eIF

eIF製品

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  • eIF阻害剤 (11)
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S2923 Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Cell Death Dis, 2024, 15(1):31
Cell Rep, 2023, 42(2):112042
Int J Mol Sci, 2023, 24(23)16814
S7369 4EGI-1 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.
Brain Sci, 2023, 13(5)745
Brain Sci, 2023, 13(5)745
Adv Skin Wound Care, 2023, 36(5):249-258
S0706 ISRIB ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM.
Nat Commun, 2024, 15(1):546
Exp Mol Med, 2024, 56(2):408-421.
Mol Cancer, 2023, 10.1186/s12943-023-01868-x
S8275 Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
PLoS Biol, 2023, 21(8):e3002227
Hum Exp Toxicol, 2023, 42:9603271231158047
JCI Insight, 2022, 7(22e158060)
S7370 4E1RCat 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E.
Cell Chem Biol, 2021, S2451-9456(21)00213-0
J Cell Mol Med, 2021, 10.1111/jcmm.16307
Int J Ophthalmol, 2020, 13(1):7-10
S7437 Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
Front Pharmacol, 2023, 14:1095307
bioRxiv, 2023, 2023.05.19.540602
bioRxiv, 2023, 2023.05.19.540602
S7428 Rocaglamide Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.
Elife, 2023, 12e69521
Blood Adv, 2023, 7(12):2926-2937
S9668 PKR-IN-C16 PKR-IN-C16 (C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.
Exp Mol Med, 2024, 56(2):408-421.
EMBO J, 2024, 43(5):780-805.
Cell Chem Biol, 2021, S2451-9456(21)00303-2
S8181 SBI-0640756 SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.
Sci Rep, 2021, 11(1):21689
S6533 Briciclib Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S2961 GC7 Sulfate GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
S2923 Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Cell Death Dis, 2024, 15(1):31
Cell Rep, 2023, 42(2):112042
Int J Mol Sci, 2023, 24(23)16814
S7369 4EGI-1 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.
Brain Sci, 2023, 13(5)745
Brain Sci, 2023, 13(5)745
Adv Skin Wound Care, 2023, 36(5):249-258
S0706 ISRIB ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM.
Nat Commun, 2024, 15(1):546
Exp Mol Med, 2024, 56(2):408-421.
Mol Cancer, 2023, 10.1186/s12943-023-01868-x
S8275 Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
PLoS Biol, 2023, 21(8):e3002227
Hum Exp Toxicol, 2023, 42:9603271231158047
JCI Insight, 2022, 7(22e158060)
S7370 4E1RCat 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E.
Cell Chem Biol, 2021, S2451-9456(21)00213-0
J Cell Mol Med, 2021, 10.1111/jcmm.16307
Int J Ophthalmol, 2020, 13(1):7-10
S7437 Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
Front Pharmacol, 2023, 14:1095307
bioRxiv, 2023, 2023.05.19.540602
bioRxiv, 2023, 2023.05.19.540602
S7428 Rocaglamide Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.
Elife, 2023, 12e69521
Blood Adv, 2023, 7(12):2926-2937
S9668 PKR-IN-C16 PKR-IN-C16 (C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.
Exp Mol Med, 2024, 56(2):408-421.
EMBO J, 2024, 43(5):780-805.
Cell Chem Biol, 2021, S2451-9456(21)00303-2
S8181 SBI-0640756 SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.
Sci Rep, 2021, 11(1):21689
S6533 Briciclib Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S2961 GC7 Sulfate GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.

eIF阻害剤の選択性比較

Tags: eIF inhibitor|eIF agonist|eIF activator|eIF inducer|eIF antagonist|eIF signaling pathway|eIF assay kit