DNA alkylator

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1215	Carboplatin	14 mg/mL	<1 mg/mL	'''''<1 mg/mL
S8056	Lomeguatrib	<1 mg/mL	65 mg/mL	'<1 mg/mL
S1302	Ifosfamide	52 mg/mL	52 mg/mL	''52 mg/mL
S1224	Oxaliplatin	3 mg/mL	-1 mg/mL	''''0.01 mg/mL
S1312	Streptozotocin (STZ)	53 mg/mL	53 mg/mL	''<1 mg/mL
S1692	Busulfan	<1 mg/mL	49 mg/mL	'<1 mg/mL
S8880	Lobaplatin ( D-19466)	7 mg/mL	1.5 mg/mL	4 mg/mL
S2057	Cyclophosphamide Monohydrate	7 mg/mL	55 mg/mL	'<1 mg/mL
S1278	Altretamine	<1 mg/mL	15 mg/mL	'33 mg/mL
S7829	CB1954	<1 mg/mL	50 mg/mL	<1 mg/mL
S5840	Palifosfamide	13 mg/mL	44 mg/mL	2 mg/mL
S8266	Melphalan	<1 mg/mL	10 mg/mL	<1 mg/mL

DNA alkylator製品

All (12) DNA alkylator阻害剤(2) DNA alkylator活性剤(1)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1215	Carboplatin Carboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.	Nat Commun, 2020, 24;11(1):1975 Nat Commun, 2020, 22;11(1):2573 EMBO Mol Med, 2020, 12(4):e11177	Detection of apoptotic responses was found to increase in epimorphin-treated A1847 with increasing concentrations of carboplatin compared to those of the untreated controls. Data were normalized to the controls and are represented as means ± S.D. [*p<0.05 compared with control]. Images of apoptotic cells were captured at 10X magnification, with at least 3 images per well, using an upright phase-contrast microscope (T3.15A; Fisher Scientific).
S8056	Lomeguatrib Lomeguatrib is a potent inhibitor of O⁶-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.	Nucleic Acids Res, 2018, 46(20):10888-10904 Onco Targets Ther, 2018, 11:3671-3684 Mol Cancer Ther, 2015, 14(5):1236-46	Characterization of melanoma cell lines upon MGMT status. A, representative examples of dose-response curves for MGMT+ and MGMT− cells treated with temozolomide (TMZ) with or without lomeguatrib (LOM). Graphs show the average GI50 for temozolomide in the presence or absence of lomeguatrib (B).
S1302	Ifosfamide Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.	Cancer Cell Int, 2020, 19;20:58 J Pharmacol Exp Ther, 2017, 363(1):20-34 Tumour Biol, 2016, 37(2):2341-51	Chemotherapeutic response. Ifosfamide was applied at different concentrations on Lipo-DUE1, Lipo246, and PLS-1 for 72 h. Subsequently, cell viability was determined by MTS assay at a wavelength of 490 nm. Values represent the mean±S.D. of triplicates
S1224	Oxaliplatin Oxaliplatin (L-OHP) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.	Cancer Cell, 2020, 37(3):371-386 ACS Nano, 2020, 28;14(4):5075-5089 J Control Release, 2020, 319:213-221	Immunocytochemical staining of SW620 (metastatic) cells after treatment with 10 uM oxaliplatin (F) or 10 uM ginsenosides 20(S)-Rg 3 (G) and negative staining (H). Cells demonstrated differential expression of histone H4.
S1312	Streptozotocin (STZ) Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis.	Cancer Cell Int, 2020, 19;20:58 Cytotechnology, 2020, 10.1007 Calcif Tissue Int, 2019, 104(4):390-401	Effect of telmisartan and other treatments on (a) nitric oxide, (b) serum cortisol level. Data is expressed as mean ± SEM (n = 6). Statistical significances were determined using one way ANOVA followed by dunnetts post hoc test. ###p < 0.001 as compared with normal, p < 0.05, p < 0.01, ***p < 0.001 as compared to STZ control. TMS: telmisartan, MET: metformin, FLX: fluoxetine. The figure in parenthesis indicates the dose in mg/kg po.
S1692	Busulfan Busulfan is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.	Nat Commun, 2020, 11(1):798 Cancer Cell Int, 2020, 19;20:58 Mol Ther Nucleic Acids, 2019, 17:277-288
S8880^新	Lobaplatin ( D-19466) Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.	Biochem Pharmacol, 2020, 12:114023
S2057	Cyclophosphamide Monohydrate Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.	Cancer Lett, 2020, 472:59-69 Sci Rep, 2020, 24;10(1):7004 Cancer Cell Int, 2020, 19;20:58	Conditional patched mutant tumor cells were treated with increasing concentrations cyclophosphamide (D), alone or in combination with 10 nmol/L BI-2536. Cells were cultured for 48 hours, pulsed with 3H-Td, and harvested for analysis of 3H-Td incorporation at 66 hours. Data represent means of triplicate samples ± SEM.
S1278	Altretamine Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.	Cancer Res, 2020, canres.530.2020 Cancer Cell Int, 2020, 19;20:58
S7829	CB1954 CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.
S5840	Palifosfamide Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S8266	Melphalan Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.	PLoS One, 2020, 15(6):e0232068 Nat Commun, 2019, 10(1):4632 Int J Cancer, 2019, 10.1002/ijc.32615	(C)ChIP analysis using a SIRT6 specific antibody to detect SIRT6 recruitment at Alu sequences after DNA damage triggered by doxorubicin (1μM) or melphalan (100μM), with or without pretreatment with OSS_128167 (200 μM). Occupancy at Alu sites is shown relative to background signal with IgG control antibody. n= 3 independent experiments. Data are presented as the mean ± S.D. p=0.01; * p=0.003 (Student's t test) (D) ChIP analysis to detect H3K56 acetylation at DNA damage sites in SIRT6 WT and KD MM cells upon genotoxic stress. Antibody to acetylated H3K56 was used, and levels are shown relative to the background signal with IgG control antibody. n= 4 independent experiments. Data are presented as the mean ± S.D. ****p<0.0001 (unpaired t test)

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S1215

Carboplatin

Carboplatin (JM-8, CBDCA, NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

Nat Commun, 2020, 24;11(1):1975

Nat Commun, 2020, 22;11(1):2573

EMBO Mol Med, 2020, 12(4):e11177

S8056

Lomeguatrib

Lomeguatrib is a potent inhibitor of O⁶-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.

Nucleic Acids Res, 2018, 46(20):10888-10904

Onco Targets Ther, 2018, 11:3671-3684

Mol Cancer Ther, 2015, 14(5):1236-46

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1302	Ifosfamide Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.	Cancer Cell Int, 2020, 19;20:58 J Pharmacol Exp Ther, 2017, 363(1):20-34 Tumour Biol, 2016, 37(2):2341-51	Chemotherapeutic response. Ifosfamide was applied at different concentrations on Lipo-DUE1, Lipo246, and PLS-1 for 72 h. Subsequently, cell viability was determined by MTS assay at a wavelength of 490 nm. Values represent the mean±S.D. of triplicates

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S1302

Ifosfamide

Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.

Cancer Cell Int, 2020, 19;20:58

J Pharmacol Exp Ther, 2017, 363(1):20-34

Tumour Biol, 2016, 37(2):2341-51

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1224	Oxaliplatin Oxaliplatin (L-OHP) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.	Cancer Cell, 2020, 37(3):371-386 ACS Nano, 2020, 28;14(4):5075-5089 J Control Release, 2020, 319:213-221	Immunocytochemical staining of SW620 (metastatic) cells after treatment with 10 uM oxaliplatin (F) or 10 uM ginsenosides 20(S)-Rg 3 (G) and negative staining (H). Cells demonstrated differential expression of histone H4.
S1312	Streptozotocin (STZ) Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis.	Cancer Cell Int, 2020, 19;20:58 Cytotechnology, 2020, 10.1007 Calcif Tissue Int, 2019, 104(4):390-401	Effect of telmisartan and other treatments on (a) nitric oxide, (b) serum cortisol level. Data is expressed as mean ± SEM (n = 6). Statistical significances were determined using one way ANOVA followed by dunnetts post hoc test. ###p < 0.001 as compared with normal, p < 0.05, p < 0.01, ***p < 0.001 as compared to STZ control. TMS: telmisartan, MET: metformin, FLX: fluoxetine. The figure in parenthesis indicates the dose in mg/kg po.
S1692	Busulfan Busulfan is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.	Nat Commun, 2020, 11(1):798 Cancer Cell Int, 2020, 19;20:58 Mol Ther Nucleic Acids, 2019, 17:277-288
S8880^新	Lobaplatin ( D-19466) Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.	Biochem Pharmacol, 2020, 12:114023
S2057	Cyclophosphamide Monohydrate Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.	Cancer Lett, 2020, 472:59-69 Sci Rep, 2020, 24;10(1):7004 Cancer Cell Int, 2020, 19;20:58	Conditional patched mutant tumor cells were treated with increasing concentrations cyclophosphamide (D), alone or in combination with 10 nmol/L BI-2536. Cells were cultured for 48 hours, pulsed with 3H-Td, and harvested for analysis of 3H-Td incorporation at 66 hours. Data represent means of triplicate samples ± SEM.
S1278	Altretamine Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.	Cancer Res, 2020, canres.530.2020 Cancer Cell Int, 2020, 19;20:58
S7829	CB1954 CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.
S5840	Palifosfamide Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S8266	Melphalan Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.	PLoS One, 2020, 15(6):e0232068 Nat Commun, 2019, 10(1):4632 Int J Cancer, 2019, 10.1002/ijc.32615	(C)ChIP analysis using a SIRT6 specific antibody to detect SIRT6 recruitment at Alu sequences after DNA damage triggered by doxorubicin (1μM) or melphalan (100μM), with or without pretreatment with OSS_128167 (200 μM). Occupancy at Alu sites is shown relative to background signal with IgG control antibody. n= 3 independent experiments. Data are presented as the mean ± S.D. p=0.01; * p=0.003 (Student's t test) (D) ChIP analysis to detect H3K56 acetylation at DNA damage sites in SIRT6 WT and KD MM cells upon genotoxic stress. Antibody to acetylated H3K56 was used, and levels are shown relative to the background signal with IgG control antibody. n= 4 independent experiments. Data are presented as the mean ± S.D. ****p<0.0001 (unpaired t test)

研究分野別

製品類型

DNA alkylator

阻害剤の選択性比較