IRE1

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1042 Sunitinib Malate <1 mg/mL 15 mg/mL ''<1 mg/mL
S7272 4μ8C <1 mg/mL 19 mg/mL <1 mg/mL
S6623 APY29 <1 mg/mL 32 mg/mL <1 mg/mL
S6495 6-Bromo-2-hydroxy-3-methoxybenzaldehyde <1 mg/mL 46 mg/mL 12 mg/mL
S7781 Sunitinib <1 mg/mL 25 mg/mL '''<1 mg/mL
S8875 MKC8866 ˂1 mg/mL 3 mg/mL '˂1 mg/mL
S7771 STF-083010 <1 mg/mL 63 mg/mL <1 mg/mL
S8286 MKC-3946 <1 mg/mL 38 mg/mL 3 mg/mL
S8658 kira6 <1 mg/mL 60 mg/mL 60 mg/mL

IRE1製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1042

Sunitinib Malate

Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

S7272

4μ8C

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.

S6623

APY29

APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM).

S6495

6-Bromo-2-hydroxy-3-methoxybenzaldehyde

6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine.

S7781

Sunitinib

Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.

S8875

MKC8866

MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29 μM for human IRE1α in vitro.

S7771

STF-083010

STF-083010 is a specific IRE1α endonuclease inhibitor without affecting its kinase activity.

S8286

MKC-3946

MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.

S8658

kira6

kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1042

Sunitinib Malate

Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

S7272

4μ8C

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.

S6623

APY29

APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM).

S6495

6-Bromo-2-hydroxy-3-methoxybenzaldehyde

6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine.

S7781

Sunitinib

Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.

S8875

MKC8866

MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29 μM for human IRE1α in vitro.

S7771

STF-083010

STF-083010 is a specific IRE1α endonuclease inhibitor without affecting its kinase activity.

S8286

MKC-3946

MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.

S8658

kira6

kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization.

Tags: IRE1 inhibitor | IRE1 modulator | IRE1 stress