P-gp

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S8028 Tariquidar <1 mg/mL 52 mg/mL <1 mg/mL
S7772 Elacridar (GF120918) <1 mg/mL 8 mg/mL <1 mg/mL
S3600 Schisandrin B (Sch B) <1 mg/mL 80 mg/mL 10 mg/mL
S7124 SC144 <1 mg/mL 28 mg/mL <1 mg/mL
S9145 Solamargine -1 mg/mL 100 mg/mL -1 mg/mL
S1481 Zosuquidar (LY335979) 3HCl 23 mg/mL 100 mg/mL <1 mg/mL
S6579 RCGD423 <1 mg/mL 66 mg/mL 32 mg/mL
S9201 Levistilide A -1 mg/mL 76 mg/mL -1 mg/mL

P-gp製品

新P-gp製品
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8028

Tariquidar

Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.

S7772

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

S3600

Schisandrin B (Sch B)

Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.

S7124

SC144

SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.

S9145

Solamargine

Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.

S1481

Zosuquidar (LY335979) 3HCl

Zosuquidar (LY335979) 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.

S6579

RCGD423

RCGD-423 is a modulator of gp130 signalling that regulates cartilage growth and differentiation.

S9201

Levistilide A

Levistilide A, a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8028

Tariquidar

Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.

S7772

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

S3600

Schisandrin B (Sch B)

Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.

S7124

SC144

SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.

S9145

Solamargine

Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1481

Zosuquidar (LY335979) 3HCl

Zosuquidar (LY335979) 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.

2019, 60(6):1078-1086

2019, 54:33-40

2019, 514(4):1154-1159

S6579

RCGD423

RCGD-423 is a modulator of gp130 signalling that regulates cartilage growth and differentiation.

S9201

Levistilide A

Levistilide A, a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.