RAAS

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S2199	Aliskiren Hemifumarate	100 mg/mL	100 mg/mL	100 mg/mL
S1657	Enalaprilat Dihydrate	<1 mg/mL	70 mg/mL	<1 mg/mL
S1506	Perindopril Erbumine	88 mg/mL	<1 mg/mL	88 mg/mL
S1793	Ramipril	<1 mg/mL	83 mg/mL	83 mg/mL
S2488	VTP-27999 TFA	100 mg/mL	100 mg/mL	100 mg/mL
S1941	Enalapril Maleate	<1 mg/mL	99 mg/mL	4 mg/mL
S2051	Captopril	2 mg/mL	43 mg/mL	43 mg/mL
S2076	Lisinopril dihydrate	20 mg/mL	<1 mg/mL	<1 mg/mL
S2079	Moexipril HCl	<1 mg/mL	20 mg/mL	<1 mg/mL
S2581	Quinapril HCl	95 mg/mL	18 mg/mL	95 mg/mL
S2099	Temocapril HCl	<1 mg/mL	103 mg/mL	103 mg/mL
S2100	Temocapril	<1 mg/mL	95 mg/mL	95 mg/mL
S2109	Imidapril HCl	54 mg/mL	88 mg/mL	29 mg/mL
S7382	Phosphoramidon Disodium Salt	100 mg/mL	100 mg/mL	<1 mg/mL
S5767	Aliskiren	6 mg/mL	100 mg/mL	100 mg/mL
S5728	Delapril Hydrochloride	<1 mg/mL	98 mg/mL	25 mg/mL
S5712	Zofenopril calcium	<1 mg/mL	5.33 mg/mL	<1 mg/mL
S5938	Benazepril	<1 mg/mL	85 mg/mL	85 mg/mL
S7678	Sacubitril/valsartan (LCZ696)	100 mg/mL	30 mg/mL	9 mg/mL
S6468	Trandolapril	<1 mg/mL	86 mg/mL	43 mg/mL
S2095	Fosinopril Sodium	117 mg/mL	<1 mg/mL	4 mg/mL
S1284	Benazepril HCl	19 mg/mL	92 mg/mL	92 mg/mL

亜型選択性的な製品

RAAS製品

All (22) RAAS阻害剤(21) RAASモジュレータ(1)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2199	Aliskiren Hemifumarate Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.	Kidney Int, 2018, 94(4):689-700 J Physiol, 2018, 596(15):3217-3232
S1657	Enalaprilat Dihydrate Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.	Proteomics, 2019, 19(4):e1800288 Drug Metab Dispos, 2017, 45(11):1149-1155 Drug Metab Dispos, 2016, 44(4):554-9
S1506	Perindopril Erbumine Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.
S1793	Ramipril Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
S2488^新	VTP-27999 TFA VTP-27999 TFA is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.
S1941	Enalapril Maleate Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
S2051	Captopril Captopril (SQ 14225) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.	Drug Metab Dispos, 2020, 48(8):613-621 J Cancer Res Clin Oncol, 2019, 145(6):1495-1507
S2076	Lisinopril dihydrate Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
S2079	Moexipril HCl Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.
S2581	Quinapril HCl Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
S2099	Temocapril HCl Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8
S2100	Temocapril Temocapril (CS-622) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S2109	Imidapril HCl Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
S7382	Phosphoramidon Disodium Salt Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.
S5767	Aliskiren Aliskiren is a renin inhibitor with antihypertensive activity.	Angiogenesis, 2017, 20(1):175-181 Am J Physiol Heart Circ Physiol, 2016, 311(3):H849-54
S5728	Delapril Hydrochloride Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
S5712	Zofenopril calcium Zofenopril calcium is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.
S5938	Benazepril Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure.
S7678	Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.	J Mol Cell Cardiol, 2017, 108:138-148 RSC Adv, 2017, 10.1039/C7RA01404J	Histological analysis staining of three groups. (a) Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×200). (b) Masson staining of three groups (original magnification ×200). Collagen content (%) of heart tissues were presented as fibrosis (**P < 0.001, n = 7 per group). (c) Cardiac section of three group mice hearts stained with WGA (original magnification ×400) (P < 0.05, n = 7 per group). (d) The expression of Drp1 significantly increased in DOX group (*P < 0.001, n = 7 per group) and it decreased in DOX + LCZ696 group (P < 0.01, n = 7 per group).
S6468	Trandolapril Trandolapril is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
S2095	Fosinopril Sodium Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
S1284	Benazepril HCl Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.	Mol Pharm, 2015, 12(9):3399-407

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2199	Aliskiren Hemifumarate Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.	Kidney Int, 2018, 94(4):689-700 J Physiol, 2018, 596(15):3217-3232
S1657	Enalaprilat Dihydrate Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.	Proteomics, 2019, 19(4):e1800288 Drug Metab Dispos, 2017, 45(11):1149-1155 Drug Metab Dispos, 2016, 44(4):554-9
S1506	Perindopril Erbumine Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.
S1793	Ramipril Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
S2488^新	VTP-27999 TFA VTP-27999 TFA is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.
S1941	Enalapril Maleate Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
S2051	Captopril Captopril (SQ 14225) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.	Drug Metab Dispos, 2020, 48(8):613-621 J Cancer Res Clin Oncol, 2019, 145(6):1495-1507
S2076	Lisinopril dihydrate Lisinopril dihydrate is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
S2079	Moexipril HCl Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.
S2581	Quinapril HCl Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
S2099	Temocapril HCl Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8
S2100	Temocapril Temocapril (CS-622) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S2109	Imidapril HCl Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
S7382	Phosphoramidon Disodium Salt Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.
S5767	Aliskiren Aliskiren is a renin inhibitor with antihypertensive activity.	Angiogenesis, 2017, 20(1):175-181 Am J Physiol Heart Circ Physiol, 2016, 311(3):H849-54
S5728	Delapril Hydrochloride Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
S5712	Zofenopril calcium Zofenopril calcium is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.
S5938	Benazepril Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure.
S7678	Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.	J Mol Cell Cardiol, 2017, 108:138-148 RSC Adv, 2017, 10.1039/C7RA01404J	Histological analysis staining of three groups. (a) Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×200). (b) Masson staining of three groups (original magnification ×200). Collagen content (%) of heart tissues were presented as fibrosis (**P < 0.001, n = 7 per group). (c) Cardiac section of three group mice hearts stained with WGA (original magnification ×400) (P < 0.05, n = 7 per group). (d) The expression of Drp1 significantly increased in DOX group (*P < 0.001, n = 7 per group) and it decreased in DOX + LCZ696 group (P < 0.01, n = 7 per group).
S6468	Trandolapril Trandolapril is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
S2095	Fosinopril Sodium Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1284	Benazepril HCl Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.	Mol Pharm, 2015, 12(9):3399-407

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S1284