DNA alkylator

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1215 Carboplatin 14 mg/mL <1 mg/mL '''''<1 mg/mL
S8056 Lomeguatrib <1 mg/mL 65 mg/mL '<1 mg/mL
S1302 Ifosfamide 52 mg/mL 52 mg/mL ''52 mg/mL
S1224 Oxaliplatin 3 mg/mL -1 mg/mL ''''0.01 mg/mL
S1312 Streptozotocin (STZ) 53 mg/mL 53 mg/mL ''<1 mg/mL
S1692 Busulfan <1 mg/mL 49 mg/mL '<1 mg/mL
S8880 Lobaplatin ( D-19466) 7 mg/mL 1.5 mg/mL 4 mg/mL
S2057 Cyclophosphamide Monohydrate 7 mg/mL 55 mg/mL '<1 mg/mL
S1278 Altretamine <1 mg/mL 15 mg/mL '33 mg/mL
S7829 CB1954 <1 mg/mL 50 mg/mL <1 mg/mL
S5840 Palifosfamide 13 mg/mL 44 mg/mL 2 mg/mL
S8266 Melphalan <1 mg/mL 10 mg/mL <1 mg/mL

DNA alkylator製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1215

Carboplatin

Carboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

S8056

Lomeguatrib

Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.

S1302

Ifosfamide

Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.

S1224

Oxaliplatin

Oxaliplatin (L-OHP) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

S1312

Streptozotocin (STZ)

Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis.

S1692

Busulfan

Busulfan is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.

S8880

Lobaplatin ( D-19466)

Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.

S2057

Cyclophosphamide Monohydrate

Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.

S1278

Altretamine

Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.

S7829

CB1954

CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

S5840

Palifosfamide

Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.

S8266

Melphalan

Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1215

Carboplatin

Carboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

S8056

Lomeguatrib

Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1302

Ifosfamide

Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.

2020, 19;20:58

2017, 363(1):20-34

2016, 37(2):2341-51

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1224

Oxaliplatin

Oxaliplatin (L-OHP) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

2020, 37(3):371-386

2020, 28;14(4):5075-5089

2020, 319:213-221

S1312

Streptozotocin (STZ)

Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis.

2020, 19;20:58

2020, 10.1007

2019, 104(4):390-401

S1692

Busulfan

Busulfan is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.

2020, 11(1):798

2020, 19;20:58

2019, 17:277-288

S8880

Lobaplatin ( D-19466)

Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.

2020, 12:114023

S2057

Cyclophosphamide Monohydrate

Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.

2020, 472:59-69

2020, 24;10(1):7004

2020, 19;20:58

S1278

Altretamine

Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.

2020, canres.530.2020

2020, 19;20:58

S7829

CB1954

CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

S5840

Palifosfamide

Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.

S8266

Melphalan

Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.

2020, 15(6):e0232068

2019, 10(1):4632

2019, 10.1002/ijc.32615