IDO/TDO

亜型選択性的な製品

IDO/TDO製品

  • All (16)
  • IDO/TDO阻害剤 (16)
  • 新製品
製品コード 製品名称 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8037 Necrostatin-1 Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.
Antioxidants (Basel), 2024, 13(1)114
Heliyon, 2024, 10(1):e23426
J Cancer, 2024, 15(3):685-698
S7910 Epacadostat (INCB024360) Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).
Front Immunol, 2024, 15:1346686
J Pharm Biomed Anal, 2024, 237:115750
Cell Rep Med, 2023, 4(2):100941
S7111 IDO-IN-2 IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.
Acta Pharm Sin B, 2022, 12(6):2695-2709
Small, 2022, e2205694
Int J Mol Sci, 2022, 23(7)3981
S7756 Indoximod Indoximod, a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Nat Commun, 2023, 14(1):5753
Nat Commun, 2023, 14(1):5753
J Immunother Cancer, 2021, 9(7)e002840
S8957 Navoximod Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.
Acta Pharm Sin B, 2022, 12(6):2695-2709
Pharmaceuticals (Basel), 2022, 15(9)1090
Bioorg Med Chem, 2021, 39:116160
S8629 Linrodostat (BMS-986205) Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.
Front Chem, 2022, 10:998013
Front Oncol, 2021, 11:679517
Eur Respir J, 2020, 2000443
S8657 PF-06840003 PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.
Front Immunol, 2023, 14:1100041
J Immunother Cancer, 2022, 10(3)e004414
Cell, 2020, 182(5):1252-1270.e34
S8368 LM10 LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50 values of 0.62 and 2 μM for human and mouse TDO, respectively.
Sci Adv, 2023, 9(5):eadd6995
Mol Med Rep, 2021, 23(6)445
Eur J Med Chem, 2018, 160:133-145
S8557 IDO inhibitor 1 IDO inhibitor 1 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM.
J Immunol, 2023, 211(2):261-273
Eur Respir J, 2020, 2000443
S7587 Epacadostat (INCB024360) analogue Epacadostat (INCB024360) analogue (INCB14943) is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM. Phase 2.
Front Immunol, 2022, 13:966514
Oncoimmunology, 2017,
S8997 680C91 680C91 is a potent and selective inhibitor of TDO with Ki of 51 nM.
Cell, 2023, 186(22):4851-4867.e20
Int J Tryptophan Res, 2022, 15:11786469221138456
E0090 GNF-PF-3777 GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2, 3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
S8919 LY-3381916 LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. LY-3381916 exhibits anti-tumor activity.
S9137 Erianin Erianin, a natural product derived from Dendrobium chrysotoxum, has been used as an analgesic in traditional Chinese medicine and is a potential anti-tumor agent. Erianin can inhibit IDO-induced tumor angiogenesis.
S5249 Coptisine chloride Coptisine (Q-100696, NSC-119754) is an isoquinoline alkaloid isolated from Coptidis Rhizoma with anti-diabetic, antimicrobial, antiviral, anti-hepatoma, and anti-leukemia effects. Coptisine chloride is an efficient uncompetitive IDO inhibitor with IC50 value of 6.3 μM and Ki value of 5.8 μM.
S6728 IDO-IN-1 IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.
S8037 Necrostatin-1 Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.
Antioxidants (Basel), 2024, 13(1)114
Heliyon, 2024, 10(1):e23426
J Cancer, 2024, 15(3):685-698
S7910 Epacadostat (INCB024360) Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).
Front Immunol, 2024, 15:1346686
J Pharm Biomed Anal, 2024, 237:115750
Cell Rep Med, 2023, 4(2):100941
S7111 IDO-IN-2 IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.
Acta Pharm Sin B, 2022, 12(6):2695-2709
Small, 2022, e2205694
Int J Mol Sci, 2022, 23(7)3981
S7756 Indoximod Indoximod, a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Nat Commun, 2023, 14(1):5753
Nat Commun, 2023, 14(1):5753
J Immunother Cancer, 2021, 9(7)e002840
S8957 Navoximod Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.
Acta Pharm Sin B, 2022, 12(6):2695-2709
Pharmaceuticals (Basel), 2022, 15(9)1090
Bioorg Med Chem, 2021, 39:116160
S8629 Linrodostat (BMS-986205) Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.
Front Chem, 2022, 10:998013
Front Oncol, 2021, 11:679517
Eur Respir J, 2020, 2000443
S8657 PF-06840003 PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.
Front Immunol, 2023, 14:1100041
J Immunother Cancer, 2022, 10(3)e004414
Cell, 2020, 182(5):1252-1270.e34
S8368 LM10 LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50 values of 0.62 and 2 μM for human and mouse TDO, respectively.
Sci Adv, 2023, 9(5):eadd6995
Mol Med Rep, 2021, 23(6)445
Eur J Med Chem, 2018, 160:133-145
S8557 IDO inhibitor 1 IDO inhibitor 1 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM.
J Immunol, 2023, 211(2):261-273
Eur Respir J, 2020, 2000443
S7587 Epacadostat (INCB024360) analogue Epacadostat (INCB024360) analogue (INCB14943) is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM. Phase 2.
Front Immunol, 2022, 13:966514
Oncoimmunology, 2017,
S8997 680C91 680C91 is a potent and selective inhibitor of TDO with Ki of 51 nM.
Cell, 2023, 186(22):4851-4867.e20
Int J Tryptophan Res, 2022, 15:11786469221138456
E0090 GNF-PF-3777 GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2, 3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
S8919 LY-3381916 LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. LY-3381916 exhibits anti-tumor activity.
S9137 Erianin Erianin, a natural product derived from Dendrobium chrysotoxum, has been used as an analgesic in traditional Chinese medicine and is a potential anti-tumor agent. Erianin can inhibit IDO-induced tumor angiogenesis.
S5249 Coptisine chloride Coptisine (Q-100696, NSC-119754) is an isoquinoline alkaloid isolated from Coptidis Rhizoma with anti-diabetic, antimicrobial, antiviral, anti-hepatoma, and anti-leukemia effects. Coptisine chloride is an efficient uncompetitive IDO inhibitor with IC50 value of 6.3 μM and Ki value of 5.8 μM.
S6728 IDO-IN-1 IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.

IDO/TDO阻害剤の選択性比較

Tags: IDO/TDO inhibitor|IDO/TDO agonist|IDO/TDO activator|IDO/TDO inducer|IDO/TDO antagonist|IDO/TDO signaling pathway|IDO/TDO assay kit