P-gp

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S8028 Tariquidar <1 mg/mL 52 mg/mL '<1 mg/mL
S4202 Verapamil HCl 50 mg/mL 98 mg/mL '12 mg/mL
S7772 Elacridar (GF120918) <1 mg/mL 8 mg/mL <1 mg/mL
S3600 Schisandrin B (Sch B) <1 mg/mL 80 mg/mL 10 mg/mL
S3235 Sinapine -1 mg/mL 100 mg/mL ''-1 mg/mL
S4746 (20S)-Protopanaxadiol <1 mg/mL 92 mg/mL 33 mg/mL
S7124 SC144 <1 mg/mL 28 mg/mL <1 mg/mL
S9563 Evodine -1 mg/mL 66 mg/mL -1 mg/mL
S9145 Solamargine -1 mg/mL 100 mg/mL -1 mg/mL
S1481 Zosuquidar (LY335979) 3HCl 23 mg/mL 100 mg/mL '<1 mg/mL
S6579 RCGD423 <1 mg/mL 66 mg/mL 32 mg/mL
S9201 Levistilide A -1 mg/mL 76 mg/mL -1 mg/mL
S4662 Atazanavir <1 mg/mL 71 mg/mL '32 mg/mL

P-gp製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8028

Tariquidar

Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.

S4202

Verapamil HCl

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.

S7772

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

S3600

Schisandrin B (Sch B)

Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.

S3235

Sinapine

Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.

S4746

(20S)-Protopanaxadiol

20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng.

S7124

SC144

SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.

S9563

Evodine

Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia.

S9145

Solamargine

Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.

S1481

Zosuquidar (LY335979) 3HCl

Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.

S6579

RCGD423

RCGD-423 is a modulator of gp130 signalling that regulates cartilage growth and differentiation.

S9201

Levistilide A

Levistilide A, a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.

S4662

Atazanavir

Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8028

Tariquidar

Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.

S4202

Verapamil HCl

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.

S7772

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

S3600

Schisandrin B (Sch B)

Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.

S3235

Sinapine

Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.

S4746

(20S)-Protopanaxadiol

20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng.

S7124

SC144

SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.

S9563

Evodine

Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia.

S9145

Solamargine

Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1481

Zosuquidar (LY335979) 3HCl

Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.

2020, 2;12(3) pii: E577

2020, 12;14:1799-1811

2019, 60(6):1078-1086

S6579

RCGD423

RCGD-423 is a modulator of gp130 signalling that regulates cartilage growth and differentiation.

S9201

Levistilide A

Levistilide A, a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.

S4662

Atazanavir

Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.

2020, AAC.00872-20

2019, 10(6):419

2019, 39(7):3757-3765