CMV
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1516 | Cidofovir | 12 mg/mL | 2 mg/mL | '<1 mg/mL |
| S1878 | Ganciclovir | <1 mg/mL | 27 mg/mL | '''<1 mg/mL |
| S1299 | Floxuridine | 49 mg/mL | 49 mg/mL | ''10 mg/mL |
| S4050 | Valganciclovir HCl | 78 mg/mL | 78 mg/mL | ''<1 mg/mL |
| S7296 | ML324 | <1 mg/mL | 43 mg/mL | '3 mg/mL |
| S4454 | FIT-039 | ' mg/mL | ||
| S0754 | Bisindolylmaleimide IV | ' mg/mL | ||
| S8873 | Letermovir (AIC246) | <1 mg/mL | 100 mg/mL | ''100 mg/mL |
| S5065 | Ganciclovir sodium | 55 mg/mL | <1 mg/mL | ''''-1 mg/mL |
| S7889 | Xanthohumol | <1 mg/mL | 70 mg/mL | '70 mg/mL |
| S5009 | Brivudine | -1 mg/mL | 66 mg/mL | '-1 mg/mL |
CMV製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1516 |
CidofovirCidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis. |
The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir. |
|
| S1878 |
GanciclovirGanciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay. |
Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.
|
|
| S1299 |
FloxuridineFloxuridine (Deoxyfluorouridine, FUDR, NSC 27640) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV. |
||
| S4050 |
Valganciclovir HClValganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections. |
||
| S7296 |
ML324ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM. |
||
| S4454新 |
FIT-039FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription. |
||
| S0754新 |
Bisindolylmaleimide IVBisindolylmaleimide IV (Arcyriarubin A) is a potent inhibitor of protein kinase C (PKC) with IC50 ranging from 0.1 μM to 0.55 μM. Bisindolylmaleimide IV inhibits PKA with IC50 ranging from 3.1μM to 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM. |
||
| S8873 |
Letermovir (AIC246)Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. |
||
| S5065 |
Ganciclovir sodiumGanciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV). |
||
| S7889 |
XanthohumolXanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1. |
||
| S5009 |
BrivudineBrivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1516 |
CidofovirCidofovir (HPMPC) suppresses virus replication by selective inhibition of viral DNA synthesis. |
The copy numbers of the intracellular viral DNA were directly extracted from cells and were quantified by qPCR using primers specific for the KSHV ORF73 gene. Then each sample was normalized to the amount of the GAPDH gene (C), CDV (20 µM) was used as a positive control. CDV:Cidofovir. |
|
| S1878 |
GanciclovirGanciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay. |
Effect of ganciclovir on viral DNA accumulation (A,B) and induction of TGF-β1 production after human cytomegalovirus infection in human trabecular meshwork cells (C). Cells were harvested at 5 day post-infection at a high multiplicity of infection (MOI 1) under the treatment with different concentrations of ganciclovir (GAN). Treatment with 10 μmol of ganciclovir significantly decreased the viral DNA accumulation (p < 0.001) (A,B). However, treatment with ganciclovir did not affect the TGF-β production using a TGF-β1 luciferase bioassay. Results are expressed as the mean +/− standard deviation of three different experiments.
|
|
| S1299 |
FloxuridineFloxuridine (Deoxyfluorouridine, FUDR, NSC 27640) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV. |
||
| S4050 |
Valganciclovir HClValganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections. |
||
| S7296 |
ML324ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM. |
||
| S4454新 |
FIT-039FIT-039 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9), suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription. |
||
| S0754新 |
Bisindolylmaleimide IVBisindolylmaleimide IV (Arcyriarubin A) is a potent inhibitor of protein kinase C (PKC) with IC50 ranging from 0.1 μM to 0.55 μM. Bisindolylmaleimide IV inhibits PKA with IC50 ranging from 3.1μM to 11.8μM. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM. |
||
| S8873 |
Letermovir (AIC246)Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. |
||
| S5065 |
Ganciclovir sodiumGanciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV). |
||
| S7889 |
XanthohumolXanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1. |
||
| S5009 |
BrivudineBrivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
