OX受容体

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7585 SB-334867 <1 mg/mL 63 mg/mL 3 mg/mL
S1545 SB408124 <1 mg/mL 36 mg/mL <1 mg/mL
S2160 Almorexant HCl <1 mg/mL 72 mg/mL 51 mg/mL
S6717 TCS-OX2-29 <1 mg/mL 87 mg/mL 44 mg/mL

亜型選択性的な製品

OX Receptor製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7585

SB-334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

S1545

SB408124

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

S2160

Almorexant HCl

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

S6717

TCS-OX2-29

TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7585

SB-334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

2020, 17(1):187

2019, 25:2886-2895

S1545

SB408124

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

2017, 13(2):235-242

S2160

Almorexant HCl

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

2020, 31(11):107779

2017, 312(4):H808-H817

2016, 358(3):492-501

S6717

TCS-OX2-29

TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).