PMX 205 acetate

製品コード：P1208 純度：99.47%

PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

Amino-acid Sequence

PMX205 acetate, PMX-205 acetate

CAS No. 514814-49-4（free base)

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製品安全説明書

現在のバッチを見る：純度： 99.47%

99.47

化学情報

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			１ケ月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (119.18 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Ethanol : 100 mg/mL

Water : 50 mg/mL

モル濃度計算器

in vivo Batch: Add solvents to the product individually and in order.				投与溶液組成計算機
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	5.000mg/ml (5.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	16.000mg/ml (19.07mM)	Taking the 1 mL working solution as an example, add 50 μL of 320 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

生物活性

製品説明

PMX 205 acetate is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.

Targets

C5a receptor

31 nM

In Vivo
In vivo	In Tg2576 mice, PMX205 treatment decreases both total amyloid deposits and fibrillar amyloid plaques and results in less reactive glia surrounding fibrillar amyloid plaques. PMX205 treatment causes significant decreases in hyperphosphorylated tau as well as fibrillar plaques in the 3xTg mouse model.^[2]

参考
https://pubmed.ncbi.nlm.nih.gov/32064396/ https://pubmed.ncbi.nlm.nih.gov/19561098/

参考

https://pubmed.ncbi.nlm.nih.gov/32064396/
https://pubmed.ncbi.nlm.nih.gov/19561098/

製品情報

Molecular Formula	C₄₅H₆₂N₁₀O₆
Molecular Weight	839.04
CAS No.	514814-49-4（free base)
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)