DNA alkylator

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1215 Carboplatin 14 mg/mL <1 mg/mL '''<1 mg/mL
S1224 Oxaliplatin 3 mg/mL -1 mg/mL '''0.01 mg/mL
S1312 Streptozotocin (STZ) 53 mg/mL 53 mg/mL <1 mg/mL
S1692 Busulfan <1 mg/mL 49 mg/mL <1 mg/mL
S2057 Cyclophosphamide Monohydrate 7 mg/mL 55 mg/mL '<1 mg/mL
S8880 Lobaplatin ( D-19466) 7 mg/mL 1.5 mg/mL 4 mg/mL
S1278 Altretamine <1 mg/mL 15 mg/mL 33 mg/mL
S7829 CB1954 <1 mg/mL 50 mg/mL <1 mg/mL
S5840 Palifosfamide 13 mg/mL 44 mg/mL 2 mg/mL
S8266 Melphalan <1 mg/mL 10 mg/mL <1 mg/mL

DNA alkylator製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1215

Carboplatin

Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

S1224

Oxaliplatin

Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

S1312

Streptozotocin (STZ)

Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

S1692

Busulfan

Busulfan is a cell cycle non-specific alkylating antineoplastic agent.

S2057

Cyclophosphamide Monohydrate

Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.

S8880

Lobaplatin ( D-19466)

Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.

S1278

Altretamine

Altretamine is an anti-neoplastic agent.

S7829

CB1954

CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

S5840

Palifosfamide

Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.

S8266

Melphalan

Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1215

Carboplatin

Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1224

Oxaliplatin

Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

2020, 37(3):371-386

2020, 28;14(4):5075-5089

2020, 319:213-221

S1312

Streptozotocin (STZ)

Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

2020, 19;20:58

2020, 10.1007

2019, 104(4):390-401

S1692

Busulfan

Busulfan is a cell cycle non-specific alkylating antineoplastic agent.

2020, 11(1):798

2020, 19;20:58

2019, 17:277-288

S2057

Cyclophosphamide Monohydrate

Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.

2020, 472:59-69

2020, 24;10(1):7004

2020, 19;20:58

S8880

Lobaplatin ( D-19466)

Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.

2020, 12:114023

S1278

Altretamine

Altretamine is an anti-neoplastic agent.

2020, 19;20:58

S7829

CB1954

CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

S5840

Palifosfamide

Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.

S8266

Melphalan

Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.

2019, 10(1):4632

2019, 10.1002/ijc.32615

2018, 10.1158/1078-0432.CCR-18-1776