MyD88

MyD88製品

All (5)
MyD88阻害剤 (4)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S7455	Resatorvid (TAK-242)	Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.	EMBO J, 2025, 10.1038/s44318-025-00515-z Carbohydr Polym, 2025, 350:122980 J Neuroinflammation, 2025, 22(1):38
F0289	MyD88 Antibody [G4P20]	MyD88 Rabbit mAb recognizes endogenous levels of total MyD88 protein.
E1721	TJ-M2010-5	TJ-M2010-5 is a small molecule inhibitor of MyD88 that selectively binds to the Toll/Interleukin-1 receptor (TIR) domain of MyD88, disrupting its homodimerization and subsequently inhibiting the Toll-like receptor (TLR)/MyD88 signaling pathway. TJ-M2010-5 exhibits an anti-hepatic fibrosis effect with the potential to treat liver fibrosis.
S9234	Schaftoside	Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
E8318^New	T6167923	T6167923は、MyD88依存的シグナル伝達経路の選択的阻害剤です。T6167923は、MyD88のToll/IL1受容体（TIR）ドメインに直接結合し、MyD88のホモ二量体形成を阻害します。T6167923は、NF-κBによって駆動される黄色ブドウ球菌エンテロトキシンAP（SEAP）活性を阻害し、IFN-γ、IL-1β、IL-6、TNF-αに対するIC50値がそれぞれ2.7μM、2.9μM、2.66μM、2.66μMで抗炎症活性を向上させます。
S7455	Resatorvid (TAK-242)	Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.	EMBO J, 2025, 10.1038/s44318-025-00515-z Carbohydr Polym, 2025, 350:122980 J Neuroinflammation, 2025, 22(1):38
E1721	TJ-M2010-5	TJ-M2010-5 is a small molecule inhibitor of MyD88 that selectively binds to the Toll/Interleukin-1 receptor (TIR) domain of MyD88, disrupting its homodimerization and subsequently inhibiting the Toll-like receptor (TLR)/MyD88 signaling pathway. TJ-M2010-5 exhibits an anti-hepatic fibrosis effect with the potential to treat liver fibrosis.
S9234	Schaftoside	Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
E8318^New	T6167923	T6167923は、MyD88依存的シグナル伝達経路の選択的阻害剤です。T6167923は、MyD88のToll/IL1受容体（TIR）ドメインに直接結合し、MyD88のホモ二量体形成を阻害します。T6167923は、NF-κBによって駆動される黄色ブドウ球菌エンテロトキシンAP（SEAP）活性を阻害し、IFN-γ、IL-1β、IL-6、TNF-αに対するIC50値がそれぞれ2.7μM、2.9μM、2.66μM、2.66μMで抗炎症活性を向上させます。
E8318^New	T6167923	T6167923は、MyD88依存的シグナル伝達経路の選択的阻害剤です。T6167923は、MyD88のToll/IL1受容体（TIR）ドメインに直接結合し、MyD88のホモ二量体形成を阻害します。T6167923は、NF-κBによって駆動される黄色ブドウ球菌エンテロトキシンAP（SEAP）活性を阻害し、IFN-γ、IL-1β、IL-6、TNF-αに対するIC50値がそれぞれ2.7μM、2.9μM、2.66μM、2.66μMで抗炎症活性を向上させます。