Guanylate Cyclase

Guanylate Cyclase製品

All (11)
Guanylate Cyclase阻害剤 (4)
Guanylate Cyclase活性剤(1)
Guanylate Cyclase作動薬(3)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S7958	Lificiguat (YC-1)	Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).	J Transl Med, 2024, 22(1):248 Hepatol Commun, 2024, 8(1)e0350 BMC Cardiovasc Disord, 2024, 24(1):183
S8135	Riociguat	Riociguat is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.	J Exp Med, 2023, 220(2)e20211422 Open Biol, 2022, 12(8):220058 Hepatology, 2021, 10.1002/hep.31987
S4535	Methylene Blue	Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.	Cell Res, 2023, 10.1038/s41422-023-00846-8 bioRxiv, 2020, 2020/9/20.4.7.30734
S9796	ODQ	ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells.	J Ethnopharmacol, 2023, 300:115705
S9693	Vericiguat	Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.
S8128	BAY 41-2272	BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
D4009^New	Indusatumab vedotin	Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate (ADC) composed of an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody and a anti-mitotic cytotoxic agent, monomethyl auristatin E (MMAE).
S5229	Isosorbide dinitrate	Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).
S8135	Riociguat	Riociguat is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.	J Exp Med, 2023, 220(2)e20211422 Open Biol, 2022, 12(8):220058 Hepatology, 2021, 10.1002/hep.31987
S9693	Vericiguat	Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.
S8128	BAY 41-2272	BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
S7958	Lificiguat (YC-1)	Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).	J Transl Med, 2024, 22(1):248 Hepatol Commun, 2024, 8(1)e0350 BMC Cardiovasc Disord, 2024, 24(1):183
S4535	Methylene Blue	Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.	Cell Res, 2023, 10.1038/s41422-023-00846-8 bioRxiv, 2020, 2020/9/20.4.7.30734
S9796	ODQ	ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells.	J Ethnopharmacol, 2023, 300:115705
D4009^New	Indusatumab vedotin	Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate (ADC) composed of an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody and a anti-mitotic cytotoxic agent, monomethyl auristatin E (MMAE).
S5229	Isosorbide dinitrate	Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).
S8135	Riociguat	Riociguat is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.	J Exp Med, 2023, 220(2)e20211422 Open Biol, 2022, 12(8):220058 Hepatology, 2021, 10.1002/hep.31987
S9693	Vericiguat	Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.
S8128	BAY 41-2272	BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
D4009^New	Indusatumab vedotin	Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate (ADC) composed of an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody and a anti-mitotic cytotoxic agent, monomethyl auristatin E (MMAE).

Guanylate Cyclase阻害剤の選択性比較