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S7434 (S,S)-TAPI-1 (S,S)-TAPI-1 is an isomer of TAPI-1.TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).
Nat Sci Sleep, 2025, 17:1915-1928
Br J Cancer, 2024, 10.1038/s41416-024-02576-z
J Biol Chem, 2024, 300(12):107930
TAPI-1-S743401Y0420170605.gif
E1386 KP-457 KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α.
S7434 (S,S)-TAPI-1 (S,S)-TAPI-1 is an isomer of TAPI-1.TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).
Nat Sci Sleep, 2025, 17:1915-1928
Br J Cancer, 2024, 10.1038/s41416-024-02576-z
J Biol Chem, 2024, 300(12):107930
 TAPI-1-S743401Y0420170605.gif
E1386 KP-457 KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α.
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