CD markers

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
A2039 Isatuximab (anti-CD38) 145 KD mg/mL 0.2 μM filtered mg/mL
A2034 Elotuzumab (anti-SLAMF7) 145 kD mg/mL 0.2 μM filtered mg/mL
S2632 BMS-378806 <1 mg/mL 81 mg/mL 3 mg/mL
S3301 Cynarin -1 mg/mL 100 mg/mL -1 mg/mL
S0141 NQ301 <1 mg/mL 30 mg/mL '<1 mg/mL
S7487 YYA-021 <1 mg/mL 0.01 mg/mL <1 mg/mL
S8960 CD38 inhibitor 1 (compound 78c) <1 mg/mL 83 mg/mL <1 mg/mL
S6347 5'-N-Ethylcarboxamidoadenosine (NECA) <1 mg/mL 62 mg/mL '''<1 mg/mL
S9867 LY-3475070 <1 mg/mL 57 mg/mL '''10 mg/mL
S5525 SodiuM Metatungstate -1 mg/mL 30 mg/mL '-1 mg/mL
S6727 AX-024 HCl 4 mg/mL 75 mg/mL '18 mg/mL
S0215 MDK 24720 (CTLA-4 inhibitor) -1 mg/mL 85 mg/mL '-1 mg/mL
S6239 PMX-53 10 mg/mL 100 mg/mL ''''10 mg/mL
P1208 PMX 205 50 mg/mL 100 mg/mL 100 mg/mL
S0474 Avacopan (CCX168) <1 mg/mL 100 mg/mL '20 mg/mL
S0525 ADH-503 (GB1275) <1 mg/mL 100 mg/mL 4 mg/mL

亜型選択性的な製品

CD markers製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
A2039

Isatuximab (anti-CD38)

Isatuximab (anti-CD38) (SAR650984, hu38SB19) is an IgG1-derived monoclonal antibody that binds to a specific extracellular epitope of CD38 receptor with a kd of 0.12 nM.

A2034

Elotuzumab (anti-SLAMF7)

Elotuzumab (anti-SLAMF7, BMS-901608, PDL063, HuLuc63) is a humanized monoclonal antibody that binds human signaling lymphocytic activation molecule F7 (hSLAMF7, also known as CS1, CD319, or CRACC). Elotuzumab shows a dual mechanism of action that includes the direct activation of natural killer (NK) cells and the induction of NK cell–mediated antibody-dependent cellular cytotoxicity.

S2632

BMS-378806

BMS-378806 (BMS 806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.

S3301

Cynarin

Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.

S0141

NQ301

NQ301 (Compound 211), an antiplatelet and antithrombotic agent, is a selective CD45 inhibitor with IC50 of 200 nM. NQ301 inhibits thromboxane A2 receptor (TXA2) and synthase activity in rabbit platelets.

S7487

YYA-021

YYA-021 is a CD4-mimic HIV entry inhibitor, competitively inhibiting the interaction between gp120 and CD4.

S8960

CD38 inhibitor 1 (compound 78c)

CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.

S6347

5'-N-Ethylcarboxamidoadenosine (NECA)

5'-N-Ethylcarboxamidoadenosine (NECA, 5'-(N-Ethylcarboxamido)adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. 5'-N-Ethylcarboxamidoadenosine acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54)), and blocking activation of the JNK-MAPK pathway.

S9867

LY-3475070

LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase).

S5525

SodiuM Metatungstate

Sodium metatungstate (SMT) solution is an inorganic heavy liquid which is widely used in density fractionation. Sodium metatungstate (Sodium polyoxotungstates) is a potent and selective inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDases, CD39) with Ki of 0.140 μM, 0.910 μM and 0.563 μM for NTPDase1, NTPDase2 and NTPDase3, respectively.

S6727

AX-024 HCl

AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

S0215

MDK 24720 (CTLA-4 inhibitor)

MDK 24720 (CTLA-4 inhibitor, compound 6b) is an inhibitor of Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) with IC50 of 50 nM for B7.1–CD28 inhibition.

S6239

PMX-53

PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).

P1208

PMX 205

PMX 205 is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

S0474

Avacopan (CCX168)

Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.

S0525

ADH-503 (GB1275)

ADH-503 (GB1275, (Z)-Leukadherin-1 choline) is the salt form of leukadherin-1 and acts as a potent allosteric agonist of CD11b.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
A2039

Isatuximab (anti-CD38)

Isatuximab (anti-CD38) (SAR650984, hu38SB19) is an IgG1-derived monoclonal antibody that binds to a specific extracellular epitope of CD38 receptor with a kd of 0.12 nM.

A2034

Elotuzumab (anti-SLAMF7)

Elotuzumab (anti-SLAMF7, BMS-901608, PDL063, HuLuc63) is a humanized monoclonal antibody that binds human signaling lymphocytic activation molecule F7 (hSLAMF7, also known as CS1, CD319, or CRACC). Elotuzumab shows a dual mechanism of action that includes the direct activation of natural killer (NK) cells and the induction of NK cell–mediated antibody-dependent cellular cytotoxicity.

S2632

BMS-378806

BMS-378806 (BMS 806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.

S3301

Cynarin

Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.

S0141

NQ301

NQ301 (Compound 211), an antiplatelet and antithrombotic agent, is a selective CD45 inhibitor with IC50 of 200 nM. NQ301 inhibits thromboxane A2 receptor (TXA2) and synthase activity in rabbit platelets.

S7487

YYA-021

YYA-021 is a CD4-mimic HIV entry inhibitor, competitively inhibiting the interaction between gp120 and CD4.

S8960

CD38 inhibitor 1 (compound 78c)

CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.

S6347

5'-N-Ethylcarboxamidoadenosine (NECA)

5'-N-Ethylcarboxamidoadenosine (NECA, 5'-(N-Ethylcarboxamido)adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. 5'-N-Ethylcarboxamidoadenosine acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54)), and blocking activation of the JNK-MAPK pathway.

S9867

LY-3475070

LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase).

S5525

SodiuM Metatungstate

Sodium metatungstate (SMT) solution is an inorganic heavy liquid which is widely used in density fractionation. Sodium metatungstate (Sodium polyoxotungstates) is a potent and selective inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDases, CD39) with Ki of 0.140 μM, 0.910 μM and 0.563 μM for NTPDase1, NTPDase2 and NTPDase3, respectively.

S6727

AX-024 HCl

AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

S0215

MDK 24720 (CTLA-4 inhibitor)

MDK 24720 (CTLA-4 inhibitor, compound 6b) is an inhibitor of Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) with IC50 of 50 nM for B7.1–CD28 inhibition.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S6239

PMX-53

PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).

2022, 20(1):24

P1208

PMX 205

PMX 205 is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

S0474

Avacopan (CCX168)

Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.

2022, 13(5):500

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S0525

ADH-503 (GB1275)

ADH-503 (GB1275, (Z)-Leukadherin-1 choline) is the salt form of leukadherin-1 and acts as a potent allosteric agonist of CD11b.

Tags: CD markers inhibitor|CD markers agonist|CD markers activator|CD markers inducer|CD markers antagonist|CD markers signaling pathway|CD markers assay kit