Neuraminidase

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S2597	Oseltamivir Phosphate	<1 mg/mL	4 mg/mL	''<1 mg/mL
S2716	Peramivir Trihydrate	<1 mg/mL	0.2 mg/mL	''<1 mg/mL
S3007	Zanamivir	25 mg/mL	2 mg/mL	''<1 mg/mL
S0946	Theaflavin			' mg/mL
S0861	Laninamivir Octanoate	<1 mg/mL	95 mg/mL	''''''5 mg/mL
S2838	Compound Y-1			' mg/mL

Neuraminidase製品

All (6) Neuraminidase阻害剤(6)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2597	Oseltamivir Phosphate Oseltamivir Phosphate is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.	J Ethnopharmacol, 2021, S0378-8741(21)00290-7 J Cell Mol Med, 2018, 22(3):1826-1839 Infect Immun, 2015, 10.1128/IAI.03118-14	Nystatin, filipin III, and oseltamivir inhibit the labeling of trophozoites by CTXB and GM1 antibodies. (A) Trophozoites were treated with nystatin (27 μM), filipin III (7.6 μM), and oseltamivir (20 μM) for 30 min before labeling with Alexa Fluor-conjugated CTXB antibody (images a to d) and GM1 antibody (images a′ to d′). Myriocin (27 μM), a sphingolipid inhibitor, was used as a negative control (images e and e′). N, nucleus; PM, plasma membrane; F, flagella; VD, ventral disc. Bars, 5 μm. (B and C) Changes in intensity of control and inhibitor-treated trophozoites. For intensity measurements, cells were randomly selected from 10 to 15 fields from 3 to 5 separate experiments. Approximately 50 cells were considered for each condition and were analyzed using Zeiss Zen 2009 confocal software. One-way ANOVAs were performed to evaluate differences (means ± SDs) between the treatment and control groups. Mean intensities from 3 to 5 separate experiments are shown in panels B and C. Statistical significance was calculated using a one-way ANOVA test, followed by the Tukey (B) and Holm-Šídák (C) methods. , P < 0.05; , P < 0.01; **, P < 0.001; NS, not significant.
S2716	Peramivir Trihydrate Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.	Emerg Microbes Infec, 2014, 3, e78 Emerg Microbes Infect, 2014, 3(11):e78	Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of peramivir (C) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.
S3007	Zanamivir Zanamivir (GG167) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.	Front Immunol, 2019, 10:2575 Emerg Microbes Infec, 2014, 3, e78 Emerg Microbes Infect, 2014, 3(11):e78	Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of oseltamivir zanamivir (B) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.
S0946	Theaflavin Theaflavin is a suitable natural inhibitor of influenza A (H1N1) neuraminidase.
S0861	Laninamivir Octanoate Laninamivir octanoate (CS-8958, R-118958, Inavir, LANI), a prodrug of Laninamivir (R-125489), is a long-acting neuraminidase (NA) inhibitor with superior anti-influenza virus activity.
S2838	Compound Y-1 Compound Y-1 (Neuraminidase-IN-1, Y-1) is a neuraminidase inhibitor with IC50 of 0.21 μM. Compound Y-1 (Neuraminidase-IN-1, Y-1) has excellent activity against H1N1 influenza virus and good inhibitory effect on the A/WSN/33 H1N1 virus strains.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2597	Oseltamivir Phosphate Oseltamivir Phosphate is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.	J Ethnopharmacol, 2021, S0378-8741(21)00290-7 J Cell Mol Med, 2018, 22(3):1826-1839 Infect Immun, 2015, 10.1128/IAI.03118-14	Nystatin, filipin III, and oseltamivir inhibit the labeling of trophozoites by CTXB and GM1 antibodies. (A) Trophozoites were treated with nystatin (27 μM), filipin III (7.6 μM), and oseltamivir (20 μM) for 30 min before labeling with Alexa Fluor-conjugated CTXB antibody (images a to d) and GM1 antibody (images a′ to d′). Myriocin (27 μM), a sphingolipid inhibitor, was used as a negative control (images e and e′). N, nucleus; PM, plasma membrane; F, flagella; VD, ventral disc. Bars, 5 μm. (B and C) Changes in intensity of control and inhibitor-treated trophozoites. For intensity measurements, cells were randomly selected from 10 to 15 fields from 3 to 5 separate experiments. Approximately 50 cells were considered for each condition and were analyzed using Zeiss Zen 2009 confocal software. One-way ANOVAs were performed to evaluate differences (means ± SDs) between the treatment and control groups. Mean intensities from 3 to 5 separate experiments are shown in panels B and C. Statistical significance was calculated using a one-way ANOVA test, followed by the Tukey (B) and Holm-Šídák (C) methods. , P < 0.05; , P < 0.01; **, P < 0.001; NS, not significant.
S2716	Peramivir Trihydrate Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.	Emerg Microbes Infec, 2014, 3, e78 Emerg Microbes Infect, 2014, 3(11):e78	Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of peramivir (C) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.
S3007	Zanamivir Zanamivir (GG167) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.	Front Immunol, 2019, 10:2575 Emerg Microbes Infec, 2014, 3, e78 Emerg Microbes Infect, 2014, 3(11):e78	Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of oseltamivir zanamivir (B) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.
S0946	Theaflavin Theaflavin is a suitable natural inhibitor of influenza A (H1N1) neuraminidase.
S0861	Laninamivir Octanoate Laninamivir octanoate (CS-8958, R-118958, Inavir, LANI), a prodrug of Laninamivir (R-125489), is a long-acting neuraminidase (NA) inhibitor with superior anti-influenza virus activity.
S2838	Compound Y-1 Compound Y-1 (Neuraminidase-IN-1, Y-1) is a neuraminidase inhibitor with IC50 of 0.21 μM. Compound Y-1 (Neuraminidase-IN-1, Y-1) has excellent activity against H1N1 influenza virus and good inhibitory effect on the A/WSN/33 H1N1 virus strains.