Drug Metabolite

Drug Metabolite製品

• All (30)
• Drug Metabolite阻害剤 (8)
• Drug Metabolite拮抗剤(2)
• Drug Metabolite作動薬(4)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2205	DesMethyl Erlotinib (OSI-420) HCl	DesMethyl Erlotinib (OSI-420) HCl is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).	Drug Metab Dispos, 2025, 53(5):100069 J Pharm Biomed Anal, 2023, 236:115716 Front Oncol, 2022, 12:939118
S1501	Mycophenolate mofetil	Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Mycophenolate Mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.	Cell Metab, 2025, S1550-4131(25)00482-6 Haematologica, 2024, 109(12):3989-4006 eNeuro, 2023, 10(10)ENEURO.0159-23.2023
S6887	Clozapine N-oxide (CNO)	CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.	Theranostics, 2025, 15(5):1822-1841 STAR Protoc, 2025, 6(1):103542 Theranostics, 2024, 14(7):2881-2896
S4785	Nicotinamide N-oxide	Nicotinamide N-oxide (Nicotinamide 1-oxide, 1-oxynicotinamide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. Nicotinamide N-oxide is novel, potent, and selective antagonists of the CXCR2 receptor.	Front Immunol, 2025, 16:1552993 Inflammation, 2024, Cell Rep, 2023, 42(6):112566
S6889	Monomethyl Fumarate	Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.	Cell Cycle, 2022, 1-11. Aging (Albany NY), 2021, 13(13):17097-17117
S4207	Clofibric Acid	Clofibric acid(Chlorofibrinic acid) is a PPARα agonist and hypolipidemic agent.	Lab Invest, 2023, 103(1):100004
S3698	Nortriptyline hydrochloride	Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.	Front Bioinform, 2021, 1:710591
S5148	2-Methylenebutyrolactone	2-Methylenebutyrolactone (Tulipalin A, MBL, α-methylene-γ-butyrolactone), also known as α-methylene-γ-butyrolactone (MBL) (Tulipalin A), belongs to the class of sesquiterpene lactone family and is considered as cyclic analog of most common vinyl monomer methyl methacrylate (MMA).
S5681	Vinburnine	Vinburnine ((-)-Eburnamonine, Vincamone, L-Eburnamonine) is a vasodilator. It is a vinca alkaloid and a metabolite of vincamine.
S6601	(±)-Equol	(±)-Equol, an isoflavandiol estrogen, is a metabolite of the soy isoflavones, daidzin and daidzein.
E4607	Oseltamivir acid	Oseltamivir acid(GS 4071,Ro 64-0802,Oseltamivir carboxylate), a metabolite of the antiviral compound oseltamivir, acts as a competitive inhibitor of influenza neuraminidases A and influenza neuraminidases B with IC50 of 0.1 to 4.9 nM respectively, thereby preventing virus budding and release.
S5672	Hydroxyhexamide	Hydroxyhexamide is a pharmacologically active metabolite of acetohexamide, which is a sulfonylurea hypoglycemic agent.
S0320	Cycloguanil hydrochloride	Cycloguanil hydrochloride, an active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
E4922	Allopurinol riboside	Allopurinol riboside, a metabolite of allopurinol, competitively inhibits the action of purine nucleoside phosphorylase on inosine in vitro with a Ki value of 277 μM. It displays potent activities against parasites.
E7914	Desisobutyryl-ciclesonide	Desisobutyryl-ciclesonide is the active metabolite of ciclesonide. It exhibits potent anti-inflammatory activity by effectively inhibiting allergen-induced T-cell proliferation and interleukin-4 expression in vitro and that may have clinical relevance.
S6014	Isonicotinic acid	Isonicotinic acid (Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid) is a metabolite of isoniazid. It is an isomer of nicotinic acid.
S5826	Monobutyl phthalate	Monobutyl phtalate is a metabolite of di(n-butyl)phthalate. It affects the expressions of EMT-related proteins and enhances the migration and invasion of MLTC-1 cells.
E0680	Deslanoside	Deslanoside(Desacetyllanatoside C) is a cardenolide glycoside, has the effects of anti-arrhythmia and cardiotonic, also is used as an EC 3.6.3.9 (Na+/K+-transporting ATPase) inhibitor.
S4448	Imidacloprid-urea	Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid.
S5834	p-Coumaric acid ethyl ester	p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid, which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties.
S3370	3-Methoxytyramine hydrochloride	3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride, a major extracellular metabolite of dopamine, is a neuromodulator that in certain situations may be involved in movement control.
S6438	Ufiprazole	Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole.
S5840	Palifosfamide	Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S4509	4-Aminoantipyrine	4-Aminoantipyrine(Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A, Minoazophene, Aminoazophene) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
S0225	IMR-1A	IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.
S5437	4,4'-DDE	4,4'-DDE (DDE, p,p'-DDE, p,p'-dichlorodiphenyldichloroethylene), a breakdown product of DDT, is an organochlorine pesticide and may behave as a potent androgen receptor antagonist.
S6887	Clozapine N-oxide (CNO)	CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.	Theranostics, 2025, 15(5):1822-1841 STAR Protoc, 2025, 6(1):103542 Theranostics, 2024, 14(7):2881-2896
S6889	Monomethyl Fumarate	Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.	Cell Cycle, 2022, 1-11. Aging (Albany NY), 2021, 13(13):17097-17117
S4207	Clofibric Acid	Clofibric acid(Chlorofibrinic acid) is a PPARα agonist and hypolipidemic agent.	Lab Invest, 2023, 103(1):100004
S6601	(±)-Equol	(±)-Equol, an isoflavandiol estrogen, is a metabolite of the soy isoflavones, daidzin and daidzein.
S2205	DesMethyl Erlotinib (OSI-420) HCl	DesMethyl Erlotinib (OSI-420) HCl is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).	Drug Metab Dispos, 2025, 53(5):100069 J Pharm Biomed Anal, 2023, 236:115716 Front Oncol, 2022, 12:939118
S1501	Mycophenolate mofetil	Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Mycophenolate Mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.	Cell Metab, 2025, S1550-4131(25)00482-6 Haematologica, 2024, 109(12):3989-4006 eNeuro, 2023, 10(10)ENEURO.0159-23.2023
S3698	Nortriptyline hydrochloride	Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.	Front Bioinform, 2021, 1:710591
E4607	Oseltamivir acid	Oseltamivir acid(GS 4071,Ro 64-0802,Oseltamivir carboxylate), a metabolite of the antiviral compound oseltamivir, acts as a competitive inhibitor of influenza neuraminidases A and influenza neuraminidases B with IC50 of 0.1 to 4.9 nM respectively, thereby preventing virus budding and release.
E0680	Deslanoside	Deslanoside(Desacetyllanatoside C) is a cardenolide glycoside, has the effects of anti-arrhythmia and cardiotonic, also is used as an EC 3.6.3.9 (Na+/K+-transporting ATPase) inhibitor.
S6438	Ufiprazole	Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole.
S4509	4-Aminoantipyrine	4-Aminoantipyrine(Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A, Minoazophene, Aminoazophene) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
S0225	IMR-1A	IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.
S4785	Nicotinamide N-oxide	Nicotinamide N-oxide (Nicotinamide 1-oxide, 1-oxynicotinamide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. Nicotinamide N-oxide is novel, potent, and selective antagonists of the CXCR2 receptor.	Front Immunol, 2025, 16:1552993 Inflammation, 2024, Cell Rep, 2023, 42(6):112566
S5437	4,4'-DDE	4,4'-DDE (DDE, p,p'-DDE, p,p'-dichlorodiphenyldichloroethylene), a breakdown product of DDT, is an organochlorine pesticide and may behave as a potent androgen receptor antagonist.
S6887	Clozapine N-oxide (CNO)	CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.	Theranostics, 2025, 15(5):1822-1841 STAR Protoc, 2025, 6(1):103542 Theranostics, 2024, 14(7):2881-2896
S6889	Monomethyl Fumarate	Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.	Cell Cycle, 2022, 1-11. Aging (Albany NY), 2021, 13(13):17097-17117
S4207	Clofibric Acid	Clofibric acid(Chlorofibrinic acid) is a PPARα agonist and hypolipidemic agent.	Lab Invest, 2023, 103(1):100004
S6601	(±)-Equol	(±)-Equol, an isoflavandiol estrogen, is a metabolite of the soy isoflavones, daidzin and daidzein.