Bosutinib (SKI-606)

Licensed by Pfizer 製品コードS1014

Bosutinib (SKI-606)化学構造

分子量(MW):530.45

Bosutinib (SKI-606)は一種の新たな二重Src/Abl阻害剤で、無細胞試験でIC50値が1.2 nMと1 nMです。

サイズ 価格 在庫  
USD 114 あり
USD 88 あり
USD 340 あり

カスタマーフィードバック(4)

  • A,IC50 of Bosutinib that block ANDV-induced EC permeability. Endothelial cells were ANDV infected, and 3 days postinfection the permeability of cells in response to VEGF addition was determined in the presence or absence of increasing amounts of kinase inhibitor. The effect of inhibitors is presented as the percentage of ANDV-induced permeability of inhibitor-treated monolayers 3 days postinfection and 30 min post-VEGF and FITC-dextran addition. B, VEGFR2-Src inhibitors block ANDV-induced permeability. Endothelial cells were plated on vitronectin-coated Transwell inserts and infected at an MOI of 0.5 in triplicate with ANDV. Three days postinfection, the permeability of ANDV- and mock-infected endothelial cell monolayers was determined as described for Fig. 1 at indicated times in the presence or absence of Bosutinib .

    J Virol 2011 85, 2296–2303. Bosutinib (SKI-606) purchased from Selleck.

    Both parental and HR cell lines were treated with bosutinib (0.01, 0.1, and 1 μmol/L) for 24 hours. Src-related signaling pathway molecules were then analyzed.

    Mol Cancer Ther, 2017. Bosutinib (SKI-606) purchased from Selleck.

  • SFK inhibitors abrogate tyrosine phosphorylation associated with sperm capacitation. Mouse sperm were incubated in the absence or in the presence of SKI606 for 60 min in capacitating (cap, with HCO3) or non-capacitating media (NC, without HCO3). Western blot analyses were performed withanti-pY antibodies.

    J Biol Chem 2010 285, 7977–7985. Bosutinib (SKI-606) purchased from Selleck.

    Rescue ofPKAand tyrosine phosphorylation by Ser/Thr phosphatase inhibitors. A and B, spermwere incubated in capacitating medium supplemented with SFK inhibitors and different concentrations of okadaic acid (OA) (A) or calyculin-A (B), before immunodetection of p-PKA substrates (clone 100G7E). C and D, PVDF membranes used in A and B were stripped as described and used for Western blot immunodetection with anti-PY antibodies (clone 4G10).

    Dr. Pablo E.Visconti from University of Massachusetts. Bosutinib (SKI-606) purchased from Selleck.

製品安全説明書

Src阻害剤の選択性比較

生物活性

製品説明 Bosutinib (SKI-606)は一種の新たな二重Src/Abl阻害剤で、無細胞試験でIC50値が1.2 nMと1 nMです。
ターゲット
Abl [2]
(Cell-free assay)
Src [1]
(Cell-free assay)
1 nM 1.2 nM
体外試験

Bosutinib is selective for Src over non-Src family kinases with an IC50 of 1.2 nM, and potently inhibits Src-dependent cell proliferation with an IC50 of 100 nM. [1] Bosutinib significantly inhibits the proliferation of Bcr-Abl-positive leukemia cell lines KU812, K562, and MEG-01 but not Molt-4, HL-60, Ramos, and other leukemia cell lines, with IC50 of 5 nM, 20 nM and 20 nM, respectively, more potently than that of STI-571. Similar to STI-571, Bosutinib displays antiproliferative activity against the Abl-MLV-transformed fibroblasts with IC50 of 90 nM. Bosutinib ablates tyrosine phosphorylation of Bcr-Abl and STAT5 in CML cells and of v-Abl expressed in fibroblasts at the concentration of ~50 nM, 10-25 nM and 200 nM, respectively, leading to the Bcr-Abl downstream signaling inhibition of Lyn/Hck phosphorylation. [2] Although unable to inhibit the proliferation and survival of breast cancer cells, Bosutinib significantly decreases the motility and invasion of breast cancer cells with IC50 of ~250 nM, involved with an increase in cell-to-cell adhesion and membrane localization of β-catenin. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NB7 Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe0c3ZKSzVyPUCuNFgzOzFiIN88US=> M1W2dnNCVkeHUh?=
SW756 NHn5T5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHpRmxSUUN3ME2wMlE1ODJ2IDFOwG0> NHmyWG1USU6JRWK=
CTV-1 NUnPZmY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\rT2lEPTB;MD6xOlM6QCBizszN MYXTRW5ITVJ?
HSC-4 NX7uS|h5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17QSWlEPTB;MD6xO|E2QCBizszN NGHGdWNUSU6JRWK=
LAMA-84 M2G4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvtTWM2OD1yLkK4OlY1KCEQvF2= MYPTRW5ITVJ?
KU812 M3jMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;q[lZ{UUN3ME2wMlM1ODZ6IDFOwG0> NY\oNGpyW0GQR1XS
HCC1806 NVPpW2UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moq0TWM2OD1yLkO1NlE3KCEQvF2= MmiwV2FPT0WU
DOK M13BUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36wOWlEPTB;MD6zO|c5PiBizszN NWfN[ot6W0GQR1XS
NCI-H209 M{KzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\XbWlEPTB;MD60NFgxQCBizszN M2XQNHNCVkeHUh?=
EoL-1-cell M4rQUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwNEG1O|YhKM7:TR?= NF\JSnNUSU6JRWK=
H9 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfBTFV4UUN3ME2wMlQ{PDZ2IDFOwG0> MlPFV2FPT0WU
EM-2 M1TKRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS1NHlKSzVyPUCuOFM5QSBizszN MX\TRW5ITVJ?
NCI-H292 MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnZTWM2OD1yLkS0NVA5KCEQvF2= MljmV2FPT0WU
697 M2fGb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjifHBKSzVyPUCuOFU3OzNiIN88US=> NFzmbZBUSU6JRWK=
BHT-101 MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwNE[1PUAh|ryP NUjOXlgzW0GQR1XS
BE-13 NY\LSYpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\aTJZKSzVyPUCuOFg2PzJiIN88US=> NIewemxUSU6JRWK=
RS4-11 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwNEi1PFQhKM7:TR?= M4roRXNCVkeHUh?=
IGROV-1 NXL5UpF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\PVpVvUUN3ME2wMlQ5Pzl5IDFOwG0> M{\YbnNCVkeHUh?=
KE-37 M1u2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwNEm1NFkhKM7:TR?= NWjMOoxIW0GQR1XS
BV-173 NGHLRYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHRTWM2OD1yLkWwO|kzKCEQvF2= NWjBN3pUW0GQR1XS
MEG-01 MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;4UWlEPTB;MD61NVIyPCBizszN NVLBco9lW0GQR1XS
LB2241-RCC M33vOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Pzd2lEPTB;MD61N|cyQCBizszN Mn:3V2FPT0WU
ACHN NUjiOmZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwNUSwOlkhKM7:TR?= MnrMV2FPT0WU
CTB-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHKeYF1UUN3ME2wMlU1QDJiIN88US=> NIjiPHpUSU6JRWK=
HT-1080 NIHSdpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXyc|F2UUN3ME2wMlU2OzR7IDFOwG0> MWDTRW5ITVJ?
CHL-1 MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L6W2lEPTB;MD61OVQ3PSBizszN MYnTRW5ITVJ?
EW-3 Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDjTWM2OD1yLkW1PVM2KCEQvF2= NV\ZeIFkW0GQR1XS
ES1 M{e4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\zfIVKSzVyPUCuOlc1QThiIN88US=> MnLDV2FPT0WU
KASUMI-1 NVLNclNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwN{KzN{Ah|ryP NVmxVm9GW0GQR1XS
SW13 NVv4WI5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIroZ2tKSzVyPUCuO|M4QThiIN88US=> M2DrNnNCVkeHUh?=
A3-KAW MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vhfGlEPTB;MD63PVIxQCBizszN MVTTRW5ITVJ?
LB771-HNC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLPTWM2OD1yLkizNVA1KCEQvF2= M{HPdXNCVkeHUh?=
OC-314 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXnNJJKSzVyPUCuPFY6PjViIN88US=> MYrTRW5ITVJ?
MLMA M3zJUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm2TINKSzVyPUCuPVA3PzViIN88US=> Mn\GV2FPT0WU
KARPAS-45 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwOUK0OlYhKM7:TR?= M3SxRXNCVkeHUh?=
CAL-27 NVP5fYN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC5c2NJUUN3ME2wMlkzQTB4IDFOwG0> MWPTRW5ITVJ?
SK-NEP-1 M{fFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkSxTWM2OD1yLkm3NlQ5KCEQvF2= M1jTR3NCVkeHUh?=
COR-L105 NFfZS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33L[GlEPTB;MT6wNFM6PCBizszN M2fYOHNCVkeHUh?=
TI-73 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTFwMEG2OUAh|ryP MVfTRW5ITVJ?
JVM-3 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi0e|dKSzVyPUGuNFUxOTdiIN88US=> MW\TRW5ITVJ?
HAL-01 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf3cVBKSzVyPUGuNFg5OSBizszN NFSxbFdUSU6JRWK=
QIMR-WIL MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTQTWM2OD1zLkC5NFU5KCEQvF2= M4HCOXNCVkeHUh?=
HSC-3 NUDObos5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjxT5VKSzVyPUGuNVE4QDNiIN88US=> Mk\iV2FPT0WU
KY821 M2npdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P2OWlEPTB;MT6xN|M2OSBizszN MYnTRW5ITVJ?
5637 M1zK[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH33S|ZKSzVyPUGuNVM5ODNiIN88US=> NE\3fnFUSU6JRWK=
CAL-33 NHH0TIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3GwNGlEPTB;MT6xPVMxOiBizszN NYnVeVVDW0GQR1XS
ES4 MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf6Nm9GUUN3ME2xMlIxPzliIN88US=> NGrNfFlUSU6JRWK=
BHY MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHFTWM2OD1zLkKyPFkzKCEQvF2= NXWwNppDW0GQR1XS
LB1047-RCC NHHIRnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTFwMkO3PFUhKM7:TR?= M4nwcnNCVkeHUh?=
H4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwMkSyOVUhKM7:TR?= MnrUV2FPT0WU
RPMI-8866 NFvBVWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELLPJpKSzVyPUGuNlYyODZiIN88US=> NEnVTIJUSU6JRWK=
HO-1-N-1 MknwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX74UIxZUUN3ME2xMlI3OzZ7IDFOwG0> MnXJV2FPT0WU
BB30-HNC NHviOZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TkdGlEPTB;MT6yPFcyPCBizszN M1;lOXNCVkeHUh?=
PC-14 M1n3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M16zWGlEPTB;MT6yPVIxPSBizszN NYO1cIF5W0GQR1XS
NUGC-3 NUPTUoxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFwMkmzOVYhKM7:TR?= NYnQNpJXW0GQR1XS
A4-Fuk MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwM{C3NFQhKM7:TR?= MoTIV2FPT0WU
MHH-NB-11 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDafYw4UUN3ME2xMlMyOzh|IDFOwG0> MX3TRW5ITVJ?
KOSC-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTFwM{G3O|UhKM7:TR?= M3vZenNCVkeHUh?=
A498 M2Lncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFwNECxNVMhKM7:TR?= NFvibZhUSU6JRWK=
KG-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrGVWxtUUN3ME2xMlQyOjd|IDFOwG0> Ml7XV2FPT0WU
DEL NFnaNpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvsTWM2OD1zLkSzOlU4KCEQvF2= NIHHV2VUSU6JRWK=
EW-16 M3vGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnkdZVSUUN3ME2xMlQ{QTd|IDFOwG0> MVfTRW5ITVJ?
BPH-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;t[ms3UUN3ME2xMlQ1QDB3IDFOwG0> NXfXemI3W0GQR1XS
JAR NULEeI1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV64cmJDUUN3ME2xMlQ6OzZiIN88US=> Mm\PV2FPT0WU
J-RT3-T3-5 NHnWO|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPPNXBuUUN3ME2xMlUyPzJ{IDFOwG0> MX\TRW5ITVJ?
A375 NUTmWpNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LHTmlEPTB;MT61NVc4OiBizszN MkezV2FPT0WU
SW954 NHPvNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFwNUWwNFchKM7:TR?= NX[zeYNFW0GQR1XS
Ca9-22 MlW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTFwNU[yOkAh|ryP M161d3NCVkeHUh?=
D-566MG NVPSSJhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF31UXRKSzVyPUGuOVcyPTViIN88US=> MVvTRW5ITVJ?
SCC-15 NUXQOmt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTFwNkG4NFQhKM7:TR?= MV;TRW5ITVJ?
HD-MY-Z NWnlTGJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH3ZVRKSzVyPUGuOlM2QDRiIN88US=> M4fqfnNCVkeHUh?=
HT-1376 NInLSJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDXTWM2OD1zLk[0N|YhKM7:TR?= M3K1VHNCVkeHUh?=
CAL-54 NYW4bHBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W2dGlEPTB;MT62OVcxQSBizszN NUfnWW06W0GQR1XS
ONS-76 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HVVWlEPTB;MT62O|U2OSBizszN NXTMN5ZPW0GQR1XS
EFO-27 Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfNfJhSUUN3ME2xMlY5QTJiIN88US=> NGTBcYFUSU6JRWK=
769-P MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rXSWlEPTB;MT62PVU6PiBizszN NW\DR2lxW0GQR1XS
MV-4-11 M1HveGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33ybmlEPTB;MT62PVg2PiBizszN NGr5OYVUSU6JRWK=
NKM-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnLTWM2OD1zLkexPFAzKCEQvF2= MYXTRW5ITVJ?
LOXIMVI MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjwcJZKSzVyPUGuO|Q2QTliIN88US=> Mn3rV2FPT0WU
KYSE-140 M{m2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTYTWM2OD1zLke1OlU2KCEQvF2= NH3INYNUSU6JRWK=
ES5 M3jNZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rxfWlEPTB;MT64Olc1PyBizszN NFLjbJVUSU6JRWK=
BB65-RCC NFv4W5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3BTWM2OD1zLki5PFQ6KCEQvF2= M2\TfHNCVkeHUh?=
HN MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3QUFQyUUN3ME2xMlg6QDd2IDFOwG0> NWHOTZptW0GQR1XS
A101D MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW3TWM2OD1zLkmzOlI5KCEQvF2= M4nkWXNCVkeHUh?=
LoVo M{L4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwOUe2O|khKM7:TR?= M3q2SHNCVkeHUh?=
NCI-H526 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\hcZR5UUN3ME2xMlk6OzJ3IDFOwG0> M2jCNHNCVkeHUh?=
NCI-H1693 M2fISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP2TWM2OD1zLkm5PFg5KCEQvF2= MlHnV2FPT0WU
OVCAR-4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XIU2lEPTB;Mj6wNFQ{PSBizszN NEj0PWJUSU6JRWK=
SK-HEP-1 NIj5RWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TidGlEPTB;Mj6wNFc1PSBizszN NIDGSHNUSU6JRWK=
C2BBe1 NXrZfIR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPEc3hLUUN3ME2yMlA{Ozd{IDFOwG0> MV3TRW5ITVJ?
MEL-JUSO MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm4TWM2OD1{LkC0OFY1KCEQvF2= NFnn[5pUSU6JRWK=
MOLT-16 MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEThNJJKSzVyPUKuNFcxPThiIN88US=> NVzk[|Z7W0GQR1XS
NBsusSR MlPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XXS2lEPTB;Mj6wPVg5QSBizszN NFjUeXdUSU6JRWK=
TK10 M4jyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\IbYFKSzVyPUKuNVM1PThiIN88US=> MlPNV2FPT0WU
CAL-39 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rjfGlEPTB;Mj6xOFQ5KCEQvF2= MkLUV2FPT0WU
NCI-H2030 M1nnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJwMUi5O|MhKM7:TR?= MmP3V2FPT0WU
HCT-116 NWXiSZpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:1TWM2OD1{LkKyPVg1KCEQvF2= NV7vd5JJW0GQR1XS
HTC-C3 NH;5RZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJwMk[4NlQhKM7:TR?= MXvTRW5ITVJ?
TYK-nu M4T3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfsTWM2OD1{LkOwPVA6KCEQvF2= MnzxV2FPT0WU
FADU MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjtR|Q3UUN3ME2yMlMzOjl4IDFOwG0> NVPwXXVIW0GQR1XS
A431 MoHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjE[mxKSzVyPUKuN|cxOjViIN88US=> MkDqV2FPT0WU
TE-11 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVezfpBJUUN3ME2yMlM5ODF7IDFOwG0> MWHTRW5ITVJ?
CAL-12T MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPifYJQUUN3ME2yMlQxPDF5IDFOwG0> Mlu3V2FPT0WU
DB MlS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJwNEK4OlkhKM7:TR?= MWDTRW5ITVJ?
L-363 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwNEO1NFchKM7:TR?= NVnGXJZQW0GQR1XS
MSTO-211H NWTveFVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:yZWlEPTB;Mj62OlM6OSBizszN MXPTRW5ITVJ?
SK-UT-1 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDaWIFKSzVyPUKuO|E1ODZiIN88US=> M{TuOHNCVkeHUh?=
RPMI-8226 M4C4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH6XHVKSzVyPUKuO|MyPjRiIN88US=> M2PPe3NCVkeHUh?=
SF295 NVTRSHVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJwN{SzNUAh|ryP M3XEfnNCVkeHUh?=
OS-RC-2 M2nXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7iTWM2OD1{Lke2Olc{KCEQvF2= NIfCWIJUSU6JRWK=
SK-MEL-24 NW\nUo9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\5NZplUUN3ME2yMlc5OjJ2IDFOwG0> MYXTRW5ITVJ?
COR-L23 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TlcmlEPTB;Mj63PVQ3PCBizszN M4fNbHNCVkeHUh?=
MHH-PREB-1 MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\NTWM2OD1{LkiwNVYyKCEQvF2= NFe0R3dUSU6JRWK=
SK-N-DZ MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTxXJdKSzVyPUKuPFE3OzhiIN88US=> NWnrS2dOW0GQR1XS
OMC-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJwOEWwNFMhKM7:TR?= NYP1bHdCW0GQR1XS
SK-MEL-2 NHfBO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjFO|FKSzVyPUKuPFkzPDNiIN88US=> M2\rT3NCVkeHUh?=
SAS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorlTWM2OD1{Lkm5OFE2KCEQvF2= MWfTRW5ITVJ?
EPLC-272H M{K0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTNwMECyN|UhKM7:TR?= M3nMOnNCVkeHUh?=
8505C MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNwMUCzNFEhKM7:TR?= M2HDUHNCVkeHUh?=
EW-11 NU[y[|ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XGSWlEPTB;Mz6xOFI4PyBizszN M2fud3NCVkeHUh?=
YKG-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfFTWM2OD1|LkG0O|A3KCEQvF2= M2Lo[XNCVkeHUh?=
EC-GI-10 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPETWM2OD1|LkG3NlY{KCEQvF2= NILqUo9USU6JRWK=
SK-LU-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTiTWM2OD1|LkG4OFE5KCEQvF2= MkS5V2FPT0WU
P30-OHK NYCxVolDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTNwMkCxNVchKM7:TR?= NWixO3pOW0GQR1XS
T-24 NIHrbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHQOJNKSzVyPUOuNlE5OTRiIN88US=> NHH0UVNUSU6JRWK=
HSC-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUWwXGF[UUN3ME2zMlIzOjN{IDFOwG0> NFjm[2lUSU6JRWK=
SK-MES-1 NF7t[olIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTNwMkS4NlkhKM7:TR?= NYDGXYU6W0GQR1XS
SW48 MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPTTWM2OD1|LkK1OFg3KCEQvF2= M2TGW3NCVkeHUh?=
ME-180 NVHDZWY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvD[GJKSzVyPUOuNlYxPTFiIN88US=> M{H0RnNCVkeHUh?=
NCI-H2009 M{nZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELCVJJKSzVyPUOuNlkxOSBizszN NWe1N49lW0GQR1XS
HL-60 NETzUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXxW2VOUUN3ME2zMlI6OTNiIN88US=> NIjseHdUSU6JRWK=
NCI-N87 MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HLcGlEPTB;Mz6zNFE4OiBizszN M2S5[XNCVkeHUh?=
GMS-10 NIi3SHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT2OWNqUUN3ME2zMlM1ODh4IDFOwG0> NXS1blZWW0GQR1XS
SCH MojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNwNEC4OFQhKM7:TR?= MknvV2FPT0WU
C-33-A MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TyVGlEPTB;Mz60NVQzOSBizszN NY[4NYhFW0GQR1XS
NCI-H1703 M1fLcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljrTWM2OD1|LkSxPFEzKCEQvF2= NFvhVYVUSU6JRWK=
A427 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj6ZXM3UUN3ME2zMlQ3OTJ2IDFOwG0> MmHyV2FPT0WU
MOLT-4 NFHSUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjCblhKSzVyPUOuOFgyQTliIN88US=> MUHTRW5ITVJ?
NCI-H1792 M1m3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTNwNEm4NFIhKM7:TR?= M1qxUnNCVkeHUh?=
NCI-H1650 NIjFOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X4NGlEPTB;Mz61O|I6KCEQvF2= MV7TRW5ITVJ?
H-EMC-SS M1XKO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnoTWM2OD1|LkW4OVY6KCEQvF2= NX[zdpNEW0GQR1XS
SW982 NFXTdVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFWy[mRKSzVyPUOuOVg5OjliIN88US=> Ml;mV2FPT0WU
DSH1 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfxXmd1UUN3ME2zMlY1OTJ{IDFOwG0> M{LRSnNCVkeHUh?=
NOS-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\xNGlEPTB;Mz62OFI4PiBizszN NYX5c2E{W0GQR1XS
BT-549 M17hUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HZOGlEPTB;Mz62O|g2PCBizszN MWTTRW5ITVJ?
HuCCT1 NHuxe2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTNwN{SxO|chKM7:TR?= MX;TRW5ITVJ?
NCI-H1755 M1\pbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTNwOU[5O|EhKM7:TR?= NVPTdohDW0GQR1XS
KYSE-450 M2HHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO4bFQ3UUN3ME2zMlk3QTl5IDFOwG0> NUnER|RxW0GQR1XS
MIA-PaCa-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnnOo1KSzVyPUOuPVczQSBizszN MoLMV2FPT0WU
U-266 NH\aTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nHbGlEPTB;Mz65O|Q5OSBizszN NHLtdHlUSU6JRWK=
Mewo NVG1So9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz4ZmpKSzVyPUSuNFY{PjFiIN88US=> NYLZW2ZCW0GQR1XS
KYSE-520 M{i4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTRwMEm3PVkhKM7:TR?= M{H4e3NCVkeHUh?=
MN-60 NEHO[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTRwMUC1NFEhKM7:TR?= M13PZXNCVkeHUh?=
Ramos-2G6-4C10 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvwTWM2OD12LkG2O|M6KCEQvF2= NFv3OZdUSU6JRWK=
SK-MEL-1 NFPrTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfkXnNKSzVyPUSuNVg3QTViIN88US=> MlnlV2FPT0WU
ABC-1 MkGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTRwMkOzN|MhKM7:TR?= Ml3OV2FPT0WU
CAKI-1 NHTtepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n6VGlEPTB;ND6yOFU4OSBizszN NVfPUIhHW0GQR1XS
HOS NFXtb4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[5TWM2OD12LkK5NVQyKCEQvF2= NY\LOYZWW0GQR1XS
SN12C NF7sOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfJTWM2OD12LkO0NlQ1KCEQvF2= NVzkdHBJW0GQR1XS
NB13 M2OydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PuW2lEPTB;ND6zO|M2PSBizszN NFjOSXhUSU6JRWK=
M14 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;CN21KSzVyPUSuOFg4QTJiIN88US=> NEjKNXpUSU6JRWK=
GP5d MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnxfYdKSzVyPUSuOVAyOiBizszN MULTRW5ITVJ?
NCI-H720 NX\Sb5BIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnL6TWM2OD12LkWzOlEzKCEQvF2= NVHjU3NmW0GQR1XS
D-423MG M{P6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTRwNUO5NlQhKM7:TR?= M1L4enNCVkeHUh?=
ChaGo-K-1 NGLDcoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3DTndKSzVyPUSuOVk2PTliIN88US=> MVzTRW5ITVJ?
MEL-HO NWjlXoN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj0d3RKSzVyPUSuOlEzPjFiIN88US=> MXPTRW5ITVJ?
MHH-ES-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTRwNkK0NVEhKM7:TR?= MWnTRW5ITVJ?
KYSE-270 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTRwNkWxNlYhKM7:TR?= M{m2fnNCVkeHUh?=
GI-ME-N M3Hzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[4e2lEPTB;ND63NVI6OSBizszN NVvzXoR5W0GQR1XS
HOP-92 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPlSHRKSzVyPUSuPFE{PzliIN88US=> M2\HW3NCVkeHUh?=
MKN1 NFrW[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvoUHAxUUN3ME20Mlg{QTF2IDFOwG0> NFvhOWdUSU6JRWK=
ML-2 MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTRwOEW2NlYhKM7:TR?= M{XQc3NCVkeHUh?=
RO82-W-1 NVvMRVM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vrSmlEPTB;ND65Nlk5KCEQvF2= Mn7zV2FPT0WU
G-361 NVXONlZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1GwSmlEPTB;NT6wNVAxOyBizszN NWG0Xlk{W0GQR1XS
HC-1 NEK2UWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PiOWlEPTB;NT6wN|I6OSBizszN NF3aNW5USU6JRWK=
EW-24 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTuTWM2OD13LkC0NFM5KCEQvF2= MlXBV2FPT0WU
HuP-T4 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf5TWM2OD13LkG0N|M1KCEQvF2= NX[0NmQzW0GQR1XS
8-MG-BA NUPvT5lyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjUTWM2OD13LkO0NlghKM7:TR?= NYL0NGI4W0GQR1XS
HGC-27 M4G5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXkTWM2OD13LkO3OlgzKCEQvF2= NFf5TZBUSU6JRWK=
TE-12 M1TCSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHraVG1KSzVyPUWuOFE2QDViIN88US=> NGf1bYtUSU6JRWK=
GT3TKB NEG3VYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPFR5FKSzVyPUWuOFQzOTJiIN88US=> MkDHV2FPT0WU
DOHH-2 M121emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELu[WNKSzVyPUWuOFU6QDZiIN88US=> Mly5V2FPT0WU
Ca-Ski NFu1SpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLuTWM2OD13LkS2NVE2KCEQvF2= MWXTRW5ITVJ?
A172 NYj0[WtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTVwNUS5NlUhKM7:TR?= NWjkSZlVW0GQR1XS
EGI-1 Mk\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfmTWM2OD13LkW4PVM5KCEQvF2= M1TBb3NCVkeHUh?=
MZ2-MEL NULmcmU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXQ[I9tUUN3ME21MlYyPDh4IDFOwG0> NGTCWY5USU6JRWK=
SW1710 NUfGTHpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTVwNkmwPVEhKM7:TR?= NV3EToNPW0GQR1XS
HT-144 MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTVwN{K2PFUhKM7:TR?= Ml\nV2FPT0WU
PA-1 NFTNbWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTsTIhKSzVyPUWuPFE5QTNiIN88US=> MojNV2FPT0WU
HCC1937 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2OyT2lEPTB;NT64N|kzQSBizszN M{XhVnNCVkeHUh?=
SK-OV-3 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf1WmxrUUN3ME21MlkyOTJzIDFOwG0> NFexPG1USU6JRWK=
K5 MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDKdWhKSzVyPU[uNFUyPyBizszN MlvOV2FPT0WU
NMC-G1 M4nCXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDk[mRvUUN3ME22MlA4Pzl5IDFOwG0> NULFXGFoW0GQR1XS
MDA-MB-361 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTZwMEmyOlEhKM7:TR?= MkjBV2FPT0WU
EKVX MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV2weZd{UUN3ME22MlE{PTBzIDFOwG0> NVf2bnVTW0GQR1XS
ES7 NFLp[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTZwMU[xNVUhKM7:TR?= MmfYV2FPT0WU
KS-1 M3nwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPjbnJKSzVyPU[uNVc6QTNiIN88US=> MYXTRW5ITVJ?
NCI-H661 Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTZwMUiwPFEhKM7:TR?= MWfTRW5ITVJ?
ES8 M1zmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M170[WlEPTB;Nj6xPFA5OiBizszN MXPTRW5ITVJ?
NCI-H23 NH3PVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTZwMkG4NVYhKM7:TR?= MmDaV2FPT0WU
T47D NGjD[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFmwRVZKSzVyPU[uNlY1PTdiIN88US=> MYPTRW5ITVJ?
A2780 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTZwM{e3NFEhKM7:TR?= M{nuU3NCVkeHUh?=
SCC-4 MlOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTZwNEO1OlEhKM7:TR?= NH\ERXFUSU6JRWK=
VA-ES-BJ NFOwUXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTZwOUewOFMhKM7:TR?= MUjTRW5ITVJ?
no-11 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTdwMU[0NUAh|ryP MnPZV2FPT0WU
KU-19-19 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y4SmlEPTB;Nz6xOlQ4PiBizszN NVXqWIg3W0GQR1XS
MKN45 NXm3RZplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkSwTWM2OD15LkG4Olk6KCEQvF2= NUjvZnlYW0GQR1XS
SCC-25 NVrkNIdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHewfHBKSzVyPUeuNlM1OTRiIN88US=> MYfTRW5ITVJ?
ETK-1 MmPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXreVJKSzVyPUeuNlU2OTRiIN88US=> MVPTRW5ITVJ?
COR-L88 M3zoZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjRTWM2OD15LkK5N|E6KCEQvF2= NY\6R4pYW0GQR1XS
8305C NEHs[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTdwM{K0PVIhKM7:TR?= NHfTdIhUSU6JRWK=
Detroit562 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF33O|dKSzVyPUeuN|I2ODZiIN88US=> NIP4cmtUSU6JRWK=
SNU-449 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTdwM{e2OVEhKM7:TR?= Mn64V2FPT0WU
A704 NE[1cnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTdwM{iyO|ghKM7:TR?= MlLGV2FPT0WU
D-502MG NGrMe2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDpTWM2OD15LkO4OFc{KCEQvF2= MnXmV2FPT0WU
NCI-H2228 NV3kdXRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTdwNEG0OVghKM7:TR?= MXvTRW5ITVJ?
CHP-212 NV30[JliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;6PGlEPTB;Nz61NVg6PiBizszN NILDfVNUSU6JRWK=
VMRC-RCZ NGHkO|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DoNmlEPTB;Nz61PVA3PiBizszN NWTufWpHW0GQR1XS
RPMI-2650 NGTLNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTdwN{CzNVIhKM7:TR?= NHL4U3BUSU6JRWK=
HCC2218 NX;qd4Y2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzVcWhvUUN3ME23MlczOjV6IDFOwG0> M2fMZnNCVkeHUh?=
GCT MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXXTWM2OD15LkiyNVczKCEQvF2= MVzTRW5ITVJ?
SW780 MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjpbWZRUUN3ME23Mlk6ODZiIN88US=> NHfONGRUSU6JRWK=
KMOE-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HiOmlEPTB;OD6wOFA4KCEQvF2= M{W0bnNCVkeHUh?=
KYSE-180 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzNdlNKSzVyPUiuNFg3PDhiIN88US=> Mmr6V2FPT0WU
TE-1 Ml\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRThwMUGwOVchKM7:TR?= NInpc5dUSU6JRWK=
OAW-42 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;hTWM2OD16LkK1OFk3KCEQvF2= Mn[wV2FPT0WU
VM-CUB-1 M{XDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjXXIFOUUN3ME24MlI5OzZ2IDFOwG0> MXTTRW5ITVJ?
ECC10 M{Ls[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rrdmlEPTB;OD6yPFM6PyBizszN Ml;tV2FPT0WU
SW1573 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS3U5ZKSzVyPUiuOFQ1PjViIN88US=> M1faV3NCVkeHUh?=
NCI-H1299 MlXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlyyTWM2OD16LkW5O|c1KCEQvF2= NIDhNJhUSU6JRWK=
ALL-PO MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1frUmlEPTB;OD62OlU6PyBizszN MXPTRW5ITVJ?
OVCAR-5 NFqzcHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnYcmplUUN3ME24Mlc4PjJ3IDFOwG0> NHLoRopUSU6JRWK=
NCI-SNU-5 M3K2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRThwOEOwNFEhKM7:TR?= NIXGO|VUSU6JRWK=
NCI-H2342 NFXRPFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjwZ2k3UUN3ME24Mlg{OTBzIDFOwG0> M2PubXNCVkeHUh?=
RPMI-7951 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPpTWM2OD16Lki0NVU4KCEQvF2= MnHsV2FPT0WU
RCM-1 NWe2PIdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX3dJhoUUN3ME25MlA5OTR3IDFOwG0> NWnkdWpKW0GQR1XS
Daoy NEHwZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XvXGlEPTB;OT6xNlAzQCBizszN NIPXc21USU6JRWK=
HCC1395 Mn;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfy[YtKSzVyPUmuN|A5QTZiIN88US=> MorlV2FPT0WU
786-0 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTlwM{[wNlYhKM7:TR?= MWjTRW5ITVJ?
GAMG M1fiemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDHVmVzUUN3ME25MlY2PTN2IDFOwG0> MlzBV2FPT0WU
HCC1954 M3;RPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPBcXc1UUN3ME25Mlg2QDV7IDFOwG0> MmDFV2FPT0WU
NCI-H1838 NE\xWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vRbWlEPTB;OT65NFM4OSBizszN MYLTRW5ITVJ?
SW620 NVvTUHBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH1[|VKSzVyPUmuPVU{PTdiIN88US=> MoLVV2FPT0WU
NCI-H358 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFyLkSxPVchKM7:TR?= NH;vbZFUSU6JRWK=
NCI-H1793 MoTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDiUFBKSzVyPUGwMlQzPDhiIN88US=> NYX6SpdmW0GQR1XS
NCI-H1666 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXzTWM2OD1zMD60N|U2KCEQvF2= NYDxXHk2W0GQR1XS
MZ7-mel MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFyLkS3OVMhKM7:TR?= MnLMV2FPT0WU
MDA-MB-175-VII NIHzWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\sbYlKSzVyPUGwMlY{QTZiIN88US=> NGrNcmtUSU6JRWK=
COLO-829 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLNNZpjUUN3ME2xNE45ODB2IDFOwG0> M1;BTXNCVkeHUh?=
RVH-421 M{\adGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLXTWM2OD1zMT6xOVIhKM7:TR?= MX\TRW5ITVJ?
A549 NETVeYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDIbmFKSzVyPUGxMlI1PzhiIN88US=> MnLvV2FPT0WU
DJM-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrJb3FkUUN3ME2xNU4{QDN|IDFOwG0> MWHTRW5ITVJ?
IST-MEL1 NYj6OYc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7wTWM2OD1zMT63N|E6KCEQvF2= NWfJeZIyW0GQR1XS
BEN NUnEfYV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDmPVNCUUN3ME2xNU44PDB{IDFOwG0> MXzTRW5ITVJ?
KM12 NXzqWnQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r1WWlEPTB;MUGuPVA6OSBizszN NUT6cI9iW0GQR1XS
HuO9 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDCTWM2OD1zMj6wOlY3KCEQvF2= MUfTRW5ITVJ?
U-2-OS MmTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF{LkC4PVMhKM7:TR?= MkXzV2FPT0WU
RH-1 MkjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEL0fHNKSzVyPUGyMlQ1PzJiIN88US=> MYXTRW5ITVJ?
NCI-H1048 NFXQdZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\jTWM2OD1zMj61OVA3KCEQvF2= NX\1bpdNW0GQR1XS
Mo-T MmCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS1TWM2OD1zMj63N|A4KCEQvF2= M{DYXnNCVkeHUh?=
KYSE-150 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWwblhHUUN3ME2xNk44PDV3IDFOwG0> M3fn[3NCVkeHUh?=
A388 MofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF{Lke3NVMhKM7:TR?= NWjDUIUyW0GQR1XS
NCI-SNU-1 NIPi[YxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjEcFJKSzVyPUGyMlgxPDZiIN88US=> MmfVV2FPT0WU
HEL MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i0TmlEPTB;MUKuPFIyOiBizszN MnfZV2FPT0WU
UM-UC-3 M4nJcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImyNphKSzVyPUGyMlg5PzRiIN88US=> M3K5W3NCVkeHUh?=
TGBC24TKB NVWxPWZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXZTWM2OD1zMz6wNlY4KCEQvF2= NEn0fZFUSU6JRWK=
SW626 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XXZ2lEPTB;MUOuNlQ5PSBizszN NUjFV|VHW0GQR1XS
ES6 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\B[FRKSzVyPUGzMlI2OTJiIN88US=> MUXTRW5ITVJ?
NCI-H2029 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTpeY9KSzVyPUGzMlgyODhiIN88US=> M1TVRXNCVkeHUh?=
RXF393 M1vxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPiU29KSzVyPUGzMlk6OjdiIN88US=> M4f2e3NCVkeHUh?=
HMV-II MkPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TVVmlEPTB;MUSuNFc5KCEQvF2= MkL5V2FPT0WU
EW-22 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljxTWM2OD1zND6xOVAzKCEQvF2= NWjs[ZFSW0GQR1XS
AsPC-1 MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF2LkW2OEAh|ryP MY\TRW5ITVJ?
COLO-678 NUnVc4xCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;NWGlEPTB;MUSuO|I4OSBizszN NFzVVJhUSU6JRWK=
HCT-15 NFX5c2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;iWpVKSzVyPUG0Mlg5PTViIN88US=> NXXQZXo6W0GQR1XS
HCE-T NWiweVF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTF2Lki4O|QhKM7:TR?= MV;TRW5ITVJ?
SF539 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rIW2lEPTB;MUWuNFY1OyBizszN NXLad3I{W0GQR1XS
AU565 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXr4[3FJUUN3ME2xOU4zODl4IDFOwG0> NF\keY9USU6JRWK=
JVM-2 NHjoOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTF3LkK2PFEhKM7:TR?= MlL3V2FPT0WU
CaR-1 NVrBOYd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTKbpRKSzVyPUG1MlQ1OTJiIN88US=> NILxR2hUSU6JRWK=
23132-87 NV\1T|k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXiTWM2OD1zNT64OFk2KCEQvF2= NYLUWoxCW0GQR1XS
A673 M4XCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m2TGlEPTB;MUWuPVY{PiBizszN NV:0bolCW0GQR1XS
KYSE-410 NVjrXYlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF4LkCyPUAh|ryP NFPMZ4RUSU6JRWK=
TE-9 M1XIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3KRnB7UUN3ME2xOk4xPjJiIN88US=> MXrTRW5ITVJ?
LU-139 NIjyfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfJTWM2OD1zNj6xPFI{KCEQvF2= M4\KcXNCVkeHUh?=
GCIY M3vi[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LENmlEPTB;MU[uNVkyPiBizszN NGO1UYNUSU6JRWK=
JEG-3 M3zONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nWXWlEPTB;MU[uNlUhKM7:TR?= MoH0V2FPT0WU
RT-112 NWPGWnQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDuZY5KSzVyPUG2MlQyPDNiIN88US=> NIfZSlNUSU6JRWK=
COLO-680N MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fkVGlEPTB;MU[uOVExQCBizszN NGSwd41USU6JRWK=
LU-134-A NW\1OXNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTF4Lkm4PVMhKM7:TR?= NUXaNoJKW0GQR1XS
MFM-223 M2j6fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\EUoJKSzVyPUG3MlE2OzViIN88US=> M3nRO3NCVkeHUh?=
SF126 NU\FblM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTF5LkG3NFEhKM7:TR?= MYnTRW5ITVJ?
NCI-H28 NEXoUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX2SFI{UUN3ME2xO{4zODZ4IDFOwG0> MknnV2FPT0WU
BFTC-905 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTF5LkS4N|IhKM7:TR?= MmnBV2FPT0WU
SCC-9 NYHEdVZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnWU4dKSzVyPUG3MlYzQDViIN88US=> MVfTRW5ITVJ?
KNS-62 M4nVdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTF5Lk[2NlkhKM7:TR?= MXPTRW5ITVJ?
Hs-578-T MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLrXWFEUUN3ME2xO{45OTR7IDFOwG0> NUTtcplmW0GQR1XS
D-336MG NHz4UmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz2TWM2OD1zNz64Nlk1KCEQvF2= M4PkUHNCVkeHUh?=
NCI-H82 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X6U2lEPTB;MUiuNFE5OyBizszN M4j6NHNCVkeHUh?=
EFM-19 NYn1eotpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTF6LkC1O|chKM7:TR?= MWLTRW5ITVJ?
TGBC11TKB NX\sRXRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF6LkGwNlEhKM7:TR?= M{jINnNCVkeHUh?=
HEC-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF6LkK5NVghKM7:TR?= Mk\WV2FPT0WU
HuP-T3 NHfkXIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYeyZlRxUUN3ME2xPE42QTJ7IDFOwG0> M2jW[nNCVkeHUh?=
SF268 NFq4XYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzRPFlKSzVyPUG4MlY4ODJiIN88US=> MkfnV2FPT0WU
COLO-792 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjqdFBRUUN3ME2xPE44QTl5IDFOwG0> MmHxV2FPT0WU
HLE MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjiTpF4UUN3ME2xPE45OzNzIDFOwG0> M3;FbnNCVkeHUh?=
A204 NXHI[lI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUCxR4hyUUN3ME2xPE46OTZ2IDFOwG0> MXnTRW5ITVJ?
CAL-72 NHr4XpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm2T2RJUUN3ME2xPU4xQDd5IDFOwG0> MXjTRW5ITVJ?
U031 NGDCVJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvtTGZ5UUN3ME2xPU41QTB7IDFOwG0> MnTWV2FPT0WU
FTC-133 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfRS25YUUN3ME2xPU46OzB2IDFOwG0> Ml\PV2FPT0WU
SK-MEL-28 M1;udmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDZTWM2OD1{MD6zO|YyKCEQvF2= MVzTRW5ITVJ?
KGN MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJyLkS2PVkhKM7:TR?= NGDCdoZUSU6JRWK=
HCC2998 M1r0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36wbGlEPTB;MkGuN|kzPiBizszN MnvWV2FPT0WU
GOTO MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJzLkS4OUAh|ryP M{nzO3NCVkeHUh?=
AGS NUizdnkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXsU2dKSzVyPUKxMlg1PTFiIN88US=> M1PZWnNCVkeHUh?=
EW-13 Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m0XmlEPTB;MkKuNVAzOiBizszN NIHmPFdUSU6JRWK=
P12-ICHIKAWA NIjuNG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3PNJFsUUN3ME2yNk4yPjB|IDFOwG0> NUTEbHNSW0GQR1XS
NCI-H1395 M1:5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFewWFVKSzVyPUKyMlI6ODdiIN88US=> M4ezTXNCVkeHUh?=
A2058 NEWxS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W5ZmlEPTB;MkKuOFM1KCEQvF2= M1;wdHNCVkeHUh?=
SH-4 M2fMSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\wVmE2UUN3ME2yNk44ODR3IDFOwG0> NYLB[I1sW0GQR1XS
DoTc2-4510 NV7IWWczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJ|Lk[0O|IhKM7:TR?= NF21W45USU6JRWK=
MMAC-SF MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HVRWlEPTB;MkOuOlkyOSBizszN M{LTPHNCVkeHUh?=
NCI-H510A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3MTWM2OD1{Mz63PVM6KCEQvF2= MUfTRW5ITVJ?
HDLM-2 M{C5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L5XmlEPTB;MkSuNVQ3KCEQvF2= MY\TRW5ITVJ?
KINGS-1 NY\acWdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzvOVhKSzVyPUK0MlI1OiBizszN NXPZcVhmW0GQR1XS
NCI-H1648 NFPtNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJ2LkSwNlQhKM7:TR?= NYX6N3ZvW0GQR1XS
HCC1187 MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4mxRmlEPTB;MkWuNFI{PSBizszN NULlem1xW0GQR1XS
BALL-1 NUjwWW9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ3LkKwOlIhKM7:TR?= NVrBeZZ7W0GQR1XS
SBC-1 NF7KcmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7XTWM2OD1{NT6yPVk{KCEQvF2= NXz3WmRpW0GQR1XS
BFTC-909 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X5VWlEPTB;MkWuN|U2OSBizszN NWj6bVV1W0GQR1XS
MOLT-13 Mn;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\BR2lEPTB;MkWuOlc1PCBizszN Ml2wV2FPT0WU
SW1990 NWXSe3gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\lSGlEPTB;MkWuPVY2PSBizszN NFLkfFRUSU6JRWK=
DK-MG NXXKbG12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJ4LkC0OFMhKM7:TR?= MkniV2FPT0WU
TE-8 NFnVdmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[0TWM2OD1{Nj6wOlY5KCEQvF2= NV\kR2IyW0GQR1XS
Becker MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPwTWM2OD1{Nj6xOVc1KCEQvF2= MoPHV2FPT0WU
KYSE-70 NHLCbodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonlTWM2OD1{Nj61N|E4KCEQvF2= NVLIZoR{W0GQR1XS
MKN7 NVnGNIZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjKW4JYUUN3ME2yO{44PDd7IDFOwG0> NVHOe4lsW0GQR1XS
D-392MG NYPwb|dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnvTWM2OD1{Nz63Olk1KCEQvF2= NX7Obol4W0GQR1XS
NH-12 M4nkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfBRZlKSzVyPUK4MlEzOjliIN88US=> M3zhZXNCVkeHUh?=
EW-18 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rMdmlEPTB;MkiuNlIyQCBizszN MX;TRW5ITVJ?
LCLC-97TM1 M{PKeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm1bHQ5UUN3ME2yPE4zPzZ{IDFOwG0> MY\TRW5ITVJ?
NCI-H1770 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJ6LkO1OlYhKM7:TR?= NX74bYJFW0GQR1XS
BT-20 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LHOmlEPTB;MkiuN|Y5PSBizszN MYnTRW5ITVJ?
DBTRG-05MG M{fVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJ6LkS4N|ghKM7:TR?= M{HZ[3NCVkeHUh?=
HPAF-II MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJ6Lke3PUAh|ryP NWD3OlM1W0GQR1XS
SW837 MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJ7LkOzPFUhKM7:TR?= MVPTRW5ITVJ?
647-V M325d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrCUJFKSzVyPUK5MlcxODNiIN88US=> NHvLR4RUSU6JRWK=
J82 NF[wZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfROGdKSzVyPUK5MlgxOTNiIN88US=> NIL0XXVUSU6JRWK=
MC116 NVnnN3I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:wXmNKSzVyPUOwMlA4OzNiIN88US=> NXTuclBHW0GQR1XS
NCI-H69 NYHSW2FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G3bmlEPTB;M{CuOlA6OyBizszN NFK4UJBUSU6JRWK=
NB6 MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fXVGlEPTB;M{GuN|YzQSBizszN MomyV2FPT0WU
CAL-120 M{fyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPETWM2OD1|Mj60N|E4KCEQvF2= NH;WeYZUSU6JRWK=
U-87-MG NUfSSHhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml70TWM2OD1|Mz6wNlUyKCEQvF2= NVL1PIxFW0GQR1XS
NCI-H1304 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnoXmFKSzVyPUOzMlA{PTRiIN88US=> Ml;MV2FPT0WU
YH-13 M2fHR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjrdGJYUUN3ME2zN{4zPTN3IDFOwG0> NE\DPGhUSU6JRWK=
RMG-I NYHaSWl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzzNZpKSzVyPUOzMlQzQDViIN88US=> M{Ox[HNCVkeHUh?=
LU-65 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[4TWM2OD1|ND6xOFA5KCEQvF2= NY\yRXdRW0GQR1XS
GB-1 NV;jSYV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPvTWM2OD1|NT6wO|I6KCEQvF2= M3zTXnNCVkeHUh?=
DU-4475 NGTlT4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXFOIZZUUN3ME2zOU4yPTV|IDFOwG0> NUD3bpZyW0GQR1XS
SBC-5 M1fqcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN4LkW5NFIhKM7:TR?= NGrwW|BUSU6JRWK=
OE33 MkXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;4WZFOUUN3ME2zO{44PTd5IDFOwG0> MYjTRW5ITVJ?
C8166 NXK3cYplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHTWGtxUUN3ME2zPE42OjZ5IDFOwG0> NIfI[3pUSU6JRWK=
COLO-684 MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfGTWM2OD1|OD63OFI5KCEQvF2= NIq4WodUSU6JRWK=
NCI-H1155 NIPGZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3eyW2lEPTB;M{muNFQ4OSBizszN MYHTRW5ITVJ?
ATN-1 M2\OWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;JbHJKSzVyPUO5Mlc4QTJiIN88US=> M4XIXnNCVkeHUh?=
KARPAS-299 M1jk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnhSXJpUUN3ME2zPU45OzliIN88US=> NICwc4VUSU6JRWK=
KNS-81-FD MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTRyLkO2NFQhKM7:TR?= Ml7tV2FPT0WU
NCI-H1563 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHPTWM2OD12MT61NFM6KCEQvF2= MnTGV2FPT0WU
NB14 NGK5UppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7IW|JKSzVyPUSyMlczPjNiIN88US=> MXrTRW5ITVJ?
COLO-800 M{S4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX3TWM2OD12Mj64OVE4KCEQvF2= M3;iWHNCVkeHUh?=
MS-1 MnOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDtdXRsUUN3ME20N{4xPDh|IDFOwG0> NFLMepNUSU6JRWK=
OVCAR-8 NHrKSpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXacII{UUN3ME20N{43QDB7IDFOwG0> M2\vdnNCVkeHUh?=
SK-PN-DW MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTR|Lki3O|YhKM7:TR?= NXHCeY9mW0GQR1XS
G-402 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHZTWM2OD12Mz65NFA3KCEQvF2= NYLyN|ZpW0GQR1XS
NCI-H2291 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDYdmRiUUN3ME20OE45ODF5IDFOwG0> NEnBfpVUSU6JRWK=
PC-3 NIH0N2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHiPWdWUUN3ME20OU45ODJ|IDFOwG0> NXj4cpBUW0GQR1XS
NCI-H1581 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjqO25tUUN3ME20OU46QDh7IDFOwG0> M{TDXnNCVkeHUh?=
SW1116 Mor6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL6TWM2OD12Nz6wNVgzKCEQvF2= M3HxfHNCVkeHUh?=
ZR-75-30 NH3hXHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWna[oZjUUN3ME20O{4xOjN7IDFOwG0> NIfKZ5NUSU6JRWK=
OCI-AML2 NX7HWIs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rVbWlEPTB;NEeuNFkyQCBizszN M4fiPHNCVkeHUh?=
MDA-MB-231 NYLxVGxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HoXmlEPTB;NEeuOlI1QSBizszN M1S2bXNCVkeHUh?=
ES3 NVLxZ3V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXNPGFKSzVyPUS4MlM2OjliIN88US=> NELI[FFUSU6JRWK=
NCI-H630 MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDZTWM2OD12OT6xO|QzKCEQvF2= M2jGZnNCVkeHUh?=
OE19 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYizTHM5UUN3ME20PU4zQTB{IDFOwG0> M4LuOXNCVkeHUh?=
NCI-H1573 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTR7Lk[4OlEhKM7:TR?= MkHiV2FPT0WU
EW-1 NGPRR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L4[GlEPTB;NEmuPVA5PCBizszN MonsV2FPT0WU

多くの細胞株試験データを見る場合、クリックしてください

体内試験 Bosutinib (60 mg/kg/day) is active against Src-transformed fibroblasts xenografts and HT29 xenografts in nude mice with T/C of 18% and 30%, respectively. [1] Oral administration of Bosutinib for 5 days significantly suppresses K562 tumor growth in mice in a dose-dependent manner, with the large tumors eradicated at dose of 100 mg/kg and tumor free at 150 mg/kg without overt toxicity. [2] As being inactive against Colo205 xenografts in nude mice at 50 mg/kg twice daily, Bosutinib dosing at 75 mg/kg twice daily is necessary against Colo205 xenografts, and increasing the dose of Bosutinib has no additional benefit, in contrast to the significant dose-dependent ability against HT29 xenografts. [4]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

The Src and Abl kinase assays:

The Src kinase activity is measured in an ELISA format. Src (3 units/reaction), reaction buffer (50 mM Tris-HCl pH 7.5, 10 mM MgCl2, 0.1 mM EGTA, 0.5 mM Na3VO4) and cdc2 substrate peptide are added to various concentration of Bosutinib and incubated at 30 °C for 10 minutes. The reaction is started by the addition of ATP to a final concentration of 100 μM, incubated at 30 °C for 1 hour and stopped by addition of EDTA. Instructions from the manufacturer are followed for subsequent steps. The Abl kinase assay is performed in a DELFIA solid phase europium-based detection assay format. Biotinylated peptide (2 μM) is bound to streptavidin-coated microtitration plates for 1.5 hours in 1 mg/mL ovalbumin in PBS. The plates are washed for 1 hour with PBS/0.1% Tween 80, followed by a PBS wash. The kinase reaction is incubated for 1 hour at 30°C. Abl kinase (10 units) is mixed with 50 mM Tris-HCl (pH 7.5), 10 mM MgCl2, 80 μM EGTA, 100 μM ATP, 0.5 mM Na3VO4, 1% DMSO, 1 mM HEPES (pH 7.0), 200 μg/mL ovalbumin and various concentration of Bosutinib. The reaction is stopped with EDTA at a final concentration of 50 mM. The reaction is monitored with Eu-labeled phosphotyrosine antibody and DELFIA enhancement solution.
細胞試験:

[2]

+ 展開
  • 細胞株: Abl-MLV, Rat 2, KU812, K562, and MEG-01 cells
  • 濃度: Dissolved in DMSO, final concentrations ~1 μM
  • 反応時間: 72 hours
  • 実験の流れ:

    Cells are exposed to various concentrations of Bosutinib for 72 hours. Anchorage-independent proliferation of Abl-MLV-transformed fibroblasts is measured in 96-well ultra-low binding plates treated with Sigmacote to block residual cell attachment. Cell proliferation is measured with MTS or Cell-Glo. For the determination of cell cycle or cell death, cells are prepared for FACS analysis in the CycleTest Plus DNA reagent kit and analyzed on a fluorescence-activated cell sorter flow cytometer.


    (参考用のみ)
動物試験:

[2]

+ 展開
  • 動物モデル: Nude female mice injected with K562 cells
  • 製剤: Suspended in 0.5% methocel/0.4% Tween 80
  • 投薬量: ~150 mg/kg/day
  • 投与方法: Oral gavage
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (188.51 mM)
Ethanol 2 mg/mL (3.77 mM)
Water slightly soluble or insoluble
体内 順序で溶剤を入れること:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 530.45
化学式

C26H29Cl2N5O3

CAS No. 380843-75-4
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03023319 Recruiting Carcinoma, Non-Small-Cell Lung|Mesothelioma|Bladder Cancer|Ovarian Cancer|Peritoneal Cancer|Thymoma|Thymus Cancer|Uterine Cervical Cancer Nagla Karim|University of Cincinnati January 2017 Phase 1
NCT02810990 Recruiting Chronic Myeloid Leukemia Gruppo Italiano Malattie EMatologiche dellAdulto November 2016 Phase 2
NCT02906696 Recruiting Chronic Myelogenous Leukemia M.D. Anderson Cancer Center|Pfizer October 2016 Phase 2
NCT02782403 Not yet recruiting Leukemia M.D. Anderson Cancer Center|Pfizer September 2016 Phase 1|Phase 2
NCT02921477 Enrolling by invitation Mild Cognitive Impairment|Dementia Neurological Associates of West Los Angeles|Pfizer September 2016 Phase 1
NCT02693535 Recruiting Lymphoma, Non-Hodgkin|Multiple Myeloma|Advanced Solid Tumors American Society of Clinical Oncology|AstraZeneca|Bayer|Bristol-Myers Squibb|Eli Lilly and Company|Genentech, Inc.|Merck Sharp & Dohme Corp.|Pfizer March 2016 Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Can I give S1014 Bosutinib to mice by oral gavage? If so, how to dissolve the drug?

  • 回答:

    For oral gavage, S1014 Bosutinib can be dissolved in 5% Tween 80+0.5% CMC Na at 30 mg/ml as a suspension.

Src信号経路図

Src Inhibitors with Unique Features

相関Src製品

Tags: Bosutinib (SKI-606)を買う | Bosutinib (SKI-606) ic50 | Bosutinib (SKI-606)供給者 | Bosutinib (SKI-606)を購入する | Bosutinib (SKI-606)費用 | Bosutinib (SKI-606)生産者 | オーダーBosutinib (SKI-606) | Bosutinib (SKI-606)化学構造 | Bosutinib (SKI-606)分子量 | Bosutinib (SKI-606)代理店
×
細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID