SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.
Adiponectin (APN) combined with SF1670 promotes osteogenesis of human bone marrow stromal cells (hBMSCs). Cells were cultured in proliferation medium (PM) and osteoinduction conditioned medium (OM). The expression of osteogenic differentiation-related genes in hBMSCs cultured in OM with 1.0 μg/mL APN combined with 5 μM SF1670 at day 7 (a, b) and day 14 (c, d).
bpV (HOpic) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.
VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.