JNJ-77242113(Icotrokinra)

製品コード：P1252 純度：99.56%

Icotrokinra (JNJ-77242113, JNJ-2113, PN-235) is an orally available and selective antagonist of the IL-23 receptor. It also inhibits IL-23–induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM and suppresses IL-23–induced IFN-γ production in NK cells with an IC50 of 18.4 pM. It also exhibits anti-inflammatory activity in a TNBS-induced colitis model in rats and holds potential for studying psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Amino-acid Sequence

JNJ-77242113, JNJ-2113, PN-235

CAS No. 2763602-16-8

サイズ	価格(税別)	在庫状況
1mg	JPY 29500	国内在庫あり
5mg	JPY 52000	お問い合わせ
25mg	JPY 116500	お問い合わせ
100mg	JPY 265500	お問い合わせ
バルクサイズ	バルク特価あり

代表番号: 045-509-1970\|電子メール：sales@selleck.co.jp よく尋ねられる質問

製品安全説明書

現在のバッチを見る： P125201 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 3 mg/mL] false 純度： 99.56%

99.56

化学情報

保管	3年-20°C粉	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			１ケ月-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (52.68 mM)；吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : 100 mg/mL

Ethanol : 3 mg/mL

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

生物活性

製品説明	Icotrokinra (JNJ-77242113, JNJ-2113, PN-235) is an orally available and selective antagonist of the IL-23 receptor. It also inhibits IL-23–induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM and suppresses IL-23–induced IFN-γ production in NK cells with an IC50 of 18.4 pM. It also exhibits anti-inflammatory activity in a TNBS-induced colitis model in rats and holds potential for studying psoriasis, psoriatic arthritis, and inflammatory bowel disease.

製品説明

参考
https://pubmed.ncbi.nlm.nih.gov/39080319/

参考

https://pubmed.ncbi.nlm.nih.gov/39080319/

製品情報

Molecular Formula	C₉₀H₁₂₀N₂₀O₂₂S₂
Molecular Weight	1898.17
CAS No.	2763602-16-8
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)