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阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S8047 | Dynasore | <1 mg/mL | 64 mg/mL | <1 mg/mL |
| S7162 | Mdivi-1 | <1 mg/mL | 70 mg/mL | <1 mg/mL |
| S7163 | Dyngo-4a | <1 mg/mL | 67 mg/mL | 1 mg/mL |
| S5422 | Trimethyloctadecylammonium bromide | -1 mg/mL | 11 mg/mL | -1 mg/mL |
Dynamin製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8047 |
DynasoreDynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. |
Effects of dynasore on active caspase-3 expression at 3 days after SCI. c) Active caspase-3/NeuN/DAPI double labeling. Scale bars = 100 μm. |
|
| S7162 |
Mdivi-1Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. |
Cell necroptosis were detected in cells transfected with PCYT1A siRNA or treated with mitophagy inhibitor Mdivi-1 (50 μm).
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|
| S7163 |
Dyngo-4aDyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. |
Immunofluorescence analysis of EGFR distribution in HCC827 and H1650 cells treated with dynasore, dyngo-4a, or control reagents. Images were captured using a fluorescent microscope (Olympus BX63, 40X objective). Scale bar = 10 μm.
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|
| S5422新 |
Trimethyloctadecylammonium bromideTrimethyloctadecylammonium bromide is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8047 |
DynasoreDynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. |
Effects of dynasore on active caspase-3 expression at 3 days after SCI. c) Active caspase-3/NeuN/DAPI double labeling. Scale bars = 100 μm. |
|
| S7162 |
Mdivi-1Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. |
Cell necroptosis were detected in cells transfected with PCYT1A siRNA or treated with mitophagy inhibitor Mdivi-1 (50 μm).
|
|
| S7163 |
Dyngo-4aDyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. |
Immunofluorescence analysis of EGFR distribution in HCC827 and H1650 cells treated with dynasore, dyngo-4a, or control reagents. Images were captured using a fluorescent microscope (Olympus BX63, 40X objective). Scale bar = 10 μm.
|
|
| S5422新 |
Trimethyloctadecylammonium bromideTrimethyloctadecylammonium bromide is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ. |
