E1 Activating

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7129 PYR-41 <1 mg/mL 74 mg/mL <1 mg/mL
S7109 MLN4924 <1 mg/mL 88 mg/mL 88 mg/mL
S8341 TAK-243 (MLN7243) <1 mg/mL 100 mg/mL 25 mg/mL
S5841 DKM 2-93 <1 mg/mL 49 mg/mL 14 mg/mL

E1 Activating製品

新E1 Activating製品
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7129

PYR-41

PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.

S7109

MLN4924

MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.

S8341

TAK-243 (MLN7243)

TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II.

S5841

DKM 2-93

DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5).

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7129

PYR-41

PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.

S7109

MLN4924

MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.

S8341

TAK-243 (MLN7243)

TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II.

S5841

DKM 2-93

DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5).