IRE1
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S7272 | 4μ8C | <1 mg/mL | 19 mg/mL | <1 mg/mL |
| S7771 | STF-083010 | <1 mg/mL | 63 mg/mL | <1 mg/mL |
| S8286 | MKC-3946 | <1 mg/mL | 38 mg/mL | 3 mg/mL |
| S8658 | kira6 | <1 mg/mL | 60 mg/mL | 60 mg/mL |
IRE1製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S7272 |
4μ8C4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. |
H Representative immunofluorescence staining of TUNEL. Scale bars, 100 µm. I Representative images of DHE staining. Scale bars, 100 µm. Data are mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001 by unpaired Student's t-test.
|
|
| S7771 |
STF-083010STF-083010 is a specific IRE1α endonuclease inhibitor without affecting its kinase activity. |
Pretreatment with 50 μg STF-083010 could inhibit the up-regulation of XBP1s and XBP1u induced by chronic morphine treatment measured by western blots. (∗∗p < 0.01, ∗∗∗p < 0.001 compared with NS + vehicle group; #p < 0.05, ##p < 0.01 compared with morphine + vehicle group, n = 4 in each group). %MPE, percentage of maximal possible antinociceptive effect; NS, normal saline; STF, STF-083010; XBP1, X-box binding protein 1; XBP1s, spliced variant of XBP1; XBP1u, unspliced XBP1.
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| S8286 |
MKC-3946MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells. |
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| S8658 |
kira6kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S7272 |
4μ8C4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. |
H Representative immunofluorescence staining of TUNEL. Scale bars, 100 µm. I Representative images of DHE staining. Scale bars, 100 µm. Data are mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001 by unpaired Student's t-test.
|
|
| S7771 |
STF-083010STF-083010 is a specific IRE1α endonuclease inhibitor without affecting its kinase activity. |
Pretreatment with 50 μg STF-083010 could inhibit the up-regulation of XBP1s and XBP1u induced by chronic morphine treatment measured by western blots. (∗∗p < 0.01, ∗∗∗p < 0.001 compared with NS + vehicle group; #p < 0.05, ##p < 0.01 compared with morphine + vehicle group, n = 4 in each group). %MPE, percentage of maximal possible antinociceptive effect; NS, normal saline; STF, STF-083010; XBP1, X-box binding protein 1; XBP1s, spliced variant of XBP1; XBP1u, unspliced XBP1.
|
|
| S8286 |
MKC-3946MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells. |
||
| S8658 |
kira6kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization. |
