PERK

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7307 GSK2606414 <1 mg/mL 90 mg/mL 19 mg/mL
S7033 GSK2656157 <1 mg/mL 32 mg/mL <1 mg/mL
S7400 ISRIB (trans-isomer) <1 mg/mL 4 mg/mL <1 mg/mL
S2923 Salubrinal <1 mg/mL 95 mg/mL 2 mg/mL
S7437 Sal003 <1 mg/mL 93 mg/mL <1 mg/mL
S8304 Azoramide <1 mg/mL 61 mg/mL 61 mg/mL

PERK製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7307

GSK2606414

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.

S7033

GSK2656157

GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases.

S7400

ISRIB (trans-isomer)

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.

S2923

Salubrinal

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

S7437

Sal003

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

S8304

Azoramide

Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7307

GSK2606414

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.

S7033

GSK2656157

GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases.

S7400

ISRIB (trans-isomer)

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2923

Salubrinal

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

2019, 10.1093/molehr/gaz002

2018, 62(8):e1700890

2017, 6(5):e341

S7437

Sal003

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

S8304

Azoramide

Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.