Beta Amyloid

Beta Amyloid製品

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  • Beta Amyloid阻害剤 (20)
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S2215 DAPT DAPT (GSI-IX、LY-374973) は新規の γ-セクレターゼ 阻害剤であり、HEK 293 細胞で 20 nM の IC50 で Aβ 産生を阻害します。 DAPT はヒト舌癌細胞のアポトーシス(apoptosis) を促進し、オートファジー (autophagy) を調節します。
Genome Biol, 2024, 25(1):58
Br J Cancer, 2024, 10.1038/s41416-024-02576-z
Antibodies (Basel), 2024, 13(1)15
S1575 RO4929097 RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
Res Sq, 2024, rs.3.rs-3843028
Nat Commun, 2023, 14(1):6190
Nat Commun, 2023, 14(1):6190
S5742 Deferoxamine mesylate Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.
Redox Biol, 2024, 69:103008
Ecotoxicol Environ Saf, 2024, 270:115889
J Cancer, 2024, 15(3):685-698
S8185 FPS-ZM1 FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.
Pharmacol Res, 2023, 192:106791
Cell Death Dis, 2023, 14(12):825
Breast Cancer Res, 2023, 25(1):84
S1262 Avagacestat (BMS-708163) Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
Nat Commun, 2022, 13(1):6345
Sci Rep, 2022, 12(1):7
Cell, 2021, 184(2):521-533.e14
S2660 MK-0752 MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.
Cancers (Basel), 2023, 15(6)1883
J Cancer Res Clin Oncol, 2023, 149(16):14691-14699
EBioMedicine, 2022, 78:103963
S1594 Semagacestat (LY450139) Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.
Cancers (Basel), 2023, 15(6)1883
Sci Rep, 2022, 12(1):7
Calcif Tissue Int, 2022, 111(2):211-223
S1528 LY2811376 LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
Glycobiology, 2023, 33(4):325-341
J Agric Food Chem, 2022, 70(5):1536-1546
Sci Rep, 2022, 12(1):7
S4261 EUK 134 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
Front Aging Neurosci, 2022, 14:1013943
Chem Biol Interact, 2021, 351:109756
Nat Commun, 2020, 23;11(1):433
S9664 Colivelin Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.
Research Square, 2024, 10.21203/rs.3.rs-3840462/v1
Cell Death Dis, 2022, 13-9:815
J Reprod Immunol, 2022, 151:103623
S3922 (-)-epigallocatechin (-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.
J Inflamm Res, 2023, 16:2007-2020
Eur J Pharmacol, 2020, 173323
Biochim Biophys Acta Biomembr, 2020, 1863(1):183476
S4760 (2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD) (2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin) is a well-known sugar used in drug delivery, genetic vectors, environmental protection, and the treatment of Niemann-Pick disease type C1 (NPC1). It is an inhibitor of amyloid-β aggregation and widely used drug delivery vehicle to improve stability and bioavailability.
Technol Cancer Res Treat, 2021, 20:15330338211027916
Oncotarget, 2015, 6(30):29497-512
S3923 Ginsenoside Rg1 Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. Ginsenoside Rg1 reduces cerebral Aβ levels and NF-κB nuclear translocation.
CNS Neurosci Ther, 2022, 10.1111/cns.14000
J Ethnopharmacol, 2021, S0378-8741(21)00169-0
S3811 Ginsenoside Re Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.
J Ethnopharmacol, 2021, S0378-8741(21)00169-0
S0486 Hoechst 34580 Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye to stain DNA and nuclei. Hoechst 34580 is also a good candidate for treating the Alzheimer's disease by inhibiting amyloid beta (Aβ) formation with IC50 of 0.86 μM.
Front Nutr, 2022, 9:961182
E2948New β-Amyloid (25-35) β-Amyloid (25-35) (Amyloid beta-peptide (25-35), Aβ25-35, β-Amyloid peptide (25-35)) , a sequence GSNKGAIIGLM, is a highly toxic synthetic derivative of Amyloid beta-peptide (Aβ-peptides) which forms fibrillary aggregates. β-Amyloid (25-35) is involved in the pathogenesis of Alzheimer's disease.
S0529 PBD-150 PBD-150 is a potent human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor with Ki of 60 nM.
S5101 Tabersonine hydrochloride Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
E0077 Simufilam Simufilam(PTI-125) is a potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. Simufilam reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7nAChR.
S9087 Tenuifolin Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.
S6733 Edonerpic maleate Edonerpic maleate (T-817) is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
S9428 Brazilin Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.
S2418 Frentizole Frentizole (Frentizol) is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. Frentizole is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus.
S3405 CRANAD-2 CRANAD-2 is a curcumin-derivatized near-infrared (NIR) probe that meets all the requirements for a NIR contrast agent for the detection of Abeta plaques both in vitro and in vivo.
S2215 DAPT DAPT (GSI-IX、LY-374973) は新規の γ-セクレターゼ 阻害剤であり、HEK 293 細胞で 20 nM の IC50 で Aβ 産生を阻害します。 DAPT はヒト舌癌細胞のアポトーシス(apoptosis) を促進し、オートファジー (autophagy) を調節します。
Genome Biol, 2024, 25(1):58
Br J Cancer, 2024, 10.1038/s41416-024-02576-z
Antibodies (Basel), 2024, 13(1)15
S1575 RO4929097 RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
Res Sq, 2024, rs.3.rs-3843028
Nat Commun, 2023, 14(1):6190
Nat Commun, 2023, 14(1):6190
S5742 Deferoxamine mesylate Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.
Redox Biol, 2024, 69:103008
Ecotoxicol Environ Saf, 2024, 270:115889
J Cancer, 2024, 15(3):685-698
S8185 FPS-ZM1 FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.
Pharmacol Res, 2023, 192:106791
Cell Death Dis, 2023, 14(12):825
Breast Cancer Res, 2023, 25(1):84
S1262 Avagacestat (BMS-708163) Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
Nat Commun, 2022, 13(1):6345
Sci Rep, 2022, 12(1):7
Cell, 2021, 184(2):521-533.e14
S2660 MK-0752 MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.
Cancers (Basel), 2023, 15(6)1883
J Cancer Res Clin Oncol, 2023, 149(16):14691-14699
EBioMedicine, 2022, 78:103963
S1594 Semagacestat (LY450139) Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.
Cancers (Basel), 2023, 15(6)1883
Sci Rep, 2022, 12(1):7
Calcif Tissue Int, 2022, 111(2):211-223
S1528 LY2811376 LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
Glycobiology, 2023, 33(4):325-341
J Agric Food Chem, 2022, 70(5):1536-1546
Sci Rep, 2022, 12(1):7
S4261 EUK 134 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
Front Aging Neurosci, 2022, 14:1013943
Chem Biol Interact, 2021, 351:109756
Nat Commun, 2020, 23;11(1):433
S9664 Colivelin Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.
Research Square, 2024, 10.21203/rs.3.rs-3840462/v1
Cell Death Dis, 2022, 13-9:815
J Reprod Immunol, 2022, 151:103623
S4760 (2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD) (2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin) is a well-known sugar used in drug delivery, genetic vectors, environmental protection, and the treatment of Niemann-Pick disease type C1 (NPC1). It is an inhibitor of amyloid-β aggregation and widely used drug delivery vehicle to improve stability and bioavailability.
Technol Cancer Res Treat, 2021, 20:15330338211027916
Oncotarget, 2015, 6(30):29497-512
S3923 Ginsenoside Rg1 Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. Ginsenoside Rg1 reduces cerebral Aβ levels and NF-κB nuclear translocation.
CNS Neurosci Ther, 2022, 10.1111/cns.14000
J Ethnopharmacol, 2021, S0378-8741(21)00169-0
S3811 Ginsenoside Re Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.
J Ethnopharmacol, 2021, S0378-8741(21)00169-0
S0486 Hoechst 34580 Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye to stain DNA and nuclei. Hoechst 34580 is also a good candidate for treating the Alzheimer's disease by inhibiting amyloid beta (Aβ) formation with IC50 of 0.86 μM.
Front Nutr, 2022, 9:961182
S0529 PBD-150 PBD-150 is a potent human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor with Ki of 60 nM.
S5101 Tabersonine hydrochloride Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
E0077 Simufilam Simufilam(PTI-125) is a potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. Simufilam reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7nAChR.
S9087 Tenuifolin Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.
S6733 Edonerpic maleate Edonerpic maleate (T-817) is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
S2418 Frentizole Frentizole (Frentizol) is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. Frentizole is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus.
E2948New β-Amyloid (25-35) β-Amyloid (25-35) (Amyloid beta-peptide (25-35), Aβ25-35, β-Amyloid peptide (25-35)) , a sequence GSNKGAIIGLM, is a highly toxic synthetic derivative of Amyloid beta-peptide (Aβ-peptides) which forms fibrillary aggregates. β-Amyloid (25-35) is involved in the pathogenesis of Alzheimer's disease.

Beta Amyloid阻害剤の選択性比較

Beta Amyloidシグナル伝達経路

Beta Amyloidシグナル伝達経路
Tags: Beta Amyloid inhibitor|Beta Amyloid agonist|Beta Amyloid activator|Beta Amyloid inducer|Beta Amyloid antagonist|Beta Amyloid signaling pathway|Beta Amyloid assay kit