アロマターゼ

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1188	Anastrozole	<1 mg/mL	59 mg/mL	59 mg/mL
S1196	Exemestane	<1 mg/mL	54 mg/mL	15 mg/mL
S2208	Formestane	<1 mg/mL	61 mg/mL	<1 mg/mL
S1672	Aminoglutethimide	<1 mg/mL	20 mg/mL	7 mg/mL
S5158	alpha-Naphthoflavone	-1 mg/mL	31 mg/mL	-1 mg/mL
S3784	Obacunone	-1 mg/mL	90 mg/mL	-1 mg/mL

Aromatase製品

All (6) Aromatase阻害剤(6) 新Aromatase製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1188	Anastrozole Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.	Biosens Bioelectron, 2016, 87:600-606 Int J Oncol, 2015, 46(4):1481-90 Oncotarget, 2016, 7(34):54157-54173	Cell viability analysis of BCSCs transduced as in A and treated with Anastrozole or Docetaxel, alone or in combination with BKM120 up to 72 hours. Data are mean ± SD of 3 independent experiments.
S1196	Exemestane Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.	Cell Physiol Biochem, 2017, 42(1):1-12 Drug Metab Dispos, 2012, 40(7):1268-78 Breast Cancer Res Tr, 2015, 149(3):715-26	Effect of exemestane on phosphatidylserine exposure. A. Original histogram of annexin-V-binding of erythrocytes following exposure for 48 hours to Ringer solution without (grey area) and with (black line) presence of 40 µg/ml exemestane. B. Arithmetic means ± SEM (n = 24) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) exemestane (10-40 µg/ml). For comparison, the effect of the solvent DMSO is shown (grey bar). (p<0.01),*(p<0.001) indicates significant difference from the absence of exemestane (ANOVA).
S2208	Formestane Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM.
S1672	Aminoglutethimide Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM.
S5158^新	alpha-Naphthoflavone Alpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
S3784	Obacunone Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1188	Anastrozole Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.	Biosens Bioelectron, 2016, 87:600-606 Int J Oncol, 2015, 46(4):1481-90 Oncotarget, 2016, 7(34):54157-54173	Cell viability analysis of BCSCs transduced as in A and treated with Anastrozole or Docetaxel, alone or in combination with BKM120 up to 72 hours. Data are mean ± SD of 3 independent experiments.
S1196	Exemestane Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.	Cell Physiol Biochem, 2017, 42(1):1-12 Drug Metab Dispos, 2012, 40(7):1268-78 Breast Cancer Res Tr, 2015, 149(3):715-26	Effect of exemestane on phosphatidylserine exposure. A. Original histogram of annexin-V-binding of erythrocytes following exposure for 48 hours to Ringer solution without (grey area) and with (black line) presence of 40 µg/ml exemestane. B. Arithmetic means ± SEM (n = 24) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) exemestane (10-40 µg/ml). For comparison, the effect of the solvent DMSO is shown (grey bar). (p<0.01),*(p<0.001) indicates significant difference from the absence of exemestane (ANOVA).
S2208	Formestane Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM.
S1672	Aminoglutethimide Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM.
S5158^新	alpha-Naphthoflavone Alpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
S3784	Obacunone Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

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