Sigma Receptor

亜型選択性的な製品

sigma-2 receptor

Sigma Receptor製品

All (22)
Sigma Receptor活性剤(1)
Sigma Receptor拮抗剤(4)
Sigma Receptor作動薬(8)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S0106	BD-1047 dihydrobromide	BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.	Brain Res, 2024, 1838:149011 Authorea Preprints, 2023, Neuropharmacology, 2021, 196:108360
S6981	Glycerol phenylbutyrate	Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.
E7418^New	Noscapine	Noscapine ((S,R)-Noscapine) is an alkaloid derived from the opium poppy (Papaver somniferum) and is a centrally acting antitussive opiate derivative. It is a non-competitive antagonist of the bradykinin B2 receptor. It also exhibits neuroprotection by activating sigma-1 opioid receptors, which help suppress intracellular NO levels and calcium, thereby providing protection against ischemic injury.
S0295	Anavex 2-73 HCl	Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ₁ Receptor agonist with IC50 of 0.86 μM.
S0869	Carbetapentane	Carbetapentane (Pentoxyverine, CB) is an antitussive anticonvulsant nonselective sigma-1 (σ1) agonist.
S6561	4-IBP	4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
E0388	WQ 1	WQ 1 is a high affinity and selective σ1 receptor antagonist with pKi values of 10.85, 6.53 and 5.80 at σ1, σ2 receptors and dopamine transporter (DAT), displaying σ1/σ2 selectivity ratio of 20893.
E7744^New	Siramesine	Siramesine (Lu 28-179) is a potent agonist of sigma-2 receptor(σ1R) with an IC50 of 0.12 nM, exhibiting 140-fold selectivity over sigma-1 receptors. It shows strong anxiolytic effects and induces cancer cell death, highlighting its potential anticancer activity.
S2917	Cutamesine Dihydrochloride	Cutamesine dihydrochloride (SA4503 dihydrochloride,AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
S0191	BD1063 2HCL	BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (σ1R) antagonist with Ki of 4.43 nM.
S6950	PRE-084 hydrochloride	PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.	Free Radic Biol Med, 2025, 226:96-108
E7191^New	Ditolylguanidine	Ditolylguanidine (1,3-di-o-tolylguanidine) is a non-selective agonist of sigma receptor (σ receptor) with high affinity Ki values of 69 nM and 21 nM for σ1 and σ2 receptors, respectively. It effectively inhibits the growth of small cell lung cancer cells and can be used for the research of lung cancer.	HIV Med, 2025, 26(2):285-294
S6754	S1RA	S1RA (E-52862) is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.	Int Immunopharmacol, 2024, 128:111524
S6756	Siramesine HCl	Siramesine (Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively.	J Transl Med, 2025, 23(1):780
S0295	Anavex 2-73 HCl	Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ₁ Receptor agonist with IC50 of 0.86 μM.
S0869	Carbetapentane	Carbetapentane (Pentoxyverine, CB) is an antitussive anticonvulsant nonselective sigma-1 (σ1) agonist.
S6561	4-IBP	4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
E7744^New	Siramesine	Siramesine (Lu 28-179) is a potent agonist of sigma-2 receptor(σ1R) with an IC50 of 0.12 nM, exhibiting 140-fold selectivity over sigma-1 receptors. It shows strong anxiolytic effects and induces cancer cell death, highlighting its potential anticancer activity.
S2917	Cutamesine Dihydrochloride	Cutamesine dihydrochloride (SA4503 dihydrochloride,AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
S6950	PRE-084 hydrochloride	PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.	Free Radic Biol Med, 2025, 226:96-108
E7191^New	Ditolylguanidine	Ditolylguanidine (1,3-di-o-tolylguanidine) is a non-selective agonist of sigma receptor (σ receptor) with high affinity Ki values of 69 nM and 21 nM for σ1 and σ2 receptors, respectively. It effectively inhibits the growth of small cell lung cancer cells and can be used for the research of lung cancer.	HIV Med, 2025, 26(2):285-294
S6756	Siramesine HCl	Siramesine (Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively.	J Transl Med, 2025, 23(1):780
E7418^New	Noscapine	Noscapine ((S,R)-Noscapine) is an alkaloid derived from the opium poppy (Papaver somniferum) and is a centrally acting antitussive opiate derivative. It is a non-competitive antagonist of the bradykinin B2 receptor. It also exhibits neuroprotection by activating sigma-1 opioid receptors, which help suppress intracellular NO levels and calcium, thereby providing protection against ischemic injury.
S0106	BD-1047 dihydrobromide	BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.	Brain Res, 2024, 1838:149011 Authorea Preprints, 2023, Neuropharmacology, 2021, 196:108360
E0388	WQ 1	WQ 1 is a high affinity and selective σ1 receptor antagonist with pKi values of 10.85, 6.53 and 5.80 at σ1, σ2 receptors and dopamine transporter (DAT), displaying σ1/σ2 selectivity ratio of 20893.
S0191	BD1063 2HCL	BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (σ1R) antagonist with Ki of 4.43 nM.
S6754	S1RA	S1RA (E-52862) is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.	Int Immunopharmacol, 2024, 128:111524
S0295	Anavex 2-73 HCl	Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ₁ Receptor agonist with IC50 of 0.86 μM.
S0869	Carbetapentane	Carbetapentane (Pentoxyverine, CB) is an antitussive anticonvulsant nonselective sigma-1 (σ1) agonist.
S6561	4-IBP	4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
E7744^New	Siramesine	Siramesine (Lu 28-179) is a potent agonist of sigma-2 receptor(σ1R) with an IC50 of 0.12 nM, exhibiting 140-fold selectivity over sigma-1 receptors. It shows strong anxiolytic effects and induces cancer cell death, highlighting its potential anticancer activity.
S2917	Cutamesine Dihydrochloride	Cutamesine dihydrochloride (SA4503 dihydrochloride,AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
S6950	PRE-084 hydrochloride	PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.	Free Radic Biol Med, 2025, 226:96-108
E7191^New	Ditolylguanidine	Ditolylguanidine (1,3-di-o-tolylguanidine) is a non-selective agonist of sigma receptor (σ receptor) with high affinity Ki values of 69 nM and 21 nM for σ1 and σ2 receptors, respectively. It effectively inhibits the growth of small cell lung cancer cells and can be used for the research of lung cancer.	HIV Med, 2025, 26(2):285-294
S6756	Siramesine HCl	Siramesine (Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively.	J Transl Med, 2025, 23(1):780
E7418^New	Noscapine	Noscapine ((S,R)-Noscapine) is an alkaloid derived from the opium poppy (Papaver somniferum) and is a centrally acting antitussive opiate derivative. It is a non-competitive antagonist of the bradykinin B2 receptor. It also exhibits neuroprotection by activating sigma-1 opioid receptors, which help suppress intracellular NO levels and calcium, thereby providing protection against ischemic injury.
E7744^New	Siramesine	Siramesine (Lu 28-179) is a potent agonist of sigma-2 receptor(σ1R) with an IC50 of 0.12 nM, exhibiting 140-fold selectivity over sigma-1 receptors. It shows strong anxiolytic effects and induces cancer cell death, highlighting its potential anticancer activity.
E7191^New	Ditolylguanidine	Ditolylguanidine (1,3-di-o-tolylguanidine) is a non-selective agonist of sigma receptor (σ receptor) with high affinity Ki values of 69 nM and 21 nM for σ1 and σ2 receptors, respectively. It effectively inhibits the growth of small cell lung cancer cells and can be used for the research of lung cancer.	HIV Med, 2025, 26(2):285-294
E7744^New	Siramesine	Siramesine (Lu 28-179) is a potent agonist of sigma-2 receptor(σ1R) with an IC50 of 0.12 nM, exhibiting 140-fold selectivity over sigma-1 receptors. It shows strong anxiolytic effects and induces cancer cell death, highlighting its potential anticancer activity.
E7191^New	Ditolylguanidine	Ditolylguanidine (1,3-di-o-tolylguanidine) is a non-selective agonist of sigma receptor (σ receptor) with high affinity Ki values of 69 nM and 21 nM for σ1 and σ2 receptors, respectively. It effectively inhibits the growth of small cell lung cancer cells and can be used for the research of lung cancer.	HIV Med, 2025, 26(2):285-294