DNA alkylator

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1215 Carboplatin (NSC 241240) 14 mg/mL <1 mg/mL '<1 mg/mL
S8056 Lomeguatrib <1 mg/mL 65 mg/mL '<1 mg/mL
S3658 O6-Benzylguanine <1 mg/mL 48 mg/mL ''12 mg/mL
S1302 Ifosfamide (NSC109724) 52 mg/mL 52 mg/mL '52 mg/mL
S4447 Pipobroman <1 mg/mL 71 mg/mL ''71 mg/mL
S6958 Treosulfan 56 mg/mL 56 mg/mL '''<1 mg/mL
S1224 Oxaliplatin (NSC 266046) 3 mg/mL -1 mg/mL ''0.01 mg/mL
S1312 Streptozotocin (STZ) 53 mg/mL 53 mg/mL ''<1 mg/mL
S1692 Busulfan (NSC-750) <1 mg/mL 49 mg/mL '<1 mg/mL
S2057 Cyclophosphamide (NSC-26271) Monohydrate 7 mg/mL 55 mg/mL '''<1 mg/mL
S1278 Altretamine <1 mg/mL 15 mg/mL 33 mg/mL
S6984 Dianhydrogalactitol (VAL-083) 29 mg/mL 29 mg/mL ''29 mg/mL
S7829 CB1954 <1 mg/mL 50 mg/mL '<1 mg/mL
S5840 Palifosfamide 13 mg/mL 44 mg/mL 2 mg/mL
S8266 Melphalan <1 mg/mL 10 mg/mL '<1 mg/mL
S8880 Lobaplatin (D-19466) 7 mg/mL 1.5 mg/mL '4 mg/mL

亜型選択性的な製品

DNA alkylator製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1215

Carboplatin (NSC 241240)

Carboplatin (NSC 241240, JM-8, CBDCA) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

S8056

Lomeguatrib

Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.

S3658

O6-Benzylguanine

O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

S1302

Ifosfamide (NSC109724)

Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.

S4447

Pipobroman

Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.

S6958

Treosulfan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.

S1224

Oxaliplatin (NSC 266046)

Oxaliplatin (NSC 266046, L-OHP, Eloxatin) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

S1312

Streptozotocin (STZ)

Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are best fresh-prepared.

S1692

Busulfan (NSC-750)

Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.

E0609

Methyl methanesulfonate

Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.

S2057

Cyclophosphamide (NSC-26271) Monohydrate

Cyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.

S1278

Altretamine

Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.

S6984

Dianhydrogalactitol (VAL-083)

Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.

S7829

CB1954

CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

S5840

Palifosfamide

Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.

S8266

Melphalan

Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.

S8880

Lobaplatin (D-19466)

Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1215

Carboplatin (NSC 241240)

Carboplatin (NSC 241240, JM-8, CBDCA) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

S8056

Lomeguatrib

Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.

S3658

O6-Benzylguanine

O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1302

Ifosfamide (NSC109724)

Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.

2022, 8(1):44

2022, 10.1007/s13577-022-00671-y

2021, 21(1):646

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S4447

Pipobroman

Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.

S6958

Treosulfan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1224

Oxaliplatin (NSC 266046)

Oxaliplatin (NSC 266046, L-OHP, Eloxatin) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

2022, candisc.1117.2021

2022, 7(1):87

2022, 79(3):135

S1312

Streptozotocin (STZ)

Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are best fresh-prepared.

2022, 10.1038/s41591-021-01645-7

2022, 10(1):26

2022, 10.1007/s13577-022-00671-y

S1692

Busulfan (NSC-750)

Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.

2022, 10.1007/s13577-022-00671-y

2022, 3(2):154-169

2021, 23(1):100

E0609

Methyl methanesulfonate

Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.

S2057

Cyclophosphamide (NSC-26271) Monohydrate

Cyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.

2022, 23(7)3834

2022, 606:68-74

2022, 15(1):101287

S1278

Altretamine

Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.

2022, 10.1007/s13577-022-00671-y

2021, 34(6):1911-1918

2021, 10.1007/s13577-021-00579-z

S6984

Dianhydrogalactitol (VAL-083)

Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.

S7829

CB1954

CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

S5840

Palifosfamide

Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.

S8266

Melphalan

Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.

2022, 13(1):1009

2022, 13(3):197

2021, 20(2):367-378

S8880

Lobaplatin (D-19466)

Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.

2020, 12:114023

Tags: DNA alkylator inhibitor|DNA alkylator agonist|DNA alkylator activator|DNA alkylator inducer|DNA alkylator antagonist|DNA alkylator signaling pathway|DNA alkylator assay kit