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阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
水 DMSO アルコール
S2695 Nepicastat (SYN-117) HCl <1 mg/mL 66 mg/mL <1 mg/mL
S4130 Mildronate 29 mg/mL <1 mg/mL 29 mg/mL
S4586 4-Chloro-DL-phenylalanine <1 mg/mL 2 mg/mL <1 mg/mL
S7456 LCI699 15 mg/mL 45 mg/mL 45 mg/mL
S5797 Metyrosine 2 mg/mL <1 mg/mL <1 mg/mL
S6109 H-HoArg-OH 37 mg/mL <1 mg/mL -1 mg/mL
S4926 (R)-Nepicastat HCl <1 mg/mL 66 mg/mL <1 mg/mL
S8172 Ro 61-8048 <1 mg/mL 84 mg/mL <1 mg/mL
S7483 DMOG 35 mg/mL 35 mg/mL 35 mg/mL
S2173 LX 1606 hippurate <1 mg/mL 100 mg/mL <1 mg/mL
S2367 Tetrahydropapaverine HCl 76 mg/mL 7 mg/mL <1 mg/mL
S1379 Isotretinoin <1 mg/mL 60 mg/mL <1 mg/mL
S9568 Sapropterin Dihydrochloride -1 mg/mL 63 mg/mL -1 mg/mL

Hydroxylase製品

新Hydroxylase製品
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2695

Nepicastat (SYN-117) HCl

Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.
S4130

Mildronate

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
S4586

4-Chloro-DL-phenylalanine

4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.
S7456

LCI699

LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase, an enzyme catalyzing the final step of cortisol synthesis.
S5797新

Metyrosine
S6109新

H-HoArg-OH

H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.
S4926

(R)-Nepicastat HCl

(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
S8172

Ro 61-8048

Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.
S7483

DMOG

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.
Virology, 2019, 530:51-58
Hepatology, 2018, 68(6):2359-2375
J Cell Mol Med, 2018, 22(9):4507-4521
S2173

LX 1606 hippurate

Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.
S2367

Tetrahydropapaverine HCl

Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons.
S1379

Isotretinoin

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
S9568新

Sapropterin Dihydrochloride

Sapropterin Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator.
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2695

Nepicastat (SYN-117) HCl

Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.
S4130

Mildronate

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
S4586

4-Chloro-DL-phenylalanine

4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.
S7456

LCI699

LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase, an enzyme catalyzing the final step of cortisol synthesis.
S5797新

Metyrosine
S6109新

H-HoArg-OH

H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.
S4926

(R)-Nepicastat HCl

(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
S8172

Ro 61-8048

Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.
S7483

DMOG

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.
Virology, 2019, 530:51-58
Hepatology, 2018, 68(6):2359-2375
J Cell Mol Med, 2018, 22(9):4507-4521
S2173

LX 1606 hippurate

Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.
S2367

Tetrahydropapaverine HCl

Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons.
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1379

Isotretinoin

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
S9568新

Sapropterin Dihydrochloride

Sapropterin Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator.
Tags: Hydroxylase activity | Dopamine-β-Hydroxylase activity | Hydroxylase inhibitor review