PTEN
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S7310 | SF1670 | <1 mg/mL | 29 mg/mL | 1 mg/mL |
| S8651 | bpV (HOpic) | 69 mg/mL | <1 mg/mL | '<1 mg/mL |
| S8174 | VO-Ohpic trihydrate | <1 mg/mL | 72 mg/mL | <1 mg/mL |
| S9190 | Oroxin B | -1 mg/mL | 100 mg/mL | -1 mg/mL |
| S0918 | Ginkgolic acid C17:1 | <1 mg/mL | 75 mg/mL | '''''75 mg/mL |
PTEN製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S7310 |
SF1670SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM. |
A、total of 1.5 μM PTEN inhibitor SF1670 inhibited the expression of PTEN and decreased the level of CD11b
|
|
| S8651 |
bpV (HOpic)bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively. |
||
| S8174 |
VO-Ohpic trihydrateVO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM. |
||
| S9190 |
Oroxin BOroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment. |
||
| S0918 |
Ginkgolic acid C17:1Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S7310 |
SF1670SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM. |
A、total of 1.5 μM PTEN inhibitor SF1670 inhibited the expression of PTEN and decreased the level of CD11b
|
|
| S8651 |
bpV (HOpic)bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively. |
||
| S8174 |
VO-Ohpic trihydrateVO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S9190 |
Oroxin BOroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment. |
2022, 12(2):910-928 2021, 12(7):2140-2150 |
|
| S0918 |
Ginkgolic acid C17:1Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells. |
