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FENs

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FENs製品

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  • FENs阻害剤 (2)
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製品コード 製品名称 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S3397 FEN1-IN-4 FEN1-IN-4 (FEN1 Inhibitor C2, JUN93587, Compound 2) is an inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM for hFEN1-336Δ.
Sci Adv, 2025, 11(2):eads2919
Cell Rep, 2024, 43(8):114522
Int J Mol Sci, 2024, 25(4)2110
E5886New FEN1-IN-1 FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.
S3397 FEN1-IN-4 FEN1-IN-4 (FEN1 Inhibitor C2, JUN93587, Compound 2) is an inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM for hFEN1-336Δ.
Sci Adv, 2025, 11(2):eads2919
Cell Rep, 2024, 43(8):114522
Int J Mol Sci, 2024, 25(4)2110
E5886New FEN1-IN-1 FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.
E5886New FEN1-IN-1 FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.
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