alpha-MSH TFA

製品コード：P1207 純度：99.76%

alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.

Amino-acid Sequence

CAS No. 171869-93-5

サイズ	価格(税別)	在庫状況
5mg	JPY 22000	国内在庫あり
25mg	JPY 53500	国内在庫あり
バルクサイズ	バルク特価あり

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製品安全説明書

現在のバッチを見る： P120701 DMSO] 100 mg/mL] false] Water] 50 mg/mL] false] Ethanol] Insoluble] false 純度： 99.76%

99.76

化学情報

保管	3 years-20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			１ケ月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (56.21 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : 50 mg/mL

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

生物活性

製品説明

alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) は13アミノ酸ペプチドホルモンです。内因性MC4Rアゴニストです。alpha-MSH TFAは内因性MC3RおよびMC4Rアゴニストで、Hepa細胞におけるhMC3RおよびhMC4Rに対するEC50はそれぞれ0.16 nMおよび56 nMです。

Targets

hMC3R	hMC4
0.16 nM	56 nM

In vitro
In vitro	Alpha-MSH exerts an inhibitory effect on IL-8 production by macrophages, an influence that may occur via modulating NFκB activation. In human glioma cells, inflammatory reactions are modulated by α-MSH peptides, apparently by modulating NFκB activation through preventing IκB degradation.

In Vivo
In vivo	Alpha-MSH inhibits both the induction and elicitation of contact sensitivity and can lead to hapten-specific tolerance. Although IL-10–deficient mice have reduced capacity to modulate both peripheral local and systemic inflammatory reactions, they are capable of reacting to exogenous α-MSH with reduced acute inflammatory reactions.

参考
https://pubmed.ncbi.nlm.nih.gov/7714790/ https://pubmed.ncbi.nlm.nih.gov/10816650/

参考

https://pubmed.ncbi.nlm.nih.gov/7714790/
https://pubmed.ncbi.nlm.nih.gov/10816650/

製品情報

Molecular Formula	C₇₇H₁₀₉N₂₁O₁₉S.xC₂HF₃O₂
Molecular Weight	1778.91
CAS No.	171869-93-5
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)