Glycine

Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.

CAS No. 56-40-6

サイズ	価格(税別)	在庫状況
25mg	JPY 15000	国内在庫あり
1g	JPY 26100	国内在庫なし(納期7~10日)

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

文献中Selleckの製品使用例（2）

製品安全説明書

現在のバッチを見る：純度： 99.88%

99.88

Glycine関連製品

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関連化合物ライブラリー	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ Express-Pick Library	もっと見る

生物活性

製品説明

Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.

Targets

MT2 receptor ^[1]	MT1 receptor ^[1]
9.8(pKi)	9.45(pKi)

In Vitro
In vitro	Glycine significantly increases the MG-63 cell proliferation in a dosedependent manner. Activity of alkaline phosphatase (ALP) and phosphorylation of extracellular-signal-regulated kinase are increased by glycine in MG-63 cells. Glycine also increases the BrdU-incorporation and Ki-67 mRNA expression in MCF-7 cells, induces the up-regulation of estrogen receptor-β mRNA expression and estrogen response element-luciferase activity in MG-63 and MCF-7 cells^[2].
細胞実験	細胞株	MG-63 osteoblast cell line, MCF-7 estrogen-dependent cell line
	濃度	0.1, 1, and 10 μg/ml
	反応時間	48 h
	実験の流れ	--

In Vivo
In Vivo	Glycine is the most abundant amino acid in the body and is involved in multiple metabolic pathways. Circulating glycine levels in humans, rats and mice, cats, and dogs range from 0.2-0.4 mM. In rabbits and pigs, they are 1-1.5 mM. Intracellular concentrations are much higher, particularly in renal proximal tubules, which reabsorb filtered glycine and reach 4–10x circulating levels depending on whether they are being actively perfused. Glycine has been reported to lower blood pressure in an NMDA-sensitive fashion^[1]. Glycine has an estrogen-like osteoprotective effect in menopause models. It significantly increases the ALP activity, enhances bone mineral density, trabecular number, and connectivity density in OVX mice^[2].
動物実験	動物モデル	Seven-week-old female Balb/c mice
	投与量	10 mg/kg
	投与経路	orally

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試験 (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05799651	Recruiting	SARS-CoV-2	Glycovax Pharma Inc.\|Government of Canada\|JSS Medical Research Inc.\|Avance Clinical Pty Ltd.\|Seppic	April 28 2023	Phase 1
NCT06159322	Recruiting	Schizophrenia\|Schizoaffective Disorder	The Royal Ottawa Mental Health Centre\|The Royal''s Institute of Mental Health Research	January 1 2023	--
NCT05900635	Recruiting	Anemia of Chronic Kidney Disease	Alexandria University	October 1 2022	Phase 4
NCT05478525	Completed	Type 2 Diabetes	Glyscend Inc.	August 3 2022	Phase 2
NCT05270525	Recruiting	COPD	Verona Pharma plc\|University of Alabama at Birmingham	May 27 2022	Phase 2

参考
[1] JOEL M. WEINBERG, et al. Cell Mol Life Sci. 2016, 73(11-12): 2285–2308. [2] Kim MH, et al. Amino Acids. 2016, 48(3):791-800.

参考

化学情報

分子量	75.07	化学式	C₂H₅NO₂
CAS No.	56-40-6	SDF	Download Glycine SDFをダウンロードする
Smiles	C(C(=O)O)N
保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1个月-20°Cin solvent

In vitro
Batch:

Water : 15 mg/mL

DMSO : Insoluble ( 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量	濃度	体積	分子量
=	×	×

希釈計算器分子量計算器

投与溶液組成計算機(クリア溶液)

ステップ１：実験データを入力してください。（実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します）

投与量 mg/kg 動物平均体重 g 投与体積（動物毎）μL 動物数匹

ステップ２：投与溶媒の組成を入力してください。（ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください）

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

計算結果：

投与溶媒濃度： mg/ml;

DMSOストック溶液調製方法： mg 試薬を μL DMSOに溶解する（濃度 mg/mL, 注：濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法：Take μL DMSOストック溶液に μL PEG300，を加え、完全溶解後μL Tween 80，を加えて完全溶解させた後 μL ddH₂O，を加え完全に溶解させます。

投与溶媒調製方法：μL DMSOストック溶液に μL Corn oil，を加え、完全溶解。

注意：１.ストック溶液に沈殿、混濁などがないことをご確認ください；
２.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

製品安全説明書

Glycine関連製品

生物活性

化学情報

実験計算

技術サポート