S1P受容体

シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7176 SKI II <1 mg/mL 61 mg/mL 61 mg/mL
S7177 PF-543 <1 mg/mL 93 mg/mL 93 mg/mL
S7174 Opaganib (ABC294640) <1 mg/mL 76 mg/mL 28 mg/mL
S5002 Fingolimod (FTY720) HCl 69 mg/mL 69 mg/mL 69 mg/mL
S7182 JTE 013 <1 mg/mL 81 mg/mL 34 mg/mL
S7176 SKI II <1 mg/mL 61 mg/mL 61 mg/mL
S7177 PF-543 <1 mg/mL 93 mg/mL 93 mg/mL
S7174 Opaganib (ABC294640) <1 mg/mL 76 mg/mL 28 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7176

SKI II

SKI II is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.

S7177

PF-543

PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.

S7174

Opaganib (ABC294640)

Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.

S5002

Fingolimod (FTY720) HCl

Fingolimod (FTY720) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells.

S7182

JTE 013

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

S7176

SKI II

SKI II is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.

S7177

PF-543

PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.

S7174

Opaganib (ABC294640)

Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.