iGluR

iGluR製品

• All (41)
• iGluR阻害剤 (5)
• iGluR拮抗剤(13)
• iGluR作動薬(9)
• iGluRモジュレータ(4)
• 新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2876	(+)-Dizocilpine (MK 801) Maleate	(+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.(+)-Dizocilpine (MK 801) Maleate can be used to induce animal models of Schizophrenia.	Theranostics, 2025, 15(14):6901-6918 Aging -Albany NY), 2023, 15(12):5698-5712 Aging (Albany NY), 2023, 15(12):5698-5712
S7072	NMDA (N-Methyl-D-aspartic acid)	NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.	Theranostics, 2025, 15(14):6901-6918 Sci Rep, 2025, 15(1):17364 J Neurotrauma, 2025, 10.1177/08977151251374286
S1438	Topiramate	Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.	J Headache Pain, 2025, 26(1):182 Commun Biol, 2025, 8(1):28 Cell Rep, 2022, 40(5):111153
S4091	Ifenprodil Tartrate	Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.	J Immunother Cancer, 2024, 12(11)e009805 Cancer Sci, 2022, 113(8):2716-2726 Cancer Res, 2021, canres.1017.2021
S2043	Memantine HCl	Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.	Pharmaceuticals (Basel), 2023, 16(5)692 Front Genet, 2022, 13:942203 FASEB J, 2020, 10.1096/fj.202000534R
S1334	Flupirtine maleate	Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.	Assay Drug Dev Technol, 2019, 17(7):310-321 Elife, 2015, 4
S6266	(S)-Glutamic acid	(S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist.	Cell Biosci, 2024, 14(1):135 Cancer Sci, 2022, 113-6:1955-1967 CHEM ENG J, 2021, 10.1016/j.cej.2021.130083
S4821	Glycine	Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.	J Invest Dermatol, 2022, S0022-202X(22)00096-3 Free Radic Res, 2022, 1-13
S2251	(-)-Huperzine A (HupA)	(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.	Acta Pharmacol Sin, 2019, 10.1038/s41401-018-0206-4
S6906	Capric acid	Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.	Pharmaceuticals (Basel), 2023, 16(5)692
S5032	Mephenesin	Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.	Cell Rep Methods, 2023, 3(10):100599
S4721	L-Glutamic acid monosodium salt	L-Glutamic acid monosodium salt (Monosodium glutamate, MSG) is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods.	Heliyon, 2024, 10(1):e23945 Acta Biomater, 2022, 152:255-272
S1998	D-Cycloserine	D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.
S1281	Aniracetam	Aniracetam (RO 13-5057) is a nootropics and neuroprotective drug.
S3624	Quinolinic acid	Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN), a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.
S0509	NMDAR antagonist 1	NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity.
S5129	D-Aspartic acid	D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).
E1246	D-AP5	D-AP5 (D-APV; D-2-Amino-5-phosphonovaleric acid) is a selective and competitive NMDA receptor antagonist that inhibits the glutamate binding site of NMDA receptors.
E0484	CNQX	CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) is an AMPA and kainate receptor antagonist with IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively. CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.
S4957	Linalool	Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.
S3070	Piracetam	Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
S6804	CX546	CX546, a prototypical ampakine agent, is a selective positive AMPA receptor modulator.
S4745	L-Phenylalanine	L-Phenylalanine is an essential amino acid and a competitive antagonist against NMDAR glycine- and glutamate-binding sites with a Kb of 573 μM. It is widely used in food flavor and pharmaceutical production.
S6907	Rapastinel (GLYX-13)	Rapastinel (GLYX-13, BV-102, TPPT-amide) is a partial agonist of N-methyl-D-aspartate receptor (NMDAR) that targeting a glycine site. Rapastinel has long-lasting antidepressant effects.
S6224	(R)-Serine	(R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins.
E1050	PEAQX	PEAQX (NVP-AAM077) is an effective and orally available human NMDA antagonist, which shows preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over hNMDA 1A/2B receptors (IC50=29,600 nM).
S5669	Isoxsuprine hydrochloride	Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.
S5664	Orphenadrine Hydrochloride	Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.
S9686	NBQX (FG9202)	NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect.
S6803	1-BCP	1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents.
S4280	Meclofenoxate (Centrophenoxine) HCl	Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.
E5887New	Osavampator	Osavampator (TAK-653, NBI-1065845) is a positive allosteric modulator (PAM) of AMPA receptors. It enhances glutamate-induced calcium influx in CHO cells expressing human AMPA receptors with an EC50 of 3.3 µM and potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons with an EC50 of 4.4 µM.
S7072	NMDA (N-Methyl-D-aspartic acid)	NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.	Theranostics, 2025, 15(14):6901-6918 Sci Rep, 2025, 15(1):17364 J Neurotrauma, 2025, 10.1177/08977151251374286
S6266	(S)-Glutamic acid	(S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist.	Cell Biosci, 2024, 14(1):135 Cancer Sci, 2022, 113-6:1955-1967 CHEM ENG J, 2021, 10.1016/j.cej.2021.130083
S4721	L-Glutamic acid monosodium salt	L-Glutamic acid monosodium salt (Monosodium glutamate, MSG) is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods.	Heliyon, 2024, 10(1):e23945 Acta Biomater, 2022, 152:255-272
S3624	Quinolinic acid	Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN), a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.
S3070	Piracetam	Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
S6907	Rapastinel (GLYX-13)	Rapastinel (GLYX-13, BV-102, TPPT-amide) is a partial agonist of N-methyl-D-aspartate receptor (NMDAR) that targeting a glycine site. Rapastinel has long-lasting antidepressant effects.
S6224	(R)-Serine	(R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins.
S5669	Isoxsuprine hydrochloride	Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.
S6803	1-BCP	1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents.
S1438	Topiramate	Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.	J Headache Pain, 2025, 26(1):182 Commun Biol, 2025, 8(1):28 Cell Rep, 2022, 40(5):111153
S2251	(-)-Huperzine A (HupA)	(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.	Acta Pharmacol Sin, 2019, 10.1038/s41401-018-0206-4
S6906	Capric acid	Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.	Pharmaceuticals (Basel), 2023, 16(5)692
S1998	D-Cycloserine	D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.
S4280	Meclofenoxate (Centrophenoxine) HCl	Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.
S2876	(+)-Dizocilpine (MK 801) Maleate	(+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.(+)-Dizocilpine (MK 801) Maleate can be used to induce animal models of Schizophrenia.	Theranostics, 2025, 15(14):6901-6918 Aging -Albany NY), 2023, 15(12):5698-5712 Aging (Albany NY), 2023, 15(12):5698-5712
S4091	Ifenprodil Tartrate	Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.	J Immunother Cancer, 2024, 12(11)e009805 Cancer Sci, 2022, 113(8):2716-2726 Cancer Res, 2021, canres.1017.2021
S2043	Memantine HCl	Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.	Pharmaceuticals (Basel), 2023, 16(5)692 Front Genet, 2022, 13:942203 FASEB J, 2020, 10.1096/fj.202000534R
S1334	Flupirtine maleate	Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.	Assay Drug Dev Technol, 2019, 17(7):310-321 Elife, 2015, 4
S5032	Mephenesin	Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.	Cell Rep Methods, 2023, 3(10):100599
S0509	NMDAR antagonist 1	NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity.
E1246	D-AP5	D-AP5 (D-APV; D-2-Amino-5-phosphonovaleric acid) is a selective and competitive NMDA receptor antagonist that inhibits the glutamate binding site of NMDA receptors.
E0484	CNQX	CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) is an AMPA and kainate receptor antagonist with IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively. CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.
S4957	Linalool	Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.
S4745	L-Phenylalanine	L-Phenylalanine is an essential amino acid and a competitive antagonist against NMDAR glycine- and glutamate-binding sites with a Kb of 573 μM. It is widely used in food flavor and pharmaceutical production.
E1050	PEAQX	PEAQX (NVP-AAM077) is an effective and orally available human NMDA antagonist, which shows preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over hNMDA 1A/2B receptors (IC50=29,600 nM).
S5664	Orphenadrine Hydrochloride	Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.
S9686	NBQX (FG9202)	NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect.
S7072	NMDA (N-Methyl-D-aspartic acid)	NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.	Theranostics, 2025, 15(14):6901-6918 Sci Rep, 2025, 15(1):17364 J Neurotrauma, 2025, 10.1177/08977151251374286
S6266	(S)-Glutamic acid	(S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist.	Cell Biosci, 2024, 14(1):135 Cancer Sci, 2022, 113-6:1955-1967 CHEM ENG J, 2021, 10.1016/j.cej.2021.130083
S4721	L-Glutamic acid monosodium salt	L-Glutamic acid monosodium salt (Monosodium glutamate, MSG) is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods.	Heliyon, 2024, 10(1):e23945 Acta Biomater, 2022, 152:255-272
S3624	Quinolinic acid	Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN), a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.
S3070	Piracetam	Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
S6907	Rapastinel (GLYX-13)	Rapastinel (GLYX-13, BV-102, TPPT-amide) is a partial agonist of N-methyl-D-aspartate receptor (NMDAR) that targeting a glycine site. Rapastinel has long-lasting antidepressant effects.
S6224	(R)-Serine	(R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins.
S5669	Isoxsuprine hydrochloride	Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.
S6803	1-BCP	1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents.
S1281	Aniracetam	Aniracetam (RO 13-5057) is a nootropics and neuroprotective drug.
S5129	D-Aspartic acid	D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).
S6804	CX546	CX546, a prototypical ampakine agent, is a selective positive AMPA receptor modulator.
E5887New	Osavampator	Osavampator (TAK-653, NBI-1065845) is a positive allosteric modulator (PAM) of AMPA receptors. It enhances glutamate-induced calcium influx in CHO cells expressing human AMPA receptors with an EC50 of 3.3 µM and potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons with an EC50 of 4.4 µM.
E5887New	Osavampator	Osavampator (TAK-653, NBI-1065845) is a positive allosteric modulator (PAM) of AMPA receptors. It enhances glutamate-induced calcium influx in CHO cells expressing human AMPA receptors with an EC50 of 3.3 µM and potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons with an EC50 of 4.4 µM.