MAP4K

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S0268 DMX-5084 <1 mg/mL 72 mg/mL 1.5 mg/mL
S6499 PF-6260933 <1 mg/mL 59 mg/mL '2 mg/mL
S8868 NG25 <1 mg/mL 100 mg/mL 2 mg/mL
E2376 KY-05009 <1 mg/mL 70 mg/mL <1 mg/mL

亜型選択性的な製品

MAP4K製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S0268

DMX-5084

DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

S6499

PF-6260933

PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.

S8868

NG25

NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.

E2376

KY-05009

KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM, which inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S0268

DMX-5084

DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

S6499

PF-6260933

PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.

S8868

NG25

NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.

E2376

KY-05009

KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM, which inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells.

Tags: MAP4K inhibitor|MAP4K agonist|MAP4K activator|MAP4K inducer|MAP4K antagonist|MAP4K signaling pathway|MAP4K assay kit