Alkylating Agent

Alkylating Agent製品

All (6)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S1237	TMZ(Temozolomide)	テモゾロミド (Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone)) はDNA 環上の窒素原子と環外酸素を修飾することが可能な単官能性 SN1 アルキル化剤であり、中間体である MTIC を経て、活性代謝産物であるメチルジアゾニウムカチオン (methyl diazoniumcation) に分解されると、生理学的 pH において DNA にメチル基を転移します。テモゾロミドはアポトーシス (apoptosis) を誘発し、抗がん活性を呈します。L-1210 細胞および L-1210/BCNU 細胞における DNA 損傷誘導剤です。	Cancer Cell, 2025, S1535-6108(25)00223-5 Cancer Cell, 2025, 43(4):776-796.e14 Nat Commun, 2025, 16(1):5676
S2057	Cyclophosphamide Monohydrate	Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.Cyclophosphamide (NSC-26271) Monohydrate can be used to induce animal models of Anemia.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Cell Mol Life Sci, 2025, 82(1):164 Int J Mol Sci, 2025, 26(17)8494
S1692	Busulfan	Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.Busulfan (NSC-750) can be used to induce animal models of Anemia.	Biomolecules, 2025, 15(2)297 J Immunother Cancer, 2024, 12(11)e009805 iScience, 2024, 27(10):110862
S1217	Cyclophosphamide	Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.	Neurotherapeutics, 2025, 22(1):e00480 Sci Rep, 2025, 15(1):2893 Front Biosci (Landmark Ed), 2025, 30(11):45744
E0158	N-Nitroso-N-methylurea	N-Nitroso-N-methylurea (NMU, MNU, NMH, 1-Methyl-1-nitrosourea, N-Methyl-Nnitrosourea, Methylnitrosourea) is a highly reliable carcinogen, mutagen, and teratogen.N-Nitroso-N-methylurea can be used to induce animal models of Breast Carcinoma.	Phytomedicine, 2025, 141:156701
S7758	Trabectedin	Trabectedin (Ecteinascidin 743, ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata with antitumour activity. Trabectedin binds to the N2 of guanine in the minor groove, causing DNA damage and affecting transcription regulation in a promoter- and gene-specific manner.	EMBO Mol Med, 2023, e16863. Chem Biol Interact, 2022, 369:110262 Biomedicines, 2022, 10(3)624