DYRK

阻害剤の選択性比較
溶解度

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S7338	AZ191	<1 mg/mL	85 mg/mL	1 mg/mL
S7327	ID-8	<1 mg/mL	60 mg/mL	2 mg/mL
S3817	Harmine hydrochloride	21 mg/mL	21 mg/mL	-1 mg/mL

DYRK製品

All (3) DYRK阻害剤(3)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7338	AZ191 AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.	Cancer Lett, 2016, 370(2):332-44 Cell Death Dis, 2014, 5:e1548 Antiviral Res, 2017, 143:113-121	(E) BEL7402 and HepG2 cells were treated with vehicle or 10 μM of the DYRK1B inhibitor, AZ191, alone and in combination with BafA1 for 24 h. Cyclin D1 expression was examined by immunoblot analysis.
S7327	ID-8 ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.
S3817	Harmine hydrochloride Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs).

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S7338

AZ191

AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

Cancer Lett, 2016, 370(2):332-44

Cell Death Dis, 2014, 5:e1548

Antiviral Res, 2017, 143:113-121

S7327

ID-8

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.

S3817

Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs).

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S7338	AZ191 AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.	Cancer Lett, 2016, 370(2):332-44 Cell Death Dis, 2014, 5:e1548 Antiviral Res, 2017, 143:113-121	(E) BEL7402 and HepG2 cells were treated with vehicle or 10 μM of the DYRK1B inhibitor, AZ191, alone and in combination with BafA1 for 24 h. Cyclin D1 expression was examined by immunoblot analysis.
S7327	ID-8 ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.
S3817	Harmine hydrochloride Harmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs).