ヒストンアセチルトランスフェラーゼ

シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7152 C646 <1 mg/mL 13 mg/mL <1 mg/mL
S1848 Curcumin <1 mg/mL 73 mg/mL <1 mg/mL
S8740 A-485 <1 mg/mL 100 mg/mL 100 mg/mL
S8776 WM-1119 <1 mg/mL 78 mg/mL <1 mg/mL
S7582 Anacardic Acid <1 mg/mL 69 mg/mL 69 mg/mL
S9432 Ginkgolic Acid 69 mg/mL
S7476 MG149 <1 mg/mL 68 mg/mL 68 mg/mL
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7152

C646

C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases.

S1848

Curcumin

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM) and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.

S8740

A-485

A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.

S8776

WM-1119

WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively.

S7582

Anacardic Acid

Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.

S9432

Ginkgolic Acid

Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).

S7476

MG149

MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.

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