G9a/GLP

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
水 DMSO アルコール
S8006 BIX 01294 98 mg/mL 98 mg/mL 8 mg/mL
S8071 UNC0638 6 mg/mL 100 mg/mL 100 mg/mL
S7230 UNC0642 <1 mg/mL 100 mg/mL 100 mg/mL
S8068 Chaetocin <1 mg/mL 100 mg/mL <1 mg/mL
S7572 A-366 <1 mg/mL 65 mg/mL 65 mg/mL
S7591 BRD4770 <1 mg/mL 27 mg/mL <1 mg/mL
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8006

BIX 01294

BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases.
Cancer Res, 2015, 75(11):2375-86
J Pineal Res, 2018, 65(2):e12497
Hum Pathol, 2018, 72:117-126
S8071

UNC0638

UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets.
S7230新

UNC0642

UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels.
S8068

Chaetocin

Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.

S7572

A-366

A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases.
S7591

BRD4770

BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.

Tags: G9a/GLP inhibitor | G9a/GLP activator | G9a/GLP Inhibition