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γGCS

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S9728 BSO BSO is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
Redox Biol, 2024, 70:103039
Nat Commun, 2023, 14(1):1430
Front Oncol, 2023, 13:1161254
S9728 BSO BSO is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
Redox Biol, 2024, 70:103039
Nat Commun, 2023, 14(1):1430
Front Oncol, 2023, 13:1161254

γGCS阻害剤の選択性比較

Tags: γGCS inhibitor|γGCS agonist|γGCS activator|γGCS inducer|γGCS antagonist|γGCS signaling pathway|γGCS assay kit