Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。

サイズ 価格(税別)  
JPY 16600.00
JPY 18260.00
JPY 61420.00
JPY 161020.00

カスタマーフィードバック(4)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017. Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。
ターゲット
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHoU|lLUUN3ME2wMlAxODByMECzOVkh|ryP Mn7JV2FPT0WU
MV-4-11 NFPT[3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMECwNFk2PiEQvF2= MUTTRW5ITVJ?
MEG-01 MmXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzZcGhlUUN3ME2wMlAxODF{ODFOwG0> NXOzTINLW0GQR1XS
LAMA-84 NXi4cXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMECwNVY2KM7:TR?= NGjsZZVUSU6JRWK=
CGTH-W-1 NFziOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfxTWM2OD1yLkCwNVY6KM7:TR?= NHfQWlhUSU6JRWK=
KASUMI-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULHTppMUUN3ME2wMlAxOjF5IN88US=> NInB[VRUSU6JRWK=
BE-13 NULIOYQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLmVYFKSzVyPUCuNFAzPTlizszN NGTE[GhUSU6JRWK=
CTV-1 MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jHWmlEPTB;MD6wNFUzOSEQvF2= MXnTRW5ITVJ?
NKM-1 NYHxbHNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\Rb2lEPTB;MD6wNFY2PSEQvF2= M4r0cHNCVkeHUh?=
MONO-MAC-6 NVnpOWRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFeyRZRKSzVyPUCuNFA5OzdizszN MW\TRW5ITVJ?
A204 MnTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEGyNVgh|ryP MWHTRW5ITVJ?
GDM-1 NELPfYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\Ic|dKSzVyPUCuNFE5OzNizszN MnXWV2FPT0WU
AN3-CA Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\6TWM2OD1yLkCxPFc{KM7:TR?= MkHGV2FPT0WU
BL-70 M33zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfFTYpKSzVyPUCuNFIyQTlizszN MVnTRW5ITVJ?
Daudi NXzrPHZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEK1N|ch|ryP NWDycld{W0GQR1XS
KU812 NXy1VWQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXtXpZKSzVyPUCuNFI5PDhizszN MYLTRW5ITVJ?
KG-1 MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HQSWlEPTB;MD6wN|I6PCEQvF2= MnPMV2FPT0WU
DOHH-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXaTWM2OD1yLkC0PFA{KM7:TR?= NVzucZNkW0GQR1XS
HuO9 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn0SppKSzVyPUCuNFU1PDhizszN MkfZV2FPT0WU
EB2 M1TxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPTTWM2OD1yLkC1OVc3KM7:TR?= NUXVTol6W0GQR1XS
G-402 NF7LepFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwME[zOFEh|ryP M4PIOHNCVkeHUh?=
SU-DHL-1 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq1T3BGUUN3ME2wMlA3Ozd7IN88US=> MlLDV2FPT0WU
NCI-H719 NWXvVWhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLxTWM2OD1yLkC3PFg5KM7:TR?= NFW4[WJUSU6JRWK=
MLMA NH:wPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEmwOkDPxE1? NITVeodUSU6JRWK=
KM12 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\aU2lEPTB;MD6wPVc{PyEQvF2= NFP1[ZZUSU6JRWK=
SUP-T1 M4fnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TFfWlEPTB;MD6wPVk5OiEQvF2= M4\uPHNCVkeHUh?=
MZ1-PC NGXaPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rLXmlEPTB;MD6xNVM{PiEQvF2= M4nG[HNCVkeHUh?=
MFE-296 NHjibVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfFWYhLUUN3ME2wMlEyQDN7IN88US=> Ml63V2FPT0WU
ALL-PO NVLZUYRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3m[VdKSzVyPUCuNVI1PDNizszN MXjTRW5ITVJ?
GB-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrCcWg4UUN3ME2wMlEzPTF{IN88US=> NUTB[Fl3W0GQR1XS
SIG-M5 M{TH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XCRWlEPTB;MD6xN|M4KM7:TR?= Mmj3V2FPT0WU
P30-OHK MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMUW2O|Ih|ryP MV3TRW5ITVJ?
NCI-H716 MkPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMU[yOlYh|ryP MoqxV2FPT0WU
MPP-89 Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG1TWM2OD1yLkG2PVM{KM7:TR?= M1;iV3NCVkeHUh?=
SF126 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rreGlEPTB;MD6xO|A3OyEQvF2= MVfTRW5ITVJ?
CTB-1 NVnU[IVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDPc5JKSzVyPUCuNVc{OTZizszN M4PaRXNCVkeHUh?=
CA46 NHnrcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTmdZhKSzVyPUCuNVc1QDlizszN NYPlOVZSW0GQR1XS
NCI-H520 NYHWSGIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELNc49KSzVyPUCuNVc4OzJizszN M{HkbnNCVkeHUh?=
CAL-85-1 NVm3XXpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fHUGlEPTB;MD6xO|kzPyEQvF2= NEOw[ZRUSU6JRWK=
NCI-H2342 M1y1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LVTGlEPTB;MD6xPFU4PyEQvF2= MoHJV2FPT0WU
697 M2fHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLWSFZKSzVyPUCuNVg5PzFizszN NGLuPYNUSU6JRWK=
NY NWLkW2hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Ta[mlEPTB;MD6xPVI5PyEQvF2= MVLTRW5ITVJ?
T98G Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv1XZU3UUN3ME2wMlE6OzF6IN88US=> MmPmV2FPT0WU
NCI-H1703 M{jFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;vTWM2OD1yLkG5OlE2KM7:TR?= MXLTRW5ITVJ?
NCI-H2087 NF;kN|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjuTWM2OD1yLkKwOFM6KM7:TR?= MVnTRW5ITVJ?
PF-382 M1TTPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnZTWM2OD1yLkKwPFc{KM7:TR?= MUDTRW5ITVJ?
HCT-116 NFHwfYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3NcYNsUUN3ME2wMlIyODZ7IN88US=> NY\pc2tNW0GQR1XS
CAKI-1 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMkG2OlYh|ryP MoDPV2FPT0WU
CCF-STTG1 NF;MdYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\lSWpyUUN3ME2wMlIzPDd3IN88US=> M1P3ZnNCVkeHUh?=
D-392MG MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMkOxO|ch|ryP MUXTRW5ITVJ?
RT-112 NE\6dYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMkO3PVUh|ryP NX3T[m5HW0GQR1XS
MES-SA NWLUcW1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD6TWM2OD1yLkK0NVg4KM7:TR?= MoXyV2FPT0WU
LC-2-ad Mn;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnSTWM2OD1yLkK0NlY2KM7:TR?= MWLTRW5ITVJ?
NOS-1 NEDmWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMkSzOlch|ryP Ml\LV2FPT0WU
NALM-6 NH\sZ3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMkW1OFMh|ryP MUTTRW5ITVJ?
TE-15 M3P5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TaSWlEPTB;MD6yOlA6OSEQvF2= MYTTRW5ITVJ?
786-0 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzpTWM2OD1yLkK2NlI5KM7:TR?= M4TGenNCVkeHUh?=
IST-MES1 Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nRZ2lEPTB;MD6yOlgzQSEQvF2= M{DscHNCVkeHUh?=
KYSE-180 M1m4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPuc4RKSzVyPUCuNlY5QTFizszN NITV[o5USU6JRWK=
YT M1rXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYflPIlnUUN3ME2wMlI3QTd2IN88US=> M{j1XXNCVkeHUh?=
A427 NHWwU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrtTWM2OD1yLkK3NlY1KM7:TR?= M2nuN3NCVkeHUh?=
KYSE-450 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGCyUIxKSzVyPUCuNlc{OjlizszN MoHNV2FPT0WU
HuH-7 NFzadoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMke3OlMh|ryP MlPpV2FPT0WU
CAS-1 MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn5R4dKSzVyPUCuNlg{ODNizszN NH7TZWRUSU6JRWK=
KURAMOCHI NVjEWGZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFuxXGRKSzVyPUCuNlg1OTlizszN MoHBV2FPT0WU
ACHN MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLsdHpNUUN3ME2wMlI6OzJ|IN88US=> NV7mSmZkW0GQR1XS
HGC-27 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrVc|RKSzVyPUCuNlk{PTNizszN NHXiS4NUSU6JRWK=
A172 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMkm1O|ch|ryP NVv1S2dFW0GQR1XS
SNU-449 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvhTWM2OD1yLkK5PVY1KM7:TR?= NXT1WW1VW0GQR1XS
SW982 NYHLboZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HoZ2lEPTB;MD6yPVk4QCEQvF2= NVfwfmh7W0GQR1XS
EFO-21 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjiTVM4UUN3ME2wMlMxPDFzIN88US=> MYDTRW5ITVJ?
NCI-H2030 M2PBc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnGTWM2OD1yLkOxNVY1KM7:TR?= NXL3XYt1W0GQR1XS
HT-144 NH3nWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLQTWM2OD1yLkOxNlgh|ryP NW\NVXA6W0GQR1XS
MFE-280 MlH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPqb3RXUUN3ME2wMlMyPDV|IN88US=> MXrTRW5ITVJ?
SK-LU-1 NH\rUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTvVWV{UUN3ME2wMlMyPDZ4IN88US=> MU\TRW5ITVJ?
NCI-H2052 M3TNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXNTWM2OD1yLkOxOFg1KM7:TR?= NXz0VGV[W0GQR1XS
SK-HEP-1 M4L1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwM{OzOlgh|ryP NXTOUGtJW0GQR1XS
QIMR-WIL NGX4RXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PBNGlEPTB;MD6zN|QzPCEQvF2= M1jmbHNCVkeHUh?=
A2780 NV7adHo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vUe2lEPTB;MD6zOFMxPCEQvF2= M4DxbXNCVkeHUh?=
ACN Mlu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwM{S4O|Mh|ryP M2PjfXNCVkeHUh?=
BxPC-3 NX25T21DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu0TWM2OD1yLkO0PVg6KM7:TR?= Ml\qV2FPT0WU
BCPAP NH:x[oVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTLemZVUUN3ME2wMlM3ODBzIN88US=> M1LXRXNCVkeHUh?=
HOP-62 NGm5VnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[yN|NvUUN3ME2wMlM3OTB4IN88US=> MlLVV2FPT0WU
SW1710 MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\CTWM2OD1yLkO2OFU2KM7:TR?= MoHUV2FPT0WU
OPM-2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXHeopKSzVyPUCuN|Y1PzNizszN MkX0V2FPT0WU
DBTRG-05MG MoP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX5OVRKSzVyPUCuN|gxPTRizszN MoXHV2FPT0WU
SK-MEL-24 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDtRphFUUN3ME2wMlM6PzlzIN88US=> NEXLe2NUSU6JRWK=
8305C MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPWTWM2OD1yLkO5O|k{KM7:TR?= NIT1UGpUSU6JRWK=
OVCAR-4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwNEG1PFYh|ryP MYHTRW5ITVJ?
HLE MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HBeWlEPTB;MD60NVg3KM7:TR?= NV[xNo5IW0GQR1XS
NCI-H747 NEHMXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwNEKxN|ch|ryP MkDVV2FPT0WU
SW780 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\HemlEPTB;MD60NlM1PiEQvF2= NITrdoVUSU6JRWK=
KYSE-150 NUnCN5FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnxTWM2OD1yLkSyOFE2KM7:TR?= MnPPV2FPT0WU
H4 NILRWYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwNEK0OVEh|ryP M1PkT3NCVkeHUh?=
SW1088 NVrvd49ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXoe4tKSzVyPUCuOFQ{QSEQvF2= Mk\ZV2FPT0WU
SF268 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmKwTWM2OD1yLkS0PFYh|ryP MnnyV2FPT0WU
RT4 NH23OZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\4dplKSzVyPUCuOFUyOTFizszN M3zJPXNCVkeHUh?=
NCI-H522 NFO0PGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLxW|NCUUN3ME2wMlQ2OjdizszN Mn\QV2FPT0WU
LCLC-97TM1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwNE[xPVUh|ryP MlXPV2FPT0WU
CAL-39 M{OyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj5cVVKSzVyPUCuOFY2OTlizszN MXLTRW5ITVJ?
CAL-120 NE\NXpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwNEe2OFMh|ryP NGK4UY5USU6JRWK=
ESS-1 NIn6S3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjsTWM2OD1yLkS3PFIyKM7:TR?= MmP4V2FPT0WU
KARPAS-45 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP5NW5mUUN3ME2wMlQ5QTN|IN88US=> MUHTRW5ITVJ?
DU-4475 MmO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHxTWM2OD1yLkS5OVEyKM7:TR?= NVvQXmIzW0GQR1XS
VMRC-RCZ MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jjc2lEPTB;MD60PVkxPCEQvF2= NVzteFJGW0GQR1XS
HOS NVHZd3JYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;nUWlEPTB;MD61NFM3PSEQvF2= MUfTRW5ITVJ?
MOLT-16 M3vKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj1SWlwUUN3ME2wMlUyQDB6IN88US=> NV3HXI95W0GQR1XS
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NCI-H2009 NHf0TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLTd25tUUN3ME2xMlc6PzJzIN88US=> MW\TRW5ITVJ?
A498 NET1XXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXlWW9LUUN3ME2xMlgyOjh{IN88US=> NF64UXBUSU6JRWK=
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NCI-H2452 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jr[mlEPTB;MT64PVA4PCEQvF2= NFfuNpNUSU6JRWK=
SK-MEL-2 NYLISGJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXOOYMyUUN3ME2xMlkxOjdzIN88US=> MkftV2FPT0WU
OVCAR-5 NF7IfHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M360XWlEPTB;MT65NFY4PSEQvF2= MnvkV2FPT0WU
SNG-M MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfmTWM2OD1zLkm1PFU5KM7:TR?= NGjVUm9USU6JRWK=
A673 NEnISFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7mTWlIUUN3ME2xMlk4PTF4IN88US=> NVLKWXVHW0GQR1XS
L-428 M3;mWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFwOUmxO|kh|ryP NH;pXG9USU6JRWK=
KM-H2 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\DfYZKSzVyPUKuNFExQSEQvF2= MnT0V2FPT0WU
MC-IXC NVvMdJFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjCcnBxUUN3ME2yMlAzOjd|IN88US=> NXzQS|hHW0GQR1XS
COLO-678 M1P2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NICzUGVKSzVyPUKuNFQzODdizszN MlLTV2FPT0WU
MEL-JUSO M{fXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG5TWM2OD1{LkC3PFUyKM7:TR?= Mn:0V2FPT0WU
HCC38 MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwMEi0N|Mh|ryP MVTTRW5ITVJ?
UACC-62 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLMTWM2OD1{LkC4PFU2KM7:TR?= M2[wRXNCVkeHUh?=
OAW-42 NUfBdm9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjKemk1UUN3ME2yMlA6PzFzIN88US=> NV;qUXYzW0GQR1XS
LB996-RCC NVvaV|RjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwMUO4NVch|ryP M{DpenNCVkeHUh?=
COR-L105 NXPlTYhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn3dYVYUUN3ME2yMlE3Ozd|IN88US=> MY\TRW5ITVJ?
RCC10RGB MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzjfGRKSzVyPUKuNVg2PzZizszN NVj6UG9PW0GQR1XS
A431 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rmWWlEPTB;Mj6xPVAyQSEQvF2= MX7TRW5ITVJ?
NCI-H292 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWj0RYptUUN3ME2yMlI{QTVzIN88US=> NXPRZlh[W0GQR1XS
SK-UT-1 M3fkfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HsZ2lEPTB;Mj6zN|E5PCEQvF2= M{HoVnNCVkeHUh?=
PANC-08-13 M120fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH6WFJKSzVyPUKuN|MzOzVizszN NIG5RpZUSU6JRWK=
ST486 MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mwTmlEPTB;Mj60NVA1QCEQvF2= MnXiV2FPT0WU
SJSA-1 MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHXVplKSzVyPUKuOFEzPzFizszN NEHBNFBUSU6JRWK=
RKO MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PtfmlEPTB;Mj60NlAzQSEQvF2= MnnYV2FPT0WU
NCI-H1793 NFvUOZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTGTWM2OD1{LkS0NFI6KM7:TR?= MVjTRW5ITVJ?
639-V NFvVcGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJwNEWzPFIh|ryP NU\DeGwxW0GQR1XS
ES3 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJwNEm3N|ch|ryP MkXYV2FPT0WU
NCI-H1792 MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJwNU[4NlYh|ryP NH;iNGtUSU6JRWK=
NCI-H1651 M4PWdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDjWmFKSzVyPUKuOVgzOSEQvF2= MmHUV2FPT0WU
SN12C M3jYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrkXIFCUUN3ME2yMlU5PDh5IN88US=> MoXrV2FPT0WU
COLO-679 M{jmNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUOxcnBKUUN3ME2yMlU5PjB3IN88US=> NX\wOmdDW0GQR1XS
U-118-MG NEPGWIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;GTWM2OD1{LkW4PFczKM7:TR?= NG\5cmlUSU6JRWK=
Ramos-2G6-4C10 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f2eGlEPTB;Mj62OFgxPyEQvF2= MUjTRW5ITVJ?
HCT-15 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXqRXNOUUN3ME2yMlY5Pzl{IN88US=> NF3oeZZUSU6JRWK=
MDA-MB-157 NITK[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLmUmVKSzVyPUKuO|A4PDdizszN NHXoV2dUSU6JRWK=
K5 NIDRRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;jVHhiUUN3ME2yMlcyQDR3IN88US=> NWnXcG5UW0GQR1XS
MKN45 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\aTWM2OD1{LkezN|Y3KM7:TR?= MnfjV2FPT0WU
DMS-273 NEC5XmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTSV3hLUUN3ME2yMlc2PjN{IN88US=> M3m5enNCVkeHUh?=
C8166 MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJwN{i1NVMh|ryP MXnTRW5ITVJ?
Calu-3 NFzydmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwN{i5Olkh|ryP M1zSfnNCVkeHUh?=
SNB75 NITVUHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\1PFlKSzVyPUKuPFg2OzVizszN M124OnNCVkeHUh?=
BFTC-905 MlvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf3c3pKSzVyPUKuPVAyQTFizszN Mn;VV2FPT0WU
C-4-II MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Li[2lEPTB;Mj65NVM2OyEQvF2= MVzTRW5ITVJ?
MS-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X4e2lEPTB;Mj65Olc3QSEQvF2= M{L0NnNCVkeHUh?=
A375 NYTIRXBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTNwMEixPFQh|ryP M13tSnNCVkeHUh?=
KYSE-70 NGT4T25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXyTWM2OD1|LkC4PFgzKM7:TR?= NH3pXnZUSU6JRWK=
KYSE-510 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXuTWM2OD1|LkGwPVk2KM7:TR?= MlXmV2FPT0WU
LN-405 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\Jd3ZKSzVyPUOuNVM2OThizszN NEKw[JBUSU6JRWK=
BOKU M2XoVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPzcXlKSzVyPUOuNVQzPTZizszN M2\vdnNCVkeHUh?=
TE-10 NG\hSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\yWWlEPTB;Mz6xO|M3OiEQvF2= M4S0S3NCVkeHUh?=
MKN1 NWTYZ241T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTrZVVTUUN3ME2zMlE5PDh|IN88US=> NFLNdohUSU6JRWK=
M059J NXr3T4NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNwMkCxO|Mh|ryP NXPSTnhWW0GQR1XS
GOTO NYTOb|JqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4GybWlEPTB;Mz6yNlA{QSEQvF2= NX\QWHZXW0GQR1XS
DK-MG NVLRS4pYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq2e4tUUUN3ME2zMlI2QTd4IN88US=> NFrYZmFUSU6JRWK=
NCI-H727 NE\jdYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGwcnVNUUN3ME2zMlI3PThizszN NXjwSYdTW0GQR1XS
NB12 NG\CcldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNwM{OyNlQh|ryP MnjrV2FPT0WU
DOK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXLVXhCUUN3ME2zMlM3OTh4IN88US=> M2\UOnNCVkeHUh?=
KYSE-410 NF;FOJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfCNolKSzVyPUOuN|YzQDdizszN NE\NSo1USU6JRWK=
AM-38 M{LheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jpXGlEPTB;Mz6zPFA2OSEQvF2= NECyWXhUSU6JRWK=
GR-ST NWjmT|doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvhSHRvUUN3ME2zMlQ2PzN{IN88US=> MkHiV2FPT0WU
D-247MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwNEiyOlMh|ryP NEjCT|FUSU6JRWK=
TE-8 M4PRPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PGbmlEPTB;Mz60PVM{OyEQvF2= M2i1U3NCVkeHUh?=
LS-411N NEDNUJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Hid2lEPTB;Mz60PVY6OiEQvF2= MlXVV2FPT0WU
SK-MES-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXpO4NKSzVyPUOuOVY1OzNizszN M37tRnNCVkeHUh?=
SF295 NHuwVnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvPe5FKSzVyPUOuOlE2PTJizszN NUXwNm9sW0GQR1XS
SK-MEL-30 NWTrd4JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HVO2lEPTB;Mz62OVkzOSEQvF2= NHTENG1USU6JRWK=
LB2241-RCC NHniT2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTNwNk[yOkDPxE1? MYnTRW5ITVJ?
PC-14 NVfRXopoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrBTWM2OD1|Lk[2OFM4KM7:TR?= NVnaT3lYW0GQR1XS
EW-7 M2XUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nHTWlEPTB;Mz62O|Y6OyEQvF2= Mny0V2FPT0WU
NMC-G1 NHrRdnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf4b3VKSzVyPUOuO|E5OzdizszN MkfmV2FPT0WU
TE-441-T MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTNwN{OwNlgh|ryP NVjqXGVUW0GQR1XS
NCI-H1618 M1HUWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfTbJBKSzVyPUOuPFE5PzVizszN MYfTRW5ITVJ?
PANC-03-27 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTNwOEG5NVYh|ryP Mlz1V2FPT0WU
NCI-H2228 M2i2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PLNmlEPTB;Mz64N|EzPiEQvF2= MX;TRW5ITVJ?
CAPAN-1 M2nzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTNwOEewNFkh|ryP NYPhb2NqW0GQR1XS
KLE MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H1emlEPTB;Mz65NFY4KM7:TR?= Ml71V2FPT0WU
Becker M3e4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPtNHBpUUN3ME2zMlkzQDR7IN88US=> MU\TRW5ITVJ?
SK-PN-DW MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DEW2lEPTB;ND6wO|k4PCEQvF2= NX7QWlJiW0GQR1XS
Hs-578-T MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7Eeld7UUN3ME20MlA5OzB4IN88US=> M376OXNCVkeHUh?=
RS4-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XqW2lEPTB;ND6xNVI2PSEQvF2= NHvyWY9USU6JRWK=
D-502MG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRwMU[5PVch|ryP MYHTRW5ITVJ?
GI-1 NIPlb5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPpdmJTUUN3ME20MlI5Ojl7IN88US=> MnrvV2FPT0WU
NCI-H209 NWe3RWMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH3dHBKSzVyPUSuN|M4QCEQvF2= NHzSW|RUSU6JRWK=
SK-OV-3 NFL2c4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnn[45lUUN3ME20MlQ5OTR7IN88US=> MUPTRW5ITVJ?
LOUCY NWj3SIpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LpWGlEPTB;ND60PFQ{OiEQvF2= NYXlSINOW0GQR1XS
NCI-H69 NELKPHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlSyTWM2OD12LkWxO|k{KM7:TR?= MkDPV2FPT0WU
SCC-9 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7XTWM2OD12LkWzNVczKM7:TR?= MmD5V2FPT0WU
NCI-H526 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTmTWM2OD12LkW5Nlk{KM7:TR?= NE\BdVNUSU6JRWK=
NCI-H2170 M3;tZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjtTJVKSzVyPUSuOlY4PzFizszN M3jpU3NCVkeHUh?=
SR NHzXN4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HrTWlEPTB;ND63NFA1QCEQvF2= MUXTRW5ITVJ?
CMK NV;jOYRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPYTWM2OD12LkeyNVAyKM7:TR?= Mlr1V2FPT0WU
COLO-829 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XaPWlEPTB;ND63O|A1OyEQvF2= M2K5WnNCVkeHUh?=
HuO-3N1 NX;GbnN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK0bGdQUUN3ME20Mlg{OjhzIN88US=> Mny3V2FPT0WU
5637 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTRwOUC0PFch|ryP NHn5Um5USU6JRWK=
A253 NVTp[Fd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fGcWlEPTB;ND65O|cxQCEQvF2= MUnTRW5ITVJ?
NB10 NIjaXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP6W|d2UUN3ME21MlA4PDl5IN88US=> NFvqWI1USU6JRWK=
SF539 M1HPcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MortTWM2OD13LkC5PVU6KM7:TR?= Mnv1V2FPT0WU
HAL-01 MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X0XGlEPTB;NT6xOFY1PSEQvF2= NHPSfGlUSU6JRWK=
MHH-ES-1 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m0S2lEPTB;NT6xOlkzPSEQvF2= NVnKc4hLW0GQR1XS
DEL MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvsfJA6UUN3ME21MlI4PTh{IN88US=> Ml73V2FPT0WU
NCI-H1299 NH6zemFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nycGlEPTB;NT6zOVAxPyEQvF2= MXvTRW5ITVJ?
ChaGo-K-1 MlzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTVwM{WxNFch|ryP M4\PRXNCVkeHUh?=
HMV-II NGDYbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH1bm9KSzVyPUWuN|k1OyEQvF2= NXfZcVk4W0GQR1XS
NB69 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTtbXVKSzVyPUWuN|k3OzFizszN NFjWcIJUSU6JRWK=
NCI-H1882 NYLUZnFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\zTWM2OD13LkSzN|Y1KM7:TR?= NGDPWZJUSU6JRWK=
SNU-475 MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fOVGlEPTB;NT60O|E4OSEQvF2= NVfRengyW0GQR1XS
RXF393 NILMS|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv6OGdKSzVyPUWuOFg1QTRizszN NUXqZmV1W0GQR1XS
CAL-51 NFe4fm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTVwNkK4OVMh|ryP NVzEV4EyW0GQR1XS
SW1573 NXfZUFJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITxU|dKSzVyPUWuOlM2OzRizszN M{\N[HNCVkeHUh?=
GCT MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrXfINKSzVyPUWuO|U6OjlizszN NV6xflNqW0GQR1XS
COR-L88 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\DOmlEPTB;NT63Olg1PiEQvF2= MlzmV2FPT0WU
MDA-MB-134-VI NEHYXZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXIdnlKSzVyPUWuPFc2OzZizszN NITxW|NUSU6JRWK=
NB5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUmwPZF6UUN3ME21MlkzPDRizszN M4TRbXNCVkeHUh?=
GMS-10 NYn0XoVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13L[mlEPTB;NT65Olg3OSEQvF2= NF3KTJVUSU6JRWK=
CHP-212 NUHicnhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\BfWlEPTB;Nj60PFI3PyEQvF2= NEnBeVhUSU6JRWK=
TE-11 MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTZwNUWxPFIh|ryP MnPmV2FPT0WU
SW962 MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTZwNkW3O|Qh|ryP NITXWohUSU6JRWK=
MZ2-MEL M2LwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTjWGNKSzVyPU[uPFIxOTFizszN NVK1cY1LW0GQR1XS
C-33-A M1jOR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTZwOUG2PFgh|ryP M1u0SXNCVkeHUh?=
IGR-1 M4TkTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTZwOUe4NlYh|ryP NXnIT4d6W0GQR1XS
MOLT-4 NHjPeFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFr0VXVKSzVyPUeuNVU1ODZizszN MYnTRW5ITVJ?
NCI-H1650 NYSxcXhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW4PFJKSzVyPUeuNlcxPDZizszN NYr6fWZoW0GQR1XS
AsPC-1 NWHwb4I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7UTWM2OD15LkK4OlA2KM7:TR?= M1\EWnNCVkeHUh?=
SNU-C2B NFvONYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnraTWM2OD15LkK5OVcyKM7:TR?= NX\aVJlIW0GQR1XS
MKN7 NXzYTW9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLtTWM2OD15LkO3NlM2KM7:TR?= M{PXV3NCVkeHUh?=
SW620 MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z1N2lEPTB;Nz6zPFIxPSEQvF2= M3\VbnNCVkeHUh?=
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COLO-792 NHPEd2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJ{LkexNVEh|ryP MonzV2FPT0WU
CAL-62 NF3XdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjQTWM2OD1{Mj63OVE4KM7:TR?= M4nhbnNCVkeHUh?=
HCE-T M4Tremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPNN45bUUN3ME2yNk45PjB4IN88US=> Mk\uV2FPT0WU
BB65-RCC MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJ|LkCzOFQh|ryP NYrGPJgxW0GQR1XS
SiHa Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ftWGlEPTB;MkOuN|k3QCEQvF2= M{C2dnNCVkeHUh?=
NCI-H2081 NX\TZWtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HEVmlEPTB;MkSuNFY1OSEQvF2= MkjDV2FPT0WU
U251 NVu5NJJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnO[nZKSzVyPUK0MlA3PjhizszN M{\q[nNCVkeHUh?=
LoVo Mm\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofWTWM2OD1{ND65NlgzKM7:TR?= M{L3WXNCVkeHUh?=
GCIY MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH6TWM2OD1{NT6yPFc4KM7:TR?= NUTWS3d3W0GQR1XS
NUGC-3 NVrTb3hJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTiR|ZFUUN3ME2yOU4{OzF4IN88US=> NIHDWHBUSU6JRWK=
LNCaP-Clone-FGC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX3UJR{UUN3ME2yOU4{PDl6IN88US=> MWjTRW5ITVJ?
PA-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPTS|VKSzVyPUK1MlY5OzNizszN MkfuV2FPT0WU
OE33 Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJ3Lk[4OVMh|ryP NX2wd5NMW0GQR1XS
HT-29 MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJ3Lke4O|kh|ryP NYfqd5N5W0GQR1XS
RCM-1 NIPob3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXiWnNmUUN3ME2yOU46PjV4IN88US=> MX3TRW5ITVJ?
NCI-H1522 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHDTWM2OD1{NT65PVEyKM7:TR?= NWrFT5hWW0GQR1XS
LB373-MEL-D NV7wXmY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn6TWM2OD1{Nj6xO|A5KM7:TR?= MYfTRW5ITVJ?
NCI-H1436 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\MTWM2OD1{Nj6yO|M5KM7:TR?= MmXNV2FPT0WU
COLO-824 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXNTWM2OD1{Nj60NFAzKM7:TR?= NUnpR3dMW0GQR1XS
CP50-MEL-B MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPvfXlKSzVyPUK2MlU3PzVizszN MmnlV2FPT0WU
EGI-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJ5LkK2PVgh|ryP NEDq[WRUSU6JRWK=
LAN-6 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPhVnk3UUN3ME2yO{4{PTl6IN88US=> MV7TRW5ITVJ?
GAK NEOxe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j4fmlEPTB;MkeuOFIzPSEQvF2= MXXTRW5ITVJ?
MDA-MB-175-VII NYnBcJBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPIeZZKSzVyPUK3MlUxPTNizszN M1LwRnNCVkeHUh?=
JVM-2 NFvCUXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXs[VlnUUN3ME2yO{43PjJ{IN88US=> MlXDV2FPT0WU
UACC-257 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYiyVnpUUUN3ME2yO{43QDd6IN88US=> MUnTRW5ITVJ?
SW1783 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFKxdW1KSzVyPUK3Mlc4QDNizszN NYrDZopNW0GQR1XS
HT-3 MmTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV65XIFmUUN3ME2yPE4zOTZ4IN88US=> M1rwN3NCVkeHUh?=
RL Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJ6LkW5NVEh|ryP NHvJZZBUSU6JRWK=
TK10 NEX6eY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXDfndKSzVyPUK4MlY2OzVizszN Mn6xV2FPT0WU
HT55 NHjwNVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLKXndJUUN3ME2yPU4xPTZ3IN88US=> NEfVPHNUSU6JRWK=
BT-20 NY\iS3BKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrvZWNKSzVyPUK5MlA2QDZizszN NIHHe4hUSU6JRWK=
TGBC24TKB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjCUWpyUUN3ME2yPU4yQDNzIN88US=> M{DWUnNCVkeHUh?=
HSC-2 NVXCW|FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjwNY9KSzVyPUK5MlMxODFizszN NVXoOZdYW0GQR1XS
COLO-205 NHHWTI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXlOVZVUUN3ME2yPU4{QTR2IN88US=> NWfrdYF2W0GQR1XS
GT3TKB NEDZfXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rXSmlEPTB;MkmuOlg4PyEQvF2= NEPaN2ZUSU6JRWK=
T47D MoDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmK2TWM2OD1{OT64OVgzKM7:TR?= MWXTRW5ITVJ?
OMC-1 M3\FdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfITWM2OD1|MD6xPVE6KM7:TR?= MVjTRW5ITVJ?
PFSK-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXWTWM2OD1|MT6yOlU6KM7:TR?= M2O2RXNCVkeHUh?=
JEG-3 NHrido1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTNzLkO1OlEh|ryP MW\TRW5ITVJ?
RD M{PyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\XTWM2OD1|MT61NVE2KM7:TR?= M3rOZXNCVkeHUh?=
NCI-H64 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\DTmlEPTB;M{KuOFE4QSEQvF2= M2mwO3NCVkeHUh?=
DMS-114 M1zKPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTHNZpWUUN3ME2zNk41OTh{IN88US=> NHjHXFlUSU6JRWK=
NCI-H661 NX;YSmJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[zTWM2OD1|Mj62OVAyKM7:TR?= M3zteXNCVkeHUh?=
CAL-148 NH7UWmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fFcmlEPTB;M{KuOlY3PSEQvF2= MoL3V2FPT0WU
HuP-T3 NHWxe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTN{LkmzN|gh|ryP M2PVbnNCVkeHUh?=
ES4 NE[1ZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjmW4RbUUN3ME2zN{4yPzB3IN88US=> NX\QSYsxW0GQR1XS
Ca9-22 NFfTVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\VboJUUUN3ME2zN{41PjBzIN88US=> NULPPGp{W0GQR1XS
LP-1 NHnGVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLabHFrUUN3ME2zOE4xQSEQvF2= MojzV2FPT0WU
AU565 NHvqTWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;tTWM2OD1|ND61NFY6KM7:TR?= MmC3V2FPT0WU
MDA-MB-453 M3\zc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m0dmlEPTB;M{WuNVQzPiEQvF2= NHH4VXdUSU6JRWK=
SNU-C1 NE\YR2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HWSmlEPTB;M{WuNVcyKM7:TR?= MmLRV2FPT0WU
SW13 NFu1eIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHUTWM2OD1|NT60NFc3KM7:TR?= NH\Y[HVUSU6JRWK=
NCI-H2122 NYHXblJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPxTWM2OD1|NT61OVk5KM7:TR?= MV3TRW5ITVJ?
NCI-H1395 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorNTWM2OD1|NT62OlkyKM7:TR?= NXezXG5TW0GQR1XS
J-RT3-T3-5 M1PuUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWxSGlKSzVyPUO2MlAzQTRizszN NVnSTppzW0GQR1XS
COR-L279 M{e0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL3TWM2OD1|Nj6xPVgyKM7:TR?= Mn2wV2FPT0WU
ATN-1 NIPuWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjDTWM2OD1|Nj64OVE3KM7:TR?= M{X5ZXNCVkeHUh?=
HCC2998 NWfIZmc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN4Lki1O|Eh|ryP MWjTRW5ITVJ?
UM-UC-3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTN4Lki2O|Uh|ryP M{\GWnNCVkeHUh?=
DV-90 MnTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TrSWlEPTB;M{[uPVA3PyEQvF2= MYHTRW5ITVJ?
ES8 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7xZnVKSzVyPUO2Mlk{OThizszN M3u3TXNCVkeHUh?=
YAPC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTN4Lkm2OVQh|ryP NGrWV5ZUSU6JRWK=
HCC1599 NFfEdHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTN5LkG2NVgh|ryP M136O3NCVkeHUh?=
UMC-11 NVu5[XZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vPd2lEPTB;M{euNlUxOyEQvF2= Ml3TV2FPT0WU
THP-1 NYnicGloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTN5LkK4Olgh|ryP MWLTRW5ITVJ?
OCUB-M Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTN5LkK4PVEh|ryP MYDTRW5ITVJ?
NCI-H1693 M4\oPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTN5LkOyN|Mh|ryP M1HjenNCVkeHUh?=
NCI-H345 NHHuOJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnznTWM2OD1|Nz6zOlI1KM7:TR?= M2XEbXNCVkeHUh?=
COLO-800 M2Pvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDVVVZDUUN3ME2zO{42PjdizszN NUDUNnROW0GQR1XS
COLO-320-HSR MnvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjYTXM{UUN3ME2zPE4{PDl{IN88US=> MlXUV2FPT0WU
NCI-H596 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvENnR7UUN3ME2zPE41PDh7IN88US=> NF62RmxUSU6JRWK=
NCI-H187 NIP4UGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTN6LkezOFQh|ryP MV3TRW5ITVJ?
ECC4 NVXBUGVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfabmNKSzVyPUO5MlA5OTRizszN M4[zSXNCVkeHUh?=
KP-4 M2nleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYezU|NXUUN3ME2zPU4yOjN3IN88US=> NVW4eYl7W0GQR1XS
NCI-H2227 NH;yfmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXDTWM2OD1|OT6zPVQ6KM7:TR?= NVPxcZp6W0GQR1XS
22RV1 M3XoU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvoO|BGUUN3ME2zPU45Ozl6IN88US=> NIPBZnlUSU6JRWK=
SAS MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\0TWM2OD12MD6wPVYh|ryP NHPQdnNUSU6JRWK=
PANC-10-05 MkXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXuTWM2OD12MD6xPFI5KM7:TR?= NEDrNmxUSU6JRWK=
MDA-MB-468 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUixend7UUN3ME20NE42OzR4IN88US=> M1qyN3NCVkeHUh?=
RPMI-7951 M{XNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTRzLkKwO|Uh|ryP NFj3d3hUSU6JRWK=
BB49-HNC Mn\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe5XWJKSzVyPUSxMlIyPzlizszN M3;FPXNCVkeHUh?=
23132-87 Mn\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjRTlBKSzVyPUSxMlI4OzJizszN NGfadlhUSU6JRWK=
HCC1569 M2Tye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\mTWM2OD12MT6yPFg2KM7:TR?= NXznV5YzW0GQR1XS
CP66-MEL NFvGfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\UW2lEPTB;NEKuNVg5PiEQvF2= MofNV2FPT0WU
K-562 NWPPRplKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnVTWM2OD12Mj6yPFU1KM7:TR?= Ml\XV2FPT0WU
OCI-AML2 M{ixfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu1copKSzVyPUSyMlg6PzRizszN NIDV[FlUSU6JRWK=
SW756 MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13GVWlEPTB;NEOuNFM5QCEQvF2= M1SzPXNCVkeHUh?=
M14 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFK5SndKSzVyPUSzMlMyQDlizszN MXrTRW5ITVJ?
NCI-H1623 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fNXmlEPTB;NEOuOFY1KM7:TR?= NXzMV49NW0GQR1XS
KNS-81-FD NEDSNIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXqTWM2OD12Mz63OlIh|ryP M1\YeXNCVkeHUh?=
TGBC1TKB NGTHeJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG4dWw{UUN3ME20N{46ODl7IN88US=> MUXTRW5ITVJ?
RERF-LC-MS M3Sx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnVTWM2OD12Mz65NlgyKM7:TR?= NYnWT5k5W0GQR1XS
PC-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTsVmNKSzVyPUS0MlQ{PDdizszN NIT6ZVBUSU6JRWK=
HuP-T4 Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2e4SWlEPTB;NESuOFQ4PCEQvF2= NWOyNZI5W0GQR1XS
NCI-H510A NWLwVmpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTR2LkewPEDPxE1? NF3ORVlUSU6JRWK=
LB2518-MEL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTR2Lke5N|ch|ryP MUPTRW5ITVJ?
TE-5 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrETWM2OD12NT65OVgyKM7:TR?= MnvkV2FPT0WU
EW-24 M2f5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfjPGlKSzVyPUS2MlE4OjNizszN MmDNV2FPT0WU
LB647-SCLC M4\zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnXbmREUUN3ME20Ok4zOTV3IN88US=> MmT3V2FPT0WU
NCI-H524 NHX4ZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLpNoROUUN3ME20Ok44OTh3IN88US=> NXP0RVJzW0GQR1XS
EW-11 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TKe2lEPTB;NE[uPVM4OyEQvF2= M2[0fXNCVkeHUh?=
KALS-1 MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KxOGlEPTB;NEeuNlA3PiEQvF2= MW\TRW5ITVJ?
BT-474 MmXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVr4Z2M4UUN3ME20O{41OjF4IN88US=> M4rPZ3NCVkeHUh?=
SK-N-AS NWnY[XJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTR5Lki4PEDPxE1? Mkm3V2FPT0WU
HCC2157 MkDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r6VWlEPTB;NEiuNFc3KM7:TR?= NGnDN|JUSU6JRWK=
HCC1954 MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTR6LkG3NFQh|ryP M3zUTXNCVkeHUh?=
FADU NEe5cnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnifoFVUUN3ME20PE4{ODNzIN88US=> M2n3U3NCVkeHUh?=
S-117 MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvFTWM2OD12OD6zPFE2KM7:TR?= NX\HT4VrW0GQR1XS
LS-1034 NF;o[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;GW3NKSzVyPUS4MlcxPjdizszN NWPmcpd1W0GQR1XS
CAMA-1 Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\CWHQ{UUN3ME20PU42PTR|IN88US=> NV3wOFQ{W0GQR1XS
LU-134-A NWC2NnhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\ZPGlEPTB;NEmuPFA5PSEQvF2= NYnYNno{W0GQR1XS
NCI-H1838 NFfrO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\6TWM2OD12OT64NFg4KM7:TR?= M3fxbnNCVkeHUh?=

多くの細胞株試験データを見る場合、クリックしてください

体内試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞試験: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物試験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 順序で溶剤を入れること:
1% CMC Na
30mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Bcr-Abl信号経路図

Bcr-Abl Inhibitors with Unique Features

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID