEPTB;MD6zPVc6OSEQvF2= M2HuZXNCVkeHUh?=
8305C NWj1[3JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jZUWlEPTB;MD6zPVc6OyEQvF2= MVHTRW5ITVJ?
OVCAR-4 MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIS0R2pKSzVyPUCuOFE2QDZizszN NXjTNlMzW0GQR1XS
HLE MnLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwNEG4OkDPxE1? MVrTRW5ITVJ?
NCI-H747 MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfnOZB{UUN3ME2wMlQzOTN5IN88US=> M2LJZXNCVkeHUh?=
SW780 MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\1TWM2OD1yLkSyN|Q3KM7:TR?= MWLTRW5ITVJ?
KYSE-150 MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonlTWM2OD1yLkSyOFE2KM7:TR?= MUHTRW5ITVJ?
H4 NIDmflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwNEK0OVEh|ryP NYKzbmIxW0GQR1XS
SW1088 Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\HTWM2OD1yLkS0N|kh|ryP NIOxdGNUSU6JRWK=
SF268 M1jNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPmWZNKSzVyPUCuOFQ5PiEQvF2= MU\TRW5ITVJ?
RT4 NIPBWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwNEWxNVEh|ryP MkLFV2FPT0WU
NCI-H522 NVHrTG5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;abmlEPTB;MD60OVI4KM7:TR?= NHv3dFRUSU6JRWK=
LCLC-97TM1 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLIN5hKSzVyPUCuOFYyQTVizszN MmWwV2FPT0WU
CAL-39 M4n5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwNE[1NVkh|ryP NV\0O5VqW0GQR1XS
CAL-120 NUHHbpdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHiPIFKSzVyPUCuOFc3PDNizszN NXrM[mdwW0GQR1XS
ESS-1 M{nMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnuNpFIUUN3ME2wMlQ4QDJzIN88US=> MlTPV2FPT0WU
KARPAS-45 MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS2[I9UUUN3ME2wMlQ5QTN|IN88US=> MkjmV2FPT0WU
DU-4475 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjDfpZCUUN3ME2wMlQ6PTFzIN88US=> NIPifVZUSU6JRWK=
VMRC-RCZ MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne2TWM2OD1yLkS5PVA1KM7:TR?= M4PGWXNCVkeHUh?=
HOS NIDlT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv4eGpKSzVyPUCuOVA{PjVizszN NEO1TJlUSU6JRWK=
MOLT-16 NWLHdGhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS4bZpGUUN3ME2wMlUyQDB6IN88US=> NEPEXHhUSU6JRWK=
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NCI-H2009 MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTxVJFyUUN3ME2xMlc6PzJzIN88US=> Mn\vV2FPT0WU
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KNS-42 NXS1OJBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTyTWM2OD1zLki2NlY3KM7:TR?= M1TNXXNCVkeHUh?=
NCI-H2452 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHiW4lKSzVyPUGuPFkxPzRizszN MV;TRW5ITVJ?
SK-MEL-2 NIS0boJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPDTWM2OD1zLkmwNlcyKM7:TR?= M2fiW3NCVkeHUh?=
OVCAR-5 M{e3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnMNoJZUUN3ME2xMlkxPjd3IN88US=> MXjTRW5ITVJ?
SNG-M MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwOUW4OVgh|ryP NUTLPWt7W0GQR1XS
A673 NH6xeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTFwOUe1NVYh|ryP M3THdnNCVkeHUh?=
L-428 NGK2ZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoGxTWM2OD1zLkm5NVc6KM7:TR?= NVTL[XkzW0GQR1XS
KM-H2 MkC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJwMEGwPUDPxE1? MlrLV2FPT0WU
MC-IXC NEf0XW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJwMEKyO|Mh|ryP MWnTRW5ITVJ?
COLO-678 Mne0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nLcWlEPTB;Mj6wOFIxPyEQvF2= M4G1XnNCVkeHUh?=
MEL-JUSO MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJwMEe4OVEh|ryP MmTjV2FPT0WU
HCC38 NVjDd|BTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTvTJpnUUN3ME2yMlA5PDN|IN88US=> NXf0Xlg6W0GQR1XS
UACC-62 NFLQN3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDFZpVqUUN3ME2yMlA5QDV3IN88US=> Ml;VV2FPT0WU
OAW-42 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJwMEm3NVEh|ryP MYHTRW5ITVJ?
LB996-RCC M3jpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\pVVFpUUN3ME2yMlE{QDF5IN88US=> MnLOV2FPT0WU
COR-L105 M2POVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWzd3NxUUN3ME2yMlE3Ozd|IN88US=> MmfUV2FPT0WU
RCC10RGB MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3HTWM2OD1{LkG4OVc3KM7:TR?= MXLTRW5ITVJ?
A431 NWHoSoh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G3cGlEPTB;Mj6xPVAyQSEQvF2= MonLV2FPT0WU
NCI-H292 Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofpTWM2OD1{LkKzPVUyKM7:TR?= M1nO[3NCVkeHUh?=
SK-UT-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHiTWM2OD1{LkOzNVg1KM7:TR?= MXnTRW5ITVJ?
PANC-08-13 M{PyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnyzTWM2OD1{LkOzNlM2KM7:TR?= MUjTRW5ITVJ?
ST486 NHmxNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHWZYJYUUN3ME2yMlQyODR6IN88US=> MWnTRW5ITVJ?
SJSA-1 NYK1XXNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLKcWtwUUN3ME2yMlQyOjdzIN88US=> MmL1V2FPT0WU
RKO NWS4R2tPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXZPWRCUUN3ME2yMlQzODJ7IN88US=> M{[4OXNCVkeHUh?=
NCI-H1793 M2PBPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLMcYpGUUN3ME2yMlQ1ODJ7IN88US=> MXnTRW5ITVJ?
639-V NWrnOJBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH74cWhKSzVyPUKuOFU{QDJizszN NUe5cHBZW0GQR1XS
ES3 M1TXS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrCOIdKSzVyPUKuOFk4OzdizszN Mn;yV2FPT0WU
NCI-H1792 MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\SR4liUUN3ME2yMlU3QDJ4IN88US=> M{DaR3NCVkeHUh?=
NCI-H1651 Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S4bmlEPTB;Mj61PFIyKM7:TR?= NUfRPI45W0GQR1XS
SN12C NWruR5ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJwNUi0PFch|ryP MlTGV2FPT0WU
COLO-679 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D0R2lEPTB;Mj61PFYxPSEQvF2= NGPBZWdUSU6JRWK=
U-118-MG NWjKfpJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJwNUi4O|Ih|ryP MVTTRW5ITVJ?
Ramos-2G6-4C10 NYTOSHl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXMdYpKSzVyPUKuOlQ5ODdizszN MV3TRW5ITVJ?
HCT-15 NGjzcotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnxUXRKSzVyPUKuOlg4QTJizszN MWHTRW5ITVJ?
MDA-MB-157 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJwN{C3OFch|ryP MnPkV2FPT0WU
K5 NWTJN2tLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljCTWM2OD1{LkexPFQ2KM7:TR?= Mne4V2FPT0WU
MKN45 NUDiSos{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJwN{OzOlYh|ryP M4DWd3NCVkeHUh?=
DMS-273 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJwN{W2N|Ih|ryP NEfiZ3lUSU6JRWK=
C8166 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPWVI1KSzVyPUKuO|g2OTNizszN NVfZN2U5W0GQR1XS
Calu-3 NIC5UJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CwfWlEPTB;Mj63PFk3QSEQvF2= MXHTRW5ITVJ?
SNB75 NEDrbnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXoZZdKSzVyPUKuPFg2OzVizszN M{jDb3NCVkeHUh?=
BFTC-905 NXnZPVN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLGZnBKSzVyPUKuPVAyQTFizszN MU\TRW5ITVJ?
C-4-II NY\SVZlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJwOUGzOVMh|ryP M{HBR3NCVkeHUh?=
MS-1 Mo\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvwTWM2OD1{Lkm2O|Y6KM7:TR?= M3zOW3NCVkeHUh?=
A375 NFrZdXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTNwMEixPFQh|ryP NGjxboNUSU6JRWK=
KYSE-70 Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTNwMEi4PFIh|ryP MknyV2FPT0WU
KYSE-510 NGf6XWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPrTWM2OD1|LkGwPVk2KM7:TR?= MWPTRW5ITVJ?
LN-405 NUSwN4ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLhUIxKSzVyPUOuNVM2OThizszN M{LDc3NCVkeHUh?=
BOKU NV\iO2lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmyTWM2OD1|LkG0NlU3KM7:TR?= NVWycpljW0GQR1XS
TE-10 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[2PG1YUUN3ME2zMlE4OzZ{IN88US=> NELOR|ZUSU6JRWK=
MKN1 M4rmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrteXJKSzVyPUOuNVg1QDNizszN M2XQNnNCVkeHUh?=
M059J MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTNwMkCxO|Mh|ryP MWrTRW5ITVJ?
GOTO MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4qwdWlEPTB;Mz6yNlA{QSEQvF2= NGHZcmdUSU6JRWK=
DK-MG M2T3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHKS4lKSzVyPUOuNlU6PzZizszN NXvSXYNjW0GQR1XS
NCI-H727 NVrsSGY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTLPHBKSzVyPUOuNlY2QCEQvF2= M{TyV3NCVkeHUh?=
NB12 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTNwM{OyNlQh|ryP M1;SfXNCVkeHUh?=
DOK NYTOVpNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTNwM{[xPFYh|ryP MlfqV2FPT0WU
KYSE-410 M2fXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPoZXYxUUN3ME2zMlM3Ojh5IN88US=> MlrRV2FPT0WU
AM-38 NEDmOpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HZNmlEPTB;Mz6zPFA2OSEQvF2= NY\vO|ZkW0GQR1XS
GR-ST MonYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTnNZgyUUN3ME2zMlQ2PzN{IN88US=> M1rpfHNCVkeHUh?=
D-247MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7BOlRRUUN3ME2zMlQ5OjZ|IN88US=> NFnFSoRUSU6JRWK=
TE-8 NY\ncoFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH70WGFKSzVyPUOuOFk{OzNizszN NXf1PXg4W0GQR1XS
LS-411N NGj4blNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\sT2xLUUN3ME2zMlQ6Pjl{IN88US=> MoSzV2FPT0WU
SK-MES-1 Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLXcGlEUUN3ME2zMlU3PDN|IN88US=> NGrMe3FUSU6JRWK=
SF295 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPlT3lSUUN3ME2zMlYyPTV{IN88US=> MWPTRW5ITVJ?
SK-MEL-30 NHv4enJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTNwNkW5NlEh|ryP NVvQeWlnW0GQR1XS
LB2241-RCC M4DFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjzUI9mUUN3ME2zMlY3OjZizszN M32zfXNCVkeHUh?=
PC-14 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLYTpJKSzVyPUOuOlY1OzdizszN NFLqOGdUSU6JRWK=
EW-7 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnJNJFPUUN3ME2zMlY4Pjl|IN88US=> MVvTRW5ITVJ?
NMC-G1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTNwN{G4N|ch|ryP MWLTRW5ITVJ?
TE-441-T Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TPSmlEPTB;Mz63N|AzQCEQvF2= MVPTRW5ITVJ?
NCI-H1618 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ricWlEPTB;Mz64NVg4PSEQvF2= MV;TRW5ITVJ?
PANC-03-27 NIn0T25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknFTWM2OD1|LkixPVE3KM7:TR?= MXjTRW5ITVJ?
NCI-H2228 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoOyTWM2OD1|LkizNVI3KM7:TR?= MmXNV2FPT0WU
CAPAN-1 MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Gye2lEPTB;Mz64O|AxQSEQvF2= NI\vTJpUSU6JRWK=
KLE NXTjRmpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;sTWM2OD1|LkmwOlch|ryP MX;TRW5ITVJ?
Becker NWryXVI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNwOUK4OFkh|ryP M2jqdnNCVkeHUh?=
SK-PN-DW M2DtO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjMVYI{UUN3ME20MlA4QTd2IN88US=> Ml3KV2FPT0WU
Hs-578-T Mn3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLmNW9kUUN3ME20MlA5OzB4IN88US=> MmL2V2FPT0WU
RS4-11 NVfKU3Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTRwMUGyOVUh|ryP MXrTRW5ITVJ?
D-502MG M4LEdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTRwMU[5PVch|ryP MYHTRW5ITVJ?
GI-1 NVvtdWUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\4emlEPTB;ND6yPFI6QSEQvF2= NWjFOZhoW0GQR1XS
NCI-H209 M2HlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XsZ2lEPTB;ND6zN|c5KM7:TR?= NXzUdHliW0GQR1XS
SK-OV-3 M3LJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jycWlEPTB;ND60PFE1QSEQvF2= NH\QeppUSU6JRWK=
LOUCY NHj2dlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XvOGlEPTB;ND60PFQ{OiEQvF2= Mof0V2FPT0WU
NCI-H69 M{LLNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXTRW94UUN3ME20MlUyPzl|IN88US=> MnrjV2FPT0WU
SCC-9 M3X5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vZS2lEPTB;ND61N|E4OiEQvF2= MnnxV2FPT0WU
NCI-H526 NWXSPVNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHOTWM2OD12LkW5Nlk{KM7:TR?= MX7TRW5ITVJ?
NCI-H2170 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzCTWM2OD12Lk[2O|cyKM7:TR?= NHLqXndUSU6JRWK=
SR MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnye3RKSzVyPUSuO|AxPDhizszN M3TURnNCVkeHUh?=
CMK M3rUZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTRwN{KxNFEh|ryP MkjkV2FPT0WU
COLO-829 NInT[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvDc25KSzVyPUSuO|cxPDNizszN NVfiUmNKW0GQR1XS
HuO-3N1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;ZUYxKSzVyPUSuPFMzQDFizszN NYjPboF6W0GQR1XS
5637 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL3TWM2OD12LkmwOFg4KM7:TR?= M2rOenNCVkeHUh?=
A253 NE\zSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTRwOUe3NFgh|ryP MX7TRW5ITVJ?
NB10 NE\XV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL3VYdKSzVyPUWuNFc1QTdizszN NEXhbG9USU6JRWK=
SF539 M13vfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvyTWM2OD13LkC5PVU6KM7:TR?= MVPTRW5ITVJ?
HAL-01 Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTVwMUS2OFUh|ryP NV;tWWk6W0GQR1XS
MHH-ES-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTVwMU[5NlUh|ryP MmHkV2FPT0WU
DEL MljiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTVwMke1PFIh|ryP M3m4enNCVkeHUh?=
NCI-H1299 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1mwfGlEPTB;NT6zOVAxPyEQvF2= NHHQRZFUSU6JRWK=
ChaGo-K-1 M1rVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPscIhDUUN3ME21MlM2OTB5IN88US=> MYLTRW5ITVJ?
HMV-II NFvmZZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTVwM{m0N{DPxE1? NULNV|hRW0GQR1XS
NB69 NVHGcZR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe4cY5KSzVyPUWuN|k3OzFizszN NV\SWI9bW0GQR1XS
NCI-H1882 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG1OYJKSzVyPUWuOFM{PjRizszN MnfaV2FPT0WU
SNU-475 NHr2VHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnBVphqUUN3ME21MlQ4OTdzIN88US=> Mm\OV2FPT0WU
RXF393 M1LafGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Ls[2lEPTB;NT60PFQ6PCEQvF2= NEPM[Y1USU6JRWK=
CAL-51 NUHX[mxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTVwNkK4OVMh|ryP Ml:1V2FPT0WU
SW1573 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFm3VHhKSzVyPUWuOlM2OzRizszN NEXheIpUSU6JRWK=
GCT M4DyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Pkc2lEPTB;NT63OVkzQSEQvF2= MU\TRW5ITVJ?
COR-L88 MkHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfDWWxKSzVyPUWuO|Y5PDZizszN NYLG[3VFW0GQR1XS
MDA-MB-134-VI MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e3e2lEPTB;NT64O|U{PiEQvF2= NH3vWXRUSU6JRWK=
NB5 NH7iVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTVwOUK0OEDPxE1? MXXTRW5ITVJ?
GMS-10 M4TweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTVwOU[4OlEh|ryP NUT5TmZWW0GQR1XS
CHP-212 NFvZcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPkTWM2OD14LkS4NlY4KM7:TR?= M1zrN3NCVkeHUh?=
TE-11 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjsUZFMUUN3ME22MlU2OTh{IN88US=> NU\wfFZGW0GQR1XS
SW962 NGXHSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTZwNkW3O|Qh|ryP MUHTRW5ITVJ?
MZ2-MEL NXTCVGU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrkTWM2OD14LkiyNFEyKM7:TR?= MofBV2FPT0WU
C-33-A MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD4TWM2OD14LkmxOlg5KM7:TR?= M1rtVHNCVkeHUh?=
IGR-1 M1L0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTZwOUe4NlYh|ryP MWLTRW5ITVJ?
MOLT-4 NFz1WlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTKNHNKSzVyPUeuNVU1ODZizszN MoPKV2FPT0WU
NCI-H1650 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LlZWlEPTB;Nz6yO|A1PiEQvF2= MmPxV2FPT0WU
AsPC-1 M1PUUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzxU5pKSzVyPUeuNlg3ODVizszN NXfoZVJsW0GQR1XS
SNU-C2B MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XUVWlEPTB;Nz6yPVU4OSEQvF2= MnO2V2FPT0WU
MKN7 NGm1PYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTdwM{eyN|Uh|ryP Mli2V2FPT0WU
SW620 M{nab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXlTWM2OD15LkO4NlA2KM7:TR?= MoPEV2FPT0WU
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COLO-792 NGXmXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJ{LkexNVEh|ryP M1jmUXNCVkeHUh?=
CAL-62 NYnLPGxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XDV2lEPTB;MkKuO|UyPyEQvF2= NWLYeI5QW0GQR1XS
HCE-T M3q5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLEfVFmUUN3ME2yNk45PjB4IN88US=> NVHVToZ{W0GQR1XS
BB65-RCC M1X3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnj4TWM2OD1{Mz6wN|Q1KM7:TR?= MX3TRW5ITVJ?
SiHa NUXUdGp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJ|LkO5Olgh|ryP MkfHV2FPT0WU
NCI-H2081 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:yTWM2OD1{ND6wOlQyKM7:TR?= NXj6UVVkW0GQR1XS
U251 Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf3b41KSzVyPUK0MlA3PjhizszN MXfTRW5ITVJ?
LoVo M3uxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPrdphKSzVyPUK0MlkzQDJizszN Ml[3V2FPT0WU
GCIY MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnhRol2UUN3ME2yOU4zQDd5IN88US=> NYDPPYRQW0GQR1XS
NUGC-3 NWLiU2Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HvXmlEPTB;MkWuN|MyPiEQvF2= M3mwb3NCVkeHUh?=
LNCaP-Clone-FGC Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TicmlEPTB;MkWuN|Q6QCEQvF2= MVzTRW5ITVJ?
PA-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXhTWM2OD1{NT62PFM{KM7:TR?= M1LoTHNCVkeHUh?=
OE33 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ3Lk[4OVMh|ryP M4DvcXNCVkeHUh?=
HT-29 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPQNW1KSzVyPUK1Mlc5PzlizszN MnP6V2FPT0WU
RCM-1 NEf4Wo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jLOGlEPTB;MkWuPVY2PiEQvF2= M2\6N3NCVkeHUh?=
NCI-H1522 MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJ3Lkm5NVEh|ryP MoGwV2FPT0WU
LB373-MEL-D NX3U[5UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M165TmlEPTB;Mk[uNVcxQCEQvF2= MX\TRW5ITVJ?
NCI-H1436 M{SxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ4LkK3N|gh|ryP MUTTRW5ITVJ?
COLO-824 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG2UXFKSzVyPUK2MlQxODJizszN M3;HWnNCVkeHUh?=
CP50-MEL-B MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJ4LkW2O|Uh|ryP NWHCVWY3W0GQR1XS
EGI-1 NXH1[GEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPtTWM2OD1{Nz6yOlk5KM7:TR?= MljNV2FPT0WU
LAN-6 MmrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHmTWM2OD1{Nz6zOVk5KM7:TR?= NYDYTWRFW0GQR1XS
GAK NF35NWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe0SVlsUUN3ME2yO{41OjJ3IN88US=> NHrZTZJUSU6JRWK=
MDA-MB-175-VII NEDKW3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfHb2NqUUN3ME2yO{42ODV|IN88US=> M{[xTnNCVkeHUh?=
JVM-2 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDzPItiUUN3ME2yO{43PjJ{IN88US=> M1XKZXNCVkeHUh?=
UACC-257 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fTRmlEPTB;MkeuOlg4QCEQvF2= M2C5PHNCVkeHUh?=
SW1783 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnThTWM2OD1{Nz63O|g{KM7:TR?= NUDnbo4xW0GQR1XS
HT-3 NXj0RogyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[3SXBKSzVyPUK4MlIyPjZizszN NV7EPIxzW0GQR1XS
RL Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn5WFdiUUN3ME2yPE42QTFzIN88US=> NUDwOWlXW0GQR1XS
TK10 NGPjOWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXqNHdKSzVyPUK4MlY2OzVizszN MYLTRW5ITVJ?
HT55 M2fmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW3UWZUUUN3ME2yPU4xPTZ3IN88US=> M4m4fXNCVkeHUh?=
BT-20 M4rHNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonJTWM2OD1{OT6wOVg3KM7:TR?= MmrYV2FPT0WU
TGBC24TKB MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvvbHdoUUN3ME2yPU4yQDNzIN88US=> MXLTRW5ITVJ?
HSC-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fI[GlEPTB;MkmuN|AxOSEQvF2= NH3hNGpUSU6JRWK=
COLO-205 M1jSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3BTWM2OD1{OT6zPVQ1KM7:TR?= Mly2V2FPT0WU
GT3TKB Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJ7Lk[4O|ch|ryP NX\OS2FFW0GQR1XS
T47D M1zYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[0O2F{UUN3ME2yPU45PTh{IN88US=> MYTTRW5ITVJ?
OMC-1 NV3LRoRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTNyLkG5NVkh|ryP M{XzSnNCVkeHUh?=
PFSK-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHhTWM2OD1|MT6yOlU6KM7:TR?= NFzaZ4tUSU6JRWK=
JEG-3 MljmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnjO3lMUUN3ME2zNU4{PTZzIN88US=> NVntOIxHW0GQR1XS
RD NXnzfGhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLwbFdKSzVyPUOxMlUyOTVizszN M3jWRnNCVkeHUh?=
NCI-H64 NFG1VJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7qZm9KSzVyPUOyMlQyPzlizszN MkK5V2FPT0WU
DMS-114 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PjTmlEPTB;M{KuOFE5OiEQvF2= M1LCeXNCVkeHUh?=
NCI-H661 M3jzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTN{Lk[1NFEh|ryP M1OxVHNCVkeHUh?=
CAL-148 MkP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjXTWM2OD1|Mj62OlY2KM7:TR?= NWDHdpM1W0GQR1XS
HuP-T3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fTZWlEPTB;M{KuPVM{QCEQvF2= NEiyWnlUSU6JRWK=
ES4 NEnaTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPMXZBKSzVyPUOzMlE4ODVizszN Mn24V2FPT0WU
Ca9-22 NHX4UFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTVNFZKSzVyPUOzMlQ3ODFizszN M4DjcXNCVkeHUh?=
LP-1 M1jDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m4ZWlEPTB;M{SuNFkh|ryP NFqwbXpUSU6JRWK=
AU565 MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e5ZWlEPTB;M{SuOVA3QSEQvF2= NGfQVlhUSU6JRWK=
MDA-MB-453 NYC0bFY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fxW2lEPTB;M{WuNVQzPiEQvF2= M4jpV3NCVkeHUh?=
SNU-C1 NEHadFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVSwfmlrUUN3ME2zOU4yPzFizszN M2nFSXNCVkeHUh?=
SW13 M1jqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN3LkSwO|Yh|ryP NXKyN4dpW0GQR1XS
NCI-H2122 NWnQT3dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkf6TWM2OD1|NT61OVk5KM7:TR?= M{LSOXNCVkeHUh?=
NCI-H1395 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\6TWM2OD1|NT62OlkyKM7:TR?= MX;TRW5ITVJ?
J-RT3-T3-5 M2fsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\LTWM2OD1|Nj6wNlk1KM7:TR?= NV3L[IZSW0GQR1XS
COR-L279 NF\ZWZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlraTWM2OD1|Nj6xPVgyKM7:TR?= NUTMTW5NW0GQR1XS
ATN-1 NXf1bJJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LqfWlEPTB;M{[uPFUyPiEQvF2= M3K1RnNCVkeHUh?=
HCC2998 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN4Lki1O|Eh|ryP M2frfnNCVkeHUh?=
UM-UC-3 M{XHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3sbHdKSzVyPUO2Mlg3PzVizszN NGG4OG1USU6JRWK=
DV-90 M4L6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN4LkmwOlch|ryP NFi3T2JUSU6JRWK=
ES8 M{HmPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvtUYpNUUN3ME2zOk46OzF6IN88US=> NWTEdnh1W0GQR1XS
YAPC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LTXGlEPTB;M{[uPVY2PCEQvF2= NFXvepZUSU6JRWK=
HCC1599 NGHMZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPyTWM2OD1|Nz6xOlE5KM7:TR?= NWDZeZpJW0GQR1XS
UMC-11 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L6OmlEPTB;M{euNlUxOyEQvF2= MUPTRW5ITVJ?
THP-1 MljXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTN5LkK4Olgh|ryP MkS4V2FPT0WU
OCUB-M M336NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDNTWM2OD1|Nz6yPFkyKM7:TR?= MWDTRW5ITVJ?
NCI-H1693 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW4fIhKSzVyPUO3MlMzOzNizszN NYHDXZpYW0GQR1XS
NCI-H345 NF\heHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2qxUGlEPTB;M{euN|YzPCEQvF2= NW\sOHF6W0GQR1XS
COLO-800 NXPWe49[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rySmlEPTB;M{euOVY4KM7:TR?= MlfwV2FPT0WU
COLO-320-HSR NUOwZnM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGmzXIlKSzVyPUO4MlM1QTJizszN NXPY[nliW0GQR1XS
NCI-H596 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN6LkS0PFkh|ryP M17xPXNCVkeHUh?=
NCI-H187 NFvL[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vtUGlEPTB;M{iuO|M1PCEQvF2= M2nzWHNCVkeHUh?=
ECC4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHGTWM2OD1|OT6wPFE1KM7:TR?= MWHTRW5ITVJ?
KP-4 NVPCfINPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rqXWlEPTB;M{muNVI{PSEQvF2= NF3qUVVUSU6JRWK=
NCI-H2227 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjSS|RKSzVyPUO5MlM6PDlizszN NFT3T2JUSU6JRWK=
22RV1 MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfWTWM2OD1|OT64N|k5KM7:TR?= NX;oT2MxW0GQR1XS
SAS NVf2bItLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnncnVKSzVyPUSwMlA6PiEQvF2= NUjW[Jp1W0GQR1XS
PANC-10-05 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn5bYtKSzVyPUSwMlE5OjhizszN NWDHXopGW0GQR1XS
MDA-MB-468 NF33XlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG5bG5UUUN3ME20NE42OzR4IN88US=> MXPTRW5ITVJ?
RPMI-7951 NHXkcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHObYVKSzVyPUSxMlIxPzVizszN NUfDNWxkW0GQR1XS
BB49-HNC NGX4O4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1r6[GlEPTB;NEGuNlE4QSEQvF2= NI\UNlVUSU6JRWK=
23132-87 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jjU2lEPTB;NEGuNlc{OiEQvF2= MUPTRW5ITVJ?
HCC1569 M2Licmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jic2lEPTB;NEGuNlg5PSEQvF2= NHTrblRUSU6JRWK=
CP66-MEL NUjqbWRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonlTWM2OD12Mj6xPFg3KM7:TR?= M4TGdHNCVkeHUh?=
K-562 M{LiTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXG[I1KSzVyPUSyMlI5PTRizszN MkD1V2FPT0WU
OCI-AML2 NGHmdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTR{Lki5O|Qh|ryP MYDTRW5ITVJ?
SW756 M{n6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmxcHBmUUN3ME20N{4xOzh6IN88US=> M17ieXNCVkeHUh?=
M14 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jLb2lEPTB;NEOuN|E5QSEQvF2= NIX5NpRUSU6JRWK=
NCI-H1623 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\JeWlEPTB;NEOuOFY1KM7:TR?= NELoPWxUSU6JRWK=
KNS-81-FD MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:3XJgxUUN3ME20N{44PjJizszN Mn3iV2FPT0WU
TGBC1TKB NHXKXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL3VGZKSzVyPUSzMlkxQTlizszN MnnJV2FPT0WU
RERF-LC-MS MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\2TWM2OD12Mz65NlgyKM7:TR?= NIrEdFVUSU6JRWK=
PC-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XaOWlEPTB;NESuOFM1PyEQvF2= MWLTRW5ITVJ?
HuP-T4 M4C5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTjTWM2OD12ND60OFc1KM7:TR?= NWK0WoZxW0GQR1XS
NCI-H510A NIGyeWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTR2LkewPEDPxE1? MYTTRW5ITVJ?
LB2518-MEL NWX2SnRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zLTWlEPTB;NESuO|k{PyEQvF2= M4jhWnNCVkeHUh?=
TE-5 NVm1XJlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTR3Lkm1PFEh|ryP NV36UGJEW0GQR1XS
EW-24 M1;IW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jlWmlEPTB;NE[uNVczOyEQvF2= MkfIV2FPT0WU
LB647-SCLC NETKfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z1[GlEPTB;NE[uNlE2PSEQvF2= M33IcHNCVkeHUh?=
NCI-H524 NWrYdpdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfLe4Z5UUN3ME20Ok44OTh3IN88US=> NVroOGRWW0GQR1XS
EW-11 NGD4OG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4OwfGlEPTB;NE[uPVM4OyEQvF2= NEXFfFJUSU6JRWK=
KALS-1 NF\xZmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HUXWlEPTB;NEeuNlA3PiEQvF2= MYfTRW5ITVJ?
BT-474 M4e2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HqcWlEPTB;NEeuOFIyPiEQvF2= MXnTRW5ITVJ?
SK-N-AS NFjjW49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTR5Lki4PEDPxE1? M1;NO3NCVkeHUh?=
HCC2157 NWDMdVZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33DeWlEPTB;NEiuNFc3KM7:TR?= MULTRW5ITVJ?
HCC1954 M3qyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnQNIdKSzVyPUS4MlE4ODRizszN M1fDPHNCVkeHUh?=
FADU MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTBTWM2OD12OD6zNFMyKM7:TR?= NV;V[pA6W0GQR1XS
S-117 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTR6LkO4NVUh|ryP NInOXmhUSU6JRWK=
LS-1034 NV;KdlJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPKRnVKSzVyPUS4MlcxPjdizszN M3TkWXNCVkeHUh?=
CAMA-1 M4np[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rSOWlEPTB;NEmuOVU1OyEQvF2= M{GxVXNCVkeHUh?=
LU-134-A MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTR7LkiwPFUh|ryP M{HZUHNCVkeHUh?=
NCI-H1838 NIDnR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfjXoR4UUN3ME20PU45ODh5IN88US=> MVfTRW5ITVJ?

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体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
1% CMC Na
混合させたのち直ちに使用することを推奨します。
30mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Ablシグナル伝達経路

Bcr-Abl Inhibitors with Unique Features

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID