OX Receptor

亜型選択性的な製品

OX Receptor製品

• All (9)
• OX Receptor拮抗剤(7)
• OX Receptor作動薬(1)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2160	Almorexant HCl	Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.	J Adv Res, 2024, S2090-1232(24)00359-X bioRxiv, 2024, 2024.07.06.602357 Cell Rep, 2022, 40(5):111153
S7585	SB-334867	SB-334867 is a selective orexin-1 (OX1) receptor antagonist.	J Pharmacol Exp Ther, 2025, 392(7):103624 J Neuroinflammation, 2020, 17(1):187 Med Sci Monit, 2019, 25:2886-2895
S1545	SB408124	SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.	Nat Chem Biol, 2017, 13(2):235-242
E0107	EMPA	EMPA is a selective OX2 receptor antagonist and binds to human and rat OX2-HEK293 membranes with Kd values of 1.1 and 1.4 nM respectively.	Eur Heart J, 2024, 31:ehae472. Oxid Med Cell Longev, 2022, 2022:1122494
S3503New	Seltorexant	Seltorexant (JNJ-42847922) is a potent and selective antagonist of the orexin-2 receptor (OX2R) exhibiting strong affinity (pKi ~8.0) for human OX2R. It promotes sleep onset and demonstrates antidepressant effects in major depressive disorder (MDD) patients with insomnia by blocking hyperarousal linked to depression and sleep disturbance.
E4740	Oveporexton (TAK-861)	Oveporexton (TAK-861) is a potent, orally bioavailable agonist of orexin receptor 2 (OX2R), with an EC50 of 2.5 nM in calcium mobilization assays. It induces dose-dependent membrane depolarization in histaminergic neurons within the mouse tuberomammillary nucleus (TMN) with an EC50 of 31.7 nM.
S6726	MK1064	MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM.
S6717	TCS-OX2-29	TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).	J Pharmacol Exp Ther, 2025, 392(7):103624
E4740	Oveporexton (TAK-861)	Oveporexton (TAK-861) is a potent, orally bioavailable agonist of orexin receptor 2 (OX2R), with an EC50 of 2.5 nM in calcium mobilization assays. It induces dose-dependent membrane depolarization in histaminergic neurons within the mouse tuberomammillary nucleus (TMN) with an EC50 of 31.7 nM.
S2160	Almorexant HCl	Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.	J Adv Res, 2024, S2090-1232(24)00359-X bioRxiv, 2024, 2024.07.06.602357 Cell Rep, 2022, 40(5):111153
S7585	SB-334867	SB-334867 is a selective orexin-1 (OX1) receptor antagonist.	J Pharmacol Exp Ther, 2025, 392(7):103624 J Neuroinflammation, 2020, 17(1):187 Med Sci Monit, 2019, 25:2886-2895
S1545	SB408124	SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.	Nat Chem Biol, 2017, 13(2):235-242
E0107	EMPA	EMPA is a selective OX2 receptor antagonist and binds to human and rat OX2-HEK293 membranes with Kd values of 1.1 and 1.4 nM respectively.	Eur Heart J, 2024, 31:ehae472. Oxid Med Cell Longev, 2022, 2022:1122494
S3503New	Seltorexant	Seltorexant (JNJ-42847922) is a potent and selective antagonist of the orexin-2 receptor (OX2R) exhibiting strong affinity (pKi ~8.0) for human OX2R. It promotes sleep onset and demonstrates antidepressant effects in major depressive disorder (MDD) patients with insomnia by blocking hyperarousal linked to depression and sleep disturbance.
S6726	MK1064	MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM.
S6717	TCS-OX2-29	TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).	J Pharmacol Exp Ther, 2025, 392(7):103624
E4740	Oveporexton (TAK-861)	Oveporexton (TAK-861) is a potent, orally bioavailable agonist of orexin receptor 2 (OX2R), with an EC50 of 2.5 nM in calcium mobilization assays. It induces dose-dependent membrane depolarization in histaminergic neurons within the mouse tuberomammillary nucleus (TMN) with an EC50 of 31.7 nM.
S3503New	Seltorexant	Seltorexant (JNJ-42847922) is a potent and selective antagonist of the orexin-2 receptor (OX2R) exhibiting strong affinity (pKi ~8.0) for human OX2R. It promotes sleep onset and demonstrates antidepressant effects in major depressive disorder (MDD) patients with insomnia by blocking hyperarousal linked to depression and sleep disturbance.

OX Receptorシグナル伝達経路