DNA alkylator
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1215 | Carboplatin (NSC 241240) | 14 mg/mL | <1 mg/mL | '<1 mg/mL |
| S8056 | Lomeguatrib | <1 mg/mL | 65 mg/mL | '<1 mg/mL |
| S3658 | O6-Benzylguanine | <1 mg/mL | 48 mg/mL | ''12 mg/mL |
| S1302 | Ifosfamide (NSC109724) | 52 mg/mL | 52 mg/mL | '52 mg/mL |
| S4447 | Pipobroman | <1 mg/mL | 71 mg/mL | ''71 mg/mL |
| S6958 | Treosulfan | 56 mg/mL | 56 mg/mL | '''<1 mg/mL |
| S1224 | Oxaliplatin (NSC 266046) | 3 mg/mL | -1 mg/mL | ''0.01 mg/mL |
| S1312 | Streptozotocin (STZ) | 53 mg/mL | 53 mg/mL | ''<1 mg/mL |
| S1692 | Busulfan (NSC-750) | <1 mg/mL | 49 mg/mL | '<1 mg/mL |
| S6984 | Dianhydrogalactitol (VAL-083) | 29 mg/mL | 29 mg/mL | ''29 mg/mL |
| S2057 | Cyclophosphamide (NSC-26271) Monohydrate | 7 mg/mL | 55 mg/mL | '''<1 mg/mL |
| S1278 | Altretamine | <1 mg/mL | 15 mg/mL | 33 mg/mL |
| S7829 | CB1954 | <1 mg/mL | 50 mg/mL | '<1 mg/mL |
| S5840 | Palifosfamide | 13 mg/mL | 44 mg/mL | 2 mg/mL |
| S8266 | Melphalan | <1 mg/mL | 10 mg/mL | '<1 mg/mL |
| S8880 | Lobaplatin (D-19466) | 7 mg/mL | 1.5 mg/mL | '4 mg/mL |
亜型選択性的な製品
DNA alkylator製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1215 |
Carboplatin (NSC 241240)Carboplatin (NSC 241240, JM-8, CBDCA) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared. |
Detection of apoptotic responses was found to increase in epimorphin-treated A1847 with increasing concentrations of carboplatin compared to those of the untreated controls. Data were normalized to the controls and are represented as means ± S.D. [*p<0.05 compared with control]. Images of apoptotic cells were captured at 10X magnification, with at least 3 images per well, using an upright phase-contrast microscope (T3.15A; Fisher Scientific). |
|
| S8056 |
LomeguatribLomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM. |
Characterization of melanoma cell lines upon MGMT status. A, representative examples of dose-response curves for MGMT+ and MGMT− cells treated with temozolomide (TMZ) with or without lomeguatrib (LOM). Graphs show the average GI50 for temozolomide in the presence or absence of lomeguatrib (B). |
|
| S3658 |
O6-BenzylguanineO6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. |
||
| S1302 |
Ifosfamide (NSC109724)Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer. |
Chemotherapeutic response. Ifosfamide was applied at different concentrations on Lipo-DUE1, Lipo246, and PLS-1 for 72 h. Subsequently, cell viability was determined by MTS assay at a wavelength of 490 nm. Values represent the mean±S.D. of triplicates
|
|
| S4447新 |
PipobromanPipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity. |
||
| S6958 |
TreosulfanTreosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines. |
||
| S1224 |
Oxaliplatin (NSC 266046)Oxaliplatin (NSC 266046, L-OHP, Eloxatin) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared. |
Immunocytochemical staining of SW620 (metastatic) cells after treatment with 10 uM oxaliplatin (F) or 10 uM ginsenosides 20(S)-Rg 3 (G) and negative staining (H). Cells demonstrated differential expression of histone H4. |
|
| S1312 |
Streptozotocin (STZ)Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are best fresh-prepared. |
Effect of telmisartan and other treatments on (a) nitric oxide, (b) serum cortisol level. Data is expressed as mean ± SEM (n = 6). Statistical significances were determined using one way ANOVA followed by dunnetts post hoc test. ###p < 0.001 as compared with normal, *p < 0.05, *p < 0.01, ***p < 0.001 as compared to STZ control. TMS: telmisartan, MET: metformin, FLX: fluoxetine. The figure in parenthesis indicates the dose in mg/kg po. |
|
| S1692 |
Busulfan (NSC-750)Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis. |
||
| S6984新 |
Dianhydrogalactitol (VAL-083)Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity. |
||
| S2057 |
Cyclophosphamide (NSC-26271) MonohydrateCyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations. |
Conditional patched mutant tumor cells were treated with increasing concentrations cyclophosphamide (D), alone or in combination with 10 nmol/L BI-2536. Cells were cultured for 48 hours, pulsed with 3H-Td, and harvested for analysis of 3H-Td incorporation at 66 hours. Data represent means of triplicate samples ± SEM. |
|
| S1278 |
AltretamineAltretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent. |
||
| S7829 |
CB1954CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2. |
||
| S5840 |
PalifosfamidePalifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity. |
||
| S8266 |
MelphalanMelphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity. |
(C)ChIP analysis using a SIRT6 specific antibody to detect SIRT6 recruitment at Alu sequences after DNA damage triggered by doxorubicin (1μM) or melphalan (100μM), with or without pretreatment with OSS_128167 (200 μM). Occupancy at Alu sites is shown relative to background signal with IgG control antibody. n= 3 independent experiments. Data are presented as the mean ± S.D. *p=0.01; ** p=0.003 (Student's t test) (D) ChIP analysis to detect H3K56 acetylation at DNA damage sites in SIRT6 WT and KD MM cells upon genotoxic stress. Antibody to acetylated H3K56 was used, and levels are shown relative to the background signal with IgG control antibody. n= 4 independent experiments. Data are presented as the mean ± S.D. ****p<0.0001 (unpaired t test)
|
|
| S8880 |
Lobaplatin (D-19466)Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1215 |
Carboplatin (NSC 241240)Carboplatin (NSC 241240, JM-8, CBDCA) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared. |
Detection of apoptotic responses was found to increase in epimorphin-treated A1847 with increasing concentrations of carboplatin compared to those of the untreated controls. Data were normalized to the controls and are represented as means ± S.D. [*p<0.05 compared with control]. Images of apoptotic cells were captured at 10X magnification, with at least 3 images per well, using an upright phase-contrast microscope (T3.15A; Fisher Scientific). |
|
| S8056 |
LomeguatribLomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM. |
Characterization of melanoma cell lines upon MGMT status. A, representative examples of dose-response curves for MGMT+ and MGMT− cells treated with temozolomide (TMZ) with or without lomeguatrib (LOM). Graphs show the average GI50 for temozolomide in the presence or absence of lomeguatrib (B). |
|
| S3658 |
O6-BenzylguanineO6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1302 |
Ifosfamide (NSC109724)Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer. |
2021, 21(1):646 2021, 10.1007/s13577-021-00639-4 2021, 10.1007/s13577-021-00579-z |
Chemotherapeutic response. Ifosfamide was applied at different concentrations on Lipo-DUE1, Lipo246, and PLS-1 for 72 h. Subsequently, cell viability was determined by MTS assay at a wavelength of 490 nm. Values represent the mean±S.D. of triplicates
|
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S4447新 |
PipobromanPipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity. |
||
| S6958 |
TreosulfanTreosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1224 |
Oxaliplatin (NSC 266046)Oxaliplatin (NSC 266046, L-OHP, Eloxatin) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared. |
2021, 184(25):6119-6137.e26 2021, S1535-6108(21)00659-0 2021, e2103360 |
Immunocytochemical staining of SW620 (metastatic) cells after treatment with 10 uM oxaliplatin (F) or 10 uM ginsenosides 20(S)-Rg 3 (G) and negative staining (H). Cells demonstrated differential expression of histone H4. |
| S1312 |
Streptozotocin (STZ)Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are best fresh-prepared. |
2021, 10.1007/s13577-021-00639-4 2021, 10.1007/s13577-021-00579-z 2020, 12(20):1811-1824 |
Effect of telmisartan and other treatments on (a) nitric oxide, (b) serum cortisol level. Data is expressed as mean ± SEM (n = 6). Statistical significances were determined using one way ANOVA followed by dunnetts post hoc test. ###p < 0.001 as compared with normal, *p < 0.05, *p < 0.01, ***p < 0.001 as compared to STZ control. TMS: telmisartan, MET: metformin, FLX: fluoxetine. The figure in parenthesis indicates the dose in mg/kg po. |
| S1692 |
Busulfan (NSC-750)Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis. |
2021, 23(1):100 2021, 10.1007/s13577-021-00579-z 2021, 10.1007/s13577-021-00639-4 |
|
| S6984新 |
Dianhydrogalactitol (VAL-083)Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity. |
||
| S2057 |
Cyclophosphamide (NSC-26271) MonohydrateCyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations. |
2022, 15(1):101287 2021, 22(9):1107-1117 2021, 272:120770 |
Conditional patched mutant tumor cells were treated with increasing concentrations cyclophosphamide (D), alone or in combination with 10 nmol/L BI-2536. Cells were cultured for 48 hours, pulsed with 3H-Td, and harvested for analysis of 3H-Td incorporation at 66 hours. Data represent means of triplicate samples ± SEM. |
| S1278 |
AltretamineAltretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent. |
2021, 10.1007/s13577-021-00579-z 2021, 10.1007/s13577-021-00639-4 2020, canres.530.2020 |
|
| S7829 |
CB1954CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2. |
||
| S5840 |
PalifosfamidePalifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity. |
||
| S8266 |
MelphalanMelphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity. |
2021, 20(2):367-378 2021, 5(7):e602 2021, 5(9):2391-2402 |
(C)ChIP analysis using a SIRT6 specific antibody to detect SIRT6 recruitment at Alu sequences after DNA damage triggered by doxorubicin (1μM) or melphalan (100μM), with or without pretreatment with OSS_128167 (200 μM). Occupancy at Alu sites is shown relative to background signal with IgG control antibody. n= 3 independent experiments. Data are presented as the mean ± S.D. *p=0.01; ** p=0.003 (Student's t test) (D) ChIP analysis to detect H3K56 acetylation at DNA damage sites in SIRT6 WT and KD MM cells upon genotoxic stress. Antibody to acetylated H3K56 was used, and levels are shown relative to the background signal with IgG control antibody. n= 4 independent experiments. Data are presented as the mean ± S.D. ****p<0.0001 (unpaired t test)
|
| S8880 |
Lobaplatin (D-19466)Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity. |
2020, 12:114023 |
