アロマターゼ
シグナル伝達経路
研究分野
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1196 | Exemestane | <1 mg/mL | 54 mg/mL | 15 mg/mL |
| S2208 | Formestane | <1 mg/mL | 61 mg/mL | <1 mg/mL |
| S1672 | Aminoglutethimide | <1 mg/mL | 20 mg/mL | 7 mg/mL |
| S5158 | alpha-Naphthoflavone | -1 mg/mL | 31 mg/mL | -1 mg/mL |
| S3784 | Obacunone | -1 mg/mL | 90 mg/mL | -1 mg/mL |
- Aromatase阻害剤(5)
- 新Aromatase製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1196 |
ExemestaneExemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively. |
Effect of exemestane on phosphatidylserine exposure. A. Original histogram of annexin-V-binding of erythrocytes following exposure for 48 hours to Ringer solution without (grey area) and with (black line) presence of 40 µg/ml exemestane. B. Arithmetic means ± SEM (n = 24) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) exemestane (10-40 µg/ml). For comparison, the effect of the solvent DMSO is shown (grey bar). **(p<0.01),***(p<0.001) indicates significant difference from the absence of exemestane (ANOVA).
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| S2208 |
FormestaneFormestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM. |
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| S1672 |
AminoglutethimideAminoglutethimide is an aromatase inhibitor with IC50 of 10 μM. |
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| S5158新 |
alpha-NaphthoflavoneAlpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM. |
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| S3784新 |
ObacunoneObacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2. |
