Glutaminase

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S7655	CB-839	<1 mg/mL	100 mg/mL	<1 mg/mL
S7753	BPTES	<1 mg/mL	100 mg/mL	<1 mg/mL
S8778	UPGL00004	<1 mg/mL	25 mg/mL	<1 mg/mL
S6417	GK921	-1 mg/mL	33 mg/mL	-1 mg/mL
S8891	JHU-083	62 mg/mL	62 mg/mL	62 mg/mL

Glutaminase製品

All (5) Glutaminase阻害剤(4) Glutaminase拮抗剤(1) 新Glutaminase製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7655	CB-839 CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Phase 1.	Cancer Cell, 2019, 36(2):179-193 Cell, 2019, 36(2):179-193 Cell Metab, 2019, 29(1):156-173	Apoptotic sensitivity of K562 resistant (E) cells exposed to A1331852 (10 nM) for 4 h was restored following pharmacological inhibition of glutamine uptake or metabolism with GPNA (5 mM) for 48 h, CB-839 (10 μM) for 72 h, azaserine (25 μM) for 16 h and AOA (500 μM) for 24 h but not with EGCG (50 μM) for 24 h. Western blots confirmed the knockdown efficiency of the different siRNAs. *P<0.001, P<0.01; Error bars = Mean ± SEM (n=3).
S7753	BPTES BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.	Nat Commun, 2019, 10(1):3856 Autophagy, 2019, 15(7):1258-1279 Autophagy, 2019, 15(7):1258-1279	Glu-dependent associates with sensitivity to glycolytic inhibitors 3-BrPA (left) and GLN-addicted associates with sensitivity to glutaminolytic inhibitors BPTEs.
S8778	UPGL00004 UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.
S6417^新	GK921 GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition.
S8891^新	JHU-083 JHU-083 is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b⁺ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7655	CB-839 CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Phase 1.	Cancer Cell, 2019, 36(2):179-193 Cell, 2019, 36(2):179-193 Cell Metab, 2019, 29(1):156-173	Apoptotic sensitivity of K562 resistant (E) cells exposed to A1331852 (10 nM) for 4 h was restored following pharmacological inhibition of glutamine uptake or metabolism with GPNA (5 mM) for 48 h, CB-839 (10 μM) for 72 h, azaserine (25 μM) for 16 h and AOA (500 μM) for 24 h but not with EGCG (50 μM) for 24 h. Western blots confirmed the knockdown efficiency of the different siRNAs. *P<0.001, P<0.01; Error bars = Mean ± SEM (n=3).
S7753	BPTES BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.	Nat Commun, 2019, 10(1):3856 Autophagy, 2019, 15(7):1258-1279 Autophagy, 2019, 15(7):1258-1279	Glu-dependent associates with sensitivity to glycolytic inhibitors 3-BrPA (left) and GLN-addicted associates with sensitivity to glutaminolytic inhibitors BPTEs.
S8778	UPGL00004 UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.
S6417^新	GK921 GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S8891^新	JHU-083 JHU-083 is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b⁺ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S8891^新

JHU-083

JHU-083 is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b⁺ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

研究分野別

製品類型

Glutaminase

阻害剤の選択性比較

Glutaminase製品

CB-839

BPTES

UPGL00004

GK921

JHU-083

CB-839

BPTES

UPGL00004

GK921

JHU-083