PD-1/PD-L1

亜型選択性的な製品

PD-1/PD-L1製品

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  • PD-1/PD-L1阻害剤 (14)
  • PD-1/PD-L1抗体(6)
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A2002 Nivolumab (anti-PD-1) Nivolumab is a genetically engineered, fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1,PCD-1) with immune checkpoint inhibitory and antineoplastic activities. MW : 143.597 KD.
Cell Rep Med, 2024, 5(2):101416
J Immunother Cancer, 2024, 12(1)e008368
Transl Oncol, 2024,
A2004 Atezolizumab (anti-PD-L1) Atezolizumab is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD.
Int Immunopharmacol, 2024,
Research Square, 2024, 10.21203/rs.3.rs-3782509/v1
J Extracell Vesicles, 2023, 12(11):e12379
A2005 Pembrolizumab (anti-PD-1) Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.
Nat Med, 2024, 10.1038/s41591-024-02824-y
Cell Mol Immunol, 2024, 21(1):60-79
BMC Cancer, 2024,
S7912 BMS202 BMS202 is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.
Phytomedicine, 2024, 125:155370
Comput Struct Biotechnol J, 2023, 21:3355-3368
Int J Mol Sci, 2023, 24(6)5535
A2013 Durvalumab (anti-PD-L1) Durvalumab is a selective, high affinity human IgG1 mAb that blocks programmed cell death ligand-1 (PD-L1) binding to PD-1 (IC50=0.1 nM) and CD80 (IC50=0.04 nM). MW=146.3 kDa.
Heliyon, 2023, 9(6):e15782
Heliyon, 2023, 9(6):e15782.
Cancer Discov, 2022, 12(6):1482-1499
S7911 BMS-1 BMS-1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.
Int. J. Mol. Sci, 2023, 24(4)
Int J Mol Sci, 2023, 24(4)3971
Int J Mol Sci, 2023, 24(4)3971
S8158 PD-1/PD-L1 Inhibitor 3 PD-1/PD-L1 Inhibitor 3(Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3)is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM
Pharmaceuticals (Basel), 2023, 16(7)1051
Biochem Pharmacol, 2022, 197:114940
Biochem Pharmacol, 2022, 197:114940
S8275 Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
PLoS Biol, 2023, 21(8):e3002227
Hum Exp Toxicol, 2023, 42:9603271231158047
JCI Insight, 2022, 7(22e158060)
S8859 BMS-1166 BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM.
Life Sci Alliance, 2024, 10.26508/lsa.202302461
Int J Biol Sci, 2023, 19(14):4627-4643
Int J Biol Sci, 2023, 19(14):4627-4643
S8549 AUNP-12 AUNP-12 (Aur-012, Aurigene-012, Aurigene NP-12), a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.
Carcinogenesis, 2022, bgac043
Molecules, 2019, 24(15)
S0094 SR 0987 SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.
Evid Based Complement Alternat Med, 2022, 2022:8315503
A2017 Spartalizumab (anti-PD-1) Spartalizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. It binds to PD-1 with high affinity and inhibits the biological activity of PD-1, MW: 145.8 KD.
Elife, 2020, 9
E1322New GS-4224 GS-4224 (Evixapodlin, PD-1/PD-L1-IN 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. It enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. It exhibits anticancer and antiviral functions.
S8473New CA-170 (AUPM-170) CA-170 (AUPM-170, PD-1-IN-1 ) is potent and orally available inhibitor of the immune checkpoint regulatory proteins PD-L1 (programmed cell death ligand-1) and VISTA (V-domain immunoglobulin (Ig) suppressor of T-cell activation). CA-170 exhibits anti-tumor efficacy.
A2122New Anti-mouse PD-1 (CD279)-InVivo Anti-mouse PD-1 (CD279)-InVivo (Clone:RMP1-14)reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily.
S9610 BMS-1001 BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.
A2035 Sintilimab (anti-PD-1) Sintilimab (anti-PD-1, IBI 308) is a fully human IgG4 monoclonal antibody that binds to PD-1 on the surface of T-cells, blocks the PD-1/PD-Ligand 1 (PD-L1) pathway, and reactivates T-cells to kill cancer cells.
S9863 INCB086550 INCB086550 (PD-1/PD-L1-IN-8) is a potent PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM. INCB086550 binds to PD-L1 and interrupts its interaction with PD-1 and also induces PD-L1 dimerization and internalization.
A2775New Adebrelimab (Anti-B7-H1 / PD-L1 / CD274) Adebrelimab (Anti-B7-H1 / PD-L1 / CD274) is a humanized immunoglobulin G4 (IgG4) monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1, cluster of differentiation 274, CD274) with promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC). MW: 145.8 kD.
A2016 Camrelizumab (anti-PD-1) Camrelizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1 with immune checkpoint inhibitory and antineoplastic activities, MW: 146.3 KD.
A2122New Anti-mouse PD-1 (CD279)-InVivo Anti-mouse PD-1 (CD279)-InVivo (Clone:RMP1-14)reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily.
A2035 Sintilimab (anti-PD-1) Sintilimab (anti-PD-1, IBI 308) is a fully human IgG4 monoclonal antibody that binds to PD-1 on the surface of T-cells, blocks the PD-1/PD-Ligand 1 (PD-L1) pathway, and reactivates T-cells to kill cancer cells.
A2775New Adebrelimab (Anti-B7-H1 / PD-L1 / CD274) Adebrelimab (Anti-B7-H1 / PD-L1 / CD274) is a humanized immunoglobulin G4 (IgG4) monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1, cluster of differentiation 274, CD274) with promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC). MW: 145.8 kD.
S7912 BMS202 BMS202 is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.
Phytomedicine, 2024, 125:155370
Comput Struct Biotechnol J, 2023, 21:3355-3368
Int J Mol Sci, 2023, 24(6)5535
S7911 BMS-1 BMS-1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.
Int. J. Mol. Sci, 2023, 24(4)
Int J Mol Sci, 2023, 24(4)3971
Int J Mol Sci, 2023, 24(4)3971
S8158 PD-1/PD-L1 Inhibitor 3 PD-1/PD-L1 Inhibitor 3(Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3)is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM
Pharmaceuticals (Basel), 2023, 16(7)1051
Biochem Pharmacol, 2022, 197:114940
Biochem Pharmacol, 2022, 197:114940
S8275 Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
PLoS Biol, 2023, 21(8):e3002227
Hum Exp Toxicol, 2023, 42:9603271231158047
JCI Insight, 2022, 7(22e158060)
S8859 BMS-1166 BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM.
Life Sci Alliance, 2024, 10.26508/lsa.202302461
Int J Biol Sci, 2023, 19(14):4627-4643
Int J Biol Sci, 2023, 19(14):4627-4643
S8549 AUNP-12 AUNP-12 (Aur-012, Aurigene-012, Aurigene NP-12), a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.
Carcinogenesis, 2022, bgac043
Molecules, 2019, 24(15)
S0094 SR 0987 SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.
Evid Based Complement Alternat Med, 2022, 2022:8315503
E1322New GS-4224 GS-4224 (Evixapodlin, PD-1/PD-L1-IN 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. It enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. It exhibits anticancer and antiviral functions.
S8473New CA-170 (AUPM-170) CA-170 (AUPM-170, PD-1-IN-1 ) is potent and orally available inhibitor of the immune checkpoint regulatory proteins PD-L1 (programmed cell death ligand-1) and VISTA (V-domain immunoglobulin (Ig) suppressor of T-cell activation). CA-170 exhibits anti-tumor efficacy.
S9610 BMS-1001 BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.
S9863 INCB086550 INCB086550 (PD-1/PD-L1-IN-8) is a potent PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM. INCB086550 binds to PD-L1 and interrupts its interaction with PD-1 and also induces PD-L1 dimerization and internalization.
A2002 Nivolumab (anti-PD-1) Nivolumab is a genetically engineered, fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1,PCD-1) with immune checkpoint inhibitory and antineoplastic activities. MW : 143.597 KD.
Cell Rep Med, 2024, 5(2):101416
J Immunother Cancer, 2024, 12(1)e008368
Transl Oncol, 2024,
A2004 Atezolizumab (anti-PD-L1) Atezolizumab is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD.
Int Immunopharmacol, 2024,
Research Square, 2024, 10.21203/rs.3.rs-3782509/v1
J Extracell Vesicles, 2023, 12(11):e12379
A2005 Pembrolizumab (anti-PD-1) Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.
Nat Med, 2024, 10.1038/s41591-024-02824-y
Cell Mol Immunol, 2024, 21(1):60-79
BMC Cancer, 2024,
A2013 Durvalumab (anti-PD-L1) Durvalumab is a selective, high affinity human IgG1 mAb that blocks programmed cell death ligand-1 (PD-L1) binding to PD-1 (IC50=0.1 nM) and CD80 (IC50=0.04 nM). MW=146.3 kDa.
Heliyon, 2023, 9(6):e15782
Heliyon, 2023, 9(6):e15782.
Cancer Discov, 2022, 12(6):1482-1499
A2017 Spartalizumab (anti-PD-1) Spartalizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. It binds to PD-1 with high affinity and inhibits the biological activity of PD-1, MW: 145.8 KD.
Elife, 2020, 9
A2016 Camrelizumab (anti-PD-1) Camrelizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1 with immune checkpoint inhibitory and antineoplastic activities, MW: 146.3 KD.
E1322New GS-4224 GS-4224 (Evixapodlin, PD-1/PD-L1-IN 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. It enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. It exhibits anticancer and antiviral functions.
S8473New CA-170 (AUPM-170) CA-170 (AUPM-170, PD-1-IN-1 ) is potent and orally available inhibitor of the immune checkpoint regulatory proteins PD-L1 (programmed cell death ligand-1) and VISTA (V-domain immunoglobulin (Ig) suppressor of T-cell activation). CA-170 exhibits anti-tumor efficacy.
A2122New Anti-mouse PD-1 (CD279)-InVivo Anti-mouse PD-1 (CD279)-InVivo (Clone:RMP1-14)reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily.
A2775New Adebrelimab (Anti-B7-H1 / PD-L1 / CD274) Adebrelimab (Anti-B7-H1 / PD-L1 / CD274) is a humanized immunoglobulin G4 (IgG4) monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1, cluster of differentiation 274, CD274) with promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC). MW: 145.8 kD.

PD-1/PD-L1阻害剤の選択性比較

Tags: PD-1/PD-L1 inhibition | PD-1/PD-L1 cancer | PD-1/PD-L1 signaling pathway | PD-1/PD-L1 assay | PD-1/PD-L1 inhibitor cancer | PD-1/PD-L1 inhibitor review